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Tbio
KSR1
Kinase suppressor of Ras 1

Protein Summary
Description
Scaffolding protein that is part of a multiprotein signaling complex. Promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Does not have kinase activity by itself.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398988
  • ENSP00000381958
  • ENSG00000141068
  • ENST00000509603
  • ENSP00000438795

Symbol
  • KSR
  • KSR
  • RSU2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
molecular function
0.99
protein complex
0.99
hub protein
0.88
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.01   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 385   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.01   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 385   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0