Tbio LAPTM4B Lysosomal-associated transmembrane protein 4B

Protein Summary

Description

Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656).

Uniprot Accession IDs

• Q86VI4
• Q3ZCV5
• Q7L909
• Q86VH8
• Q9H060

Gene Name

• LAPTM4B

Ensembl ID

• ENST00000445593
• ENSP00000402301
• ENSG00000104341
• ENST00000521545
• ENSP00000428409
• ENST00000619747
• ENSP00000482533

Symbol

• LC27
• LAPTM4beta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	0.96
transcription factor perturbation	0.96
PubMedID	0.86
gene perturbation	0.85

Protein Classes

PANTHER Classes

Protein / Transporter / Lysosomal-associated Transmembrane Protein 4b

DTO Classes

Protein / Transporter / Lysosomal-associated Transmembrane Protein 4b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.55   (req: < 5)

Gene RIFs: 81   (req: <= 3)

Antibodies: 137   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.55   (req: >= 5)

Gene RIFs: 81   (req: > 3)

Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0