Tbio KLHL21 Kelch-like protein 21

Protein Summary

Description

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.

Uniprot Accession IDs

• Q9UJP4
• B3KQP2
• O75057
• Q5SY26
• Q5SY28
• Q8N4I6
• Q8NF10

Gene Name

• KLHL21

Ensembl ID

• ENST00000377658
• ENSP00000366886
• ENSG00000162413
• ENST00000377663
• ENSP00000366891

Symbol

• KIAA0469

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.97
kinase perturbation	0.96
protein domain	0.92
transcription factor binding site profile	0.89
transcription factor	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.08   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 84   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.08   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0