| Tbio | Integrin alpha-6 |
Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Arthritis, Rheumatoid | 174 | 0.0 | 0.0 |
| Epidermolysis bullosa with pyloric atresia | 3 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| juvenile dermatomyositis | 1187 | 3.4e-08 |
| cystic fibrosis | 1696 | 6.1e-08 |
| lung carcinoma | 2843 | 1.3e-05 |
| Breast cancer | 3578 | 1.7e-05 |
| Duchenne muscular dystrophy | 601 | 1.9e-05 |
| lung adenocarcinoma | 2716 | 5.8e-05 |
| malignant mesothelioma | 3232 | 6.4e-05 |
| ependymoma | 4679 | 8.6e-05 |
| lung cancer | 4740 | 2.4e-04 |
| non-small cell lung cancer | 2890 | 7.6e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.3e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.7e-03 |
| osteosarcoma | 7950 | 3.1e-03 |
| tuberculosis | 2010 | 3.3e-03 |
| Common variable immunodeficiency | 101 | 4.3e-03 |
| dermatomyositis | 966 | 4.7e-03 |
| medulloblastoma, large-cell | 6241 | 5.1e-03 |
| glioblastoma | 5792 | 5.7e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 8.0e-03 |
| Barrett's esophagus | 182 | 9.2e-03 |
| esophageal adenocarcinoma | 737 | 4.3e-02 |
| group 4 medulloblastoma | 1855 | 4.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Prostate cancer | 175 | 0.0 | 3.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Junctional epidermolysis bullosa with pyloric atresia | 3 | 0.0 | 5.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Epidermolysis bullosa | 21 | 5.18 | 2.6 |
| Disease | Target Count |
|---|---|
| Epidermolysis Bullosa Junctionalis With Pyloric Atresia | 3 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 1.600 | 2.3e-03 |
| Barrett's esophagus | 1.700 | 9.2e-03 |
| Breast cancer | -1.500 | 1.7e-05 |
| Common variable immunodeficiency | -1.407 | 4.3e-03 |
| cystic fibrosis | 4.377 | 6.1e-08 |
| dermatomyositis | 1.100 | 4.7e-03 |
| Duchenne muscular dystrophy | 1.033 | 1.9e-05 |
| ependymoma | 1.100 | 8.6e-05 |
| esophageal adenocarcinoma | 1.400 | 4.3e-02 |
| glioblastoma | 1.300 | 5.7e-03 |
| group 4 medulloblastoma | -1.100 | 4.6e-02 |
| intraductal papillary-mucinous carcinoma... | 1.100 | 8.0e-03 |
| intraductal papillary-mucinous neoplasm ... | 2.000 | 2.7e-03 |
| juvenile dermatomyositis | 1.155 | 3.4e-08 |
| lung adenocarcinoma | -1.100 | 5.8e-05 |
| lung cancer | 1.200 | 2.4e-04 |
| lung carcinoma | -1.200 | 1.3e-05 |
| malignant mesothelioma | -1.500 | 6.4e-05 |
| medulloblastoma, large-cell | -1.900 | 5.1e-03 |
| non-small cell lung cancer | 1.074 | 7.6e-04 |
| osteosarcoma | 2.203 | 3.1e-03 |
| tuberculosis | 1.100 | 3.3e-03 |
MAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAE 1 - 70 ALPLQRANRTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQH 71 - 140 VNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGT 141 - 210 YNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYLGLLFLTSVSYTDPDQFVYKTRP 211 - 280 PREQPDTFPDVMMNSYLGFSLDSGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEG 281 - 350 LASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAV 351 - 420 KNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDVA 421 - 490 VGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSISIVGT 491 - 560 LEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEP 561 - 630 SSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGV 631 - 700 PELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQN 701 - 770 GSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSG 771 - 840 VAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKV 841 - 910 ESKGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPL 911 - 980 RGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQVRVTVFPSKTVAQYS 981 - 1050 GVPWWIILVAILAGILMLALLVFILWKCGFFKRSRYDDSVPRYHAVRIRKEEREIKDEKYIDNLEKKQWI 1051 - 1120 TKWNENESYS 1121 - 1130 //
