Property Summary

NCBI Gene PubMed Count 29
PubMed Score 56.47
PubTator Score 39.87

Knowledge Summary

Patent

No data available

TINX Plot

Expression

  Differential Expression (8)

Disease log2 FC p
psoriasis -1.800 4.3e-05
osteosarcoma -2.488 7.0e-08
tuberculosis -1.500 5.1e-06
intraductal papillary-mucinous adenoma (... 1.500 3.8e-04
intraductal papillary-mucinous carcinoma... 1.400 1.3e-03
lung cancer 1.700 8.1e-04
subependymal giant cell astrocytoma -1.448 4.0e-02
ovarian cancer 1.200 1.8e-03

Gene RIF (20)

PMID Text
25939703 JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression
25645357 Jarid2 is an important component of PRC2 that has a central role in coordinating hematopoietic stem and progenitor cell function
25620564 Results suggest a regulation loop where Jarid2 protein methylation fine-tunes polycomb repressive complex 2 (PRC2) activity depending on the chromatin context.
25542019 TGF-ss-dependent expression changes of EMT-related genes were inhibited by JARID2 knockdown and enhanced by JARID2 overexpression.
25155265 Data further strengthen the conclusion that JARID2 polymorphisms are associated with NSOC susceptibility.
24889693 Decreased miRNA-940 affects the proliferation and migration of the progenitor cells of the secondary heart field by targeting JARID2.
24856900 miR-155 regulates the fate of Th17 and Treg cells and miR-155 contributes to Th17 cell function by suppressing the inhibitory effects of Jarid2.
24462204 Jarid2 is an important mediator of Xist-induced PRC2 targeting.
24374312 The presence of long noncoding RNAs stimulated JARID2-EZH2 interactions in vitro and JARID2-mediated recruitment of PRC2 to chromatin.
23435416 The interaction of JARID2 at these promoters is dependent on EED.
23294540 Patients carrying JARID2 deletion manifested with cognitive impairment, gait disturbance and a characteristic facial appearance, whereas patients with deletion of ATXN1 seemed to be characterized by intellectual disability and behavioural abnormalities
22190018 In chronic myeloproliferative neoplasms & myelodysplastic syndromes, there were frequent deletions in a 1.1 Mb region of the short arm of chromosome 6 containing only the JARID2 gene. This del6p was associated with leukemic transformation.
20075857 JARID2 is essential for the binding of PcG proteins to target genes and, consistent with this, for the proper differentiation of embryonic stem cells and normal development
19884986 Two SNPs in JARID2 showed association in allelic, genotypic and haplotypic tests with schizophrenia patients from Chang Le area.
19884986 Observational study of gene-disease association. (HuGE Navigator)
19759154 Based on the findings the authors propose that miR-155 has a prosurvival function that is mediated through the downregulation of targets including JARID2.
18805276 JARID2 appears important in transcriptional regulation of fetal genes and may emerge as a diagnostic marker for left ventricular decompensation in aortic stenosis.
16967465 Observational study of gene-disease association. (HuGE Navigator)
16967465 JARID2 should be viewed as a candidate gene for 6p22.3-linked schizophrenia
15057990 JMJ was evaluated against risk factors for spinal dysraphism and congenital heart defects. Variations within exons and introns of JMJ might be in linkage disequlibrium.

