| Tbio | Interleukin-22 receptor subunit alpha-2 |
Isoform 1 may play a role in establishing and maintaining successful pregnancy.
This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 1.5e-13 |
| non primary Sjogren syndrome sicca | 891 | 1.9e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Multiple Sclerosis | 540 | 0.0 | 3.0 |
| Disease | log2 FC | p |
|---|---|---|
| non primary Sjogren syndrome sicca | -1.100 | 1.9e-02 |
| psoriasis | 1.100 | 1.5e-13 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| OMA EggNOG | ||
| OMA EggNOG |
MMPKHCFLGFLISFFLTGVAGTQSTHESLKPQRVQFQSRNFHNILQWQPGRALTGNSSVYFVQYKIMFSC 1 - 70 SMKSSHQKPSGCWQHISCNFPGCRTLAKYGQRQWKNKEDCWGTQELSCDLTSETSDIQEPYYGRVRAASA 71 - 140 GSYSEWSMTPRFTPWWETKIDPPVMNITQVNGSLLVILHAPNLPYRYQKEKNVSIEDYYELLYRVFIINN 141 - 210 SLEKEQKVYEGAHRAVEIEALTPHSSYCVVAEIYQPMLDRRSQRSEERCVEIP 211 - 263 //
