Tbio IP6K1 Inositol hexakisphosphate kinase 1

Protein Summary

Description

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. This gene encodes a member of the inositol phosphokinase family. The encoded protein may be responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• Q92551
• A8K157
• A8MUX4
• Q7L3I7
• Q96E38
• InsP6 kinase 1

Gene Name

• IP6K1

Ensembl ID

• ENST00000321599
• ENSP00000323780
• ENSG00000176095
• ENST00000395238
• ENSP00000378659
• ENST00000460540
• ENSP00000420762
• ENST00000613416
• ENSP00000482032

Symbol

• IHPK1
• KIAA0263
• PiUS
• IHPK1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
histone modification site profile	0.85
kinase perturbation	0.84
transcription factor perturbation	0.84
microRNA	0.71

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Inositol Hexakisphosphate Kinase 1

DTO Classes

Protein / Kinase / Unclassified Protein / Inositol Hexakisphosphate Kinase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.27   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 222   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.27   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0