Tbio ITGB5 Integrin beta-5

Protein Summary

Description

Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C. This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 integrin is involved in adhesion to vitronectin. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• P18084
• B0LPF8
• B2RD70

Gene Name

• ITGB5

Ensembl ID

• ENST00000296181
• ENSP00000296181
• ENSG00000082781

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
protein domain	0.97
transcription factor perturbation	0.97
disease perturbation	0.96
protein complex	0.91

Protein Classes

PANTHER Classes

Protein / Receptor / Integrin Beta-5

Protein / Cell Adhesion Molecule / Integrin Beta-5

DTO Classes

Protein / Receptor / Integrin Beta-5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.23   (req: < 5)

Gene RIFs: 70   (req: <= 3)

Antibodies: 502   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.23   (req: >= 5)

Gene RIFs: 70   (req: > 3)

Antibodies: 502   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0