| Tbio | IST1 homolog |
ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888).
This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 9.2e-10 |
| osteosarcoma | 7950 | 3.5e-05 |
| medulloblastoma, large-cell | 6241 | 3.7e-04 |
| glioblastoma | 5792 | 1.2e-03 |
| astrocytoma | 1146 | 2.3e-02 |
| breast carcinoma | 1638 | 2.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Paraplegia | 74 | 4.129 | 2.1 |
| Shigellosis | 21 | 3.015 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytoma | 1.300 | 2.3e-02 |
| breast carcinoma | 1.100 | 2.4e-02 |
| glioblastoma | -1.100 | 1.2e-03 |
| medulloblastoma, large-cell | -1.200 | 3.7e-04 |
| osteosarcoma | -2.517 | 3.5e-05 |
| ovarian cancer | -1.300 | 9.2e-10 |
MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYLVEAME 1 - 70 ILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQ 71 - 140 IGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPG 141 - 210 RGGSGGFTAPVGGPDGTVPMPMPMPMPSANTPFSYPLPKGPSDFNGLPMGTYQAFPNIHPPQIPATPPSY 211 - 280 ESVDDINADKNISSAQIVGPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSASEDIDF 281 - 350 DDLSRRFEELKKKT 351 - 364 //
