Tbio | Kinesin-like protein KIF6 |
This gene encodes a member of a family of molecular motors which are involved in intracellular transport of protein complexes, membrane organelles, and messenger ribonucleic acid along microtubules. Kinesins function as homodimeric molecules with two N-terminal head domains that move along microtubules and two C-terminal tail domains that interact with the transported cargo, either directly or indirectly, through adapter molecules. This gene is ubiquitously expressed in coronary arteries and other vascular tissue. A naturally occurring mutation in this gene is associated with coronary heart disease. [provided by RefSeq, May 2017]
Comments
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Myocardial Infarction | 151 | 0.0 | 0.0 |
Disease | Target Count | P-value |
---|---|---|
ependymoma | 4679 | 5.1e-05 |
medulloblastoma, large-cell | 6241 | 1.3e-04 |
subependymal giant cell astrocytoma | 2287 | 2.5e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Attention deficit hyperactivity disorder | 278 | 0.0 | 1.4 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Coronary artery disease | 268 | 4.341 | 2.2 |
Disease | log2 FC | p |
---|---|---|
ependymoma | 1.400 | 5.1e-05 |
medulloblastoma, large-cell | 1.100 | 1.3e-04 |
subependymal giant cell astrocytoma | -1.010 | 2.5e-02 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG |
MVKQTIQIFARVKPPVRKHQQGIYSIDEDEKLIPSLEIILPRDLADGFVNNKRESYKFKFQRIFDQDANQ 1 - 70 ETVFENIAKPVAGSVLAGYNGTIFAYGQTGSGKTFTITGGAERYSDRGIIPRTLSYIFEQLQKDSSKIYT 71 - 140 THISYLEIYNECGYDLLDPRHEASSLEDLPKVTILEDPDQNIHLKNLTLHQATTEEEALNLLFLGDTNRM 141 - 210 IAETPMNQASTRSHCIFTIHLSSKEPGSATVRHAKLHLVDLAGSERVAKTGVGGHLLTEAKYINLSLHYL 211 - 280 EQVIIALSEKHRSHIPYRNSMMTSVLRDSLGGNCMTTMIATLSLEKRNLDESISTCRFAQRVALIKNEAV 281 - 350 LNEEINPRLVIKRLQKEIQELKDELAMVTGEQRTEALTEAELLQLEKLITSFLEDQDSDSRLEVGADMRK 351 - 420 VHHCFHHLKKLLNDKKILENNTVSSESKDQDCQEPLKEEEYRKLRDILKQRDNEINILVNMLKKEKKKAQ 421 - 490 EALHLAGMDRREFRQSQSPPFRLGNPEEGQRMRLSSAPSQAQDFSILGKRSSLLHKKIGMREEMSLGCQE 491 - 560 AFEIFKRDHADSVTIDDNKQILKQRFSEAKALGESINEARSKIGHLKEEITQRHIQQVALGISENMAVPL 561 - 630 MPDQQEEKLRSQLEEEKRRYKTMFTRLKALKVEIEHLQLLMDKAKVKLQKEFEVWWAEEATNLQVNSPAV 631 - 700 NSLDHTKPFLQTSDSQHEWSQLLSNKSSGGWEVQDQGTGRFDVCDVNARKILPSPCPSPHSQKQSSTSTP 701 - 770 LEDSIPKRPVSSIPLTGDSQTDSDIIAFIKARQSILQKQCLGSN 771 - 814 //