Tbio INTS13 Integrator complex subunit 13

Protein Summary

Description

Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing (PubMed:23904267).

Uniprot Accession IDs

• Q9NVM9
• B4DNK1
• Q86WE2
• Q96HM2
• Q9BTX2
• Q9NTB6
• Q9NVM5

Gene Name

• INTS13

Ensembl ID

• ENST00000261191
• ENSP00000261191
• ENSG00000064102

Symbol

• ASUN
• C12orf11
• GCT1
• ASUN
• GCT1
• NET48
• Mat89Bb
• SPATA30
• C12orf11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.21   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 55   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.21   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0