Property Summary

NCBI Gene PubMed Count 52
PubMed Score 75.55
PubTator Score 102.22

Knowledge Summary


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  Disease (1)


Gene RIF (44)

27089063 Findings indicate that the release of interleukin 25 (IL-25) from tumour-associated fibroblasts (TAFs) may serve as a check point for control of mammary tumour metastasis.
27000993 Therefore, IL-17E/IL-17RB signaling represents a potential therapeutic target for treatment of hepatocellular carcinoma
26845056 IL-8 and IL-25 are targets of miR-20b.
26762527 Our findings indicate that the alarmin cytokines IL-33 and IL-25 increase basophil activation and migratory potential, and may pose as a novel therapeutic targets for the treatment of allergic asthma.
26356122 expression of immunoreactivity for IL-17A, IL-17RA, IL-17E, and IL-17F was significantly elevated in prostatic tissue from benign prostatic hyperplasia and prostate cancer compared with that in controls
26347322 The IL17E rs79877597 SNP was a modifier of the risk for psoriasis disease severity and psoriatic arthritis.
26321145 IL-25 upregulated PD-L1 surface expression through the signaling pathways of JNK and STAT3, with STAT3 found to constitutively occupy the proximal region of the PD-L1 promoter.
25975248 IL-25 overexpression was observed in eosinophilic chronic rhinosinusitis and may serve as a mediator of eosinophilic CRS.
25903653 we have demonstrated that the expression of ET-1 and IL-25 was coordinately upregulated in the lesional keratinocytes of patients with AD and a murine AD model.
25705788 This article focuses on evidence for the role of IL-25, IL-33 and TSLP in human allergic disease; although this triad of cytokines is described as epithelial derived, it is clear that their expression within lung tissue is much more widespread.[Review]
25704964 increased levels in patients with chronic rhinosinusitis with nasal polyps
25676453 The levels of mRNA for IL-25 were not significantly elevated in parotid gland tissues from Kimura Disease patients as compared to controls.
25273095 asthmatic epithelial cells have an increased intrinsic capacity for expression of a pro-type 2 cytokine in response to a viral infection, and IL-25 is a key mediator of RV-induced exacerbations of pulmonary inflammation
25133876 Because IL-25 has a major role in triggering type 2 responses, bronchial epithelial IL-25 expression is likely a key determinant of type 2 response activation in asthma
24746746 Human chorionic gonadotropin up-regulates Il25, promoting the proliferation of decidual stromal cells by activation of JNK and AKT signal pathways.
24344271 IL-25 and type 2 innate lymphoid cells have roles in development of pulmonary fibrosis
24323357 IL-25 and IL-33-driven type-2 innate lymphoid cells have roles in atopic dermatitis
24247484 The increased IL-25 levels in plasma and the expression of IL-17RA and IL-17RB on eosinophils in allergic asthma patients suggests that IL-25 may activate eosinophils during allergic inflammation.
23957336 Patients with the 'IL-5, IL-17A, IL-25-high' airway inflammatory pattern are often uncontrolled asthmatics, despite daily treatment.
23810766 Our data demonstrate that IL-33 plays a critical role in the rapid induction of airway contraction by stimulating the prompt expansion of IL-13-producing type 2 innate lymphoid cells, whereas IL-25-induced responses are slower and less potent.
23657503 IL-25 enhances herpes simplex virus (HSV)-1 and vaccinia virus replication by inhibiting filaggrin expression, and IL-25 acts synergistically with IL-4 and IL-13 to enhance HSV-1 replication in vitro
23590308 Suggest that IL-25 production by airway epithelial cells is regulated by the transcription and protein release levels and that allergen proteases likely play pivotal roles in both biological processes.
23564603 IL-25 expression is markedly reduced during human and experimental fulminant hepatitis.
23429464 IL-25 Is Decreased in Sera of Patients With inflammatory bowel disease.
22691357 IL-25 secreted from epithelial cells has the potential to promote airway remodeling in asthma.
22266274 We observed significant downregulation of IL-25 in women with recurrent miscarriage compared with controls.
21570719 Allergen provocation induces functionally relevant, increased expression of IL-25 and its receptor in the asthmatic bronchial mucosa and dermis of sensitized atopic subjects.
21205894 Findings suggest that IL-25 is elevated in asthma and contributes to angiogenesis.
20944558 IL-25 production is differently regulated by TNF-alpha and TGF-beta1 in the human g
20861853 IL-25 may have a role in atopic dermatitis
20729468 Eosinophils are the main source of IL-25, whereas activated CD4+ memory T cells are the IL-17RB-expressing cells in Churg-Strauss syndrome.
20492545 production is linked to the amount of specific IgE antibodies in blood samples of 6 yr old children in Germany
20237496 Observational study of gene-disease association. (HuGE Navigator)
19968632 IL-17A and IL-25 had opposing effects on thymic stromal lymphopoietin regulation in human nasal epithelial cells
19329997 MMP7 coordinates allergic lung inflammation by activating interleukin 25 while simultaneously inhibiting retinoid-dependent development of regulatory T cells.
19129540 IL-25 is a negative regulator of monocyte proinflammatory cytokine responses
19095584 Higher expressions of IL-17E, IL-17A, IL-17BR and IL-17R are associated with oral inflammation.
17889290 Blocking IL-25 in an experimental model of allergic asthma prevents airway hyperresponsiveness, a critical feature of clinical asthma.
17719653 The upregulation of costimulation-induced IL-25 receptors and release of cytokines and chemokines from IL-25 treated costimulated Th cells were differentially regulated by intracellular JNK, p38 MAPK and NF-kappaB activity.
17635955 IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of TSLP-DC activated adaptive Th2 memory cells
16950278 IL-25 acts by amplifying TH2 cell-mediated allergic airway inflammation. IL-25 itself does not significantly induce allergic inflammation in vivo.
16522458 IL-17E may contribute to the induction and maintenance of eosinophilic inflammation by acting on lung fibroblasts. This supports a role for IL-17E in asthma pathophysiology.
12239140 Transgenic overexpression from humans into mice results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production.
11714825 Overexpression of IL-17E up-regulates gene expression of Th2 cytokines and induces growth retardation, jaundice, and multiorgan inflammation in a transgenic mouse model.

