| Tbio | Lymphocyte activation gene 3 protein |
Involved in lymphocyte activation. Binds to HLA class-II antigens.
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 3.0e-48 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.8e-06 |
| medulloblastoma | 720 | 7.0e-06 |
| medulloblastoma, large-cell | 6241 | 9.2e-04 |
| cutaneous lupus erythematosus | 1057 | 1.6e-03 |
| Common variable immunodeficiency | 101 | 3.8e-03 |
| osteosarcoma | 7950 | 4.1e-03 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 1.200 | 1.8e-06 |
| Common variable immunodeficiency | 1.185 | 3.8e-03 |
| cutaneous lupus erythematosus | 2.000 | 1.6e-03 |
| medulloblastoma | 1.100 | 7.0e-06 |
| medulloblastoma, large-cell | 1.200 | 9.2e-04 |
| osteosarcoma | -1.195 | 4.1e-03 |
| psoriasis | 1.700 | 3.0e-48 |
MWEAQFLGLLFLQPLWVAPVKPLQPGAEVPVVWAQEGAPAQLPCSPTIPLQDLSLLRRAGVTWQHQPDSG 1 - 70 PPAAAPGHPLAPGPHPAAPSSWGPRPRRYTVLSVGPGGLRSGRLPLQPRVQLDERGRQRGDFSLWLRPAR 71 - 140 RADAGEYRAAVHLRDRALSCRLRLRLGQASMTASPPGSLRASDWVILNCSFSRPDRPASVHWFRNRGQGR 141 - 210 VPVRESPHHHLAESFLFLPQVSPMDSGPWGCILTYRDGFNVSIMYNLTVLGLEPPTPLTVYAGAGSRVGL 211 - 280 PCRLPAGVGTRSFLTAKWTPPGGGPDLLVTGDNGDFTLRLEDVSQAQAGTYTCHIHLQEQQLNATVTLAI 281 - 350 ITVTPKSFGSPGSLGKLLCEVTPVSGQERFVWSSLDTPSQRSFSGPWLEAQEAQLLSQPWQCQLYQGERL 351 - 420 LGAAVYFTELSSPGAQRSGRAPGALPAGHLLLFLILGVLSLLLLVTGAFGFHLWRRQWRPRRFSALEQGI 421 - 490 HPPQAQSKIEELEQEPEPEPEPEPEPEPEPEPEQL 491 - 525 //