AA Sequence

MSKERPKRNIIQKKYDDSDGIPWSEERVVRKVLYLSLKEFKNSQKRQHAEGIAGSLKTVNGLLGNDQSKG      1 - 70
LGPASEQSENEKDDASQVSSTSNDVSSSDFEEGPSRKRPRLQAQRKFAQSQPNSPSTTPVKIVEPLLPPP     71 - 140
ATQISDLSKRKPKTEDFLTFLCLRGSPALPNSMVYFGSSQDEEEVEEEDDETEDVKTATNNASSSCQSTP    141 - 210
RKGKTHKHVHNGHVFNGSSRSTREKEPVQKHKSKEATPAKEKHSDHRADSRREQASANHPAAAPSTGSSA    211 - 280
KGLAATHHHPPLHRSAQDLRKQVSKVNGVTRMSSLGAGVTSAKKMREVRPSPSKTVKYTATVTKGAVTYT    281 - 350
KAKRELVKDTKPNHHKPSSAVNHTISGKTESSNAKTRKQVLSLGGASKSTGPAVNGLKVSGRLNPKSCTK    351 - 420
EVGGRQLREGLQLREGLRNSKRRLEEAHQAEKPQSPPKKMKGAAGPAEGPGKKAPAERGLLNGHVKKEVP    421 - 490
ERSLERNRPKRATAGKSTPGRQAHGKADSASCENRSTSQPESVHKPQDSGKAEKGGGKAGWAAMDEIPVL    491 - 560
RPSAKEFHDPLIYIESVRAQVEKFGMCRVIPPPDWRPECKLNDEMRFVTQIQHIHKLGRRWGPNVQRLAC    561 - 630
IKKHLKSQGITMDELPLIGGCELDLACFFRLINEMGGMQQVTDLKKWNKLADMLRIPRTAQDRLAKLQEA    631 - 700
YCQYLLSYDSLSPEEHRRLEKEVLMEKEILEKRKGPLEGHTENDHHKFHPLPRFEPKNGLIHGVAPRNGF    701 - 770
RSKLKEVGQAQLKTGRRRLFAQEKEVVKEEEEDKGVLNDFHKCIYKGRSVSLTTFYRTARNIMSMCFSKE    771 - 840
PAPAEIEQEYWRLVEEKDCHVAVHCGKVDTNTHGSGFPVGKSEPFSRHGWNLTVLPNNTGSILRHLGAVP    841 - 910
GVTIPWLNIGMVFSTSCWSRDQNHLPYIDYLHTGADCIWYCIPAEEENKLEDVVHTLLQANGTPGLQMLE    911 - 980
SNVMISPEVLCKEGIKVHRTVQQSGQFVVCFPGSFVSKVCCGYSVSETVHFATTQWTSMGFETAKEMKRR    981 - 1050
HIAKPFSMEKLLYQIAQAEAKKENGPTLSTISALLDELRDTELRQRRQLFEAGLHSSARYGSHDGSSTVA   1051 - 1120
DGKKKPRKWLQLETSERRCQICQHLCYLSMVVQENENVVFCLECALRHVEKQKSCRGLKLMYRYDEEQII   1121 - 1190
SLVNQICGKVSGKNGSIENCLSKPTPKRGPRKRATVDVPPSRLSASSSSKSASSSS                 1191 - 1246
//

Text Mined References (33)

PMID Year Title
25939703 2015 JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression.
25645357 2015 Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2.
25620564 2015 Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.
25542019 2014 JARID2 is involved in transforming growth factor-beta-induced epithelial-mesenchymal transition of lung and colon cancer cell lines.
25155265 2015 Association of JARID2 polymorphisms with non-syndromic orofacial clefts in northern Chinese Han population.
24889693 2014 miRNA-940 reduction contributes to human Tetralogy of Fallot development.
24856900 2014 miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression.
24462204 2014 Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome.
24374312 2014 Interactions between JARID2 and noncoding RNAs regulate PRC2 recruitment to chromatin.
23435416 2014 JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells.
23349640 2013 Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies.
23294540 2013 Haploinsufficiency of two histone modifier genes on 6p22.3, ATXN1 and JARID2, is associated with intellectual disability.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22190018 2012 Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies.
22116950 2012 Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
20075857 2010 JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells.
19884986 2009 Whole genome association study in a homogenous population in Shandong peninsula of China reveals JARID2 as a susceptibility gene for schizophrenia.
19759154 2009 Reticuloendotheliosis virus strain T induces miR-155, which targets JARID2 and promotes cell survival.
19608861 2009 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19010793 2009 Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
18805276 2008 Induction by left ventricular overload and left ventricular failure of the human Jumonji gene (JARID2) encoding a protein that regulates transcription and reexpression of a protective fetal program.
16967465 2007 Positive association of schizophrenia to JARID2 gene.
15542826 2004 Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15057990 2004 Evaluation of the jumonji gene and risk for spina bifida and congenital heart defects.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14574404 2003 The DNA sequence and analysis of human chromosome 6.
12890668 2003 JUMONJI, a critical factor for cardiac development, functions as a transcriptional repressor.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
10913339 2000 Jumonji is a nuclear protein that participates in the negative regulation of cell growth.
10807864 2000 Jumonji, a nuclear protein that is necessary for normal heart development.
8894700 1996 Characterization of the human jumonji gene.