ING1
Inhibitor of growth protein 1
Protein Summary
Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene. This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
- ENST00000333219
- ENSP00000328436
- ENSG00000153487
- ENST00000338450
- ENSP00000345202
- ENST00000375775
- ENSP00000364930
- p33
- p47
- p33ING1
- p24ING1c
- p33ING1b
- p47ING1a
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
transcription factor binding site profile | 0.94 | ||
disease perturbation | 0.93 | ||
hub protein | 0.92 | ||
virus perturbation | 0.92 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 150.75 (req: < 5)
Gene RIFs: 75 (req: <= 3)
Antibodies: 458 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 150.75 (req: >= 5)
Gene RIFs: 75 (req: > 3)
Antibodies: 458 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0