| Tbio | Probable leucine--tRNA ligase, mitochondrial |
This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| HYDROPS, LACTIC ACIDOSIS, AND SIDEROBLASTIC ANEMIA | 1 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 3.1e-06 |
| osteosarcoma | 7950 | 2.3e-05 |
| psoriasis | 6694 | 8.0e-04 |
| tuberculosis and treatment for 3 months | 179 | 4.0e-03 |
| lung cancer | 4740 | 4.4e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Perrault syndrome | 19 | 6.639 | 3.3 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Premature ovarian failure | 65 | 4.005 | 2.0 |
| Mitochondrial myopathy | 26 | 3.871 | 1.9 |
| Sleeping sickness | 37 | 3.289 | 1.6 |
| Sensorineural hearing loss | 106 | 3.153 | 1.6 |
| Lactic acidosis | 51 | 3.122 | 1.6 |
| Disease | Target Count |
|---|---|
| PERRAULT SYNDROME 4 | 1 |
| Disease | log2 FC | p |
|---|---|---|
| lung cancer | 1.100 | 4.4e-03 |
| osteosarcoma | -1.991 | 2.3e-05 |
| ovarian cancer | 1.800 | 3.1e-06 |
| psoriasis | 1.200 | 8.0e-04 |
| tuberculosis and treatment for 3 months | -1.100 | 4.0e-03 |
| Accession | Q15031 |
| Symbols |
HLASA LEURS PRLTS4 mtLeuRS |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid EggNOG |
MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQ 1 - 70 ASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAV 71 - 140 ERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPV 141 - 210 DQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCH 211 - 280 LDFTLKVHGQATGEKLTAYTATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNM 281 - 350 LTQQEVPVVILAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQ 351 - 420 DAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVTLPNIASFTGK 421 - 490 GGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPHSPFNTAVADYWMPVDLYIGG 491 - 560 KEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLPSGQYLQREEVDLTGSVPVHAKTK 561 - 630 EKLEVTWEKMSKSKHNGVDPEEVVEQYGIDTIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTT 631 - 700 RFIEARASGKSPQPQLLSNKEKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSV 701 - 770 ILHSPEFEDALCALMVMAAPLAPHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEVVQ 771 - 840 MAVLINNKACGKIPVPQQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALINFLVQD 841 - 903 //
