KLF8
Krueppel-like factor 8
Protein Summary
Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK). This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
- ENST00000374928
- ENSP00000364063
- ENSG00000102349
- ENST00000468660
- ENSP00000417303
- ENST00000640927
- ENSP00000492126
- BKLF3
- ZNF741
- BKLF3
- ZNF741
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.57 | ||
cell type or tissue | 0.54 | ||
microRNA | 0.53 | ||
biological term | 0.47 | ||
gene perturbation | 0.47 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 79.81 (req: < 5)
Gene RIFs: 46 (req: <= 3)
Antibodies: 211 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 79.81 (req: >= 5)
Gene RIFs: 46 (req: > 3)
Antibodies: 211 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0