| Tbio | Importin-9 |
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| acute quadriplegic myopathy | 1158 | 5.5e-07 |
| ovarian cancer | 8520 | 4.1e-06 |
| pediatric high grade glioma | 1064 | 1.6e-05 |
| osteosarcoma | 7950 | 2.4e-04 |
| psoriasis | 6694 | 6.3e-04 |
| lung cancer | 4740 | 7.2e-04 |
| glioblastoma | 5792 | 2.0e-03 |
| group 3 medulloblastoma | 4104 | 2.1e-03 |
| oligodendroglioma | 2850 | 5.2e-03 |
| primitive neuroectodermal tumor | 3035 | 1.5e-02 |
| astrocytoma | 1146 | 1.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Atypical lipomatous tumor | 2 | 3.76 | 1.9 |
| Disease | log2 FC | p |
|---|---|---|
| acute quadriplegic myopathy | 1.014 | 5.5e-07 |
| astrocytoma | 1.500 | 1.8e-02 |
| glioblastoma | 1.100 | 2.0e-03 |
| group 3 medulloblastoma | 1.100 | 2.1e-03 |
| lung cancer | 1.500 | 7.2e-04 |
| oligodendroglioma | 1.200 | 5.2e-03 |
| osteosarcoma | 1.481 | 2.4e-04 |
| ovarian cancer | 1.600 | 4.1e-06 |
| pediatric high grade glioma | 1.200 | 1.6e-05 |
| primitive neuroectodermal tumor | 1.100 | 1.5e-02 |
| psoriasis | 1.300 | 6.3e-04 |
MAAAAAAGAASGLPGPVAQGLKEALVDTLTGILSPVQEVRAAAEEQIKVLEVTEEFGVHLAELTVDPQGA 1 - 70 LAIRQLASVILKQYVETHWCAQSEKFRPPETTERAKIVIRELLPNGLRESISKVRSSVAYAVSAIAHWDW 71 - 140 PEAWPQLFNLLMEMLVSGDLNAVHGAMRVLTEFTREVTDTQMPLVAPVILPEMYKIFTMAEVYGIRTRSR 141 - 210 AVEIFTTCAHMICNMEELEKGAAKVLIFPVVQQFTEAFVQALQIPDGPTSDSGFKMEVLKAVTALVKNFP 211 - 280 KHMVSSMQQILPIVWNTLTESAAFYVRTEVNYTEEVEDPVDSDGEVLGFENLVFSIFEFVHALLENSKFK 281 - 350 STVKKALPELIYYIILYMQITEEQIKVWTANPQQFVEDEDDDTFSYTVRIAAQDLLLAVATDFQNESAAA 351 - 420 LAAAATRHLQEAEQTKNSGTEHWWKIHEACMLALGSVKAIITDSVKNGRIHFDMHGFLTNVILADLNLSV 421 - 490 SPFLLGRALWAASRFTVAMSPELIQQFLQATVSGLHETQPPSVRISAVRAIWGYCDQLKVSESTHVLQPF 491 - 560 LPSILDGLIHLAAQFSSEVLNLVMETLCIVCTVDPEFTASMESKICPFTIAIFLKYSNDPVVASLAQDIF 561 - 630 KELSQIEACQGPMQMRLIPTLVSIMQAPADKIPAGLCATAIDILTTVVRNTKPPLSQLLICQAFPAVAQC 631 - 700 TLHTDDNATMQNGGECLRAYVSVTLEQVAQWHDEQGHNGLWYVMQVVSQLLDPRTSEFTAAFVGRLVSTL 701 - 770 ISKAGRELGENLDQILRAILSKMQQAETLSVMQSLIMVFAHLVHTQLEPLLEFLCSLPGPTGKPALEFVM 771 - 840 AEWTSRQHLFYGQYEGKVSSVALCKLLQHGINADDKRLQDIRVKGEEIYSMDEGIRTRSKSAKNPERWTN 841 - 910 IPLLVKILKLIINELSNVMEANAARQATPAEWSQDDSNDMWEDQEEEEEEEEDGLAGQLLSDILATSKYE 911 - 980 EDYYEDDEEDDPDALKDPLYQIDLQAYLTDFLCQFAQQPCYIMFSGHLNDNERRVLQTIGI 981 - 1041 //
