Property Summary

NCBI Gene PubMed Count 6
PubMed Score 0.57
PubTator Score 0.54

Knowledge Summary


No data available


  Disease (1)

Disease Target Count P-value
psoriasis 6685 2.5e-38
osteosarcoma 7933 1.4e-08
ovarian cancer 8491 9.6e-07


  Differential Expression (3)

Disease log2 FC p
osteosarcoma -2.654 1.4e-08
ovarian cancer 2.200 9.6e-07
psoriasis -1.200 2.5e-38


Accession Q0VGL1
Symbols C7orf59


  Ortholog (1)

Species Source Disease
Macaque OMA EggNOG

Protein-protein Interaction (3)

Gene RIF (1)

22980980 Study identified HBXIP and C7orf59 as two additional Ragulator components that are required for mTORC1 activation by amino acids.

AA Sequence

GEHTLLVTVSGQRVFVVKRQNRGREPIDV                                              71 - 99

Text Mined References (13)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25567906 2015 Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
25561175 2015 SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
25416956 2014 A proteome-scale map of the human interactome network.
23414517 2013 A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22980980 2012 Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
21269460 2011 Initial characterization of the human central proteome.
19413330 2009 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
17562024 2007 Large-scale identification of human genes implicated in epidermal barrier function.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.