| Tbio | Interleukin-26 |
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.
This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq, Jul 2008]
This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 5.4e-103 |
| Atopic dermatitis | 952 | 6.8e-05 |
| cystic fibrosis | 1696 | 3.5e-04 |
| group 3 medulloblastoma | 4104 | 8.2e-03 |
| interstitial cystitis | 2312 | 3.0e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| ulcerative colitis | 1819 | 0.0 | 2.3 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Crohn's disease | 321 | 3.585 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| psoriasis | 4.500 | 5.4e-103 |
| Atopic dermatitis | 1.200 | 6.8e-05 |
| cystic fibrosis | -1.727 | 3.5e-04 |
| group 3 medulloblastoma | 1.900 | 8.2e-03 |
| interstitial cystitis | 1.500 | 3.0e-02 |
