Property Summary

NCBI Gene PubMed Count 71
PubMed Score 188.21
PubTator Score 107.52

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (16)

Disease log2 FC p
cutaneous lupus erythematosus 1.200 8.1e-03
psoriasis 1.800 2.8e-04
osteosarcoma 1.975 6.4e-05
astrocytoma -1.100 2.7e-03
atypical teratoid / rhabdoid tumor 1.300 3.3e-05
glioblastoma 1.400 2.4e-04
group 4 medulloblastoma 1.500 7.8e-04
medulloblastoma, large-cell 2.100 1.4e-05
primitive neuroectodermal tumor 1.100 3.3e-04
ulcerative colitis -1.071 5.4e-03
pancreatic ductal adenocarcinoma liver m... 1.603 1.6e-02
intraductal papillary-mucinous carcinoma... 1.100 3.8e-03
progressive supranuclear palsy -1.100 1.2e-02
ovarian cancer 2.500 2.2e-04
Down syndrome 1.100 1.0e-02
dermatomyositis 1.300 3.5e-03

Gene RIF (49)

PMID Text
26991731 Data suggest that light-chain subunits/fragments of kinesin-1 inhibit the pathological aggregation of amyloid(beta).
26627252 differences between the structural kinetics of Eg5 and kinesin-1 yield insights into how these two motors adapt their enzymologies for their distinct functions
26598607 KIF5B is essential for Ostm1 intracellular dispersion.
26268359 data suggest one-step screening platform for KIF5B-RET as well as EGFR, K-RAS, ALK oncogenic mutations be necessary for lung adenocarcinoma patients
25902401 Kinesin-1 is primarily front-head gated, and its neck linker length is tuned to enhance unidirectional processivity and velocity.
25818289 the front head of a kinesin dimer is gated by the backward orientation of its neck linker until the rear head releases from the microtubule
25676575 In this work, we performed normal mode analysis with elastic network model using different conformation of kinesin to determine the effect of tail binding.
25660542 Myo1c significantly increases the frequency of kinesin-1-driven microtubule-based runs that begin at actin/microtubule intersections. The actin-binding protein tropomyosin 2 abolishes Myo1c-specific effects on both run initiation and run termination.
25537000 This study has provided a comprehensive structural and dynamic picture of kinesin's major ATPase states.
25516977 nesprin-dependent recruitment of kinesin-1 to the nuclear envelope through the interaction of a conserved LEWD motif with kinesin light chain might be a general mechanism for cell-type-specific nuclear positioning during development.
25378581 A novel role of KIF5B was shown in the spatial regulation of Cdo-BNIP-2-p38MAPK signaling and discloses a previously unappreciated linkage between the intracellular transporting system and myogenesis regulation.
25348260 Kinesin-14 blocks microtubule nucleation in yeast and reveal that this inhibition is countered by the kinesin-5 protein, Cut7.[Cut7, Pkl1]
25231297 Authors find that pharmacological or small interfering RNA (siRNA)-mediated inhibition of cytoplasmic dynein or the kinesin 1 heavy chain KIF5B delays HIV-1 uncoating.
25231297 HIV-1 uncoating is facilitated by dynein motor function since siRNA knockdown of KIF5B increases the amount of HIV-1 p24 associated with cytoplasmic virions
25047660 Our data suggest that KIF5B-RET promotes the cell growth and tumorigenicity of non-small cell lung cancers through multilevel activation of STAT3 signaling, providing possible strategies for the treatment of KIF5B-RET positive lung cancers.
24821626 Kinesin-1 transports c-MYC for proteasomal degradation in the cytoplasm.
24072715 when cargo is transported by both dynein and phosphorylated kinesin, a common occurrence in the cell, there may be a bias that favors motion toward the minus-end of microtubules.
23884313 Anti-oncogenic miR-203 had a pivotal role in melanoma through reducing melanosome transport and promoting melanogenesis by targeting kif5b and through negative regulation of the CREB1/MITF/Rab27a pathway.
23378251 Patients without KIF5B-RET fusions had a better prognosis than those with KIF5B-RET fusions (median survival, 52.6 months vs 21.0 months).
22514732 Study found the secretion of calu-1/2-EGFP required microtubule integrity, and that calu-1/2-EGFP-containing vesicles were transported by the motor proteins Kif5b and cytoplasmic dynein.
22404429 Nesca directly binds KIF5B, kinesin light-chain and syntaxin-1
