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Tchem Kynureninase

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.

Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

 Comments

Property Summary

Ligand Count 3
NCBI Gene PubMed Count 19
PubMed Score 39.18
PubTator Score 21.30

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.8
Disease Target Count Z-score Confidence
Pellagra 26 4.445 2.2

Expression

  Differential Expression (27)

Disease log2 FC p
active Crohn's disease 4.853 3.6e-03
active ulcerative colitis 1.367 3.8e-03
adrenocortical carcinoma -1.621 5.3e-03
adult high grade glioma 1.200 1.4e-02
Astrocytoma, Pilocytic 1.800 2.5e-07
Atopic dermatitis 1.900 3.8e-04
breast carcinoma 1.100 2.4e-07
chronic rhinosinusitis 1.916 2.1e-02
cutaneous lupus erythematosus 2.200 4.8e-03
cystic fibrosis 1.879 1.1e-04
ductal carcinoma in situ 1.200 3.2e-02
glioblastoma 1.300 1.8e-03
intraductal papillary-mucinous adenoma (... 2.000 8.0e-03
intraductal papillary-mucinous neoplasm ... 1.300 2.9e-03
invasive ductal carcinoma 1.300 2.1e-02
lung cancer -1.900 3.9e-03
lung carcinoma -3.200 2.2e-28
malignant mesothelioma -6.700 8.0e-10
mucosa-associated lymphoid tissue lympho... 1.871 2.1e-02
ovarian cancer -1.700 2.0e-03
pancreatic cancer 1.300 2.6e-04
pancreatic ductal adenocarcinoma liver m... -1.249 3.1e-02
posterior fossa group A ependymoma 1.300 2.2e-04
primary Sjogren syndrome 1.800 1.5e-03
psoriasis 2.200 1.5e-12
tuberculosis -1.500 7.4e-06
Waldenstrons macroglobulinemia -1.538 4.6e-02

Synonym

Accession Q16719 B2RCZ5 D3DP79 Q6I9T2 Q9BVW3
Symbols KYNUU
VCRL2

Gene

KYNU

PANTHER Protein Class (1)

  Ortholog (14)

Species Source Disease
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA
OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (11)

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 GO Function (3)

 GO Component (2)

 GO Process (9)

 Compartment GO Term (25)

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 GWAS Trait (2)

 HCA RNA Cell Line (56)

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Pathway (17)

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PDB (2)

Ligand (3)

Structure of CHEMBL120534

CHEMBL120534
pKi 7.00

Structure of CHEMBL280572

CHEMBL280572
pKi 7.16

Structure of CHEMBL88626

CHEMBL88626
pKi 7.16

Gene RIF (7)

AA Sequence 

MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLSLVNKDENAIY      1 - 70
FLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLMKDIVGANEKEIALMNALTVN     71 - 140
LHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLRIEDILEVIEK    141 - 210
EGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNA    211 - 280
GAGGIAGAFIHEKHAHTIKPALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFK    281 - 350
QATMKALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEK    351 - 420
RGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN                             421 - 465
//

Text Mined References (26)

PMID Year Title