Tchem KCTD12 BTB/POZ domain-containing protein KCTD12

Protein Summary

Description

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).

Uniprot Accession IDs

• Q96CX2

Gene Name

• KCTD12

Ensembl ID

• ENST00000377474
• ENSP00000366694
• ENSG00000178695

Symbol

• C13orf2
• KIAA1778
• PFET1
• PFET1
• PFETIN
• C13orf2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
interacting protein	0.93
PubMedID	0.9
cell type or tissue	0.86
microRNA	0.79

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Btb/poz Domain-containing Protein Kctd12

DTO Classes

Protein / Enzyme Modulator / Btb/poz Domain-containing Protein Kctd12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.16   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 131   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.16   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 23

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0