22327624 Expression of exogenous KIF5B-RET, induced morphological transformation and anchorage-independent growth of NIH3T3 fibroblasts
22198464 Data indicate that mutant KIF5B kinesin-1 binds ATP similarly in the presence of either metal ion, but its ATP hydrolysis activity is greatly diminished in the presence of Mg(2+).
22172677 Arl8 and SKIP are required for lysosomes to distribute away from the microtubule-organizing center. We identify two kinesin light chain binding motifs in SKIP that are required for lysosomes to accumulate kinesin-1 and redistribute to the cell periphery.
21925109 Kinesin-1-mediated capsid disassembly and disruption of the nuclear pore complex promote virus infection.
21915095 findings show a bipartite tryptophan-based motif in vaccinia virus A36 is required for kinesin-1-dependent transport of the virus; bioinformatic analysis reveals that related bipartite tryptophan-based motifs are present in over 450 human proteins
21910419 The conventional kinesin-microtubule binding free energy is dominated by van der Waals interactions and electrostatic interactions.
21656749 The discovery of the novel KIF5B-ALK variant further consolidated the role of aberrant anaplastic lymphoma kinase signaling in lung carcinogenesis.
20071331 a kinesin-1 tail fragment associates with microtubules with submicromolar affinity and binding is largely electrostatic
19913510 This indicates that kinesin-1 facilitates the transport of SNAP-25 containing vesicles as a prerequisite to SNAP-25 driven membrane fusion events.
19773350 Na,K-ATPase traffic toward the plasma membrane in alveolar epithelial cells is driven by kinesin-1, where KLC2 is the isoform regulating this process.
19675065 role of the kinesin I isoform Kif5b in the trafficking of a cardiac voltage-gated potassium channel, Kv1.5 in Kv1.5-expressing HEK293 cells and H9c2 cardiomyoblasts
19348763 the interaction between the kinesin-1 head and its regulatory tail domain
19305391 RANBP2 is the first native and positive allosteric activator known to jump-start and boost directly the activity of KIF5B.
19242560 KIF5B is a cancer relevant lysosomal motor protein with additional functions in autophagosome formation
18984674 training-induced changes in submaximal exercise stroke volume may be due to mitochondrial function and variation in KIF5B expression as determined by functional SNPs in its promoter.
18984674 Observational study of gene-disease association. (HuGE Navigator)
18817524 data implicate kinesin-1 in the spatial organization of the ER/Golgi interface as well as in traffic outside the ER
18579780 The interaction of the Switch I region of the kinesin-1 head with the tail is strikingly similar to the interactions of small GTPases with their regulators, indicating that other kinesin motors may share similar regulatory mechanisms.
18514191 Data suggest that the promotion of lamellipodia formation by HGF in MDA-MB-231 cells is Rac1-dependent and requires KIF5B-mediated transport of WAVE2 and IQGAP1 to the cell periphery along microtubules.
17925227 We demonstrate that KIF5B mediates post-Golgi transport of an apical protein in epithelial cells, but only after polarity has developed.
17887960 binding of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function
17394562 kinesin-1, but not kinesin-2, contributes to the specific cytoplasmic distribution of three of the four steps of VV morphogenesis tested.
16498388 Demonstrates the utility of screening for PDGFRA kinase domain overexpression in patients with IHES and has identified KIF5B as a third PDGFRA fusion partner in chronic myeloproliferative disorders.
16385451 Observational study of gene-disease association. (HuGE Navigator)
16260607 CRMP-2 transports the Sra-1/WAVE1 complex to axons in a kinesin-1-dependent manner and thereby regulates axon outgrowth and formation
15184079 Results identify the ribosome receptor, p180, as a binding partner of the kinesin heavy chain isoform KIF5B.
12475239 With residues 814-963 of human ubiquitous kinesin heavy chain (uKHC) used as bait, a synaptosome-associated protein of 25 kDa (SNAP25) has been identified as a kinesin-binding protein in a human brain cDNA library.
12191989 links neurofibromin and merlin in a common cellular pathway of neurofibromatosis

