You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
IL31RA
Interleukin-31 receptor subunit alpha

Protein Summary
Description
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 (PubMed:11877449, PubMed:14504285, PubMed:15627637, PubMed:15194700). May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity). The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297015
  • ENSP00000297015
  • ENSG00000164509
  • ENST00000354961
  • ENSP00000347047
  • ENST00000359040
  • ENSP00000351935
  • ENST00000396834
  • ENSP00000380046
  • ENST00000396836
  • ENSP00000380048
  • ENST00000447346
  • ENSP00000415900
  • ENST00000490985
  • ENSP00000427533

Symbol
  • CRL3
  • GPL
  • CRL
  • GPL
  • CRL3
  • GLMR
  • GLM-R
  • PLCA2
  • hGLM-R
  • IL-31RA
  • PRO21384
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.83
tissue
0.64
molecular function
0.6
gene perturbation
0.59
cell type or tissue
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.74   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.74   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0