| Tbio | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 |
Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.
This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 2.3e-08 |
| ovarian cancer | 8520 | 1.3e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.8e-04 |
| osteosarcoma | 7950 | 5.8e-04 |
| glioblastoma | 5792 | 2.2e-03 |
| adult high grade glioma | 3801 | 5.2e-03 |
| group 3 medulloblastoma | 4104 | 6.1e-03 |
| lung cancer | 4740 | 1.5e-02 |
| medulloblastoma, large-cell | 6241 | 1.5e-02 |
| non primary Sjogren syndrome sicca | 891 | 2.3e-02 |
| ependymoma | 4679 | 3.8e-02 |
| acute myeloid leukemia | 783 | 4.0e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Primary cutaneous amyloidosis | 29 | 4.29 | 2.1 |
| Periodontal disease | 40 | 3.977 | 2.0 |
| Intramuscular hemangioma | 1 | 3.412 | 1.7 |
| Trigeminal Neuralgia | 24 | 3.215 | 1.6 |
| Dental caries | 164 | 3.146 | 1.6 |
| Chorioretinal scar | 1 | 3.099 | 1.5 |
| Vascular disease | 319 | 3.01 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | 1.300 | 4.0e-02 |
| adult high grade glioma | -1.200 | 5.2e-03 |
| atypical teratoid / rhabdoid tumor | -1.600 | 1.8e-04 |
| ependymoma | -1.100 | 3.8e-02 |
| glioblastoma | 1.400 | 2.2e-03 |
| group 3 medulloblastoma | 1.300 | 6.1e-03 |
| lung cancer | -1.400 | 1.5e-02 |
| medulloblastoma, large-cell | -1.100 | 1.5e-02 |
| non primary Sjogren syndrome sicca | 1.200 | 2.3e-02 |
| osteosarcoma | -1.578 | 5.8e-04 |
| ovarian cancer | 1.500 | 1.3e-05 |
| psoriasis | -1.200 | 2.3e-08 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
U2SURP
SFSWAP
CAAP1
PHRF1
TFIP11
ZNF24
DKC1
CDCA2
RPS7
PUF60
RBM27
RBM26
RBM25
NSRP1
RSRC2
DDX46
RBM23
RBM39
NUDT21
PAXBP1
U2AF2
SCAF1
CDK11B
LUC7L3
CPSF7
WDR48
PRPF38A
PPIG
SCAF8
SCAF4
RBMX2
WDR33
CPSF4
SCAF11
DIDO1
SREK1
RNPC3
UAP1
PPIL4
CHERP
DHX40
RABL6
SRSF11
CACTIN
CPSF6
ZMYM1
BRD4
SETD2
PRPF38B
ARGLU1
USP42
NFKBIL1
CLK4
HBS1L
ZC3H4
DHX38
GTF2F1
CCNL2
ZRSR2P1
RNF138
TAF7
CCNL1
MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEEFVERYERPYKPV 1 - 70 VLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEH 71 - 140 PKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFP 141 - 210 TSTPRELIKVTRDEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDT 211 - 280 TIAITQNFASSTNFPVVWHKTVRGRPKLSRKWYRILKQEHPELAVLADSVDLQESTGIASDSSSDSSSSS 281 - 350 SSSSSDSDSECESGSEGDGTVHRRKKRRTCSMVGNGDTTSQDDCVSKERSSSR 351 - 403 //
