Property Summary

NCBI Gene PubMed Count 20
PubMed Score 14.34
PubTator Score 14.97

Knowledge Summary


No data available


  Differential Expression (12)

Disease log2 FC p
Rheumatoid Arthritis 1.300 2.8e-02
osteosarcoma -1.384 1.1e-02
ependymoma 1.200 7.4e-06
medulloblastoma, large-cell 1.200 1.0e-02
adrenocortical carcinoma -1.106 4.0e-03
primary pancreatic ductal adenocarcinoma -1.036 4.9e-03
non-small cell lung cancer 1.564 4.0e-11
psoriasis 1.900 1.1e-10
spina bifida -1.372 4.1e-02
mucosa-associated lymphoid tissue lympho... 1.839 1.2e-02
ovarian cancer 1.400 2.7e-03
axial spondyloarthropathy 1.200 1.5e-02

Gene RIF (11)

26206087 Kremen1 has a pro-apoptotic activity that is decreased upon Dkk1 binding or by cancer mutations.
23041840 Six Dkk-1, three Sost, one Kremen-1 and 10 LRP-5 polymorphisms were significantly associated with radiological progression of rheumatoid arthritis joint destruction.
20935629 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20846389 The mRNA expression levels of DKK-1 binding receptor LRP5/6 and Krm1/2 in SCs from patients with MM were significantly higher than those in myeloma cells and in SCs from healthy donors.
20634891 Observational study of gene-disease association. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20153141 This study demonstrated that a representative tSNP of KREMEN1 might modulate the risk of schizophrenia in the Japanese population.
20153141 Observational study of gene-disease association. (HuGE Navigator)
19453261 Observational study of gene-disease association. (HuGE Navigator)
18502762 Kremen may not be essential for Dkk1-mediated Wnt antagonism and Kremen may only play a role when cells express a high level of LRP5/6
12050670 Functional characterization of related Kremen proteins in mouse.

AA Sequence


Text Mined References (20)

PMID Year Title
26206087 2016 Kremen1 and Dickkopf1 control cell survival in a Wnt-independent manner.
25086665 2014 Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
23041840 2013 Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis.
20935629 2010 Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
20846389 2010 Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma.
20634891 2010 Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
20153141 2010 Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population.
19453261 2009 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
18538647 2008 Genetic analysis and effect of triiodothyronine and prednisone trial on bone turnover in a patient with craniotubular hyperostosis.
18502762 2008 Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism.
17804805 2007 R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6.
16751776 2006 A germline-specific class of small RNAs binds mammalian Piwi proteins.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15146197 2004 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12050670 2002 Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.
10737800 2000 Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.
10591208 1999 The DNA sequence of human chromosome 22.