Tbio IRX2 Iroquois-class homeodomain protein IRX-2

Protein Summary

Description

IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[supplied by OMIM, Apr 2004]

Uniprot Accession IDs

• Q9BZI1
• Q68A19
• Q7Z2I7

Gene Name

• IRX2

Ensembl ID

• ENST00000302057
• ENSP00000307006
• ENSG00000170561
• ENST00000382611
• ENSP00000372056

Symbol

• IRXA2
• IRXA2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
tissue sample	0.72
virus perturbation	0.72
PubMedID	0.68
kinase perturbation	0.66

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Homeodomain Transcription Factor / Iroquois-class Homeodomain Protein Irx-2

Protein / Nucleic Acid Binding / Iroquois-class Homeodomain Protein Irx-2

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Homeodomain Transcription Factor / Iroquois-class Homeodomain Protein Irx-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.2   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 167   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.2   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0