| Tdark | Kelch domain-containing protein 8B |
Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis (PubMed:20107318). Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells (PubMed:22988245, PubMed:23713010).
This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma. [provided by RefSeq, Sep 2010]
This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma. [provided by RefSeq, Sep 2010]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Leg, Absence Deformity of, with Congenital Cataract | 1 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Hodgkin Disease | 15 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 3.2e-18 |
| pituitary cancer | 1972 | 1.9e-09 |
| breast carcinoma | 1638 | 3.4e-04 |
| osteosarcoma | 7950 | 4.8e-04 |
| invasive ductal carcinoma | 2951 | 6.5e-03 |
| ductal carcinoma in situ | 1745 | 7.3e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hodgkin's lymphoma | 15 | 4.023 | 2.0 |
| Disease | Target Count |
|---|---|
| Lymphoma, Hodgkin, Classic | 1 |
| Disease | log2 FC | p |
|---|---|---|
| breast carcinoma | -1.200 | 3.4e-04 |
| ductal carcinoma in situ | -1.100 | 7.3e-03 |
| invasive ductal carcinoma | -1.400 | 6.5e-03 |
| lung carcinoma | 1.400 | 3.2e-18 |
| osteosarcoma | -1.194 | 4.8e-04 |
| pituitary cancer | 2.100 | 1.9e-09 |
| Accession | Q8IXV7 |
| Symbols |
CHL |
MSAGGGRAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARA 1 - 70 GAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTA 71 - 140 PQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPS 141 - 210 RRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLG 211 - 280 GHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGVAQGPSQAVEALCL 281 - 350 RDGV 351 - 354 //
