Property Summary

NCBI Gene PubMed Count 23
PubMed Score 12.75
PubTator Score 16.73

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (18)

Disease log2 FC p
urothelial carcinoma 1.500 3.8e-02
posterior fossa group B ependymoma 2.600 5.7e-08
osteosarcoma -2.099 3.4e-02
non-small cell lung cancer -2.054 4.9e-20
intraductal papillary-mucinous adenoma (... -2.300 1.2e-04
intraductal papillary-mucinous carcinoma... -2.500 3.8e-04
intraductal papillary-mucinous neoplasm ... -2.600 1.1e-04
lung cancer -3.100 9.4e-06
colon cancer -2.400 9.6e-05
breast carcinoma -2.200 9.8e-05
fibroadenoma -2.600 3.7e-03
lung adenocarcinoma -2.900 2.2e-12
sonic hedgehog group medulloblastoma 1.200 4.3e-03
invasive ductal carcinoma -4.200 2.5e-04
Breast cancer -2.600 5.2e-47
ductal carcinoma in situ -3.000 2.8e-04
pituitary cancer 1.800 6.0e-04
head and neck cancer -1.200 3.4e-02

Gene RIF (15)

PMID Text
27143355 The current study describes a novel mechanism linking the TSG-6 transfer of the newly described HC5 to the HA-dependent control of cell phenotype. The interaction of HC5 with cell surface HA was essential for TGFbeta1-dependent differentiation of fibroblasts to myofibroblasts, highlighting its importance as a novel potential therapeutic target.
26252352 ITIH5 may be a novel putative tumor suppressor gene in NSCLC with a potential molecular significance in the squamoid ADC subtype and further clinical impact for risk stratification of adenocarcinoma patients.
25809190 Hence, we can strengthen the presumption that ITIH5 may constitute a novel regulatory molecule of the human skin that could play an important role in in fl ammation via its interaction with hyaluronic acid.
25093535 ITIH5 is a novel putative tumor suppressor gene in colon cancer with a potential impact in the CIMP-related pathway.
24913813 ITIH5 expression is decreased in gastric cancer and that low expression of this protein is associated with poor clinical outcome.
24265292 provide evidence that down-regulation of ITIH5 by aberrant DNA hypermethylation may provoke invasive phenotypes in human bladder cancer
23320751 Tumor-specific methylation of the three-gene panel (ITIH5, DKK3, and RASSF1A) might be a valuable biomarker for the early detection of breast cancer.
22616691 ITIH5 gene expression is regulated both by obesity and by the region between visceral and subcutaneous adipose tissue.
21852814 ITIH-5 is highly expressed in sc adipose tissue, increased in obesity, down regulated after weight loss, and associated with measures of body size and metabolism.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20200953 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
18810445 Both ITIH5 protein expression and ITIH5 promoter methylation may serve as prognostic biomarkers, thereby helping improve clinical patient outcome.
17653090 Promoter methylation-mediated loss of ITIH5 expression is associated with unfavourable outcome in breast cancer patients.
16385451 Observational study of gene-disease association. (HuGE Navigator)
14744536 expression is consistantly lost or strongly downregulated in invasive ductal carcinoma; proposed that loss of ITIH5 expression may be involved in breast cancer development

