Tbio KIF23 Kinesin-like protein KIF23

Protein Summary

Description

Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q02241
• B4E1K0
• Q8WVP0

Gene Name

• KIF23

Ensembl ID

• ENST00000260363
• ENSP00000260363
• ENSG00000137807
• ENST00000352331
• ENSP00000304978
• ENST00000647715
• ENSP00000497065

Symbol

• KNSL5
• MKLP1
• CHO1
• KNSL5
• MKLP1
• MKLP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.98
molecular function	0.98
transcription factor perturbation	0.88
drug perturbation	0.87
histone modification site profile	0.84

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Kinesin-like Protein Kif23

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Kinesin-like Protein Kif23

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.57   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 172   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.57   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0