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  4. microtubule family cytoskeletal protein
  5. microtubule binding motor protein
  6. Kinesin-like protein KIF6

Tbio Kinesin-like protein KIF6

This gene encodes a member of a family of molecular motors which are involved in intracellular transport of protein complexes, membrane organelles, and messenger ribonucleic acid along microtubules. Kinesins function as homodimeric molecules with two N-terminal head domains that move along microtubules and two C-terminal tail domains that interact with the transported cargo, either directly or indirectly, through adapter molecules. This gene is ubiquitously expressed in coronary arteries and other vascular tissue. A naturally occurring mutation in this gene is associated with coronary heart disease. [provided by RefSeq, May 2017]

 Comments

Property Summary

NCBI Gene PubMed Count 48
PubMed Score 38.41
PubTator Score 48.29

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Myocardial Infarction 151 0.0 0.0
Disease Target Count P-value
ependymoma 4679 5.1e-05
medulloblastoma, large-cell 6241 1.3e-04
subependymal giant cell astrocytoma 2287 2.5e-02
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 1.1
Large intestine cancer 126 0.0 0.7
Disease Target Count Z-score Confidence
Attention deficit hyperactivity disorder 278 0.0 1.4
Disease Target Count Z-score Confidence
Coronary artery disease 268 4.341 2.2

Expression

  Differential Expression (3)

Disease log2 FC p
ependymoma 1.400 5.1e-05
medulloblastoma, large-cell 1.100 1.3e-04
subependymal giant cell astrocytoma -1.010 2.5e-02

Synonym

Accession Q6ZMV9 Q2MDE3 Q2MDE4 Q5T8J6 Q6ZWE3 Q86T87 Q8WTV4
Symbols C6orf102
dJ137F1.4
dJ188D3.1
dJ1043E3.1

Gene

KIF6

PANTHER Protein Class (3)

  Ortholog (9)

Species Source Disease
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (11)

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 GO Function (4)

 GO Component (4)

 GO Process (1)

 Compartment GO Term (25)

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 GWAS Trait (7)

 HCA RNA Cell Line (55)

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Pathway (8)

Protein-protein Interaction (5)

HEATR5A   SNX16   ACADS   FEZ2   MLLT10  

Gene RIF (40)

AA Sequence 

MVKQTIQIFARVKPPVRKHQQGIYSIDEDEKLIPSLEIILPRDLADGFVNNKRESYKFKFQRIFDQDANQ      1 - 70
ETVFENIAKPVAGSVLAGYNGTIFAYGQTGSGKTFTITGGAERYSDRGIIPRTLSYIFEQLQKDSSKIYT     71 - 140
THISYLEIYNECGYDLLDPRHEASSLEDLPKVTILEDPDQNIHLKNLTLHQATTEEEALNLLFLGDTNRM    141 - 210
IAETPMNQASTRSHCIFTIHLSSKEPGSATVRHAKLHLVDLAGSERVAKTGVGGHLLTEAKYINLSLHYL    211 - 280
EQVIIALSEKHRSHIPYRNSMMTSVLRDSLGGNCMTTMIATLSLEKRNLDESISTCRFAQRVALIKNEAV    281 - 350
LNEEINPRLVIKRLQKEIQELKDELAMVTGEQRTEALTEAELLQLEKLITSFLEDQDSDSRLEVGADMRK    351 - 420
VHHCFHHLKKLLNDKKILENNTVSSESKDQDCQEPLKEEEYRKLRDILKQRDNEINILVNMLKKEKKKAQ    421 - 490
EALHLAGMDRREFRQSQSPPFRLGNPEEGQRMRLSSAPSQAQDFSILGKRSSLLHKKIGMREEMSLGCQE    491 - 560
AFEIFKRDHADSVTIDDNKQILKQRFSEAKALGESINEARSKIGHLKEEITQRHIQQVALGISENMAVPL    561 - 630
MPDQQEEKLRSQLEEEKRRYKTMFTRLKALKVEIEHLQLLMDKAKVKLQKEFEVWWAEEATNLQVNSPAV    631 - 700
NSLDHTKPFLQTSDSQHEWSQLLSNKSSGGWEVQDQGTGRFDVCDVNARKILPSPCPSPHSQKQSSTSTP    701 - 770
LEDSIPKRPVSSIPLTGDSQTDSDIIAFIKARQSILQKQCLGSN                              771 - 814
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Text Mined References (50)

PMID Year Title