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Tbio Lysine-specific demethylase 3B

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.

 Comments

Property Summary

NCBI Gene PubMed Count 21
PubMed Score 11.27
PubTator Score 8.35

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Heavy Metal Poisoning 1 0.0 0.0
Disease Target Count
Toxic effect of heavy metal 1
Disease Target Count P-value
ovarian cancer 8520 3.0e-03
oligodendroglioma 2850 4.6e-03
subependymal giant cell astrocytoma 2287 6.8e-03
astrocytoma 1146 1.1e-02
ependymoma 4679 1.1e-02
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 1.3
Kidney cancer 2613 0.0 0.9
Liver cancer 604 0.0 0.5
Disease Target Count Z-score Confidence
Persistent hyperplastic primary vitreous 20 3.736 1.9

Expression

  Differential Expression (5)

Disease log2 FC p
astrocytoma 1.200 1.1e-02
ependymoma 1.100 1.1e-02
oligodendroglioma 1.200 4.6e-03
ovarian cancer 1.400 3.0e-03
subependymal giant cell astrocytoma -1.110 6.8e-03

Synonym

Accession Q7LBC6 A6H8X7 Q9BVH6 Q9BW93 Q9BZ52 Q9NYF4 Q9UPS0
Symbols 5qNCA
NET22
C5orf7
JMJD1B

Gene

KDM3B

PANTHER Protein Class (2)

  Ortholog (11)

Species Source Disease
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid EggNOG
OMA EggNOG
Inparanoid OMA
Inparanoid OMA

 UniProt Keyword (19)

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 GO Function (7)

 GO Component (3)

 GO Process (4)

 Compartment GO Term (23)

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 GWAS Trait (3)

 HCA RNA Cell Line (56)

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Pathway (4)

PDB (1)

Gene RIF (5)

AA Sequence 

MADAAASPVGKRLLLLFADTAASASASAPAAAAASGDPGPALRTRAWRAGTVRAMSGAVPQDLAIFVEFD      1 - 70
GCNWKQHSWVKVHAEEVIVLLLEGSLVWAPREDPVLLQGIRVSIAQWPALTFTPLVDKLGLGSVVPVEYL     71 - 140
LDRELRFLSDANGLHLFQMGTDSQNQILLEHAALRETVNALISDQKLQEIFSRGPYSVQGHRVKIYQPEG    141 - 210
EEGWLYGVVSHQDSITRLMEVSVTESGEIKSVDPRLIHVMLMDNSAPQSEGGTLKAVKSSKGKKKRESIE    211 - 280
GKDGRRRKSASDSGCDPASKKLKGDRGEVDSNGSDGGEASRGPWKGGNASGEPGLDQRAKQPPSTFVPQI    281 - 350
NRNIRFATYTKENGRTLVVQDEPVGGDTPASFTPYSTATGQTPLAPEVGGAENKEAGKTLEQVGQGIVAS    351 - 420
AAVVTTASSTPNTVRISDTGLAAGTVPEKQKGSRSQASGENSRNSILASSGFGAPLPSSSQPLTFGSGRS    421 - 490
QSNGVLATENKPLGFSFGCSSAQEAQKDTDLSKNLFFQCMSQTLPTSNYFTTVSESLADDSSSRDSFKQS    491 - 560
LESLSSGLCKGRSVLGTDTKPGSKAGSSVDRKVPAESMPTLTPAFPRSLLNARTPENHENLFLQPPKLSR    561 - 630
EEPSNPFLAFVEKVEHSPFSSFASQASGSSSSATTVTSKVAPSWPESHSSADSASLAKKKPLFITTDSSK    631 - 700
LVSGVLGSALTSGGPSLSAMGNGRSSSPTSSLTQPIEMPTLSSSPTEERPTVGPGQQDNPLLKTFSNVFG    701 - 770
RHSGGFLSSPADFSQENKAPFEAVKRFSLDERSLACRQDSDSSTNSDLSDLSDSEEQLQAKTGLKGIPEH    771 - 840
LMGKLGPNGERSAELLLGKSKGKQAPKGRPRTAPLKVGQSVLKDVSKVKKLKQSGEPFLQDGSCINVAPH    841 - 910
LHKCRECRLERYRKFKEQEQDDSTVACRFFHFRRLIFTRKGVLRVEGFLSPQQSDPDAMNLWIPSSSLAE    911 - 980
GIDLETSKYILANVGDQFCQLVMSEKEAMMMVEPHQKVAWKRAVRGVREMCDVCETTLFNIHWVCRKCGF    981 - 1050
GVCLDCYRLRKSRPRSETEEMGDEEVFSWLKCAKGQSHEPENLMPTQIIPGTALYNIGDMVHAARGKWGI   1051 - 1120
KANCPCISRQNKSVLRPAVTNGMSQLPSINPSASSGNETTFSGGGGPAPVTTPEPDHVPKADSTDIRSEE   1121 - 1190
PLKTDSSASNSNSELKAIRPPCPDTAPPSSALHWLADLATQKAKEETKEAGSLRSVLNKESHSPFGLDSF   1191 - 1260
NSTAKVSPLTPKLFNSLLLGPTASNNKTEGSSLRDLLHSGPGKLPQTPLDTGIPFPPVFSTSSAGVKSKA   1261 - 1330
SLPNFLDHIIASVVENKKTSDASKRACNLTDTQKEVKEMVMGLNVLDPHTSHSWLCDGRLLCLHDPSNKN   1331 - 1400
NWKIFRECWKQGQPVLVSGVHKKLKSELWKPEAFSQEFGDQDVDLVNCRNCAIISDVKVRDFWDGFEIIC   1401 - 1470
KRLRSEDGQPMVLKLKDWPPGEDFRDMMPTRFEDLMENLPLPEYTKRDGRLNLASRLPSYFVRPDLGPKM   1471 - 1540
YNAYGLITAEDRRVGTTNLHLDVSDAVNVMVYVGIPIGEGAHDEEVLKTIDEGDADEVTKQRIHDGKEKP   1541 - 1610
GALWHIYAAKDAEKIRELLRKVGEEQGQENPPDHDPIHDQSWYLDQTLRKRLYEEYGVQGWAIVQFLGDA   1611 - 1680
VFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFRLTQEFRHLSNTHTNHEDKLQVKNIIYHAVKDAVGT   1681 - 1750
LKAHESKLARS                                                              1751 - 1761
//

Text Mined References (31)

PMID Year Title