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Tbio
KCNK16
Potassium channel subfamily K member 16

Protein Summary
Description
Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373227
  • ENSP00000362324
  • ENSG00000095981
  • ENST00000373229
  • ENSP00000362326
  • ENST00000425054
  • ENSP00000391498
  • ENST00000437525
  • ENSP00000415375

Symbol
  • TALK1
  • TALK1
  • TALK-1
  • K2p16.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
cell line
0.61
gene perturbation
0.53
transcription factor
0.42
protein domain
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.79   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.79   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0