| Tbio | Integrin beta-5 |
(Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C.
This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 integrin is involved in adhesion to vitronectin. [provided by RefSeq, Aug 2017]
This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 integrin is involved in adhesion to vitronectin. [provided by RefSeq, Aug 2017]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Arthritis, Juvenile | 126 | 0.0 | 0.0 |
| Thyroid Diseases | 24 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Juvenile arthritis | 126 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 7.1e-08 |
| lung carcinoma | 2843 | 7.4e-07 |
| psoriasis | 6694 | 4.3e-06 |
| posterior fossa group B ependymoma | 416 | 5.7e-06 |
| medulloblastoma, large-cell | 6241 | 4.5e-05 |
| Atopic dermatitis | 952 | 2.0e-04 |
| pancreatic carcinoma | 562 | 9.4e-04 |
| pancreatic cancer | 2398 | 9.4e-04 |
| osteosarcoma | 7950 | 1.1e-03 |
| diabetes mellitus | 1728 | 2.8e-03 |
| astrocytoma | 1146 | 2.8e-03 |
| cutaneous lupus erythematosus | 1057 | 4.0e-03 |
| primary pancreatic ductal adenocarcinoma | 1109 | 6.2e-03 |
| glioblastoma | 5792 | 1.1e-02 |
| group 3 medulloblastoma | 4104 | 1.5e-02 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 1.5e-02 |
| invasive ductal carcinoma | 2951 | 2.0e-02 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytoma | 2.100 | 2.8e-03 |
| Atopic dermatitis | -1.100 | 2.0e-04 |
| cutaneous lupus erythematosus | -1.200 | 4.0e-03 |
| diabetes mellitus | -1.100 | 2.8e-03 |
| glioblastoma | 1.300 | 1.1e-02 |
| group 3 medulloblastoma | -1.400 | 1.5e-02 |
| invasive ductal carcinoma | -1.200 | 2.0e-02 |
| lung carcinoma | -1.100 | 7.4e-07 |
| medulloblastoma, large-cell | -1.100 | 4.5e-05 |
| mucosa-associated lymphoid tissue lympho... | 2.211 | 1.5e-02 |
| osteosarcoma | -2.126 | 1.1e-03 |
| ovarian cancer | -1.600 | 7.1e-08 |
| pancreatic cancer | 1.100 | 9.4e-04 |
| pancreatic carcinoma | 1.100 | 9.4e-04 |
| posterior fossa group B ependymoma | 1.100 | 5.7e-06 |
| primary pancreatic ductal adenocarcinoma | 1.067 | 6.2e-03 |
| psoriasis | -1.100 | 4.3e-06 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA |
MPRAPAPLYACLLGLCALLPRLAGLNICTSGSATSCEECLLIHPKCAWCSKEDFGSPRSITSRCDLRANL 1 - 70 VKNGCGGEIESPASSFHVLRSLPLSSKGSGSAGWDVIQMTPQEIAVNLRPGDKTTFQLQVRQVEDYPVDL 71 - 140 YYLMDLSLSMKDDLDNIRSLGTKLAEEMRKLTSNFRLGFGSFVDKDISPFSYTAPRYQTNPCIGYKLFPN 141 - 210 CVPSFGFRHLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFTTDDV 211 - 280 PHIALDGKLGGLVQPHDGQCHLNEANEYTASNQMDYPSLALLGEKLAENNINLIFAVTKNHYMLYKNFTA 281 - 350 LIPGTTVEILDGDSKNIIQLIINAYNSIRSKVELSVWDQPEDLNLFFTATCQDGVSYPGQRKCEGLKIGD 351 - 420 TASFEVSLEARSCPSRHTEHVFALRPVGFRDSLEVGVTYNCTCGCSVGLEPNSARCNGSGTYVCGLCECS 421 - 490 PGYLGTRCECQDGENQSVYQNLCREAEGKPLCSGRGDCSCNQCSCFESEFGKIYGPFCECDNFSCARNKG 491 - 560 VLCSGHGECHCGECKCHAGYIGDNCNCSTDISTCRGRDGQICSERGHCLCGQCQCTEPGAFGEMCEKCPT 561 - 630 CPDACSTKRDCVECLLLHSGKPDNQTCHSLCRDEVITWVDTIVKDDQEAVLCFYKTAKDCVMMFTYVELP 631 - 700 SGKSNLTVLREPECGNTPNAMTILLAVVGSILLVGLALLAIWKLLVTIHDRREFAKFQSERSRARYEMAS 701 - 770 NPLYRKPISTHTVDFTFNKFNKSYNGTVD 771 - 799 //
