Tbio KLK9 Kallikrein-9

Protein Summary

Description

The protein encoded by this gene is a kallikrein-related serine protease. This gene is activated by steroid hormones in a human breast cancer cell line, making it a good marker for cancer detection. The encoded protein is found primarily in the cytoplasm.[provided by RefSeq, Oct 2010]

Uniprot Accession IDs

• Q9UKQ9
• Q6QA55

Gene Name

• KLK9

Ensembl ID

• ENST00000544410
• ENSP00000443289
• ENSG00000213022
• ENST00000594211
• ENSP00000469417

Symbol

• KLKL3
• KLK-L3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.6
protein domain	0.58
cell line	0.53
transcription factor	0.42
chemical	0.41

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Kallikrein-9

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Kallikrein-9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.73   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 169   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.73   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0