Property Summary

NCBI Gene PubMed Count 29
PubMed Score 19.33
PubTator Score 17.05

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (14)

Disease log2 FC p
nephrosclerosis 1.032 2.3e-04
osteosarcoma -1.960 2.1e-02
non diabetic and post-ischemic heart fai... 1.100 8.7e-03
adrenocortical carcinoma -1.672 1.3e-03
non-small cell lung cancer -2.856 4.6e-27
intraductal papillary-mucinous neoplasm ... -1.200 4.1e-03
lung cancer -3.800 2.4e-06
interstitial cystitis -1.200 1.6e-03
lung adenocarcinoma -1.900 9.6e-13
lung carcinoma -2.800 3.6e-16
Pick disease 1.400 1.3e-05
pituitary cancer -1.400 8.0e-04
head and neck cancer -1.900 1.9e-02
psoriasis -1.100 1.2e-30

 GO Function (1)

 CSPA Cell Line (3)

Protein-protein Interaction (4)

Gene RIF (16)

PMID Text
24700879 In 15 of 590 families, we identified recessive mutations in the genes FRAS1, FREM2, GRIP1, FREM1, ITGA8, and GREM1, all of which function in the interaction of the ureteric bud and the metanephric mesenchyme.
24667918 Microarray analysis indicates HIV-1 Tat-induced upregulation of integrin, alpha 8 (ITGA8) in primary human brain microvascular endothelial cells
24439109 Mutations of ITGA8 are a genetic cause of bilateral renal agenesis and that, at least in some cases, bilateral renal agenesis is an autosomal-recessive disease.
23153507 the ITGA8 gene might have gender-specific roles in the development of schizophrenia.
23142384 Analysis of the data demonstrated that Itga8 expression is CArG box-serum response factor independent, but myocardin dependent through an as yet unknown sequence module that is distal from the promoter region.
20942236 The mRNA levels of Integrinalpha8 were significantly lower in LSCC tissues than that in corresponding adjacent normal tissues.
20678483 alpha8beta1 is a prerequisite for the proper conduct of anoikis in normal human intestinal epithelial crypt cells, whereas its loss contributes to the illicit acquisition of anoikis resistance.
19527220 In intestinal crypt cells, integrin alpha8beta1 is closely involved in the regulation of adhesion, migration and cell proliferation via a predominant RhoA/ROCK-dependent mechanism.
19342381 These results indicate that the specific high-affinity binding of nephronectin to alpha8beta1 integrin is achieved by bipartite interaction of the integrin with the RGD motif and LFEIFEIER sequence.
18277079 A polymorphism of the ITGA8 promoter modifies the progression of renal failure in ADPKD.
18277079 Observational study of gene-disease association. (HuGE Navigator)
16385451 Observational study of gene-disease association. (HuGE Navigator)
15592496 Mammary carcinoma cells do express alpha8 integrin.
15579315 genomic analysis of the human integrin subunit alpha8 gene
12787402 Role in regulation of mesangial cell phenotype. Seems to promote adhesion, but inhibit migration and proliferation of mesangial cells. Alpha8 integrin could play important role in maintaining tissue integrity in glomerulus during glomerular injury.
12060755 expressed in developing kidney

AA Sequence

MSPGASRGPRGSQAPLIAPLCCAAAALGMLLWSPACQAFNLDVEKLTVYSGPKGSYFGYAVDFHIPDART      1 - 70
ASVLVGAPKANTSQPDIVEGGAVYYCPWPAEGSAQCRQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATV     71 - 140
KAHKGKVVACAPLYHWRTLKPTPEKDPVGTCYVAIQNFSAYAEFSPCRNSNADPEGQGYCQAGFSLDFYK    141 - 210
NGDLIVGGPGSFYWQGQVITASVADIIANYSFKDILRKLAGEKQTEVAPASYDDSYLGYSVAAGEFTGDS    211 - 280
QQELVAGIPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNSDGLDDVLVGAPLFMEREF    281 - 350
ESNPREVGQIYLYLQVSSLLFRDPQILTGTETFGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQRGKVL    351 - 420
IYNGNKDGLNTKPSQVLQGVWASHAVPSGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAVYRARPVVTVD    421 - 490
AQLLLHPMIINLENKTCQVPDSMTSAACFSLRVCASVTGQSIANTIVLMAEVQLDSLKQKGAIKRTLFLD    491 - 560
NHQAHRVFPLVIKRQKSHQCQDFIVYLRDETEFRDKLSPINISLNYSLDESTFKEGLEVKPILNYYRENI    561 - 630
VSEQAHILVDCGEDNLCVPDLKLSARPDKHQVIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVG    631 - 700
IERNNKGFRPLSCEYKMENVTRMVVCDLGNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNP    701 - 770
DSNFVSLQINITAVAQVEIRGVSHPPQIVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTISDTIL    771 - 840
EVGWPFSARDEFLLYIFHIQTLGPLQCQPNPNINPQDIKPAASPEDTPELSAFLRNSTIPHLVRKRDVHV    841 - 910
VEFHRQSPAKILNCTNIECLQISCAVGRLEGGESAVLKVRSRLWAHTFLQRKNDPYALASLVSFEVKKMP    911 - 980
YTDQPAKLPEGSIVIKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGFFDRARPPQEDMT    981 - 1050
DREQLTNDKTPEA                                                            1051 - 1063
//

Text Mined References (29)

PMID Year Title
24700879 2014 Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract.
24439109 2014 Integrin alpha 8 recessive mutations are responsible for bilateral renal agenesis in humans.
24024966 2013 Genome-wide association study of chronic periodontitis in a general German population.
23154389 2013 Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
23153507 2013 A missense mutation in the ITGA8 gene, a cell adhesion molecule gene, is associated with schizophrenia in Japanese female patients.
23142384 2013 Expression and promoter analysis of a highly restricted integrin alpha gene in vascular smooth muscle.
21423176 2011 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for ?-Pix in negative regulation of focal adhesion maturation.
21335239 2011 The basement membrane of hair follicle stem cells is a muscle cell niche.
20942236 2010 [Expression and significance of integrins subunits in laryngeal squamous cell carcinoma].
20678483 2010 Integrin alpha8beta1 confers anoikis susceptibility to human intestinal epithelial crypt cells.
19915575 2009 Genome-wide association study reveals genetic risk underlying Parkinson's disease.
19527220 2009 Integrin alpha8beta1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK-dependent mechanism.
19342381 2009 Molecular basis of the recognition of nephronectin by integrin alpha8beta1.
19197348 2009 Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
18277079 2008 A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease.
16385451 2006 A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
15721307 2005 Integrin alpha8beta1-fibronectin interactions promote cell survival via PI3 kinase pathway.
15592496 2005 Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro.
15579315 2004 Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8).
15164054 2004 The DNA sequence and comparative analysis of human chromosome 10.
12787402 2003 Role of alpha8 integrin in mesangial cell adhesion, migration, and proliferation.
12415008 2002 Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1.
12060755 2002 Hoxa 11 is upstream of Integrin alpha8 expression in the developing kidney.
11668187 2001 Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas.
10504498 1999 Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis.
9614184 1998 Identification of osteopontin as a novel ligand for the integrin alpha8 beta1 and potential roles for this integrin-ligand interaction in kidney morphogenesis.
7768999 1995 Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells.
7559467 1995 The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin.
7541634 1995 The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C.