Property Summary

NCBI Gene PubMed Count 22
PubMed Score 170.76
PubTator Score 82.37

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (14)

Disease log2 FC p
psoriasis -1.700 1.1e-03
osteosarcoma 1.800 6.7e-05
posterior fossa group A ependymoma 1.600 9.4e-09
glioblastoma 2.100 9.5e-07
medulloblastoma 1.900 3.7e-06
astrocytoma 1.100 9.0e-03
atypical teratoid / rhabdoid tumor 2.600 4.2e-11
medulloblastoma, large-cell 2.200 1.5e-06
primitive neuroectodermal tumor 1.500 8.2e-07
lung cancer 1.900 3.7e-03
pediatric high grade glioma 1.800 1.9e-06
pilocytic astrocytoma 1.600 4.2e-07
lung adenocarcinoma 1.022 1.1e-03
dermatomyositis -1.100 8.4e-04

 GO Function (1)

Gene RIF (10)

PMID Text
26861384 KDELR protein mediated the intracellular trafficking of Japanese encephalitis virus particles.
26064897 We propose a model whereby in analogy to previous findings (e.g., the RAS-RAF signalling pathway), PHB can act as a signalling scaffold protein to assist in KDELR-dependent Src activation
25682866 A Golgi-based KDELR-dependent signalling pathway controls invadopodia-dependent extracellular matrix degradation.
25117681 KDEL receptor activates CREB1 and other transcription factors that upregulate transport-related genes
23873287 It discuss the particular role of KDEL receptor signaling in the regulation of important pathways involved in the maintenance of the homeostasis of the transport apparatus, and in particular, of the Golgi complex.
22580821 These findings reveal an unexpected GPCR-like mode of action of the KDEL-R and shed light on a core molecular control mechanism of intra-Golgi traffic.
22363504 Cystinosin, MPDU1, SWEETs and KDELR belong to a well-defined protein family with putative function of cargo receptors.
21684323 our data provide evidence that KDELR, as a novel inducer of autophagy, participates in the degradation of misfolded neurodegenerative disease-related proteins.
12975382 Src relocated the KDEL receptor (KDEL-R) from the Golgi apparatus to the endoplasmic reticulum
12821650 the KDEL receptor participates in the ER stress response not only by its retrieval ability but also by modulating MAP kinase signaling

AA Sequence

MNLFRFLGDLSHLLAIILLLLKIWKSRSCAGISGKSQVLFAVVFTARYLDLFTNYISLYNTCMKVVYIAC      1 - 70
SFTTVWLIYSKFKATYDGNHDTFRVEFLVVPTAILAFLVNHDFTPLEILWTFSIYLESVAILPQLFMVSK     71 - 140
TGEAETITSHYLFALGVYRTLYLFNWIWRYHFEGFFDLIAIVAGLVQTVLYCDFFYLYITKVLKGKKLSL    141 - 210
PA                                                                        211 - 212
//

Text Mined References (26)

PMID Year Title
26861384 2016 A KDEL Retrieval System for ER-Golgi Transport of Japanese Encephalitis Viral Particles.
26064897 2015 Prohibitin: A Novel Molecular Player in KDEL Receptor Signalling.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25682866 2015 A Golgi-based KDELR-dependent signalling pathway controls extracellular matrix degradation.
25117681 2014 Control systems of membrane transport at the interface between the endoplasmic reticulum and the Golgi.
23873287 2013 Regulation of Golgi signaling and trafficking by the KDEL receptor.
22580821 2012 The KDEL receptor couples to G?q/11 to activate Src kinases and regulate transport through the Golgi.
22363504 2012 Cystinosin, MPDU1, SWEETs and KDELR belong to a well-defined protein family with putative function of cargo receptors involved in vesicle trafficking.
21684323 2011 The KDEL receptor induces autophagy to promote the clearance of neurodegenerative disease-related proteins.
17353931 2007 Large-scale mapping of human protein-protein interactions by mass spectrometry.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15308636 2004 Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46.
15057824 2004 The DNA sequence and biology of human chromosome 19.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14517323 2003 The retrieval function of the KDEL receptor requires PKA phosphorylation of its C-terminus.
12975382 2003 Src regulates Golgi structure and KDEL receptor-dependent retrograde transport to the endoplasmic reticulum.
12821650 2003 The KDEL receptor modulates the endoplasmic reticulum stress response through mitogen-activated protein kinase signaling cascades.
12761501 2003 Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11703931 2001 KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET.
10708517 2000 A transcript map of the chromosome 19q-arm glioma tumor suppressor region.
9405360 1997 The KDEL receptor, ERD2, regulates intracellular traffic by recruiting a GTPase-activating protein for ARF1.
9118249 1996 The dynamic organisation of the secretory pathway.
8392934 1993 Mutational analysis of the human KDEL receptor: distinct structural requirements for Golgi retention, ligand binding and retrograde transport.
2172835 1990 A human homologue of the yeast HDEL receptor.
1310258 1992 Ligand-induced redistribution of a human KDEL receptor from the Golgi complex to the endoplasmic reticulum.