AA Sequence

YRRPCHGEKGTHKGYCLERRLYRVSLACVCVRPRVMG                                     141 - 177

Text Mined References (52)

PMID Year Title
27089063 2016 Induction of IL-25 secretion from tumour-associated fibroblasts suppresses mammary tumour metastasis.
27000993 2016 Non-CSCs nourish CSCs through interleukin-17E-mediated activation of NF-?B and JAK/STAT3 signaling in human hepatocellular carcinoma.
26845056 2015 Disease-specific signature of serum miR-20b and its targets IL-8 and IL-25, in myasthenia gravis patients.
26762527 2016 IL-25 and IL-33 induce Type 2 inflammation in basophils from subjects with allergic asthma.
26356122 2015 Expression of IL-17A, E, and F and their receptors in human prostatic cancer: Comparison with benign prostatic hyperplasia.
26347322 2015 Association between single nucleotide polymorphisms IL17RA rs4819554 and IL17E rs79877597 and Psoriasis in a Spanish cohort.
26321145 2015 Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses.
25975248 Interleukin-25 and interleukin-33 as mediators of eosinophilic inflammation in chronic rhinosinusitis.
25903653 2015 Mutual upregulation of endothelin-1 and IL-25 in atopic dermatitis.
25705788 2015 Epithelial cytokines and pulmonary allergic inflammation.
25704964 2015 Interleukin-25 and mucosal T cells in noneosinophilic and eosinophilic chronic rhinosinusitis.
25676453 2015 Increased expression of thymic stromal lymphopoietin and its receptor in Kimura's disease.
25273095 2014 Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation.
25133876 2014 Epithelial interleukin-25 is a key mediator in Th2-high, corticosteroid-responsive asthma.
24746746 2014 Interleukin-25 induced by human chorionic gonadotropin promotes the proliferation of decidual stromal cells by activation of JNK and AKT signal pathways.
24344271 2014 IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis.
24323357 2013 A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.
24247484 2014 IL-25 and IL-25 receptor expression on eosinophils from subjects with allergic asthma.
23957336 2013 Sputum cytokine mapping reveals an 'IL-5, IL-17A, IL-25-high' pattern associated with poorly controlled asthma.
23810766 2013 IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction.
23657503 2013 IL-25 enhances HSV-1 replication by inhibiting filaggrin expression, and acts synergistically with Th2 cytokines to enhance HSV-1 replication.
23590308 2013 Transcription of interleukin-25 and extracellular release of the protein is regulated by allergen proteases in airway epithelial cells.
23564603 2013 IL-25 prevents and cures fulminant hepatitis in mice through a myeloid-derived suppressor cell-dependent mechanism.
23429464 IL-25 downregulates Th1/Th17 immune response in an IL-10-dependent manner in inflammatory bowel disease.
22691357 2012 [IL-25 derived from epithelial cells has the potential to promote airway remodeling in asthma].
22266274 2012 The involvement of inflammatory cytokines in the pathogenesis of recurrent miscarriage.
21980299 2011 A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
21570719 2011 Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses.
21205894 2011 T-helper cell type 2 (Th2) memory T cell-potentiating cytokine IL-25 has the potential to promote angiogenesis in asthma.
20944558 2011 Interleukin-25 production is differently regulated by TNF-? and TGF-?1 in the human gut.
20861853 2011 IL-25 in atopic dermatitis: a possible link between inflammation and skin barrier dysfunction?
20729468 2010 Interleukin-25: a cytokine linking eosinophils and adaptive immunity in Churg-Strauss syndrome.
20492545 2010 IL-17E but not IL-17A is associated with allergic sensitization: results from the LISA study.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
19968632 2010 Opposing roles of IL-17A and IL-25 in the regulation of TSLP production in human nasal epithelial cells.
19329997 2009 Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma.
19129540 2009 Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3.
19095584 2008 Chosen IL-17 family proteins in neutrophils of patients with oral inflammation.
17889290 2007 Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma.
17719653 2007 Intracellular JNK, p38 MAPK and NF-kappaB regulate IL-25 induced release of cytokines and chemokines from costimulated T helper lymphocytes.
17635955 2007 IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
16950278 2006 IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice.
16522458 2006 IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15340161 2004 Signal peptide prediction based on analysis of experimentally verified cleavage sites.
12975309 2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12239140 2002 Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production.
11754819 2001 IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo.
11714825 2001 Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice.
11058597 2001 IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1.