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Tclin
KEAP1
Kelch-like ECH-associated protein 1

Protein Summary
Description
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provide ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000171111
  • ENSP00000171111
  • ENSG00000079999
  • ENST00000393623
  • ENSP00000377245

Symbol
  • INRF2
  • KIAA0132
  • KLHL19
  • INrf2
  • KLHL19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.97
interacting protein
0.96
protein domain
0.92
virus perturbation
0.92
kinase perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2233.15   (req: < 5)
Gene RIFs: 349   (req: <= 3)
Antibodies: 642   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2233.15   (req: >= 5)
Gene RIFs: 349   (req: > 3)
Antibodies: 642   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 157
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1