Tbio KIF20B Kinesin-like protein KIF20B

Protein Summary

Description

Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).

Uniprot Accession IDs

• Q96Q89
• A8MXM7
• O43277
• Q09471
• Q2KQ73
• Q32NE1
• Q561V3
• Q58EX8
• Q5T9M8
• Q5T9M9
• Q5T9N0
• Q5T9N1
• Q7KZ68
• Q7Z5E0
• Q7Z5E1
• Q7Z6M9
• Q86X82
• Q9H3R8
• Q9H6Q9
• Q9H755
• Q9NTC1
• Q9UFR5

Gene Name

• KIF20B

Ensembl ID

• ENST00000260753
• ENSP00000260753
• ENSG00000138182
• ENST00000371728
• ENSP00000360793

Symbol

• KRMP1
• MPHOSPH1
• CT90
• MPP1
• KRMP1
• MPP-1
• MPHOSPH1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
interacting protein	0.92
histone modification site profile	0.88
transcription factor binding site profile	0.84
tissue	0.72

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Kinesin-like Protein Kif20b

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Kinesin-like Protein Kif20b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.69   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 75   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.69   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0