Tbio IPO11 Importin-11

Protein Summary

Description

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity). Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008]

Uniprot Accession IDs

• Q9UI26
• A6NGJ5
• B4DZ73
• D3DW98
• Q8N5R2
• Q9NSJ6
• Q9NVB1
• Imp11

Gene Name

• IPO11

Ensembl ID

• ENST00000325324
• ENSP00000316651
• ENSG00000086200
• ENST00000409296
• ENSP00000386992

Symbol

• RANBP11
• RanBP11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
transcription factor binding site profile	0.76
transcription factor	0.75
virus perturbation	0.72
disease perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Transporter / Importin-11

Protein / Enzyme Modulator / G-protein / Small Gtpase / Importin-11

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Importin-11

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.8   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 191   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.8   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0