Tbio KIF2A Kinesin-like protein KIF2A

Protein Summary

Description

Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• O00139
• A5YM42
• A5YM54
• B4DY54
• D3DW97
• E9PB70
• Q7Z5I3
• Q8N5Q7

Gene Name

• KIF2A

Ensembl ID

• ENST00000381103
• ENSP00000370493
• ENSG00000068796
• ENST00000401507
• ENSP00000385622
• ENST00000407818
• ENSP00000385000
• ENST00000506857
• ENSP00000423772

Symbol

• KIF2
• KNS2
• HK2
• KIF2
• CDCBM3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
disease perturbation	0.93
virus perturbation	0.88
transcription factor perturbation	0.84
transcription factor binding site profile	0.78

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Kinesin-like Protein Kif2a

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Kinesin-like Protein Kif2a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.47   (req: < 5)

Gene RIFs: 46   (req: <= 3)

Antibodies: 192   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.47   (req: >= 5)

Gene RIFs: 46   (req: > 3)

Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0