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Tbio Insulin-induced gene 2 protein

Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.

The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 88
PubMed Score 88.71
PubTator Score 109.79

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (4)

Disease Target Count Z-score Confidence
Liver Cirrhosis, Experimental 769 0.0 0.0
Weight Gain 100 0.0 0.0
Disease Target Count P-value
psoriasis 6694 2.6e-06
ovarian cancer 8520 9.9e-05
tuberculosis 2010 1.4e-03
medulloblastoma, large-cell 6241 1.0e-02
Disease Target Count Z-score Confidence
Osteoporosis 363 0.0 3.0
Disease Target Count Z-score Confidence
Obesity 678 4.903 2.5

Expression

  Differential Expression (4)

Disease log2 FC p
medulloblastoma, large-cell -1.200 1.0e-02
ovarian cancer -1.500 9.9e-05
psoriasis -1.100 2.6e-06
tuberculosis -1.100 1.4e-03

Synonym

Accession Q9Y5U4 A8K5W8 Q8TBI8 INSIG-2
Symbols INSIG-2

Gene

INSIG2

  Ortholog (10)

Species Source Disease
Inparanoid OMA
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA
Inparanoid OMA EggNOG
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA

 UniProt Keyword (11)

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 GO Function (1)

 GO Component (2)

 GO Process (11)

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 Compartment GO Term (32)

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 MGI Phenotype (3)

 GWAS Trait (1)

 HCA RNA Cell Line (56)

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Pathway (5)

PDB (1)

Gene RIF (114)

AA Sequence 

MAEGETESPGPKKCGPYISSVTSQSVNLMIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVIASIFSSA      1 - 70
WWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNIQLSLTLAAL     71 - 140
SIGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQL    141 - 210
AMYECKVIAEKSHQE                                                           211 - 225
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Text Mined References (91)

PMID Year Title