| Tbio | Laminin subunit beta-3 |
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Amelogenesis imperfecta local hypoplastic form | 1 | 0.0 | 0.0 |
| Epidermolysis Bullosa, Junctional | 4 | 0.0 | 0.0 |
| Epidermolysis Bullosa, Junctional, Non-Herlitz Type | 5 | 0.0 | 0.0 |
| Wounds and Injuries | 18 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 2.9e-19 |
| Breast cancer | 3578 | 5.5e-16 |
| pancreatic cancer | 2398 | 9.7e-10 |
| malignant mesothelioma | 3232 | 2.7e-09 |
| non-small cell lung cancer | 2890 | 8.7e-09 |
| tuberculosis | 2010 | 4.3e-07 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 6.4e-05 |
| breast carcinoma | 1638 | 7.1e-05 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 3.8e-04 |
| lung cancer | 4740 | 2.6e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.9e-03 |
| interstitial cystitis | 2312 | 9.6e-03 |
| invasive ductal carcinoma | 2951 | 1.2e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 3.6e-02 |
| esophageal adenocarcinoma | 737 | 3.9e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Epidermolysis bullosa | 21 | 7.223 | 3.6 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Dilated cardiomyopathy 1D | 3 | 3.696 | 1.8 |
| Age related macular degeneration 1 | 4 | 3.639 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| Breast cancer | -2.700 | 5.5e-16 |
| breast carcinoma | -1.900 | 7.1e-05 |
| esophageal adenocarcinoma | 1.300 | 3.9e-02 |
| interstitial cystitis | -1.700 | 9.6e-03 |
| intraductal papillary-mucinous adenoma (... | 3.900 | 6.4e-05 |
| intraductal papillary-mucinous carcinoma... | 3.400 | 3.8e-04 |
| intraductal papillary-mucinous neoplasm ... | 3.700 | 2.9e-03 |
| invasive ductal carcinoma | -1.300 | 1.2e-02 |
| lung cancer | -1.300 | 2.6e-03 |
| lung carcinoma | -1.900 | 2.9e-19 |
| malignant mesothelioma | -4.200 | 2.7e-09 |
| non-small cell lung cancer | 1.537 | 8.7e-09 |
| pancreatic cancer | 2.600 | 9.7e-10 |
| pancreatic ductal adenocarcinoma liver m... | 1.696 | 3.6e-02 |
| tuberculosis | -3.500 | 4.3e-07 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYGEWQMKCCKCD 1 - 70 SRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVMMEFQGPMPAGMLIERSSDFG 71 - 140 KTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRPNARLNGGKVQLNLMDLVSGIPATQSQKIQE 141 - 210 VGEITNLRVNFTRLAPVPQRGYHPPSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCV 211 - 280 CQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHT 281 - 350 EGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL 351 - 420 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLS 421 - 490 PQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLT 491 - 560 GPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFGRLRNATASLWSGPGLEDRGLASRILDAKSK 561 - 630 IEQIRAVLSSPAVTEQEVAQVASAILSLRRTLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKR 631 - 700 EQFEKISSADPSGAFRMLSTAYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVAL 701 - 770 RLEMSSLPDLTPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR 771 - 840 GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLTDPDTDAATIQ 841 - 910 EVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARARRLQAEAEEARSRAHAVEGQV 911 - 980 EDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQVLRPAEKLVTSMTKQLGDFWTRMEELRHQA 981 - 1050 RQQGAEAVQAQQLAEGASEQALSAQEGFERIKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETM 1051 - 1120 EMMDRMKDMELELLRGSQAIMLRSADLTGLEKRVEQIRDHINGRVLYYATCK 1121 - 1172 //