AA Sequence

MLLLLGLCLGLSLCVGSQEEAQSWGHSSEQDGLRVPRQVRLLQRLKTKPLMTEFSVKSTIISRYAFTTVS      1 - 70
CRMLNRASEDQDIEFQMQIPAAAFITNFTMLIGDKVYQGEITEREKKSGDRVKEKRNKTTEENGEKGTEI     71 - 140
FRASAVIPSKDKAAFFLSYEELLQRRLGKYEHSISVRPQQLSGRLSVDVNILESAGIASLEVLPLHNSRQ    141 - 210
RGSGRGEDDSGPPPSTVINQNETFANIIFKPTVVQQARIAQNGILGDFIIRYDVNREQSIGDIQVLNGYF    211 - 280
VHYFAPKDLPPLPKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDRFSIIGFSNRIKVWKDHLISV    281 - 350
TPDSIRDGKVYIHHMSPTGGTDINGALQRAIRLLNKYVAHSGIGDRSVSLIVFLTDGKPTVGETHTLKIL    351 - 420
NNTREAARGQVCIFTIGIGNDVDFRLLEKLSLENCGLTRRVHEEEDAGSQLIGFYDEIRTPLLSDIRIDY    421 - 490
PPSSVVQATKTLFPNYFNGSEIIIAGKLVDRKLDHLHVEVTASNSKKFIILKTDVPVRPQKAGKDVTGSP    491 - 560
RPGGDGEGDTNHIERLWSYLTTKELLSSWLQSDDEPEKERLRQRAQALAVSYRFLTPFTSMKLRGPVPRM    561 - 630
DGLEEAHGMSAAMGPEPVVQSVRGAGTQPGPLLKKPYQPRIKISKTSVDGDPHFVVDFPLSRLTVCFNID    631 - 700
GQPGDILRLVSDHRDSGVTVNGELIGAPAPPNGHKKQRTYLRTITILINKPERSYLEITPSRVILDGGDR    701 - 770
LVLPCNQSVVVGSWGLEVSVSANANVTVTIQGSIAFVILIHLYKKPAPFQRHHLGFYIANSEGLSSNCHG    771 - 840
LLGQFLNQDARLTEDPAGPSQNLTHPLLLQVGEGPEAVLTVKGHQVPVVWKQRKIYNGEEQIDCWFARNN    841 - 910
AAKLIDGEYKDYLAFHPFDTGMTLGQGMSREL                                          911 - 942
//

Text Mined References (26)

PMID Year Title
27143355 2016 Tumor Necrosis Factor-stimulated Gene 6 (TSG-6)-mediated Interactions with the Inter-?-inhibitor Heavy Chain 5 Facilitate Tumor Growth Factor ?1 (TGF?1)-dependent Fibroblast to Myofibroblast Differentiation.
26252352 2015 Low expression of ITIH5 in adenocarcinoma of the lung is associated with unfavorable patients' outcome.
25809190 2015 Inter-?-trypsin inhibitor heavy chain 5 (ITIH5) is overexpressed in inflammatory skin diseases and affects epidermal morphology in constitutive knockout mice and murine 3D skin models.
25093535 2014 Epigenetic inactivation of the novel candidate tumor suppressor gene ITIH5 in colon cancer predicts unfavorable overall survival in the CpG island methylator phenotype.
24913813 2014 Decreased ITIH5 expression is associated with poor prognosis in primary gastric cancer.
24265292 2014 Epigenetic inactivation of ITIH5 promotes bladder cancer progression and predicts early relapse of pT1 high-grade urothelial tumours.
23320751 2013 Promoter hypermethylation of the tumor-suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening.
22616691 2012 Functional annotation of the human fat cell secretome.
21852814 2012 ITIH-5 expression in human adipose tissue is increased in obesity.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
20200953 2010 Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study.
19809427 2009 Gene expression profiling associated with the progression to poorly differentiated thyroid carcinomas.
18810445 2008 [Novel prognostic marker in invasive breast cancer. ITIH5 expression is abrogated by aberrant promoter methylation].
18226209 2008 Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: a systematic expression analysis.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
17653090 2008 The extracellular matrix protein ITIH5 is a novel prognostic marker in invasive node-negative breast cancer and its aberrant expression is caused by promoter hypermethylation.
16385451 2006 A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16303743 2005 Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.
15498874 2004 Large-scale cDNA transfection screening for genes related to cancer development and progression.
15164054 2004 The DNA sequence and comparative analysis of human chromosome 10.
14744536 2004 ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancer.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12975309 2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11853319 2001 Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins.