Tbio KDF1 Keratinocyte differentiation factor 1

Protein Summary

Description

Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity).

Uniprot Accession IDs

• Q8NAX2
• Q5QP32
• Q8N0S7

Gene Name

• KDF1

Ensembl ID

• ENST00000320567
• ENSP00000319179
• ENSG00000175707

Symbol

• C1orf172
• ECTD12
• C1orf172

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.7
tissue sample	0.6
phenotype	0.54
biological process	0.51
cell type or tissue	0.45

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.59   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 92   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.59   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0