Tbio ITFG2 KICSTOR complex protein ITFG2

Protein Summary

Description

As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.

Uniprot Accession IDs

• Q969R8
• A8K4Z5
• D3DUQ2
• Q6PKU5
• Q96SX6

Gene Name

• ITFG2

Ensembl ID

• ENST00000228799
• ENSP00000228799
• ENSG00000111203
• ENST00000540929
• ENSP00000443329
• ENST00000644517
• ENSP00000496068

Symbol

• FGGAP1
• MDS028

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.92
cell type or tissue	0.76
histone modification site profile	0.67
phenotype	0.63
virus perturbation	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.14   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 215   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.14   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0