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Tbio Inhibitor of growth protein 2

Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).

This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

 Comments

Property Summary

NCBI Gene PubMed Count 45
PubMed Score 34.96
PubTator Score 827.93

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
ovarian cancer 8520 8.0e-05
psoriasis 6694 1.1e-03
non primary Sjogren syndrome sicca 891 1.5e-02
Breast cancer 3578 2.7e-02
Disease Target Count Z-score Confidence
X-linked dystonia-parkinsonism 9 3.172 1.6

Expression

  Differential Expression (4)

Disease log2 FC p
Breast cancer 2.600 2.7e-02
non primary Sjogren syndrome sicca 1.400 1.5e-02
ovarian cancer -1.200 8.0e-05
psoriasis 1.200 1.1e-03

Synonym

Accession Q9H160 B6ZDS1 O95698
Symbols ING1L
p33ING2

Gene

ING2

PANTHER Protein Class (3)

  Ortholog (13)

Species Source Disease
Inparanoid OMA
Inparanoid OMA EggNOG
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (15)

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 GO Function (6)

 GO Component (7)

 GO Process (18)

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 Compartment GO Term (45)

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 IMPC Phenotype (2)

 MGI Phenotype (7)

 HCA RNA Cell Line (56)

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Pathway (9)

Protein-protein Interaction (19)

SAP30   HDAC1   HDAC2   ARID4A   SIN3A   SIN3B   SAP130   SUDS3   AHNAK   TARSL2   ARID4B   RBBP7   BRMS1L   SAP30L   CENPH   PCM1   BRMS1   BAHCC1   EP300  

Gene RIF (29)

AA Sequence 

MLGQQQQQLYSSAALLTGERSRLLTCYVQDYLECVESLPHDMQRNVSVLRELDNKYQETLKEIDDVYEKY      1 - 70
KKEDDLNQKKRLQQLLQRALINSQELGDEKIQIVTQMLELVENRARQMELHSQCFQDPAESERASDKAKM     71 - 140
DSSQPERSSRRPRRQRTSESRDLCHMANGIEDCDDQPPKEKKSKSAKKKKRSKAKQEREASPVEFAIDPN    141 - 210
EPTYCLCNQVSYGEMIGCDNEQCPIEWFHFSCVSLTYKPKGKWYCPKCRGDNEKTMDKSTEKTKKDRRSR    211 - 280
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Text Mined References (47)

PMID Year Title