Property Summary

NCBI Gene PubMed Count 16
PubMed Score 25.61
PubTator Score 10.28

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (14)

Disease log2 FC p
astrocytic glioma 2.100 3.4e-03
oligodendroglioma 2.000 4.6e-03
posterior fossa group B ependymoma 3.800 4.5e-11
glioblastoma 3.600 2.7e-03
primitive neuroectodermal tumor 2.800 3.3e-02
Hydrolethalus syndrome -1.116 4.9e-02
pediatric high grade glioma 3.100 8.6e-04
pilocytic astrocytoma 3.000 3.9e-06
sonic hedgehog group medulloblastoma 3.000 3.0e-03
non primary Sjogren syndrome sicca 1.400 1.6e-02
psoriasis -1.400 9.9e-38
Breast cancer -5.600 1.3e-24
breast carcinoma -2.600 3.5e-30
invasive ductal carcinoma -2.600 1.1e-02

Gene RIF (11)

PMID Text
25822025 In osteosarcoma cells and lines, IRX1 overexpression was associated with hypomethylation of its own promoter. Experimental modulation in cell lines altered migration, invasion, and resistance to anoikis in vitro, and influenced lung metastasis in mice.
23456299 Findings suggest that methylation-associated down-regulation of EBF3 and IRX1 genes may play an important role in a pathogenic effect of TGF-beta on RASFs.
21649733 Helicobacter pylori infection contributes to IRX1 promoter methylation in gastric mucosa.
21602894 enforcing IRX1 expression effectively suppresses peritoneal spreading and pulmonary metastasis via anti-angiogenesis and anti-VM mechanisms, in addition to previously found cell growth and invasion.
20440264 IRX1 could potentially serve as a biomarker for gastric cancer.
20440264 Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma.
20306291 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20029986 Results verify IRX1, EBF3, SLC5A8, SEPT9, and FUSSEL18 as valid methylation markers in two separate sets of HNSCC specimens; also preliminarily show a trend between HPV16 positivity and target gene hypermethylation of IRX1, EBF3, SLC5A8, and SEPT9.
19240061 Observational study of gene-disease association. (HuGE Navigator)
18559491 Frequent methylation of IRX1 gene is associated with head and neck squamous cell carcinoma
18421076 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGGGAGAAAVTSVLGMYAAAGPY      1 - 70
AGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGVHPATFAAHTAPAYYPYGQFQYGDPGRPKNATRESTS     71 - 140
TLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSKDQEDGALFGSDT    141 - 210
EGDPEKAEDDEEIDLESIDIDKIDEHDGDQSNEDDEDKAEAPHAPAAPSALARDQGSPLAAADVLKPQDS    211 - 280
PLGLAKEAPEPGSTRLLSPGAAAGGLQGAPHGKPKIWSLAETATSPDGAPKASPPPPAGHPGAHGPSAGA    281 - 350
PLQHPAFLPSHGLYTCHIGKFSNWTNSAFLAQGSLLNMRSFLGVGAPHAAPHGPHLPAPPPPQPPVAIAP    351 - 420
GALNGDKASVRSSPTLPERDLVPRPDSPAQQLKSPFQPVRDNSLAPQEGTPRILAALPSA              421 - 480
//

Text Mined References (16)

PMID Year Title
25822025 2015 IRX1 hypomethylation promotes osteosarcoma metastasis via induction of CXCL14/NF-?B signaling.
23456299 2013 Hypermethylation of EBF3 and IRX1 genes in synovial fibroblasts of patients with rheumatoid arthritis.
22542470 2012 Genome-wide association study of antibody response to smallpox vaccine.
21649733 2011 Helicobacter pylori induces promoter hypermethylation and downregulates gene expression of IRX1 transcription factor on human gastric mucosa.
21602894 2011 IRX1 influences peritoneal spreading and metastasis via inhibiting BDKRB2-dependent neovascularization on gastric cancer.
20440264 2010 Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma.
20306291 2010 A three-stage genome-wide association study of general cognitive ability: hunting the small effects.
20029986 2010 HPV status-independent association of alcohol and tobacco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinomas.
19240061 2009 Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
18559491 2008 Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma.
18421076 2008 A genome-wide scan maps a novel high myopia locus to 5p15.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11435706 2001 Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes.
10370142 1999 Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.