Property Summary

NCBI Gene PubMed Count 17
PubMed Score 138.29
PubTator Score 67.17

Knowledge Summary


No data available


  Differential Expression (1)

Disease log2 FC p
psoriasis 1.300 1.6e-13

Gene RIF (6)

27309818 crystal structures of human IZUMO1 and JUNO in unbound and bound conformations
27309808 crystal structures of human IZUMO1, JUNO and the IZUMO1-JUNO complex, establishing the structural basis for the IZUMO1-JUNO-mediated sperm-oocyte interaction
23279005 these findings indicate that human sperm expresses Izumo protein, and the immunoinfertile female sera have circulating isoantibodies against this protein.
18082733 We observed in our populations two combinations of four polymorphisms that appeared to be preferentially linked (CGG-CG and TAA-TT) without any significant difference between different genotype repartitions.
18082733 Observational study of gene-disease association. (HuGE Navigator)
15759005 human sperm contain Izumo and addition of the antibody against human Izumo left the sperm unable to fuse with zona-free hamster eggs [Izumo]

AA Sequence


Text Mined References (18)

PMID Year Title
27309818 2016 Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex.
27309808 2016 Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization.
24739963 2014 Juno is the egg Izumo receptor and is essential for mammalian fertilization.
23636237 2013 Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake.
23372041 2013 Novel locus including FGF21 is associated with dietary macronutrient intake.
23279005 2013 Presence and incidence of izumo antibodies in sera of immunoinfertile women and men.
23128233 2012 Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
22957301 2012 Positive Selection and the Evolution of izumo Genes in Mammals.
21926972 2011 Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
21060863 2010 Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.
19658160 2009 Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm.
18952059 2008 Putative sperm fusion protein IZUMO and the role of N-glycosylation.
18082733 2008 Preliminary study on the role of the human IZUMO gene in oocyte-spermatozoa fusion failure.
17047026 2006 Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization.
15759005 2005 The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15057824 2004 The DNA sequence and biology of human chromosome 19.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.