| Tbio | La-related protein 4 |
RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744).
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Polycystic ovary syndrome | 360 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| breast carcinoma | 1638 | 1.7e-19 |
| osteosarcoma | 7950 | 2.5e-07 |
| hepatocellular carcinoma | 547 | 2.3e-06 |
| medulloblastoma, large-cell | 6241 | 6.9e-06 |
| atypical teratoid / rhabdoid tumor | 5112 | 9.5e-06 |
| glioblastoma | 5792 | 3.8e-05 |
| primitive neuroectodermal tumor | 3035 | 4.2e-04 |
| ependymoma | 4679 | 4.6e-04 |
| ovarian cancer | 8520 | 4.9e-04 |
| ductal carcinoma in situ | 1745 | 5.6e-04 |
| pancreatic cancer | 2398 | 1.4e-03 |
| pancreatic carcinoma | 562 | 1.4e-03 |
| invasive ductal carcinoma | 2951 | 1.6e-03 |
| hereditary spastic paraplegia | 318 | 3.5e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 5.6e-03 |
| group 4 medulloblastoma | 1855 | 6.3e-03 |
| adult high grade glioma | 3801 | 7.3e-03 |
| active Crohn's disease | 922 | 2.0e-02 |
| progressive supranuclear palsy | 676 | 2.3e-02 |
| lung cancer | 4740 | 3.7e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 4.9e-02 |
| Disease | log2 FC | p |
|---|---|---|
| active Crohn's disease | 1.201 | 2.0e-02 |
| adult high grade glioma | 1.100 | 7.3e-03 |
| atypical teratoid / rhabdoid tumor | 1.700 | 9.5e-06 |
| breast carcinoma | 1.100 | 1.7e-19 |
| ductal carcinoma in situ | 1.200 | 5.6e-04 |
| ependymoma | 1.100 | 4.6e-04 |
| glioblastoma | 1.400 | 3.8e-05 |
| group 4 medulloblastoma | 1.100 | 6.3e-03 |
| hepatocellular carcinoma | 1.100 | 2.3e-06 |
| hereditary spastic paraplegia | -1.222 | 3.5e-03 |
| intraductal papillary-mucinous neoplasm ... | 1.200 | 4.9e-02 |
| invasive ductal carcinoma | 1.100 | 1.6e-03 |
| lung cancer | 1.100 | 3.7e-02 |
| medulloblastoma, large-cell | 2.000 | 6.9e-06 |
| osteosarcoma | 2.155 | 2.5e-07 |
| ovarian cancer | -1.100 | 4.9e-04 |
| pancreatic cancer | 1.200 | 1.4e-03 |
| pancreatic carcinoma | 1.200 | 1.4e-03 |
| pancreatic ductal adenocarcinoma liver m... | -1.168 | 5.6e-03 |
| primitive neuroectodermal tumor | 1.200 | 4.2e-04 |
| progressive supranuclear palsy | -1.100 | 2.3e-02 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MLLFVEQVASKGTGLNPNAKVWQEIAPGNTDATPVTHGTESSWHEIAATSGAHPEGNAELSEDICKEYEV 1 - 70 MYSSSCETTRNTTGIEESTDGMILGPEDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRENLSKDL 71 - 140 YLISQMDSDQFIPIWTVANMEEIKKLTTDPDLILEVLRSSPMVQVDEKGEKVRPSHKRCIVILREIPETT 141 - 210 PIEEVKGLFKSENCPKVISCEFAHNSNWYITFQSDTDAQQAFKYLREEVKTFQGKPIMARIKAINTFFAK 211 - 280 NGYRLMDSSIYSHPIQTQAQYASPVFMQPVYNPHQQYSVYSIVPQSWSPNPTPYFETPLAPFPNGSFVNG 281 - 350 FNSPGSYKTNAAAMNMGRPFQKNRVKPQFRSSGGSEHSTEGSVSLGDGQLNRYSSRNFPAERHNPTVTGH 351 - 420 QEQTYLQKETSTLQVEQNGDYGRGRRTLFRGRRRREDDRISRPHPSTAESKAPTPKFDLLASNFPPLPGS 421 - 490 SSRMPGELVLENRMSDVVKGVYKEKDNEELTISCPVPADEQTECTSAQQLNMSTSSPCAAELTALSTTQQ 491 - 560 EKDLIEDSSVQKDGLNQTTIPVSPPSTTKPSRASTASPCNNNINAATAVALQEPRKLSYAEVCQKPPKEP 561 - 630 SSVLVQPLRELRSNVVSPTKNEDNGAPENSVEKPHEKPEARASKDYSGFRGNIIPRGAAGKIREQRRQFS 631 - 700 HRAIPQGVTRRNGKEQYVPPRSPK 701 - 724 //
