Protein Summary
Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012]
- ENST00000395308
- ENSP00000378719
- ENSG00000126777
- ENST00000395309
- ENSP00000378720
- ENST00000395311
- ENSP00000378722
- ENST00000395314
- ENSP00000378725
- ENST00000413890
- ENSP00000394992
- ENST00000438792
- ENSP00000391964
- ENST00000459737
- ENSP00000432149
- CG1
- KIAA0004
- CG1
- KNT
- MU-RMS-40.19
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 1 | ||
interacting protein | 0.91 | ||
transcription factor perturbation | 0.91 | ||
ligand (protein) perturbation | 0.83 | ||
cell type or tissue | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.1 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 168 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.1 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 168 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0