Property Summary

NCBI Gene PubMed Count 22
PubMed Score 16.63
PubTator Score 6.24

Knowledge Summary


No data available


  Differential Expression (24)

Disease log2 FC p
Multiple myeloma 1.836 2.3e-02
psoriasis -2.100 6.2e-08
medulloblastoma, large-cell -1.800 1.3e-04
ulcerative colitis 1.200 2.4e-03
Duchenne muscular dystrophy 1.636 9.0e-05
autosomal dominant Emery-Dreifuss muscul... 1.446 3.1e-02
adrenocortical carcinoma -1.478 7.6e-03
non-small cell lung cancer -2.316 1.4e-17
intraductal papillary-mucinous neoplasm ... -1.800 4.9e-02
colon cancer -2.300 1.3e-02
lung cancer -4.200 8.9e-07
active Crohn's disease 1.405 4.1e-02
sarcoidosis 1.600 3.7e-03
breast carcinoma -2.300 1.2e-41
lung adenocarcinoma -2.200 1.5e-11
pilocytic astrocytoma 1.200 1.8e-03
invasive ductal carcinoma -2.800 1.6e-03
severe Alzheimer's disease -1.108 3.4e-02
Breast cancer -3.500 4.1e-19
lung carcinoma -1.500 5.0e-08
mucosa-associated lymphoid tissue lympho... -1.065 1.4e-02
ductal carcinoma in situ -1.500 2.6e-03
ovarian cancer -3.300 1.6e-09
pituitary cancer -1.900 1.4e-04

Gene RIF (5)

26691219 ITM2A is a new biomarker of poor prognosis in ovarian cancer and a novel tumor suppressor that induces cell cycle arrest, acts as a chemosensitizer, and has therapeutic potential for ovarian cancer.
26125709 The upregulated gene with the largest effect size in ankylosing spondylitis was ITM2A, which plays a role in activation of T cells. (Meta-analysis)
25951193 ITM2A expression is positively regulated by PKA-CREB signaling and ITM2A expression interferes with autophagic flux by interacting with vacuolar ATPase.
24516404 our results show one of the first links between phenotypic variation in a population sample and an XCI-escaping locus and pinpoint ITM2A as a potential contributor to the sexual dimorphism in height
19541402 Enhanced ITM2A expression inhibits chondrogenic differentiation of mesenchymal stem cells.

AA Sequence


Text Mined References (23)

PMID Year Title
26691219 2016 Loss of ITM2A, a novel tumor suppressor of ovarian cancer through G2/M cell cycle arrest, is a poor prognostic factor of epithelial ovarian cancer.
26125709 2015 Meta-analysis of differentially expressed genes in ankylosing spondylitis.
25951193 2015 The integral membrane protein ITM2A, a transcriptional target of PKA-CREB, regulates autophagic flux via interaction with the vacuolar ATPase.
25416956 2014 A proteome-scale map of the human interactome network.
24516404 2014 Chromosome X-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation.
23612905 2013 Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis.
19541402 Enhanced ITM2A expression inhibits chondrogenic differentiation of mesenchymal stem cells.
18391951 2008 Many sequence variants affecting diversity of adult human height.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15983050 2005 The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production.
15772651 2005 The DNA sequence of the human X chromosome.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12975309 2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11042152 2000 Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
10432285 1999 ITM2A is induced during thymocyte selection and T cell activation and causes downregulation of CD8 when overexpressed in CD4(+)CD8(+) double positive thymocytes.
9892734 1999 Genomic organization and chromosomal localization of the Itm2a gene.
9653160 1998 Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.
8702637 1996 Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins.
8570611 1996 Analysis of differential gene expression by display of 3' end restriction fragments of cDNAs.
8125298 1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.