Tbio INPP5A Type I inositol 1,4,5-trisphosphate 5-phosphatase

Protein Summary

Description

Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction. The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q14642
• D3DXI3
• Q14640
• Q5JSF1
• 5PTase

Gene Name

• INPP5A

Ensembl ID

• ENST00000368594
• ENSP00000357583
• ENSG00000068383

Symbol

• 5PTASE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
transcription factor binding site profile	0.82
transcription factor perturbation	0.8
kinase perturbation	0.76
tissue sample	0.7

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Type I Inositol 1,4,5-trisphosphate 5-phosphatase

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Type I Inositol 1,4,5-trisphosphate 5-phosphatase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.79   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 148   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.79   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0