AA Sequence

MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQVYNDCAKKIV      1 - 70
KDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLD     71 - 140
KIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLI    141 - 210
NVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDS    211 - 280
KMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEK    281 - 350
NKILRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRK    351 - 420
CEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKE    421 - 490
VLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLK    491 - 560
DLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELA    561 - 630
ACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQA    631 - 700
VEQQIQSHRETHQKQISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTV    701 - 770
MQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLE    771 - 840
QLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKN    841 - 910
MARRGHSAQIAKPIRPGQHPAASPTHPSAIRGGGAFVQNSQPVAVRGGGGKQV                     911 - 963
//

Text Mined References (83)

PMID Year Title
26991731 2016 Kinesin-1 inhibits the aggregation of amyloid-? peptide as detected by fluorescence cross-correlation spectroscopy.
26627252 2015 The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5.
26598607 2015 Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking.
26268359 2015 KIF5B-RET Fusion gene may coincide oncogenic mutations of EGFR or KRAS gene in lung adenocarcinomas.
25902401 2015 Examining kinesin processivity within a general gating framework.
25818289 2015 Kinesin's front head is gated by the backward orientation of its neck linker.
25676575 2015 Identification of tail binding effect of kinesin-1 using an elastic network model.
25660542 2015 Control of the initiation and termination of kinesin-1-driven transport by myosin-Ic and nonmuscle tropomyosin.
25537000 2015 Decrypting the structural, dynamic, and energetic basis of a monomeric kinesin interacting with a tubulin dimer in three ATPase states by all-atom molecular dynamics simulation.
25516977 2015 Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.
25468996 2014 E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
25378581 2015 KIF5B transports BNIP-2 to regulate p38 mitogen-activated protein kinase activation and myoblast differentiation.
25348260 2014 Kinesin-14 and kinesin-5 antagonistically regulate microtubule nucleation by ?-TuRC in yeast and human cells.
25231297 2014 HIV-1 uncoating is facilitated by dynein and kinesin 1.
25047660 2014 KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer.
24821626 2014 Transport of c-MYC by Kinesin-1 for proteasomal degradation in the cytoplasm.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24129315 2014 Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
24072715 2013 Motor domain phosphorylation modulates kinesin-1 transport.
23884313 2014 MicroRNA-203 regulates melanosome transport and tyrosinase expression in melanoma cells by targeting kinesin superfamily protein 5b.
23378251 2013 KIF5B-RET fusions in Chinese patients with non-small cell lung cancer.
23092984 2012 Genome-wide association of mood-incongruent psychotic bipolar disorder.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22514732 2012 The intracellular transport and secretion of calumenin-1/2 in living cells.
22404429 2012 Nesca, a novel neuronal adapter protein, links the molecular motor kinesin with the pre-synaptic membrane protein, syntaxin-1, in hippocampal neurons.
22327624 2012 KIF5B-RET fusions in lung adenocarcinoma.
22223895 2012 Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-?-acetylation features.
22198464 2011 A metal switch for controlling the activity of molecular motor proteins.
22172677 2011 Arl8 and SKIP act together to link lysosomes to kinesin-1.
21925109 2011 Kinesin-1-mediated capsid disassembly and disruption of the nuclear pore complex promote virus infection.
21915095 2011 A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome.
21910419 2011 Probing the structural and energetic basis of kinesin-microtubule binding using computational alanine-scanning mutagenesis.
21656749 2011 A novel KIF5B-ALK variant in nonsmall cell lung cancer.
21269460 2011 Initial characterization of the human central proteome.
20682791 2010 A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.
20386726 2010 Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry.
20071331 2010 Microtubule-associated protein-like binding of the kinesin-1 tail to microtubules.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
19946888 2010 Defining the membrane proteome of NK cells.
19913510 2010 Kinesin-1 plays a role in transport of SNAP-25 to the plasma membrane.
19773350 2010 Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells.
19675065 2009 Kif5b is an essential forward trafficking motor for the Kv1.5 cardiac potassium channel.
19413330 2009 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19348763 2009 The Kinesin-1 tail conformationally restricts the nucleotide pocket.
19305391 2009 RANBP2 is an allosteric activator of the conventional kinesin-1 motor protein, KIF5B, in a minimal cell-free system.
19242560 2009 Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells.
19164528 2009 Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization.
18984674 2009 KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise.
18817524 2008 Kinesin-1 (uKHC/KIF5B) is required for bidirectional motility of ER exit sites and efficient ER-to-Golgi transport.
18579780 2008 The kinesin-1 motor protein is regulated by a direct interaction of its head and tail.
18514191 2008 Requirement of kinesin-mediated membrane transport of WAVE2 along microtubules for lamellipodia formation promoted by hepatocyte growth factor.
17925227 2007 Polarization-dependent selective transport to the apical membrane by KIF5B in MDCK cells.
17887960 2007 Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.
17532644 2007 Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport.
17470637 2007 The beginning of kinesin's force-generating cycle visualized at 9-A resolution.
17394562 2007 Kinesin-1 plays multiple roles during the vaccinia virus life cycle.
17353931 2007 Large-scale mapping of human protein-protein interactions by mass spectrometry.
17220478 2007 Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.
17081983 2006 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
16498388 2006 Identification of a novel imatinib responsive KIF5B-PDGFRA fusion gene following screening for PDGFRA overexpression in patients with hypereosinophilia.
16385451 2006 A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
16260607 2005 CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation.
15905402 2005 The intracellular fate of Salmonella depends on the recruitment of kinesin.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15459722 2004 Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons.
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
15324660 2004 Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.
15184079 2004 The ribosome receptor, p180, interacts with kinesin heavy chain, KIF5B.
15164054 2004 The DNA sequence and comparative analysis of human chromosome 10.
15161933 2004 Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12475239 2002 The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23.
12368902 2002 Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy.
12191989 2002 The motor protein kinesin-1 links neurofibromin and merlin in a common cellular pathway of neurofibromatosis.
11986669 2002 Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites.
10964943 2000 KIF5C, a novel neuronal kinesin enriched in motor neurons.
10913441 2000 Kinectin-kinesin binding domains and their effects on organelle motility.
10491391 1999 Defective kinesin heavy chain behavior in mouse kinesin light chain mutants.
9657148 1998 Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria.
9624122 1998 Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins.
8606779 1996 Crystal structure of the kinesin motor domain reveals a structural similarity to myosin.
7514426 1994 Cloning and localization of a conventional kinesin motor expressed exclusively in neurons.
1607388 1992 Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells.