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PMID |
Text |
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27116880 |
Exposure to nosocomial pneumonia associated with haplotypes IL-1RN * 4-IL-1beta (-511) C-->T gene of the same name cytokines having polar biological effects. |
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27078871 |
The study investigates Il-1 gene cluster polymorphisms and their association with coronary artery disease. Significant differences in association statuses were seen for IL1A +4845 G>T, IL1B -511 C>T. |
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27055013 |
Dynorphin 1-17 and Its N-Terminal Biotransformation Fragments Modulate Lipopolysaccharide-Stimulated Nuclear Factor-kappa B Nuclear Translocation, Interleukin-1beta and Tumor Necrosis Factor-alpha |
|
27046197 |
LX-2 exposure to IL-1, TNF-alpha and IL-8 can reverse the phenotype of pro-fibrogenic activated cells |
|
27010153 |
The levels of ESM1, CLDN5, IL-1beta, IL-6, and TNF-alpha were significantly higher in the migraine attack group than in the control group |
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26944557 |
Suggest that high glucose-induced phenotypic transition of endothelial cells might require IL-beta activation via the PKCbeta pathway. |
|
26937653 |
The IL-1beta-31TT genotype and homozygous APOEepsilon4 combined are associated with increased risk of developing Alzheimer disease with sleep disturbance. |
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26909953 |
IL-1A rs17561 and IL-1B rs1143634 polymorphisms are associated with periodontitis. |
|
26858253 |
These findings thereby provide new mechanistic insight into the regulation of TXNIP and beta-cell biology and reveal novel links between proinflammatory cytokines, carbohydrate response element binding protein-mediated transcription, and microRNA signaling. |
|
26842496 |
IL1ss rs16944 polymorphism may be a potential marker of severe renal manifestations and renal sequelae in Henoch-Schonlein purpura. |
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26831735 |
Data suggest elevated interleukin-1beta secretion from tyrosine kinase inhibitor- (TKI-)resistant chronic myeloid leukemia (CML) cells contributes to TKI/imatinib resistance via promotion of cell viability/migration; cells used lack BCR-ABL mutation. |
|
26823694 |
IL-1beta-511TT/CC influence on the risk of myocardial infarction and ischemic stroke at young age through NF-kappaB, iNOS, MMP-2 and Bax. |
|
26813462 |
there is a poor correlation of T/C substitution at the -31 position of IL-1beta promoter in febrile convulsions |
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26811540 |
IL-1beta promotes FGF-2 expression in chondrocytes |
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26808616 |
Inactivation of the EGFR with a blocking antibody decreased the S. aureus-mediated IL-1beta induction in primary keratinocytes. Inflammasomes mediate induced secretion but not induced gene expression of IL-1beta . |
|
26799482 |
Role of IL-1beta in the Il-6 induction in the developing enterocyte |
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26798640 |
Effect of Short-Term Stimulation with Interleukin-1beta and Differentiation Medium on Human Mesenchymal Stromal Cell Paracrine Activity in Coculture with Osteoblasts. |
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26790130 |
Effects of the New Generation Synthetic Reconstituted Surfactant CHF5633 on Pro- and Anti-Inflammatory Cytokine Expression in Native and LPS-Stimulated Adult CD14+ Monocytes. |
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26786651 |
Tuberculosis antigen specific IL-1beta may be an additional biomarker for active TB diagnosis among HIV positive subjects. |
|
26753875 |
Our data imply that at sites of tissue damage, when inflammatory mediators are present, for example in lungs of COPD patients, MSCs become more potent inducers of repair, in addition to their well-known immune-modulatory properties. |
|
26753456 |
results suggest that tested SNPs associated with differential production of IL-1 female and IL-10 are not risk factors for PCa and do not correlate with the presence of distant metastasis in eastern Croatians |
|
26728383 |
Data show that the expressions of interleukins IL-1 and IL-6 in the discs of discogenic low back pain (DLBP) patients were significantly elevated and negatively correlated with the Japanese Orthopedic Association (mJOA) scores of low back pain. |
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26718437 |
The IL-1B -511 C/T polymorphism is associated with susceptibility to rheumatoid arthritis (RA) in Caucasians; the IL-1B +3953 C/T polymorphism is associated with susceptibility to RA in Caucasians and Asians. (Meta-analysis) |
|
26711529 |
These results indicate that the LPS/IL-1beta-MyD88 axis plays a crucial role for stabilization of IkappaB-zeta mRNA. |
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26707272 |
These results indicate that MF inhibited the production and expression of MMP-1 and -13 and inflammatory mediators, at least in part, through suppressing the activation of either NF-kappaB or p38 MAPK in IL-1b-treated SW1353 chondrocytes. |
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26663052 |
Data show that the single nucleotide polymorphism (SNP) rs16944 in the interleukin 1 beta (IL1B) gene and its interaction with childhood maltreatment may influence the effect of antidepressant treatment for patients with major depressive disorder (MDD). |
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26657940 |
The IL6 rs1818879 (GA) heterozygous genotype was associated with severe influenza A (H1N1) virus infection and two IL1B SNPs were associated with a decreased risk of infection |
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26608362 |
MiR-29a and MiR-140 synergistically protect chondrocytes against the anti-proliferation and cell matrix signaling changes by IL-1b. |
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26596049 |
The lower content of secretory immunoglobulin A and interferon-gamma plus increased level of interleukin l-beta in saliva of patients with caries of contact surfaces of lateral teeth can be considered as factor predisposing to development of caries. |
|
26585190 |
Our study suggests that CC genotype and C allele at -31 and + 3954 polymorphic sites of IL-1beta gene are associated with an increased risk for FMF. |
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26581830 |
Data indicate that better cognitive control specifically following an emotional stressor is uniquely associated with less pronounced salivary IL1B increase in response to such stress. |
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26575253 |
Interleukin-1beta plasma levels were positively correlated with depression scores in patients with temporal lobe epilepsy. |
|
26560040 |
Altered expression of EP2 in patients with aspirin-exacerbated respiratory disease contributes to deficient induction of IL-1RI, reducing the capacity of IL-1beta to increase COX-2 and mPGES-1 expression, which results in low PGE2 production |
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26559977 |
these data suggest that, following calcium influx into the cell, pro-IL-1beta interacts with calmodulin and that this interaction is important for IL-1beta processing and release. |
|
26531703 |
Haplotype analysis for IL-1beta -31 and IL-1beta -511, with moderate linkage disequilibrium |
|
26523392 |
The authors found that cytoplasmic IL-1beta associates with the autophagosome and m-IL-1beta enters into the lumen of a vesicle intermediate but not into the cytoplasmic interior formed by engulfment of the autophagic membrane. |
|
26520031 |
Results indicate that IL-1beta plays an important role in development of uterine luminal epithelium by stimulating cell proliferation, and these effects are coordinately regulated by activation of the ERK1/2 and P38 MAPK cell signaling cascades. |
|
26517486 |
The authors demonstrated that polymorphisms in the promoter region of the IL-1B gene (at positions -511 and -31) are associated with an enhanced risk of Helicobacter pylori infection as well as gastritis in Helicobacter pylori-positive patients. |
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26515928 |
Necrotic trophoblastic debris induced endothelial cell activation through the IL-1beta/IL-1R pathway. However, the NALP3 inflammasome in endothelial cells was not involved in this process. |
|
26515063 |
results clarify how commensal bacteria affect hepcidin expression and reveal a novel connection between IL-1beta and activation of BMP signaling. |
|
26505399 |
we...investigate the genetic variants Interleukin-1beta(IL-1beta) +3953 C/T (rs1143634), IL-6 -174G/C (rs1800795), IL-8 -251T/A (rs4073), and IL-10 -1082A/G (rs1800896) and -819C/T (rs1800871) in the development of coronary artery disease |
|
26504029 |
Interleukin-1beta Polymorphism is associated with Prostate Cancer. |
|
26496436 |
Genetic polymorphisms in Il-1beta are not associated with individual susceptibility to silicosis. |
|
26481854 |
SHIP levels and activity are lower in intestinal tissues and peripheral blood samples from patients with Crohn's disease, resulting in induction of Il1-beta. |
|
26462562 |
There is evidence for association of gout with functional variants in CARD8, IL1B and CD14. |
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26404542 |
Data show reduced cytokines IL-10 and IL-19 expression, and enhanced IL-20 and il-1 beta expression in chronic recurrent multifocal osteomyelitis (CRMO) monocytes. |
|
26401715 |
IL1B polymorphisms may contribute to metformin's glucose-lowing efficacy in overweight or obese Chinese Type 2 diabetes mellitus patients. |
|
26396484 |
Glaucomatous MYOC mutations activate the IL-1beta/NF-kappaB inflammatory stress response and the glaucoma marker SELE in trabecular meshwork cells. |
|
26391839 |
Data suggest that production of reactive oxygen species finely tunes vascular endothelial cell function and inflammatory response; mechanisms include pro-inflammatory and pro-oxidant effects of IL1B in up-regulation of production of superoxide anions. |
|
26385345 |
It is concluded that IL6 -174 G>C and IL1B +3954 C>T SNPs might be involved in the development of congenital Toxoplasma gondii infection. |
|
26366788 |
Our findings indicate that epidermal growth factor, interleukin-1beta and angiotensin II receptor, type 1 may play important roles in the pathogenesis of endometriosis. |
|
26363312 |
individuals carrying the -511T and -31 C alleles experience HPA activation in response to opioid administration and therefore may be less likely to undertake subsequent self-administration |
|
26362269 |
Aggressive breast cancer cells secrete IL-1beta, which increases the production of chemokines by mesenchymal stem cells. |
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26357657 |
The data identifies IL-1beta as a novel target in ovarian surface epithelial cells expressing the 185delAG BRCA1 mutation. |
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26341894 |
expression profiles, roles and therapeutic potential of IL-1beta in intervertebral disk degeneration |
|
26330006 |
Results indicate there is a lack of association between the IL1B (-511 and +3954) polymorphisms and tuberculosis risk. [Meta-Analysis] |
|
26324708 |
formation of the 20-kDa form of IL-1beta may prevent the generation of mature bioactive IL-1beta and thus may limit inflammation |
|
26317859 |
results demonstrate AT-RvD1 treatment reduced IL-1beta-mediated alveolar epithelial cell activation. This is a key step in unraveling the protective effects of resolvins, especially AT-RvD1, during injury. |
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26314292 |
IL-1beta is elevated in patients with connective tissue diseases that have both anti-Ro/SSA antibodies and prolonged QTc intervals. |
|
26308798 |
NF-kappaB stimulates BMP-2 mRNA expression in rat and human beta cells upon IL-1b cytokine exposure. |
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26301593 |
IL-1b secretion induced by infectious supernatant harvested from two independent Vero cell lines was not enhanced by antibody. Secretion of multiple other inflammatory cytokines was also independent of antibody signaling |
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26300289 |
Data suggest that the interleukin-1beta-511 T>C (rs16944) gene polymorphism plays an important role in the development of silent myocardial ischemia (SMI) in diabetic patients. |
|
26284424 |
Data show that human monoclonal antibody canakinumab does not cross-react with Interleukin-1beta (IL-1beta) from mouse, rat, rabbit, or macaques. |
|
26279136 |
Elevated IL-1beta levels and IL-1beta-to-IL-1RA ratio as early as 4 days before the first pregnancy test are associated with an ectopic pregnancy after embryo transfer. |
|
26277062 |
possible role for IL-1beta in chondrocyte differentiation of vascular smooth muscle cells and calcification stimulated by glucose |
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26276670 |
It is demonstrated that IL-1beta is crucial in the development of blood-induced joint damage, whereas TNFalpha is not. |
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26276663 |
Polymorphic changes were observed for IL-1beta gene in 26 of 62 patients (41.9%), and 16 of the 80 (25.8%) in the control group. |
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26269588 |
analysis of the mechanistic link between neutrophil elastase expression in atherosclerotic plaques and concomitant pro-inflammatory bioactive IL-1beta secretion from endothelial cells |
|
26269197 |
RTD-1 reduced the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, and IL-8 in lipopolysaccharide (LPS)-stimulated human blood monocytes and THP-1 macrophages |
|
26263533 |
significant differences were found in carriage rate of both minor alleles of IL-1A (C-889T) and IL-1B (C+3954T) polymorphisms of aggressive periodontitis (AgP) cases compared with healthy controls in the Algerian population; the polymorphisms of the IL-1 genes appear to be associated with susceptibility to AgP in the Algerian population |
|
26232108 |
This study, besides defining a serum panel for glioblastoma discrimination, identified IL1beta as a potential candidate for developing targeted therapy. |
|
26223656 |
Data show that VvpE elastase induces the hypomethylation of the interleukin 1 beta {IL-1beta) promoter and the transcriptional regulation of NF-kappaappaB through annexin A (ANXA)2 recruitment to promote IL-1beta production in intestinal epithelial cells. |
|
26208636 |
Collectively, our findings indicate that DLX4 exerts opposing effects on the megakaryocytic and erythroid lineages in part by inducing IL-1beta and NF-kappaB signaling. |
|
26204886 |
CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells |
|
26202987 |
Data show that nicotinic agonists decrease interleukin 1 beta (IL-1beta) release from primary blood cells. |
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26201022 |
strong expression of TGF-beta1, IL-1beta and VEGF was evident in the extracellular matrix and in the cytoplasm of fibroblasts and myofibroblasts in Dupuytren's nodular tissues, as compared to control tissues |
|
26198339 |
Inhibition of interleukin-1 beta in patients with Schnitzler's syndrome is associated with suppression of inflammation. |
|
26188264 |
This meta-analysis demonstrated that IL1B -31C > T polymorphism might increase Helicobacter pylori infection risk in Asian and Latin American population. |
|
26187330 |
TNF-alpha (-308 G > A) and IL-1beta (-511 C < T) polymorphisms that lead to increased production of TNF-alpha and IL-1beta appear to be risk for development of brain abscess in North Indian population |
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26184031 |
miR-381 was induced in vitro by IL-1beta in ATDC5 cells, PMCs, and PHCs, and was expressed in areas of cartilage degradation or absorption in vivo |
|
26182076 |
IL-1beta is involved in the pathogenesis of juvenile-onset systemic lupus erythematosus. |
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26176534 |
IL-1beta and IL-1R1 promote cancer growth and metastasis by up-regulating CXCR4 expression and that CXCR4 may be a link between inflammation and cancer. |
|
26169021 |
indicates that the IL-1beta -511T/C polymorphism is associated with TB decreased risk in Africans, and IL-6 -174C/G polymorphism in Asians. Further well-designed, large scale studies are required to confirm this conclusion |
|
26162701 |
Farrerol inhibited IL-1beta-induced inflammatory responses in osteoarthritis chondrocytes by blocking PI3K/Akt/NF-kappaB signaling pathway. |
|
26158864 |
Data show that SNP interactions among H. pylori-related genes PGC, PTPN11, and IL1B, are associated with susceptibility to gastric carcinogenesis. |
|
26156812 |
Calcitriol suppresses Il-1beta induced inflammatory response in periodontal tissues. |
|
26156811 |
Thymoquinone inhibited IL-1beta-induced inflammatory mediator production by inhibition of NF-kappaB and MAPKs signaling pathways in osteoarthritis chondrocytes. |
|
26156202 |
In Tunisian ischemic stroke patients, there was no significant difference in the distribution of IL-1beta -31 T/C genotypes and allele frequencies between patients with or without type 2 diabetes and controls. IL-1beta correlated positively with blood glucose. |
|
26141218 |
Our study provided evidence that IL1B SNPs might be implicated in the pathogenesis of NSCLC in the Chinese population. |
|
26125891 |
IL-1beta+3954 C/T and IL-10-1082 A/G polymorphisms are associated with an increased risk of recurrent oral ulceration. |
|
26125871 |
We found that the IL-8 -251T/A polymorphism is associated with an increased risk of acute pancreatitis, and no significant association between IL-1betaand IL-10 gene polymorphisms and risk of acute pancreatitis was detected |
|
26120586 |
Patients with Primary Open-Angle Glaucoma are characterized by an increased mRNA expression of MMP1, MMP9, MMP12, TIMP1 and IL-1b genes as compared to the control group . |
|
26118062 |
Frequency of allelic variants of IL-1beta and IL-10 genes in chronic glomerulonephritis in children are related to the disease course and indices of hematopoiesis. |
|
26116704 |
Data show that P2 purinergic receptor P2X7R and the NLRP3 inflammasome pathway are involved in the secretion of interleukin-1beta (IL-1beta) from monosodium urate (MSU)-stimulated macrophages. |
|
26096304 |
Study provides evidence that IL-1b is key regulatory factor for the postictal suppression, and its receptor IL-1R1 may be a potential target for adjuvant treatment of postictal problems |
|
26076780 |
IL1B-511C/T was not associated with presence of immune thrombocytopenia. |
|
26075243 |
Nampt/PBEF/visfatin upregulation in colorectal tumors, mirrored in normal tissue and whole blood of colorectal cancer patients, is associated with metastasis, hypoxia, IL1beta, and anemia. |
|
26074413 |
familial Mediterranean fever demonstrate reduced NLRP3-mediated IL-1beta production |
|
26069103 |
Our study found that TNF-alpha expression may play a vital role in peritoneal metastasis of gastric cancer, while IL-1B expression might not be correlated with peritoneal metastasis |
|
26067154 |
DLX4 induces CD44 by stimulating IL-1beta-mediated NF-kappaB activity, thereby promoting peritoneal metastasis of ovarian cancer |
|
26065428 |
IL-1beta promotes nuclear DNaseI translocation in inactive form in lupus nephritis renal tubular cells . |
|
26045743 |
Sclareol exerts anti-osteoarthritic activities in interleukin-1beta-induced rabbit chondrocyte model of osteoarthritis. |
|
26041434 |
3D topography transiently induces concomitant upregulation of IL-1beta and MAPK ERK1/2 through nuclear factor-kappaB-dependent signaling pathway. |
|
26038188 |
IL-1b -511C>T and +3954C>T polymorphisms are not the risk factors for developing aggressive periodontitis. |
|
26032420 |
An inflammatory Syk-ERK signaling axis requires DENV immune complexes, because DENV-2 in the presence of serotype-matched anti-DENV-2 mAb, but not anti-DENV-1 mAb, activates Syk, ERK, and IL-1beta secretion. |
|
26031165 |
The occurrence of bone fractures was inversely correlated with level of soluble receptors of TNF (gamma = 0.3; p = 0.0029), and occurrence of ischemic heart disease with soluble receptors of IL-1 |
|
26021263 |
The results suggests LCN2 upregulation protects hepatocytes from IL-1beta-induced stress. |
|
26003199 |
For IL1- beta gene, a significantly higher frequency of the -511C/C genotype was observed in RA patients in comparison to controls, especially in women. Men with this genotype had less erosive forms. |
|
25993444 |
Uropathogenic Escherichia coli activates an NLRP3-independent cell death pathway and an aalpha-hemolysin-independent IL-1beta secretion pathway in human macrophages. |
|
25975153 |
Our results confirm the significant role of rs1143634 of the IL1B gene in Peptic ulcer disease development. |
|
25966220 |
This meta-analysis suggests that the IL-1beta-511C/T promoter polymorphism deceases the risk of chronic obstructive pulmonary disease in Asians. |
|
25954061 |
IL-1beta has a role in bone resorption during rheumatic diseases [review] |
|
25948251 |
IL-1Beta secretion is increased in mononuclear phagocytes dependent on increased CX3CR1. |
|
25941031 |
IL1beta was higher in synovial fluid of rheumatoid arthritis patients than spondyloarthritis patients. |
|
25922276 |
the various mechanisms by which macrophages have been proposed to secrete IL-1 family cytokines, and the potential involvement of caspase-1 therein. |
|
25922060 |
Elevated concentrations of IL-1 beta were observed in patients with poorer response speed performance and perceived cognitive disturbances in breast cancer. |
|
25910374 |
IL-1beta genetic polymorphisms may take part in the pathophysiology of gastroesophageal reflux disease. |
|
25907558 |
Stress-activated Dendritic Cells (DC) Induce Dual Interleukin (IL)-15- and IL1beta-mediated Pathways, Which May Elicit CD4+ Memory T Cells and Interferon (IFN)-stimulated Genes. |
|
25896300 |
studies showed that miR-146a was crucial for monocytic cell-based IL-1beta tolerance and cross-tolerance, and thus opens the way for future research in the development of therapeutics for inflammatory diseases. |
|
25895146 |
Hormone and Cytokine Responses to Repeated Endotoxin Exposures-No Evidence of Endotoxin Tolerance After 5 Weeks in Humans. |
|
25893807 |
persistent HPV16/18 infection in the cervix due to the presence of the HLA-DQB1 A-allele and chronic inflammation due to the presence of the IL-1beta -511 T-allele might predispose women to uterine cervical cancer development. |
|
25876154 |
These observations add further evidence in favor of anti-NGF therapy in autoimmune diseases and also unlock a new area of research about the role of NGF in IL-1beta mediated diseases. |
|
25872797 |
H2S inhibited the activation of the extracellular signal-regulated kinase (ERK)/IkappaBalpha/NF-kappaB pathway which was induced by IL-1beta. |
|
25858413 |
The findings of this study suggested that the IL-1beta-511C/T polymorphism may not be related to schizophrenia or smoking status in Chinese individuals, but may affect the severity of nicotine dependence among male smokers with schizophrenia. |
|
25853464 |
Here we show that downregulation of MITF-M expression by IL-1ss was paralleled by an upregulation of miR-155 expression in four melanoma lines. |
|
25847326 |
Hantavirus induces the formation of the NLRP3 inflammasome in THP-1 cells and this may be responsible for the elevated IL-1beta levels in HFRS patients. |
|
25821855 |
This meta-analysis provided strong evidence that the IL-1RA polymorphism was a risk factor of asthma, especially in Caucasian populations. However, no association was found for IL-1beta -511C/T genotype carriers. |
|
25809479 |
Interleukin-1beta has a role in reduction of CD44 Ser-325 phosphorylation in human epidermal keratinocytes that promotes CD44 homomeric complexes, binding to ezrin, and extended, monocyte-adhesive hyaluronan coats |
|
25802122 |
secreted IL-1beta by the endothelial cells contributes to influenza-induced inflammation, and blockade of IL-1beta signals is a potential treatment or therapeutic target for influenza-induced inflammation. |
|
25787827 |
The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture. |
|
25786687 |
CT, mmCT, and dmLT promote human Th17 responses via cAMP-dependent protein kinase A and caspase-1/inflammasome-dependent IL-1 signaling. |
|
25773799 |
Haplotype analysis of IL-1beta-31 and IL-1beta-511 showed decreased association of IL- 1beta-31 T with IL-1beta-511 C with gastric carcinoma (OR 0.728; P value 0.03). Expression study of 50 samples by immunohistochemistry (IHC) and RT-PCR showed association with grade III and stage III+IV. After correlating the expression with polymorphism no association was found |
|
25760020 |
NF-kappaBp65 bound to elements located at -1177 and -1335 in the ADAMTS9 promoter region, in contrast to the untreated samples. The results of the present study suggested that NF-kappaB may be involved in IL-1beta-induced activation of ADAMTS9 in human chondrocytes |
|
25754623 |
Cord blood IL-1beta were predictive for the development of bronchitis and wheezing by the age of 2 years. |
|
25741583 |
IL-1beta C-511T polymorphism is not associated with the risk of developing chronic periodontitis. Additional research is warranted to further explore and confirm the association of genetic polymorphism and chronic periodontitis. |
|
25738867 |
The results of the current study demonstrated that pro-inflammatory cytokines, including TGF-beta1, IL-1beta and IL-6 exhibited increased expression in human vestibular schwannoma tissue compared with normal vestibular nerve samples |
|
25735143 |
Combinations of cytokine gene network polymorphic markers as potential predictors of myocardial infarction |
|
25730877 |
In CAPS monocytes, LPS induces the externalization of copious amounts of ATP (10-fold), which drive IL-1beta, IL-18, and IL-1alpha release via activation of the P2X purinoceptor 7. |
|
25730036 |
In the current study, we evaluated the effect of IL-1b +3954 C/T (rs1143634) and IL-1b -511 C/T (rs16944) and IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796) on the development of acute pancreatitis risk. |
|
25728492 |
IL-1beta was higher in RA synovial fluid than in osteoarthritis synovial fluid. |
|
25710474 |
the study population examined, the SNP in the IL1B gene (+3954) and VNTR polymorphisms in the IL1RN gene were found to have a significant association with chronic periodontitis susceptibility |
|
25693732 |
Data indicate that the interleukin (IL)-1 family of cytokines are key regulators of the inflammatory network. |
|
25684535 |
IL-1B (C+3954T) gene polymorphism is associated with gastric cancer. |
|
25681340 |
Date show significantly increased interleukin 1 beta (IL-1beta) production in patients' stimulated leukapheresis concentrates and peripheral blood samples after extracorporeal photopheresis (ECP). |
|
25658624 |
This study examined the relative influence of adversities during childhood and adulthood in accounting for individual differences in pro-inflammatory gene expression, IL1B, in late life |
|
25652861 |
Mycoplasma genitalium LAMP negatively regulate TNF-alpha and IL-1beta secretion by inducing HO-1 expression in placental trophoblast cells. |
|
25639477 |
Both 1,25(OH)2D3 - and 25(OH)D3 induced IL-1beta release from THP-1 cells, and these effects were blocked with application of the caspase-1 inhibitor YVAD and the NLRP3 inhibitors glyburide and Bay 11-7082. |
|
25634659 |
Results show no significant association was found between TNF-alpha (-308 G/A) and IL-1beta (-511 C/T) polymorphisms and polycystic ovary syndrome (PCOS) risk in the overall population or subgroup analysis under all genetic models; results indicate that the IL-6 (-174 G/C) polymorphism likely conveys a protective effect against PCOS.[Meta-analysis] |
|
25629767 |
NFKBIZ gene knockdown in bronchial epithelial cells suppresses the release of IL-1b-induced IL-6 and GMCSF. |
|
25616863 |
Patients with neutrophilic asthma have impairment in anti-inflammatory ratio of gal-3/gal-3BP and IL-1RA/IL-1beta. |
|
25613133 |
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta |
|
25609807 |
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta |
|
25600910 |
Data suggest that secretion of IL1B and HSP70 (heat-shock protein 70) by fetal membranes is up-regulated during chorioamnionitis/infection with Escherichia coli; secretion of IL1B, HSP70, and HSP60 follow different temporal patterns. |
|
25596176 |
-511C allele in IL1beta was associated with more severe depression following chronic interpersonal stress exposure, relative to T/T homozygotes. The moderating effect was specific to interpersonal stressors and did not generalize to non-interpersonal stress. |
|
25595815 |
These data indicate that IL-1beta and IL-6 gene single nucleotide polymorphisms are associated with sickle cell anemia (SCA) complications among Brazilian patients and may act as genetic predictors of SCA clinical heterogeneity. |
|
25586177 |
These results indicate that 2 h of exposure of beta cells to a low but not a high concentration of IL-1b enhances glucose-stimulated insulin secretion through focal adhesion and actin remodeling, as well as modulation of gene expression. |
|
25580516 |
O157:H7-induced IL-1beta production was largely dependent upon caspase-1 activation and partially dependent upon ATP signalling and cathepsin B release, which were both involved in NLRP3 activation. |
|
25571868 |
the IL1beta 31 CC genotype was inversely associated with susceptibility to dyspeptic symptoms, in particular, upper abdominal pain and EPSlike symptoms. |
|
25562992 |
The data conclude that IL-6 plays an important role in the pathogenesis of Vt-T1D patients and is likely to gain favour as a therapeutic target in these patients. |
|
25560300 |
SNPs across IL-1b and BDNF Val66Met may influence antipsychotic-induced weight gain |
|
25555350 |
(PEG+PVA)-NH2 and PVA-NH2 AuNPs were internalized to a higher extent and caused interleukin-1beta secretion. |
|
25551602 |
The mRNA levels of Homer1, IL-1beta, and TNF-alpha in coronary artery disease patients were significantly higher than those in the control group, but not Homer2 and Homer3. |
|
25548434 |
IL-6, TNF-alpha, and IL-1beta are involved in systemic lupus erythematosus in Indian patients |
|
25548252 |
the secretion of IL-1alpha, IL-1beta, IL-12b, and CCL4 occurs during gelatinase degranulation, a process controlled by STX3. |
|
25546243 |
low levels of active JNK is significantly associated with the presence of IL-1beta in stage III melanoma. |
|
25545008 |
treatment of transfected cells with tumour necrosis factor (TNF), interleukin (IL)-1beta and IL-10 exerted variable effects on TNF-R1 ectodomain cleavage. |
|
25529283 |
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta |
|
25521228 |
Findings were SNPs in TICAM2 (P = 3.6 x 10(-6)) and IL1B (P = 4.3 x 10(-5)) associated with TB. |
|
25476526 |
These results suggest that XT-1 expression is refractory to the disease process and to inhibition by inflammatory cytokines and that signaling through AP-1, Sp1, and Sp3 is important in the maintenance of XT-1 levels in NP cells. |
|
25469832 |
Single-nucleotide polymorphism in IL-1beta gene was associated with a high symptom burden in multiple myeloma. |
|
25463072 |
Interleukin-1 has an important role in 25-hydroxycholesterol-induced synergistic cytokine production in smooth muscle cell-monocyte interactions |
|
25460081 |
HPV16 E2 potentiated NF-kappaB activation induced by inflammatory mediators, IL-1beta and SDF-1alpha, in HEK293 cells |
|
25451151 |
review of caspase-8 and its role in modulating IL-1beta and inflammation [review] |
|
25449573 |
Authors conclude that ECSIT appears to be a novel Hepatitis B virus X protein-interacting signal molecule and their interaction is mechanistically important in IL-1beta induction of NF-kappaB activation. |
|
25446437 |
The the IL-1B SNP rs187238,not contribute to late-onset Alzheimers disease susceptibility in the Hunan Han Chinese population. |
|
25437548 |
The exocytosed granzyme A enters target cells and mediates IL-1beta maturation independently of caspase-1 and without inducing cytotoxicity. |
|
25436985 |
Inflammatory status in rheumatoid arthritis is associated with an increased expression of TLR3 and of IL-1beta in CD34+ cells, which appear to affect cell number. |
|
25436214 |
Data indicate the role of tumor necrosis factor-alpha (TNFalpha) in the Th17 cell differentiation in rheumatoid arthritis through interleukin-6 (IL-6) and interleukin-1 beta (IL-1beta) production. |
|
25433580 |
data indicate that 30-day supplementation with 112 mg/day CFB (CFB-1) resulted in a significant reduction of LDL, TG, TC, IL-1beta, IL-6, MCP-1, and CRP. |
|
25428391 |
We for the first time proposed the role interleukin-1beta-mir-101-EZH2 axes in the particle-induced lung cancer |
|
25422961 |
Genetic variants of IL1B may modulate the development of internalizing symptoms in the face of childhood adversity. |
|
25421594 |
It is a pro-inflammatory cytokine. |
|
25418470 |
IL-1b, which normally bridges innate and adaptive immunity, induces the production of the major haematopoietic/proleukaemic growth factor SCF through the PI-3K/mTOR pathway and the HIF-1a transcription complex. |
|
25398456 |
Functional polymorphisms in IL1B and DEFB1 influence susceptibility to mold infection in solid-organ transplant recipients. |
|
25389708 |
Decreased production of IL-1beta in low birth weight newborns was correlated with reduced expression of TLR-4 and MyD88 mRNA. |
|
25374200 |
IL1-Beta polymorphism is significantly associated with prostate cancer risk. |
|
25372293 |
caspase-1/ASC inflammasomes play a significant role in the activation of IL-1beta/ROS and NF-kappaB signaling of cytokine gene expression for T. cruzi control in human and mouse macrophages. |
|
25353097 |
Results show that an increase in IL-1b and CXCL10 correlated with a decreased progression free survival, indicating their important prognostic role. |
|
25329476 |
Higher IL-1beta expression did not suppress the activity of IFN-gamma-producing T cells |
|
25315113 |
TNF-alpha -308G/A and IL-8 -251T/A were significantly associated with AD and IL-1beta +3953C/T with late-life depression, while the significance of these associations was lost after Bonferroni correction. |
|
25311115 |
Impaired NLRP3 inflammasome activity during fetal development regulates IL-1beta production in human monocytes. |
|
25310146 |
An association between the SNPs of the IL1 beta and susceptibility to Hashimoto's thyroiditis among the group of Caucasian-Polish population studied was found. |
|
25294684 |
IL-1beta stimulation causes sequential phosphorylation of IRAK-1, c-Jun N-terminal kinase, and p300 and enhances recruitment of the p300/CBP/NF-Y complex to Gankyrin promoter |
|
25292060 |
IL1B gene polymorphism is associated with gastritis. |
|
25284686 |
NLRP3 was higher in degenerated intervertebral discs than in healthy controls. |
|
25263616 |
Choriodecidual tissue punches released IL-1alpha and IL-1beta in response to group-B-Streptococcus and this medium significantly stimulated release of HBD-2 by amnion cell cultures. |
|
25261722 |
results show that U373 cells produce and secrete CRYAB via exosomes and that stimulation with IL-1beta and TNF-alpha significantly increase the levels of CRYAB in not only the cells but also in the secreted exosomes |
|
25258120 |
The IL-1beta-511 C/T polymorphism was found to enhance the risk of stomach cancer. |
|
25252591 |
present study suggests strong association of TT genotype of -511 and CT genotype of +3954 variant of interleukin 1beta with chronic periodontitis. the -31 variant did not show significant association with disease. |
|
25240611 |
Cleaved IL1B was present in sera from familial Mediterranean fever patients during febrile attack periods, but not in healthy controls or FMF patients in remission periods. FMF patients had increased cleaved IL1B levels compared to RA patients. |
|
25231464 |
keratinocyte-derived SAA triggers a key inflammatory mediator, IL-1beta, via NLRP3 inflammasome activation, providing new potential targets for the treatment of this chronic skin disease. |
|
25229885 |
the role of C5a as an endogenous priming signal that is required for the initiation of uric acid crystal-induced IL-1beta production. |
|
25223243 |
Inflammation of the fetal side of the placenta was associated with elevated fetal IL1B at delivery. |
|
25223242 |
IL-1b gene polymorphisms were associated with more severe impairments after stroke. |
|
25222025 |
Polymorphisms within IL1B are associated with preeclampsia in a Chinase Han population. |
|
25221996 |
Polymorphisms within IL1B are associated with vitiligo susceptibility. |
|
25207923 |
The IL1A (T)/IL1RN (A) genotype, but not the IL1B (T)/IL1RN (A) genotype, may increase the risk of a chronic pain outcome in patients following disc herniation. |
|
25205101 |
we report that ATP-mediated suppression of IFNgamma production by Th17 cells can be overcome by genetic ablation of CD73 or by using IL1beta instead of TGFbeta to program Th17 cells ex vivo |
|
25204733 |
IL-1beta can be induced participates in the early and late stages of oral carcinogenesis |
|
25201247 |
SFAs, but not unsaturated fatty acids (UFAs), increased interleukin (IL)-1beta secretion and decreased IL-1 receptor antagonist (IL-1Ra) secretion |
|
25200056 |
IL-1beta protein levels in human thoracic aortic aneurysms were approximately 20-fold more than in normal thoracic aortas. |
|
25185259 |
Hypoxia potentiates IL-1B expression in cultured macrophages. |
|
25174605 |
The IL1B (-511), (-31) and IL1RN (VNTR) polymorphisms are associated with COPD risk in East Asians. |
|
25172489 |
Helicobacter pylori-induced IL-1beta secretion in innate immune cells is regulated by the NLRP3 inflammasome and requires the cag pathogenicity island. |
|
25135735 |
The results showed that the expression of SP and CGRP was significantly enhanced in the neurogenic SMSCs in response to IL-1beta, IL-6 and TNF-alpha, and the effect was remarkably inhibited by HA. |
|
25135221 |
an IL-1beta/IL-1RI/beta-catenin signaling pathway induces beta-catenin accumulation due to GSK3beta inactivation by Akt phosphorylation |
|
25130968 |
relationship between IL-6-643 (C/G) and IL-1beta-31 (C/T) polymorphisms and lung cancer risk among female non-smokers |
|
25117345 |
IL-1B-31 locus polymorphism may be associated with gastric cancer susceptibility |
|
25109676 |
A remarkable positive association has been found between the IL-1beta -511 T/T polymorphism and the development of juvenile systemic lupus erythematosus in Iranian patients. |
|
25103771 |
IL-1B can drive prostate cancer (PCa) progression in an inflammatory microenvironment through androgen receptor repression and p62 induction to promote the development and survival of androgen independent PCa. |
|
25098998 |
IL-1 beta (+3954) TT genotype and T allele were significantly associated with CHPDM group when compared with CHP, whereas CC genotype and allele C was higher in CHP subjects |
|
25095741 |
Cyclooxygenase 2, toll-like receptor 4 and interleukin 1beta mRNA expression in atherosclerotic plaques of type 2 diabetic patients |
|
25080789 |
The detection of basal level of IgM rheumatoid factor, IgM and also certain cytokines can be useful in prognosis of effectiveness of rituximab therapy under rheumatoid arthritis. |
|
25080058 |
activating effect of PI3K inhibitor on IL-1beta release was mediated mainly by the enhancement of the intracellular IL-1beta and caspase-1 content release to the extracellular medium and not by increasing the corresponding mRNA and protein expression levels |
|
25066273 |
interleukin-1beta (IL-1beta)-induced IER3 expression is mediated by the ERK1/2 target, transcription factor Elk-1. |
|
25061439 |
Increased IL-1beta secretion by peripheral blood mononuclear cells of Chronic recurrent multifocal osteomyelitis patients during active disease was shown. IL-1beta transcript levels were significantly higher also in remission compared to healthy controls. |
|
25058342 |
The frustrated host response to Legionella pneumophila is bypassed by MyD88-dependent translation of pro-inflammatory cytokines. |
|
25054228 |
IL-1beta expression is aberrantly induced in malignant glioma cells. |
|
25048991 |
Human macrophage inflammasome activation and IL-1beta secretion requires calcium but does not involve NADPH oxidases |
|
25039313 |
IL-1beta and TNFalpha prevent IL-2- and TGF-beta1-driven CD8(+) iTregs suppressive function in human T cells. |
|
25036364 |
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta |
|
25025954 |
Higher levels of IL-1beta and IL-1alpha were found in peripheral blood mononuclear cells supernatants of patients during crises compared to those in remission and to controls. |
|
25022753 |
Studies show transient induction of Wnt5a by interleukin-1beta (IL-1beta) stimulation proceeds through NF-kappaB in human corneal endothelial cells. |
|
25012128 |
THP-1 monocyte-secreted IL-1beta/IL-18 promotes vascular smooth muscle cell proliferation. |
|
25009387 |
Suggest cagA status, Il-1beta genotype and pork consumption are associated with the development of gastric cancer. |
|
25004092 |
IL-1beta and IFNgamma induces mSREBP-1 and iPLA2beta expression and induce beta-cell apoptosis. |
|
25003726 |
p53 and nitric oxide are involved in cytokine-induced apoptosis in Kasumi-1 and Molt-4 Leukemics cells. |
|
24996056 |
IL-32theta; reduces PKCdelta-mediated phosphorylation of PU.1, resulting in attenuation of IL-1beta production |
|
24988959 |
This is the first report of the interaction between IL-1Beta and IDO genes in schizophrenia. |
|
24981555 |
spermatozoa from the asthenozoospermic group presented an increased expression of IL-1beta, COX-2, and HIF-1alpha compared with the normospermic fertile subjects |
|
24974860 |
IL-1beta is suggested to stimulate tryptophan catabolism and production of IL-6 and IL-8 by increasing TDO expression in endometriosis. |
|
24960456 |
ratio of lipoxin A4/IL-1beta in the pre-eclampsia groups were significantly decreased compared to the control group |
|
24958470 |
IL-1beta upregulated Lin28B by downregulating miR-101. |
|
24952309 |
meta-analysis. Our results indicate that IL-6, IL-1A, and IL-1B genetic polymorphisms are statistically correlated with an increased risk of osteoarthritis under the allele and dominant models. |
|
24939850 |
HIV-1 infection induced the expression of pro-IL-1beta via TLR8-mediated mechanisms and activated caspase-1 through the NLRP3 inflammasome to cleave pro-IL-1beta into bioactive IL-1beta |
|
24939850 |
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta |
|
24933945 |
The character of the morphological changes of the mucous membrane of the large intestine and the genetic polymorphism of IL-1RA, IL-1B, IL-4 TNFA in patient with irritable bowel syndrome |
|
24928389 |
In conclusion, we demonstrated that IL-1beta can amplify the TNF downstream protein signals in human synoviocytes in a TNF-independent manner; in addition, p62 is a potential FLS biomarker for synovitis. |
|
24918199 |
Data suggest that macrophages secret IL1B to modulate signal transduction in white adipocytes in response to insulin; IL1B-mediated macrophage-adipocyte cross-talk may be involved in insulin resistance. |
|
24905619 |
IL-1beta-511C/T polymorphism was associated with increased risk of cervical cancer. |
|
24890729 |
interfering with IL-1beta and IL-12 signaling in Th17 cells during inflammation may be a promising therapeutic approach to reduce their differentiation into "pathogenic" CCR6+ CXCR3+ Th1/17 cells in patients with autoimmune diseases. |
|
24878968 |
There is an association of IL-1B gene polymorphisms with osteosarcoma risk in humans. |
|
24876157 |
IL1B was not associated with demyelination and secondary neurodegeneration of the optic nerve in optic neuritis in multiple sclerosis patients. |
|
24874542 |
Results suggest that infiltrating CCR2(+) monocytes do not contribute to IL-1beta-mediated amyloid plaque clearance |
|
24873879 |
Modulation of miR-145 affects the expression of Smad3 causing a change of its downstream target gene expression as well as IL1B-induced extracellular matrix degradation. |
|
24867167 |
The results of this study found that the expression level of IL-1B in MS patients increased 3.336 times more than controls in PBMCs but the rs16944 SNP in the promoter region of IL-1B did not affect the expression level of this gene. |
|
24866792 |
Thus, this study demonstrated that Pseudomonas aeruginosa, through the combined effects of Ndk and flagellin, upregulates the expression of proinflammatory cytokines IL1-alpha and IL1-beta via the Akt/NF-kappaB signaling pathways. |
|
24855648 |
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta |
|
24853301 |
Pro-inflammatory SNPs of the IL-8, IL-10 and IL-1beta genes, but not TNF-alpha, were associated with more severe lung disease in cystic fibrosis patients. |
|
24846290 |
the innate neutrophil immune response against SAA involves a two-step activation process: an initial signal promoting expression of pro-IL-1beta and a second signal involving Syk-dependent activation of the NLRP3 inflammasome and caspase-1. |
|
24843315 |
The polymorphisms observed in IL-1alpha(+4845) and IL-1beta(+3954) single nucleotide polymorphisms (SNPs), was significantly different among the study groups (healthy controls, mild, moderate and severe periodontitis with p<0.05, d.f.=1. |
|
24840847 |
IL-1beta (+3954) polymorphisms did not play a role in the pathogenesis of colorectal cancer. |
|
24839897 |
provided evidence that the IL1B C-511T variant might be associated with development of diabetic nephropathy |
|
24837562 |
Methylation increased in PDK4, IL1 B, IL6, and TNF promoters 12 months after gastric bypass. |
|
24820890 |
human sebocytes are important immunocompetent cells that induce the NLRP3 inflammasome, and P. acnes-induced IL-1beta activation in sebaceous glands may have a role in combating skin infections and in acne pathogenesis |
|
24806317 |
-1beta and TNF-alpha significantly inhibited the expression of chondrogenic-related genes in SDSCs, an effect which was antagonized by knockdown of NF-kappaB and C/EBPbeta. |
|
24796745 |
Data indicate that both classical and nonclassical pathway secretion vectors could express human IL-1beta in HepG2 cells, but erythropoietin(EPO) signal-peptide mediated classical pathway secreted much higher mature IL-1beta than that of nonclassical pathway. |
|
24789460 |
Results show that EGF and IL-1beta additively activated ERK1/2, increased migration and invasion than either EGF or IL-1beta alone in gastric adenocarcinoma cells. |
|
24787052 |
show here that IL1A, IL1B and IL1F7 regulatory regions come in close proximity in LPS stimulated cells but not in resting human monocytes |
|
24784935 |
IL-1beta -511T>C genetic variant may be a predisposing factor to recurrent pregnancy loss susceptibility. |
|
24782217 |
IL-6 rs1800796 and IL-1beta rs1864169 polymorphisms are associated with ischemic stroke risk in the Chinese population. |
|
24771848 |
Differently, costimulation of TLR2, TLR4, and TLR7/8 enhances IL-1beta secretion but severely inhibits IL-1Ra production. |
|
24768095 |
demonstrated a key role of IL-1beta and TGF-beta in the disappearance of occludin at cellular border in placentas with chorioamnionitis |
|
24754437 |
IL-1beta gene variability is linked to posttraumatic epilepsy development. |
|
24747159 |
IL1-beta levels were related with cancer onset status. |
|
24738292 |
In patients with exudative erythema multiforme Immunovac-VP-4 therapy facilitated a significant (p < 0.05) increase of serum IFN-gamma level, insignificant (p > 0.05) increase of IL-1beta and decrease of IL-17. |
|
24716804 |
The complex crosstalk between leptin, IL-1 and Notch could differentially drive breast cancer growth and angiogenesis |
|
24712845 |
IL-1B -511 C/T polymorphism is associated with cervical cancer. |
|
24701032 |
caspase-1, IL-1beta, and IL-18 are regulated by AIM2, which mediates inflammation-associated renal damage in hepatitis B virus-associated glomerulonephritis |
|
24690098 |
analysis demonstrated IL1B gene variations had in predicting chronic periodontitis. study validated influence of IL-1 genetic factors on severity of chronic periodontitis in 4 different ethnicities. |
|
24668571 |
The risk of susceptibility to nasal polyps was significantly higher in patients with nasal polyps who had -511 T/T genotype of IL-1beta than in controls. |
|
24665821 |
H2S upregulates GCLC and GSH and inhibits IL-1beta levels, which may be what mediates the beneficial effects of H2S-rich compounds in mitigating the pathogenesis of metabolic syndrome and atherosclerosis |
|
24654313 |
presence of SNPs in IL12B, TNFA, and IL1B was significantly associated with asthma, atopy, and severity of asthma. |
|
24626561 |
IL-1beta-induced urokinase plasminogen activator expression via activation of the ERK1/2 and NF-kappaB pathways, which results in invasion of gastric cancer cells. |
|
24625401 |
HIV-1 Tat proteins induce neuroglial cells to produce tumor necrosis factor (TNF)-alpha and IL-1beta. |
|
24622053 |
the effects of IL1beta, TGFbeta1, and IL1beta in combination with TGFbeta1 on myofibroblast formation |
|
24621265 |
The secretion of IL-1beta from glioblastoma cells in turn stimulates the expression of COX-2 in human or mouse neuroblastoma cells. Similar |
|
24613731 |
IL-1beta-induced MMP-13 expression and changes in cell proliferation and apoptosis in alpha7(+)hSMSC-OB cells are regulated by ADAM-28. |
|
24611340 |
found no association of rs1143634 in IL1-B with LBP Permutation test showed significant association of rs1143634 in IL1-RN with LBP group and presence of wild type allele A was protective in LBP group |
|
24598699 |
statistical evidence for the interactions between 1) TNF/LTA SNP rs2229094 and depression symptoms for average pain intensity and duration and 2) IL1B two SNP diplotype and kinesiophobia for average shoulder pain intensity |
|
24582800 |
Exposure resulted in significant downregulation of GDF-5 during both TNF-a exposure (5.83-fold change, p=0.044) and IL-1b exposure (3.38-fold change, p=0.015). |
|
24581590 |
secreted from macrophages but not tumors in melanoma |
|
24571667 |
our data support a critical role for NF-kappaB-dependent upregulation of miR-425, which represents a new pathway for the repression of phosphatase and tensin homolog activation and the promotion of cell survival upon IL-1beta induction. |
|
24568914 |
There is no association between rs16944 polymorphism of the IL-1beta-511T gene and the incidence of FS in Han children in Northern China. |
|
24563688 |
Angiopoietin-1 upregulates de novo expression of IL-1beta and Il1-Ra, and the exclusive release of Il1-Ra from human neutrophils |
|
24561215 |
the interleukin-1beta -511 C/T polymorphism may have a role in tobacco-associated cancer in northeast India |
|
24557417 |
Genetic variations in the IL-1beta and IL-1RN genes influence disease progression in gastric cancer.Heterozygous genotypes of the IL-1RN and IL-1beta C-511T variation are associated with enhanced disease-free survival in gastric cancer patients. |
|
24557363 |
Genipin inhibits IL-1beta-induced CCL20 and IL-6 production from human periodontal ligament cells |
|
24557062 |
In the Han Chinese population, genetic variants in IL1B were significantly correlated to susceptibility to colorectal cancer. |
|
24554772 |
Data indicate that cholesterol crystals (CC) employed C5a in the release of IL-1beta. |
|
24552038 |
IL-1beta-511 polymorphism may not play a major role in the genetic predisposition to obsessive-compulsive disorder (OCD) in Chbetainese Han population. |
|
24550444 |
IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans. |
|
24535893 |
Urgent section (foetal distress) and vaginal delivery (labour) were each associated with elevated IL-1beta cord blood levels in noninfected full-term neonates, while only elective caesarean section was associated with decreased IL-1beta levels. |
|
24534280 |
Our data identified for the first time synchronous changes in endometrial IL-1R throughout early gestation in vivo and point to a deep modulation of endometrial receptivity to IL-1 by embryo-driven signals. |
|
24520123 |
Human data identified IL-1beta as a key player of a paracrine inflammatory pathway previously unidentified in adipose tissue, with a pathological relevance to obesity-induced type 2 diabetes. |
|
24515998 |
The present meta-analysis showed that two alleles of proinflammatory cytokines (IL-1alpha-889 and IL-1beta-511) in addition to the serum concentration of IL-6 were significantly associated with febrile seizures and epilepsy or both [review] |
|
24504887 |
Results show that IL-1RN rs2234663/IL-1b rs16944 haplotypes are associated with pulmonary pulmonary function test parameters in Chronic obstructive pulmonary disease patients. |
|
24490166 |
In children with single episode of urticaria, level of IL-1RA correlated with C-reactive protein (CRP), D-dimer, and IL-1beta levels. |
|
24484294 |
Our findings suggest that the IL1b -511 'C' allele has a protective role from disease development. |
|
24479681 |
the IL-1beta/p38/AP-1(c-fos)/MMP2 & MMP9 pathway play an important role in metastasis in gastric adenocarcinoma |
|
24477584 |
Our study provided evidence to IDE, PON1, WFS1, POU2F1, IL1alpha and IL1beta associated with T2D in Pakistanis. |
|
24472657 |
report that shear stress upregulates cyclic AMP (cAMP) and interleukin-1beta (IL-1beta) release, which in turn promotes the invasion of chondrosarcoma cells via the induction of MMP-1 in a phosphoinositide 3-kinase (PI3-K)- and ERK1/2-dependent manner |
|
24470197 |
These results suggest that FSTL-1 may act on the NLRP3 inflammasome to promote IL-1beta secretion from monocytes/macrophages. |
|
24465880 |
The IL1B (-511) polymorphism, but not the IL1B (+3954) and IL1RN (VNTR) polymorphisms was associated with Grave's disease risk in Asians. |
|
24460370 |
The heterozygous variant genotype of the IL1 rs16944 was significantly associated with a reduced risk of periodontal disease in young Japanese women. |
|
24458711 |
IL1R1- and IL1beta-related transcripts are elevated in the setting of obesity; IL1R1/IL1beta augment both megakaryocyte and platelet functions, promoting a prothrombotic environment during infection and obesity; potentially contributing to the development of atherothrombotic disease |
|
24457964 |
Interleukin-1beta promotes hypoxia-induced apoptosis of glioblastoma cells by inhibiting HIF-1 mediated adrenomedullin production. |
|
24452718 |
These findings support a potential role of IL-1 polymorphisms, particularly the composite genotype of IL-1A (-889) and IL-1B (+3954), in peri-implant disease susceptibility. |
|
24446526 |
Patients with IL1B -31C carrier, or IL1RA 2/4 genotype carry a risk for DSS, implying that IL1B may play a role in pathogenesis of dengue shock syndrome. |
|
24446182 |
IL1B_1473G/C and TLR4_896A/G SNPs are implicated in rectal cancer development in a Russian population. |
|
24439748 |
Vascular endothelial cadherin is lost at the membrane when endothelial cells are exposed to TNF-alpha, IFN-gamma, and peripheral blood mononuclear cells (PBMC). IL-1ss can mimic the effects of PBMCs, indicating a role of IL-1ss in this process. |
|
24434549 |
conclude that TRIM38 negatively regulates TNFalpha- and IL-1beta-induced signaling by mediating lysosome-dependent degradation of TAB2/3, two critical components in TNFalpha- and IL-1beta-induced signaling pathways |
|
24431314 |
alveolar bone regeneration proceeds more slowly in patients with the IL-1B-511 2/2 genotype compared to those with alleles 1/1 and 1/2. |
|
24424266 |
Thrombin-activated microglia expression of tumor necrosis factor-a, interleukin-1b and MMP-12 was significantly reduced through contact-dependent and paracrine mechanisms when the HAESCs were co-cultured with microglia cells |
|
24403855 |
TNF and IL-1beta induce dissemination of nontransformed breast epithelial cells and their reseeding at the primary tumor site. |
|
24399675 |
The proinflammatory cytokine interleukin 1beta (IL-1beta) was the most investigated and also gene associated with susceptibility to febrile seizures. |
|
24379597 |
TNF-alpha and IL-1beta genotypes may be related to susceptibility to H. pylori infection in Indonesian population. |
|
24379400 |
N-terminal hydrophobic amino acids play an important role in the regulation of ATF5 protein expression in IL-1beta-mediated immune response and that ATF5 is a negative regulator for IL-1beta-induced expression of SAA1 and SAA2 in HepG2 cells. |
|
24356959 |
defective autophagy can prime monocytes for mitochondria-mediated NLRP3 inflammasome activation, thereby contributing to hypersecretion of IL-1beta in mevalonate kinase deficiency. |
|
24356306 |
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta |
|
24342296 |
a critical role of IL-1beta gene polymorphisms in susceptibility to bacteremia after kidney transplantation |
|
24340055 |
The release of IL-8 and IL-1beta after stimulation of whole blood with A. versicolor was increased in subjects exposed to moisture damage. |
|
24339952 |
IL-34 expression in human gingival fibroblasts, stimulated by TNF-alpha and IL-1beta |
|
24338609 |
The combination of tumor necrosis factor (TNF)-alpha and IL1beta leads to a decrease of matrix synthesis gene expression, such as collagen type II, and increases the degradation gene expression of cyclooxygenase (COX)-2 and matrix (MMP)-3 in cell culture. |
|
24322806 |
Because the genotype and allele frequency of both polymorphisms are identical, it is most likely that IL1beta-511C>T and IL1RN VNTR polymorphisms do not play a role in the development of KC in the Turkish population. |
|
24314919 |
Interleukin-1beta levels were markedly higher in menstrual effluents of women with chronic endometritis. |
|
24313836 |
Data indicate a significant increase in the levels of IL-8, TNF-alpha and IL-1R2 in the CSF of both meningitis groups as compared to controls, and the concentrations of IFN-gamma and IL-1 differed significantly only between the mumps group and control. |
|
24275551 |
leptin enhances IL-18 secretion via modulation of the caspase-1 inflammasome function but has no effect on IL-1betamRNA levels or IL-1beta secretion. |
|
24275344 |
we did not confirmed the previously suggested association between Periodontitis and IL1 gene cluster polymorphisms. |
|
24274595 |
The association of single nucleotide polymorphisms in IL1B, IL1RN and IL15 with chronic cavitary pulmonary aspergillosis supports a role for the IL1 pathway, as well as implicating the IL15 gene, in disease susceptibility. |
|
24265545 |
Aqueous humor concentrations of the cytokines (IL-1 alpha, IL-1 beta, IL-6, FasL, and TNF- alpha) in patients with open angle glaucoma, were measured using multiplex bead analysis. |
|
24256257 |
the endocannabinoid system, which has neuroprotective and immunomodulatory actions mediated by IL-1 signalling cascades in the brain, could assist the process of proliferation and differentiation of embryonic or adult neural stem cells |
|
24252536 |
Data suggest that interleukin-1 beta released in neuromyelitis optica (NMO)lesions and interleukin-1 beta-induced production/accumulation of complement factors facilitate neutrophil entry and blood-brain barrier breakdown in the vicinity of NMO lesions |
|
24246233 |
cord blood level elevated in funisitis |
|
24246157 |
High interleukin 1 beta expression is associated with cardiomyocyte hypertrophy in Type 1 diabetes mellitus and fatal diabetic ketoacidosis patients. |
|
24238405 |
Our results show that SOCS1 is induced by IL1-beta in osteoarthritis chondrocytes |
|
24222244 |
No evidence of association between the IL-1beta +3954 C>T polymorphism and risk of external apical root resorption in orthodontic treatment patients. [Meta-analysis] |
|
24217014 |
IL1B polymorphism is associated with the late age of onset of psoriasis. |
|
24194923 |
Genetically determined low COX-2 and high IL-1beta activity were associated with increased risk of colorectal cancer in a prospective Danish cohort. |
|
24186874 |
Expression of IL-1beta in the epithelium of the distal airways disrupts the development of the airspaces and capillaries in the fetal lung. |
|
24162774 |
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta |
|
24158569 |
Identify a novel innate immune signaling pathway (NLRP3-ASC-caspase-1-IL-1beta) activated by Ni(2+). |
|
24157462 |
We show that IL-1beta mRNA and the active processed form of IL-1beta are abundant in inflammatory acne lesions. |
|
24155145 |
The present study does not support a role for IL1B in schizophrenia susceptibility |
|
24147028 |
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta |
|
24146121 |
Il-1 blockade may affect morbidity and mortality in cardiovascular disease with an acceptible risk. |
|
24142467 |
interleukin-1beta-induced vascular endothelial growth factor in airway smooth muscle cells |
|
24136334 |
NLRP3 inflammasome is upregulated in neutrophilic asthma and may regulate the inflammation process observed in this asthma phenotype through production of IL-1beta |
|
24081990 |
IL-1beta is a platelet agonist, IL-1beta acts through an autocrine stimulatory loop, an IL-1beta autocrine loop is required to amplify platelet activation by LPS, and platelets immobilized in occlusive thrombi are activated over time to produce IL-1beta. |
|
24081898 |
IL-6 produced from IL-1beta-stimulated human periodontal ligament cells could increase CCL20 production. |
|
24080970 |
IL-1B +3954 C/T polymorphism is associated with the risk of gastric cancer. |
|
24080160 |
These results provide evidence for a key role of Rac1 in a pathway that regulates IL-1-induced gene expression depending on receptor endocytosis. |
|
24078775 |
palmitic acid can stimulate IL-6, TNF- alpha, and IL-1 beta production and cell proliferation in HaCaT keratinocytes |
|
24072654 |
There were no significant associations between IL-1beta, IL-6 and IL-10 gene polymorphisms and acute pancreatitis risk. |
|
24067094 |
study found the C + 3953T of the IL-1B gene is associated with male infertility risk in the asthenozoospermic patients from an Indian population |
|
24063999 |
This study evaluated the prognostic capability for biochemical progression after radical prostatectomy of expression of IL-1, TNF-alpha and related signaling components, in the tumor and surrounding stroma |
|
24063998 |
IL-1 beta in unstimulated whole saliva may be useful for detection of early stage oral squamous cell carcinoma. |
|
24063019 |
The relationships between IL-1 beta (C-511T) and IL-1 alpha (C-889T) genes polymorphisms and the risk of ischemic stroke (IS) classified by TOAST criteria in the north Chinese Han population, were investigated. |
|
24054992 |
is a major proinflammatory cytokine that initiates and amplifies diverse cellular responses. Elevated IL-1b has been linked to diseases, such as Alzheimer's disease. |
|
24046015 |
Data indicate that TLR-induced IL-1beta overproduction in FANCA- and FANCC-deficient mononuclear phagocyte cell lines and primary cells requires activation of the inflammasome. |
|
24037056 |
The objective of this study is to investigate the possible role of inflammatory mediators such as IL-6, IL-1beta, and TNF-alpha in Kashin-Beck disease (KBD) children and rats fed with T-2 toxin under a selenium-deficient nutrition. |
|
24036988 |
TLR4-NFkappaB-IL1beta signaling might play a crucial role in the development of acute inflammation in primary gout patients. |
|
24035972 |
IL-1b is upregulated in amnion epithelial cells following exposure to zinc ferrite nanoparticles; in situ nanoparticles induce oxidative stress, alterations in cellular membrane and DNA strand breaks. |
|
24025329 |
proinflammatory cytokines IL-1/TNFalpha trigger a novel antiviral mechanism involving AID to regulate host cell permissiveness to HBV infection. |
|
24024208 |
It was observed that the release of IL-1beta increases instantaneously after the initiation of incubation and reaches a maximum at 3 to 5 hours and then gradually decreases and gets stabilized for both pyrogens. |
|
24023501 |
IL-1beta induces dose-dependent methylation of TGF-beta1 in gastric cancer patients. |
|
24022484 |
Lactic acidosis, induced by the addition of 25 mm lactic acid, also induced the release of 20-kDa IL-1beta. This 20-kDa product was produced independently of NLRP3 and caspase-1 but was inhibited by the cathepsin D inhibitor pepstatin A. |
|
23996710 |
investigation do not substantiates the role of IL-1beta +3954 and TNF-alpha -308 polymorphisms, separately, as risk determinants for aggressive periodontitis in Iranian population |
|
23995914 |
associated with gastritis and intestinal carcinogenesis in Helicobacter pylori-infected patients |
|
23963575 |
The complex ROS-mediated regulation of neutrophil IL-1beta secretion might constitute a physiological mechanism to control IL-1beta-dependent inflammatory processes where neutrophils play a crucial role. |
|
23953530 |
Recipient IL-1beta polymorphisms were not associated with the presence of pneumonia in kidney transplantation. |
|
23936458 |
induction and tolerance regulate the immediate early genes encoding interleukin 1beta and tumor necrosis factor alpha |
|
23936223 |
Data indicate that recombinant bacterial interleukin receptor I (BilRI) bound human IL-1beta both in the outer membrane of E. coli and as soluble protein. |
|
23935506 |
pro-IL-1beta is degraded in a proteasome-dependent manner in E6-positive cells which is mediated via the ubiquitin ligase E6-AP and p53. |
|
23927441 |
genetic variants of IL-1A and IL-1B may exert a substantial impact on the susceptibility of A(H1N1)pdm09 virus infection. |
|
23911403 |
Data indicate that Aloe vera-mediated reduction of IL-1beta appears to be the consequence of the reduced expression of both pro-IL-1beta as well as Nlrp3 inflammasome components via suppressing specific signal transduction pathways. |
|
23898208 |
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta |
|
23892937 |
Continuous theta-burst transcranial magnetic stimulation caused a long-term potentiation (LTP)-like synaptic phenomenon correlated with the concentration of the pro-inflammatory cytokine interleukin-1beta in the cerebrospinal fluid. |
|
23892591 |
On stimulation with IL-1beta or CpG-A, an increased level of IL-20 expression was also observed in psoriatic lesions of patients carrying the risk-associated G allele. |
|
23891856 |
Conditions which lead to increased systemic maternal or placental IL-1beta levels may attenuate the effects of maternal insulin on placental function and consequently fetal growth. |
|
23884363 |
These results show that late caspase-1 activation within DENV-infected monocytes can contribute to pro-inflammatory outcomes that might play a role in dengue immunopathogenesis. |
|
23884315 |
Oour results indicate that Propionibacterium acnes triggers a key inflammatory mediator, IL-1beta, via NLRP3 and caspase-1 activation, suggesting a role for inflammasome-mediated inflammation in acne pathogenesis. |
|
23849770 |
The association between allele 1 of IL-1 RN VNTR, T allele of IL1B-511 and C allele of IL1-B +3953 polymorphisms seems to predispose to the synthesis of citrullinated antipeptide antibodies(ACPA) and occurrence of ACPA positive rheumatoid arthritis. |
|
23845419 |
TLR3 stimulation in keratinocytes induces a caspase-4 dependent release of pro-IL-1beta, but further processing to active IL-1beta is limited. Furthermore, TLR3 stimulation results in pyroptotic- and apoptotic cell death. |
|
23841472 |
Effects of omalizumab on eosinophil cationic peptide, 25-hydroxyvitamin-D, IL-1beta and sCD200 in cases of Samter's syndrome |
|
23840644 |
The pattern recognition receptor NLRP3 is involved in the activation of inflammation mediators, including Il-1B in retinal pigment epithelial cells . |
|
23839215 |
Study shows that T. gondii-induced IL-1beta production is dependent on the classical inflammasome components caspase-1 and ASC.Additionally, a role for a specific parasite factor, dense granule protein GRA15, in T. gondii induction of IL-1beta was demonstrated. |
|
23822621 |
No significant association of IL1 composite genotype (IL1 -889A:IL1B +3962) with periodontitis in Macedonians was found |
|
23821953 |
Association between IL1B, IL6, and IL8 gene polymorphisms and risk of recurrent erosion development in patients with hereditary corneal stromal dystrophies. |
|
23800300 |
In conclusion, we suggest that the -1607 1G/2G MMP1, -1562 C/T MMP9, -511 C/T IL-1beta gene polymorphisms can be considered as an important risk factors associated with POAG. |
|
23793845 |
Studies suggest that caspase 1, IL-1 beta and IL-18 are involved in inflammasosme activation and prostate cancer initiation. |
|
23784458 |
Studies suggest that the interleukin 1, beta (IL1B) -31 T/C and +3954 C/T polymorphisms are associated with lung cancer risk. |
|
23773024 |
These results suggest that tissue damage and ulcers occur in Helicobacter pylori-infected patients who produce more IL-8 and IL-1beta than patients who do not develop ulcers. |
|
23762029 |
1,25D-stimulated autophagy in macrophages but dependent upon epithelial IL1R1 signaling and IL-1beta-driven epithelial production of the antimicrobial peptide DEFB4/HBD2. |
|
23749763 |
A combined biomarker model of IL-1alpha, IL-1beta, and IL-1ra can predict term labor with 86% sensitivity and 92% specificity. |
|
23747396 |
no sufficient evidence was available to support any associations between IL1beta+3953C/T and susceptibility to systemic lupus erythematosus. [META-ANALYSIS] |
|
23740952 |
The CXCL10 gene is activated by interleukin (IL)-1beta, a response that is synergistic with concomitant activation of the interferon (IFN)-gamma-signaling pathway. |
|
23737648 |
H1N1 virus infection induces an early and significant upregulation of both interleukins IL1 beta and IL-6 plasma expressions. |
|
23728092 |
It is produced by macrophages and exhibits proliferative activity on thymocytes and fibroblasts, B cell activation and endogenous pyrogen activity. (review) |
|
23726808 |
Interleukin 1B rs16944 G>A polymorphism is associated with a decreased risk of esophageal cancer in a Chinese population. |
|
23723976 |
Interleukin-1alpha (IL-1alpha), interleukin-1beta (IL-1beta) and interleukin-18 (IL-18), were released from rhinovirus infected epithelia. |
|
23722873 |
There was no difference in IL1 SNPs between patients with systemic lupus erythematosus and healthy controls. |
|
23717664 |
data further identified a complex interaction between IL1 and hCG, which, despite a synergistic action on several significant endometrial target genes, may encompass a tight control of endogenous IL1 and extends to other IL1 family members |
|
23704929 |
Both the IL-1B -511C/T and +3954C/T polymorphisms might modulate cancer susceptibility. |
|
23702978 |
Studies indicate that inflammasomes activate the highly pro-inflammatory cytokines interleukin-1beta (IL-1beta) and IL-18. |
|
23689297 |
There was no significant association between polymorphism in gene IL-1beta and hearing loss associated with occupational exposure. |
|
23680697 |
Data indicate that cobalt-alloy particles induce expression of IL-1beta, TNF-alpha and IL-8 via toll-like receptor 4 signaling pathway. |
|
23666803 |
Sphingosine 1-phosphate counteracts the effects of interleukin-1beta in human chondrocytes. |
|
23660804 |
Data indicate that RANTES/C-C motif ligand 5 (CCL5) expression was correlated significantly with expression of IL-1beta. |
|
23659674 |
genetic polymorphism in the donor is associated with development of graft-versus-host disease in Brazil |
|
23657597 |
TNF-alpha and IL-1beta increased the in vitro osteoblastic differentiation of cultured human periosteal-derived cells by enhancing the ALP activity and mineralization process, but not by Runx2 activation. |
|
23656735 |
these studies show that the IL-1beta-induced increase in intestinal tight junction permeability was regulated by p38 kinase activation of ATF-2 and by ATF-2 regulation of MLCK gene activity |
|
23654353 |
polymorphisms of IL-1beta and IL-10 genes may be valuable markers to predict the risk for the development of TB in household contacts. |
|
23651237 |
Data indicate that interleukin-1beta (IL-1beta) +3954 in oral lichen planus was associated with other comorbid factors in both allelic and genotypic combinations. |
|
23650922 |
There was a significant positive association between distribution of IL-1beta genotypes and the risk of periodontitis disease |
|
23643268 |
In Bcap-37 cells, S.aureus exposure could up-regulate the expression of TLR2 at both mRNA and protein levels, increase the production of IL-1beta and TNF-alpha, and stimulate the expression of NF-kappaB. |
|
23633957 |
viral engagement of the NLRP3 inflammasome stimulates IL-1beta production to drive proinflammatory cytokine, chemokine, and immune-regulatory gene expression networks linked with Chronic hepatitis C disease severity. |
|
23630220 |
Lonlier breast cancer survivors exposed to acute stress exhibited greater synthesis of interleukin-1 beta lipopolysaccharide stimulated peripheral blood mononuclear cells than their counterparts who felt more socially connected. |
|
23610862 |
Interleukin-1 beta is thought to play an important role in the pathogenesis of periodontal disease. |
|
23594042 |
we have found significantly decreased frequency of IL-1B -511 genotype (p = 0.004) in Multiple sclerosis |
|
23592922 |
IL1B may play an important role in the development of keratoconus through genetic polymorphisms. |
|
23592910 |
miR-146a and miR-146b-5p are expressed in human RPE cells in culture and their expression is highly induced by proinflammatory cytokines (IFN-gamma + TNF-alpha + IL-1beta). |
|
23592003 |
genotype and protein production of IL-1alpha, IL-1beta and IL-1RN are associated with chronic periodontitis in a Chinese population. |
|
23584371 |
These results showed that IL-1beta and IL-1RN VNTR are significantly associated with the susceptibility to alopecia areata. |
|
23571448 |
reduced secretion by neutrophils in synovial fluid from patients with rheumatic arthritis |
|
23564444 |
IL-1beta was downregulated in CD34+/CD38- acute myelogenous leukemia cells via epigenetic mechanisms. Therefore, the inhibition of STAT5 signaling by IL-1beta may be a promising treatment strategy to eradicate leukemia stem cells. |
|
23555186 |
Epithelial cancer cells use IL-1beta as a communication factor instructing stromal fibroblasts through p53 to generate a protumorigenic inflammatory microenvironment. |
|
23554905 |
Neutrophil priming led to the rapid expression of a common set of transcripts for cytokines, chemokines and cell surface receptors (CXCL1, CXCL2, IL1A, IL1B, IL1RA, ICAM1). |
|
23546865 |
Data indicate that p38 MAPK and toll-like receptor 2 (TLR2) are required for pLGV440_p5 (ORF5) protein induced tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and interleukin-8 (IL-8) in human monocyte. |
|
23536554 |
Findings indicate that IL-1beta supports the skeletal colonization and metastatic progression of prostate cancer cells with an acquired neuroendocrine phenotype. |
|
23533059 |
Different molecular weight hyaluronic acid effects on human macrophage interleukin 1beta production. |
|
23531221 |
The study evaluates insulin secretion and IL1-BETA dependent mechanisms in human diabetes remission after gastric bypass and sleeve gastrectomy. |
|
23509682 |
Particulate matter induces release of IL-1 beta in the absence of LPS priming in human THP-1 derived macrophages |
|
23508571 |
IL-1beta inhibits human osteoblast migration. |
|
23500159 |
Acrp30, in dose- and time-dependent manner, reduces cytotoxic effects of TNFalpha and/or IL-1ss improving cell viability and decreasing apoptosis. In addition, Acrp30 inhibits NF-kappaB nuclear trans-activation |
|
23484124 |
the expression of resistin, TNF- alpha , IL-6, and IL-1 beta from human mononuclear cells, might be enhanced by the hyperinsulinemia and hyperleptinemia and possibly by the hyperglycemia in metabolic diseases as obesity, type 2 diabetes, and atherosclerosis. |
|
23472661 |
IL-1B and IL-1RN gene polymorphisms could be involved in the risk of developing Takayasu's arteritis in the Mexican population. |
|
23460908 |
IL-1beta was identified as a major factor contributing to the decrease in RBP4. |
|
23460603 |
study provides preliminary evidence of a genetic association between IL1B and IL17A genes and RLS |
|
23460134 |
the ability of LfcinB to antagonize IL-1 and LPS-mediated suppression of PG is upheld in an en bloc intradiscal microinjection model followed by ex vivo organ culture using both mouse and rabbit IVD tissue |
|
23459183 |
The Hirsutella sinensis mycelium extract suppresses IL-1beta and IL-18 secretion, and ATP-induced activation of caspase-1. |
|
23457635 |
ERK1/2 signals downstream of C/EBPbeta to facilitate IL-1beta-induced astrocyte TIMP-1 expression. |
|
23452206 |
CSC induced IL-1beta production from RA patient-derived synoviocytes. |
|
23442095 |
Based on our data, IL1 B C+3953T polymorphism does not seem to contribute to Early Pregnancy loss in North Indian Population. |
|
23437386 |
CIRBP regulates the expression of interleukin-1beta in an NF-kappaB-dependent fashion. |
|
23437386 |
RNA interference against cold inducible RNA binding protein inhibits UV-, LPS- and cisplatin-induced expression of interleukin 1 through decreased NFkappaB activity. |
|
23425136 |
PBMNs and macrophages from healthy subjects with previous ReA show normal inflammasome activation and low TNF-alpha and IL-23 production. |
|
23421536 |
Data indicate that thrombin-induced IL-1ss and IL-6 cytokine release in naive PBMCs is PAR-1-dependent. |
|
23417678 |
methylation of different CpG sites in the proximal promoters of the human MMP13 and IL1B genes modulates their transcription by distinct mechanisms |
|
23406266 |
HO-1 down-regulation is involved in the inhibition of SOX9 and COL2A1 expression by IL-1beta. |
|
23391392 |
lymphangiogenesis triggered by IL-1beta overexpression in mouse airways is driven by VEGF-C/D from macrophages, but not neutrophils, recruited by chemokines from epithelial cells that express IL1R1. |
|
23386602 |
Induction of autophagy and modulatation of cytokine IL-1beta production by B. burgdorferi. |
|
23383347 |
The activation of EGF signaling and increase of IL-1beta contributed to chemotherapeutic resistance of cancer cells, suggesting that the expression of IL-1beta may be used as a biomarker to evaluate successful cancer treatment. |
|
23383108 |
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta |
|
23375040 |
T allele of the 511 site of IL-1beta gene and V allele of the second introne of IL-1Ra gene are associated with the infertility occurrence of polycystic ovary syndrome patients |
|
23363559 |
The polymorphisms studied in the promoter regions of IL-1beta and IL-6 genes did not reveal a strong association with urolithiasis |
|
23349093 |
metal particles induced higher amounts of IL-6 and IL-1 but very low amounts of TNF-alpha. T-lymphocyte activation was evaluated by the quantification of IL-2 and IFN-gamma levels |
|
23331079 |
Il-1beta enhances cell migration through AP-1 and NF-kappaB pathway-dependent FGF2 expression in human corneal endothelial cells. |
|
23328930 |
Resveratrol attenuates TNF-alpha-induced production of IL-1beta and MMP-3 via inhibition of PI3K-Akt signaling pathway in rheumatoid arthritis fibroblast-like synoviocytes. |
|
23328087 |
Results suggest a TET1-dependent anti-inflammatory pathway, which may include TET2. In particular, IL-1beta transcriptional regulation is likely to depend on TET1-regulated chromatin domains. |
|
23323013 |
IL-1B and IL-RN genotypes may differentially contribute to gastric cancer among the Tibet, Hui, and Han ethnicities in the Qinghai area of China |
|
23322904 |
Studies indicate that interleukin-1 (IL-1), IL-6, IL-17, and tumor necrosis factor are critical for the pathogenesis of inflammation in specific brain disorders. |
|
23317890 |
Studied association between SNP of rs3811047 in IL-1 F7 gene and RA susceptibility among the Han population in central plains of China. No significant correlation between RA susceptibility and rs3811047 SNP inIL-1 F7 gene is observed. |
|
23315075 |
Human monocytes produce IL-1beta in response to self double-stranded (ds)DNA in the presence of anti-dsDNA antibody-positive serum. |
|
23314944 |
This study observed a significant genotype effect on the cingulate cortex and the T/T carriers had significantly reduced FC with several prefrontal areas and putamen compared to the C/C or C/T carriers. |
|
23313749 |
These data show that OSM and IL-1beta are not only a biological characteristic signature of hypertensive leg ulcer, but these cytokines reflect a specific inflammatory state, directly involved in the pathogenesis. |
|
23276701 |
IL-1beta-511T/T genotype individually was independently associated with both prevalent depression at baseline and persistent depression at one year follow-up |
|
23269671 |
Transfection of caspase-1 into airway epithelial cells restored their ability to secrete IL-1beta following B. cenocepacia infection, suggesting that a deficiency in caspase-1 is responsible, at least in part, for the attenuated IL-1beta secretion. |
|
23264411 |
Could not find a significant relationship between serum interleukin 1beta concentration and febrile convulsion. |
|
23241110 |
subjects homozygous for allele2 of the IL-1beta+3954 and IL-1alpha-889 were significantly more at risk for severe periodontitis with OR of 51.42. |
|
23239492 |
TiO NPs are potent inducers and regulators of MMP-1 expression and activity, partly via an IL-1beta-dependent mechanism. |
|
23237500 |
The total mole fraction of unelongated xylose residues per aggrecan was significantly less (p = 0.03) after IL-1beta treatment compared to control cultures. |
|
23233369 |
Our findings indicate that TNFalpha and IL-1beta modulate the expression of CCL3 in nucleus pulposis cells by controlling the activation of MAPK, NF-kappaB, and C/EBPbeta signaling. |
|
23229544 |
findings suggest that DUSP14 negatively regulates TNF- or IL-1-induced NF-kappaB activation by dephosphorylating TAK1 at Thr-187 |
|
23226468 |
Monocyte/macrophage-expressed A1PI-M antagonizes IL-1beta secretion possibly via caspase-1 inhibition. |
|
23226210 |
Chronic IL-1beta overproduction in the skin of NOMID patients results in the deregulated genes and pathways leading to "adaptive" mechanisms to control inflammation and maintain tissue homeostasis. |
|
23220433 |
Studies indicate evidence for association between interleukin-1beta C (3953/4)T polymorphism and chronic periodontitis (CP). |
|
23217179 |
The IL1B gene -5839C > T and IL4R 1902A > G polymorphisms and IL12RB1 -1094A/-641C and TNF -1031 T/-863A/-857 T/-308 G/-238 G haplotypes were associated with malaria susceptibility. |
|
23216199 |
Women carriers of the 1-2-1-1 haplotype [IL-1A(rs1800587) - IL-1B(rs1143634) - IL-1B(rs16944) - IL-1RN(VNTR)] had sixfold lower risk to develop knee osteoarthritis. |
|
23215728 |
genetic polymorphism is associated with lymph node metastasis in Korean patients with papillary thyroid carcinoma |
|
23215648 |
Modulation of the release of inflammatory IL-1beta by activated peritoneal macrophages of tumor necrosois factor (TNF)-transgenic mice is examined after exposure to distinct low and intermediate doses of X-ray. |
|
23210983 |
These preliminary findings indicate a key role of IL-1 in the hepatitis b virus-mediated disease chronicity, in the Indian population. |
|
23209696 |
Ehx plays a crucial role in EHEC O157:H7-induced IL-1beta production and its cytotoxicity to THP-1 cells and activation of NLRP3 inflammasome |
|
23209664 |
progesterone acts via GR to repress IL-1beta-driven COX-2 activation; p65 and PRB may have roles in the repression of progesterone driven gene expression, but not necessarily in progesterone repression of IL-1beta-induced COX-2 expression |
|
23209411 |
Our studies thus define the NLRP3 inflammasome pathway and IL-1beta signaling as key features controlling WNV infection and immunity in the CNS |
|
23209292 |
Deubiquitinases regulate the activity of caspase-1 and interleukin-1beta secretion via assembly of the inflammasome |
|
23208827 |
Rage in rugby players was related to il1b. We propose the IL-1beta as a potential biological marker of anger. |
|
23199001 |
The study of this study provided evidence that the rs1143627 C/T polymorphism of the IL1B gene may modulate regional spontaneous brain activity in amnestic mild cognitive impairment patients. |
|
23195574 |
Results indicate that the ability to express IL-1beta and TNFalpha is linked to a cell type specific promoter structure, which is established during monocytic but not granulocytic differentiation. |
|
23195019 |
Recipient IL-1 beta -511CC genotype or IL-1 beta -511C allele was associated with susceptibility to bacteremia within the first year after kidney transplantation. |
|
23192617 |
We did not find any association between any of the IL-1B polymorphisms and colorectal cancer |
|
23184659 |
Bacterial LPS enhances NLRP3 inflammasome components in endometrial cells and induces Il-1beta secretion. |
|
23181791 |
Our study demonstrates that eosinophils can enhance the production of IL-17A in activated CD4+ T lymphocytes through the release of IL-1ss. |
|
23169178 |
Report synergistic effect of IL-1beta and TNF-alpha polymorphisms on the H. pylori-related gastric pre-malignant disease. |
|
23110185 |
Data indicate that IL-1beta, TNFalpha and IL-8 seem to be involved in the enhanced release of neutrophil extracellular traps (NETs) in systemic inflammatory response syndrome (SIRS) subjects. |
|
23105097 |
Study concludes that IL-1beta regulates FoxO1 activity through a novel neutral sphingomyelinase 2 -dependent pathway. |
|
23079713 |
The IL-1beta -511C/T polymorphism might be associated with Alzheimer's disease risk. |
|
23065753 |
IL-1beta-mediated anti-tumour effects depend on infiltrated immunostimulatory neutrophils |
|
23062767 |
A high simvastatin dose or the combination of a low-dose simvastatin with ezetimibe reduce to a similar extent TLR2, TLR4 membrane expression and LPS-induced IL-6 and IL-1beta production in monocytes of hypercholesterolemic patients. |
|
23052182 |
No association between common variants in the IL-1 region and multiple sclerosis risk was found in a meta-analysis. |
|
23029154 |
This meta-analysis suggested that there were no associations between IL-1 gene cluster polymorphisms and CHD. |
|
23020284 |
we found a significant relationship between IL-1B genetic polymorphism and the gastric mucosal IL-1b level. In addition, the risk of erosive esophagitis was related to the low gastric mucosal IL-1b level. |
|
23018032 |
RPA and ELISA data showed that alloferon decreased the production of UVB-induced pro-inflammatory cytokines, such as IL-1alpha, IL-1beta, IL-6 and IL-18, both on the mRNA and protein level. |
|
23013363 |
Polymorphisms in the IL-1beta -511 and IL-1beta +3953 loci were assessed for evidence of association with SSNHL. |
|
23009887 |
Data indicate that SNP (rs452204) in the IL1RN gene was significantly associated with higher levels of IL-2 secretion, and IL12RB2 SNP rs3790567 was associated with a decrease in IL-1beta secretion. |
|
23006543 |
Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome is linked to dysregulated monocyte IL-1beta production. |
|
22997256 |
The inability of renal parenchymal cells to secrete IL-1beta may explain why uromodulin remains immunologically inert inside the luminal compartment of the urinary tract. |
|
22995155 |
IL-1beta serum concentrations allow the discrimination between atrophic thyroiditis and papillary thyroid cancer groups. |
|
22960943 |
found an association between the rs1143634 C allele and higher serum IL1beta concentrations and a lower response to infliximab treatment in Crohn's disease. |
|
22955577 |
human cementoblasts in vitro express increased levels of RANKL, in particular during the combination of inflammation and compression. |
|
22951596 |
a lung cancer risk haplotype in the IL1B gene regulatory region is associated with increased expression of IL1B and increased lung cancer risk |
|
22947907 |
IL-lbeta (C+3954T) polymorphism not considered as a marker of susceptibility to preeclampsia in Iranian population. |
|
22946471 |
concentration in maternal plasma is an indicator of Group B Streptococcus status |
|
22937208 |
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta |
|
22923190 |
The study suggested for the first time a role for epigenetic modifications in the regulation of the expression of IL1B, IL6, and IL8. |
|
22911481 |
The IL-1beta (-511) G/A and the IL-10 (-1082) G/A genotype combination was found to be higher in patients with febrile seizure.And IL-1 beta production was not influenced by the single nucleotide polymorphisms in the pathogenesis of febrile seizures. |
|
22909148 |
the placenta may contribute to the elevation in serum IL-1beta and IL-1Ra in preeclampsia by increased secretion of these cytokines into the maternal circulation, and that MgSO(4) is able to attenuate this increased secretion of IL-1beta, and possibly IL-1Ra |
|
22904187 |
MARCH8-mediated polyubiquitination and degradation of IL1RAP is an important mechanism for negative regulation of IL-1beta-induced signaling pathways. |
|
22902304 |
identified polymorphic markers in TNFalpha, IL10, IL1beta and TGFbeta1 genes to be associated with alcoholic liver disease in the Bengali population |
|
22898394 |
Viable Aggregatibacter actinomycetemcomitans biofilms may disturb the critical first steps of local inflammation in periodontitis by binding and internalising IL-1beta. |
|
22894561 |
There is no relationship between concentration of IL-1beta and the level of bone mineral density in menopausal women. |
|
22884587 |
genetic association studies in population in Austria: Data suggest that an SNP in exon 5 of IL1B (rs1143634) is associated with risk reduction for preterm birth in Caucasian women; an SNP/mutation in IL1B promoter (rs16944) is not associated. |
|
22884582 |
COX-2 level was significantly higher in cancer associated fibroblasts than that in normal fibroblasts with or without stimulation of IL-1beta. |
|
22878044 |
IL-1beta could play a role in the pathogenesis of thyroid autoimmunity. |
|
22869038 |
This study demonistrated that IL-1B is changed in the dorsolateral prefrontal cortex of individuals with schizophrenia |
|
22829643 |
These findings suggest that IL-1beta, IL-1Ra, and granulocyte colony-stimulating factor are functional markers of EV71-related cardiac dysfunction. |
|
22829602 |
The antagonistic actions of endogenous interleukin-1beta and 15-deoxy-Delta12,14-prostaglandin J2 regulate the temporal synthesis of matrix metalloproteinase-9 in sheared chondrocytes |
|
22822059 |
Cyclooxygenase-2, not microsomal prostaglandin E synthase-1, is the mechanism for interleukin-1beta-induced prostaglandin E2 production and inhibition of insulin secretion in pancreatic islets |
|
22818222 |
An essential role in the central nervous system is supported for IL-1beta in the central nervous system. New CCAAT enhancer-binding protein (C/EBP)beta functions in astrocytes are also identified. |
|
22818022 |
Data indicate that IL-1beta [+3954 C>T (rs1143634)], IL-6 [-174 G>C (rs1800795)] and IL-10 [-1082 A>G (rs1800896)] were associated with breast cancer risk. |
|
22815289 |
Use of a ratiometric biosensor allows monitoring of IL-1beta processing in real time, as well as a kinetic study of inflammasome activity in individual living macrophages. |
|
22811570 |
Human chorionic gonadotropin triggers angiogenesis via the modulation of endometrial stromal cell responsiveness to interleukin 1. |
|
22808497 |
carriers of -31TT/+3954CT genotype were characterized by low IL-1beta stimulation index in response to mitogen in comparison with carriers of other genotype combinations |
|
22805115 |
Data indicate that children exposed to secondhand smoke had lower concentrations of IL-1beta, IL-4, IL-5, and IFN-gamma than those with no exposure. |
|
22804923 |
The results of this study supported that IL1B contributes to the genetic risk of schizophrenia. |
|
22796605 |
IL-1B & TGFB3 synergistically activated MMP)-1, MMP-3,& MMP-10 gene expression in NSCLC cells via MAPK-dependent pathways. Consistent with this, both cytokines stimulated epithelial to mesenchymal transition and MAPK-dependent invasion |
|
22796220 |
the phagocytosis of ox-LDL can induce human macrophages to secrete IL-1beta by activating the NLRP3 inflammasome. |
|
22796164 |
endogenous IL-1beta play a role in elastin gene upregulation and this upregulation is mediated by the Ras-ERK1/2 pathway in 3D cultures |
|
22795647 |
Simultaneous stimulation of monocyte-derived DCs resulted in highly increased production of IL-1beta, IL-23 and SOCS2 |
|
22795101 |
In this series, we observed that polymorphisms of the IL-1b gene do not play a major role in the development of preeclampsia in the Taiwanese women. |
|
22791816 |
Stromal cell and colonocyte EGFRs are required for robust EGFR signals and efficient tumor growth, which involve EGFR-interleukin-1 crosstalk. |
|
22768033 |
Genetic variation in the promoter region of IL1B may not be associated with incident acute coronary syndrome in men or women above the age of 50 years. |
|
22764136 |
up-regulation of L1CAM augmented expression of IL-1beta and NF-kappaB activation. |
|
22763186 |
findings support a role for IL1B variability in the dorsolateral prefrontal cortex dysfunction classically associated with schizophrenia. |
|
22763042 |
Data show in pulmonary microvascular endothelial cells (HPMECs), unfractionated heparin (UFH) significantly attenuated LPS-induced production of IL-1beta, IL-6, E-selectin and ICAM-1, as well as phosphorylation of p38 MAPK and NF-kappaB translocation. |
|
22759516 |
meta-analysis suggests that there was no evidence of a significant association between IL-1beta -511 C/T polymorphism and duodenal ulcer with or without Helicobacter pylori infection |
|
22750393 |
beta-carotene reverses the IL-1beta-mediated reduction in paraoxonase-1 expression via induction of the CaMKKII pathway in human endothelial cells |
|
22739237 |
the microenvironment at the verge between inflammation (IL-1beta) and tissue remodeling (TGFbeta2) can strongly promote the process of EndMT. |
|
22738689 |
Three genes, MMP9, IL1B, and SOD2 were down regulated in all the 3 ethnic groups making them potential biomarker candidates for CAD across all three ethnicities. |
|
22727020 |
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta |
|
22714811 |
Our results indicate that the IL-1beta -511 C/C and C/T gene polymorphisms are associated with chronic gastritis and gastric cancer development in H. pylori-infected individuals. |
|
22710193 |
data suggest that interleukin-1beta directly promotes trophoblast motility of first trimester extravillous trophoblasts |
|
22708826 |
This study demonistrated that the expression of proinflammatory cytokine IL-1beta and posttranscriptional inflammation-associated miR-146a is variable depending on the disease stage in children with mesial temporal lobe epilepsy. |
|
22673037 |
Data indicate that heritabilities were moderate for IL-1beta (range: 0.27-0.32) and IL-10 (0.30) and low for IL-6 (range: 0.15-0.16) and TNF-alpha (range: 0.17-0.23). |
|
22649552 |
Our data do not support the hypothesis that increased IL-1beta production in cystic fibrosis subjects is due to an intrinsic increase in NF-kappaB activity through loss of CFTR function. |
|
22629855 |
Effect of myelopeptides on reactive oxygen species generation and IL-1beta and TNF-alpha production by peripheral blood cells |
|
22629474 |
These data suggest that IL-1beta possibly is a key player determining the severity of the disease in diffuse cutaneous leishmaniasis patients. |
|
22622830 |
A review of interleukin-1beta (IL-1beta) gene polymorphisms, changes of IL-1beta levels and the putative role of IL-1beta in the generation of febrile seizures. |
|
22621214 |
subjects homozygous for the IL1B gene have a two times increased risk of post-orthodontic external apical root resorption in root filled teeth |
|
22621205 |
proinflammatory cytokines, such as IL-1beta and TNF, influence the presence and rhythm of molecular clocks |
|
22596214 |
IL-1beta measurement in LPS-stimulated WBC is useful to predict responsiveness to anti-TNF agents. |
|
22580886 |
This study did not reveal sufficient evidence for a significant association of the investigated IL-1beta polymorphisms with asbestos or silica-induced diseases in the population studied. |
|
22569251 |
Data suggest differential usage of IKK subunits in activation of NFkappaB in pancreatic beta cells; TNFalpha uses both IKK-alpha and IKK-beta, IL-1beta uses IKK-alpha only (by induction of IKK-beta degradation via proteasomes). |
|
22568934 |
functional variant of the gene contributes to the susceptibility to prosthetic joint infection |
|
22547706 |
IL-1beta is important for neutrophil-mediated host immunity against Klebsiella pneumoniae infection in the lung, consistent with findings showing requirement of IL-1 receptor activation in host immunity against systemic infections. |
|
22545750 |
low doses of X-rays induce an anti-inflammatory phenotype of activated macrophages by lowering the amount of secreted IL-1beta in a NF-kappaB dependent manner |
|
22540426 |
A functional polymorphism in the promoter region of the IL1B gene is associated with risk of multiple myeloma. |
|
22537218 |
higher secretion by peritoneal macrophages in endometriosis |
|
22513786 |
IL-1beta contributes to psoriasis by dual effects. First, it induces insulin resistance through p38MAPK (mitogen-activated protein kinase), which blocks insulin-dependent differentiation of keratinocytes, and at the same time IL-1beta drives proliferation of keratinocytes, both being hallmarks of psoriasis. |
|
22503230 |
Microbial keratitis were less likely to occur in wearers with the nonmutated IL-6 haplotype; wearers carrying an IL-12B SNP had an increased risk of sterile keratitis compared with controls. |
|
22498095 |
The results of this study suggested that there is a relevant role of IL-1 genes cluster in Alzheimer's disease pathogenesis in this Brazilian population. |
|
22493010 |
IL-1beta release was detected after HRV infection in both BECs and brushed cells, but BzATP did not significantly increase IL-1beta release further |
|
22487523 |
We have identified three potential invasive markers, uPA, MMP-1 and IL1-R1, whose gene expression may differentiate PDAC from other pancreatic neoplasms. |
|
22481167 |
Serum levels of TNF-alpha, IL-1beta, and IL-6 do not correlate with involuntary weight loss but are associated with cancer. |
|
22467534 |
the presence of a C allele at the -31 position may lead to decreased expression of the IL1B gene due to a specific binding of YY1 in lung epithelial cells. |
|
22466287 |
findings demonstrate that by eliciting different cytokines C. albicans and S. aureus prime TH17 cells that produce either IFN-gamma or IL-10, and identify IL-1beta and IL-2 as pro- and anti-inflammatory regulators of TH17 cells both at priming and in the effector phase |
|
22455686 |
Polycystic ovarian syndrome patients who carried T allele of IL-1beta gene promoter region (-511) and V allele of IL-1ra gene were high risk of obesity. |
|
22449968 |
Results describe an important role of KLF4 in regulating expression of IL-1beta. |
|
22425785 |
The molecular mechanism that controls TssRII fate in IL-1ss treated cells, was investigated. |
|
22425603 |
IL-1B gene polymorphism affects the modulation of serum oxLDL levels. |
|
22417897 |
IL1beta-511C/T polymorphism might be moderately associated with increased risk of ischemic stroke. |
|
22414649 |
high capsaicin consumption synergistically increased GC risk in genetically susceptible individuals il1b 31c alleles carriers infected with the more virulent H. pylori strains |
|
22395218 |
IL-1beta -511 polymorphism is associated with severe veno-occlusive disease in pediatric-matched allogeneic hematopoietic stem cell transplantation |
|
22389405 |
S. dysenteriae-induced expression of interleukin-1beta upregulates MUC2 expression and the differential expression of MUC5AC. |
|
22386525 |
higher plasma concentrations are associated with depression score in pregnant African-American women |
|
22384091 |
analysis of shear stress modulation of IL-1beta-induced E-selectin expression in human endothelial cells |
|
22384041 |
Interleukin-1 stimulates ADAM17 through a mechanism independent of its cytoplasmic domain or phosphorylation at threonine 735 |
|
22382666 |
IL-1beta levels was two times lower in triathletes than in cyclists (p < 0.05) and IL-1beta levels were lower in cyclists than in recreational athletes |
|
22371121 |
the present study demonstrates the functional role of inflammatory cytokine IL-1beta to stimulate peripheral blood endothelial progenitor cmigration, adhesion, and proliferation functions and positively modulate the VEGF-A level |
|
22349547 |
human primary cementoblasts subjected to compression and IL-1beta stimulation impeded BSP and CEMP-1 expression, proteins that are associated with cementogenesis. |
|
22348697 |
IL1A and IL1B genetic variations are significant contributors to chronic periodontitis in whites |
|
22344672 |
The presence of the IL-1B 3954 gene polymorphism does not appear to be a risk factor for chronic periodontal disease. |
|
22341060 |
The development of EARR in subjects with root-filled teeth who undergo orthodontic treatment might be attributable to genetic variations in the interleukin-1beta gene (rs1143634). |
|
22340390 |
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta |
|
22312160 |
None of the single nucleotide polymorphisms showed an association with anklyosing spondyloarthritis. |
|
22311026 |
IL-1beta polymorphisms are susecptibility factors for visceral leishamaniasis. |
|
22286731 |
There is a possible heterogeneity in the association of IL-1B gene polymorphism with cancer, in populations of similar ethnic background and settled in the same risk area. |
|
22285242 |
There is no significant association between the risk of recurrent pregnancy loss and IL1B gene variants. |
|
22280559 |
There was no synergy between Streptococcus agalactiae and Escherichia coli for inducing the secretion of inflammatory factors IL-1beta, TNFalpha or degradative metalloproteinase proMMP-9; thus these two bacteria could initiate different pathways to induce chorioamnioitis. |
|
22275254 |
During an acute attack of multiple sclerosis, inflammation increases brain IL-1beta signaling, which enhances in turn glutamate-mediated synaptic excitability and neurotoxicity. |
|
22267217 |
dectin-1 acted as an extracellular sensor for pathogens that induced both IL-1beta production and maturation through a noncanonical caspase-8-dependent inflammasome for protective immunity |
|
22266275 |
this is the first study that demonstrates association between TNFalpha 1031 T/C and IL1beta 511 C/T polymorphisms and cerebral palsy in very preterm infants. |
|
22251538 |
The genetic polymorphisms of IL-1ss-2023 C allele, IL- 1RAcP -8261 T allele and -8183 A allele are probable host factors for persistent HBV infection. |
|
22227487 |
Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects. Polymorphism in IL1B was significantly associated to the HIV-1 infection. |
|
22195044 |
These findings document for the first time that activation of neutrophils in gout is associated with the formation of proinflammatory neutrophil extracellular traps and links this process to both autophagy and IL-1beta. |
|
22183425 |
Serum levels of TNF-alpha and IL-1beta in patients with mild preeclampsia were similar to those in the control group. |
|
22178859 |
IL-1beta-induced CXCL10 protein expression in astrocytes was potentiated by co-exposure to alpha-synuclein |
|
22173128 |
Data suggest that c-kit is an important regulator of IL-1 receptor 1/IL-1beta signaling and effector functions in mast cells; such signaling is IL-relevant for IL-6 release. |
|
22172512 |
RANKL induced large resorption pits (10,876 +/- 2190mum(2)) whereas TNF-alpha/IL-1 and LIGHT generated smaller pits (respectively 1328 +/- 210 and 1267 +/- 173mum(2)) |
|
22160471 |
The results show a significant association between IL-1beta -511 C/T gene polymorphism and febrile seizures. |
|
22155307 |
The inhibition of nuclear factor-kappaB activation induced by IL-1beta in osteoarthritis (OA) osteoblasts may contribute to some of the heme oxygenase-1 effects. |
|
22154780 |
Low values of intracellular pH enhance the production of IL-1beta, at least in part, by stimulating the synthesis of its precursor. |
|
22128229 |
Single nucleotide polymorphisms rs1143634 of IL-1beta and rs8192284 of IL-6 receptor act as susceptibility variations in Korean non-Sjogren dry eye patients. |
|
22126705 |
Elevated cerebrospinal fluid and serum concentrations of interleukin (IL)-8, but not IL-1beta, are reported in fibromyalgia patients. |
|
22125454 |
inflammasome is an important innate immune pathway that regulates at least two host responses protective against infections: (1) secretion of the proinflammatory cytokines IL-1beta and IL-18 and (2) induction of pyroptosis, a form of cell death |
|
22124068 |
Association was not found for the effect of allele, genotype, composite genotype, and haplotypes of IL-1B+3954 polymorphism with periodontitis. Its utility as a risk marker in this population was not borne out by the study. |
|
22108531 |
p65-Dependent production of interleukin-1beta by osteolytic prostate cancer cells causes an induction of chemokine expression in osteoblasts. |
|
22103356 |
findings show PSA production and proliferation of LNCaP prostate cancer cells were down-regulated by NF-kappaB mediated by IL-1beta promoting anti-apoptotic signalling and co-suppressor factors of PSA expression |
|
22101739 |
A molecular understanding of the interactions of apoE4 with Abeta, nitric oxide and IL-1beta on the regulation of the COX-2/prostaglandin pathway may open new avenues in understanding the mechanism of development of neurodegenerative disease. |
|
22095718 |
Inhibition of IL-1beta signaling provides disease-modifying benefits in an Alzheimer's disease (AD) transgenic mouse model; the IL-1 signaling cascade may be a key mechanism for AD. |
|
22092925 |
The alleles 1 and 2 of IL1A gene and the alleles 1 and 2 of IL1B gene were statistically associated with the success or no success of the dental implants. |
|
22073367 |
lumican and fibromodulin display different behaviors and that lumican may promote regeneration of the TMJ after degeneration and deformation induced by IL-1 beta. |
|
22073249 |
investigate the relationship between host (mucin) and pathogen interaction, including Shigella induced expression of MUC2 and IL-1beta during shigellosis |
|
22072054 |
genetic polymorphism is associated with increased myocardial infarction risk |
|
22071871 |
IL-1beta regulates neurogenesis by inhibition of the kynurenine pathway, which may provide a new therapy to revert inflammatory-induced reduction in neurogenesis. |
|
22068351 |
serum levels of IL1-beta in Kashin-Beck disease were increased compared with healthy controls, but the increase was not correlated with disease severity. |
|
22065068 |
Sp1 transcription factor partly mediates IL-1 induction of ADAMTS-4. |
|
22064385 |
Data suggest that IL-1beta facilitates progesterone metabolism in cervical fibroblasts by regulating expression of aldo-keto reductases AKR1C1 and AKR1C2. |
|
22059992 |
study showed that variation in the IL1RN associates with susceptibility to idiopathic pulmonary fibrosis (IPF); the subsequent imbalance between IL-1beta and IL-1Ra might have a significant pathogenetic effect in IPF patients |
|
22027397 |
Data show that in HIV-1-infected astrocytes, IL-1beta-induced increases in CD38 levels were regulated through the MAPK signaling pathway and by the transcription factor NF-kappaB. |
|
22023756 |
Interleukin-1beta released during an immune response acts as messenger that helps to modulate behaviour by influencing relevant neurotransmitter systems, and in some cases, by directly acting within the brain. |
|
22021895 |
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta |
|
22019906 |
secretion of IL-1beta occurs on a continuum, dependent upon stimulus strength and the extracellular IL-1beta requirement |
|
22010855 |
IL-1beta polymorphisms are risk factors in the pathogenesis of recurrent spontaneous abortion in the Chinese Han population. |
|
22003203 |
IL-1beta and IL-23 are identified as critical factors in the generation of egg antigen-specific transgenic T helper (Th)17 cells involved in the pathogenesis of severe schistosomiasis. |
|
21994456 |
These results indicate that the V protein of measles virus suppresses NLRP3 inflammasome-mediated IL-1beta secretion by directly or indirectly interacting with NLRP3. |
|
21992747 |
Significant differences were found in the response to induced ketosis among non-carriers of putative gain-of-function polymorphisms in rs1143627 and rs16944 in the IL-1beta gene and among variants of the polymorphism rs2251101 in the insulysin gene. |
|
21988351 |
Carriers of -511/+3954 CTCT are at risk of developing functional pancreatic neuroendocrine tumors (pNETs) (p=0.006) and carriers of -511/+3954 CTCC are at risk of developing nonfunctional pNETs. |
|
21978003 |
Data show that the modulation of both TNF-alpha and IL-1beta production by autophagy was induced at the level of gene transcription. |
|
21968104 |
study evaluated genetic variation in genes encoding IL1A, IL1B and IL1RN with repeated measures of global cognition and processing speed; results provide evidence that genetic variants in IL1 genes may be involved in inflammatory-related lowered cognition |
|
21962386 |
IL-1F10.3 and IL-1A+889 polymorphisms are associated with the development of ankylos-ing spondylitis in Europeans but not in Asians. |
|
21949132 |
in nucleus pulposus, TNF-alpha and IL-1beta regulate SDC4 expression, which plays a key role in pathogenesis of degenerative disc disease by promoting aggrecan degradation by ADAMTS-5. |
|
21948112 |
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta |
|
21940680 |
Hemorrhagic shock, via HMGB1, activates interleukin (IL)-1beta release at an early stage following inflammatory stimulation and resuscitation in transgenic mice. |
|
21935932 |
Macrophage accumulation in adipose tissue has a central role in stimulating matrix metalloproteinase 1 and 3 production by preadipocytes, and this is partially mediated by IL-1beta via activation of the MAPK and NF-kappa B signaling pathways. |
|
21923858 |
The activation of platelets with anti-HLA Class I alloantibody caused the formation of platelet-monocyte aggregates, followed by the production of IL-1beta and IL-8. |
|
21914069 |
The authors showed that the precursor form of the precore protein, p25, inhibits NF-kappaB activation by up to 30% and the cytosolic form, p22, inhibits NF-kappaB activation by 70% in PH5CH8 cells stimulated with IL-1beta. |
|
21898353 |
DDAH-2 could play an important role in IL-1beta-induced NO production and in osteoarthritis pathogenesis. |
|
21878622 |
Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta8 through altering chromatin architecture. |
|
21878338 |
Results show that cryopreservation of monocytes or iDCs leads to an impaired cytokine response for IL-10, TNF-alpha, IL-12p70 and IL-1beta. |
|
21871094 |
HMGB1 in complex with lipopolysaccharide, IL-1alpha or IL-1beta boosted proinflammatory cytokine- and matrix metalloproteinase production in synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients |
|
21866808 |
An association between more pronounced inflammation of gastric mucosa with the T allele of interleukin-1beta C -511 C > T gene polymorphous locus (Chi2 = 14.006; p = 0.001). |
|
21862584 |
Mutation of HuR Thr-118 reduced the association between HuR and cPLA(2)alpha mRNA under IL-1beta treatment |
|
21854541 |
Recombinant human OSM and native OSM secreted by human granulocytes both reduced the gene expression and secretion of IL-1beta and CXCL8, but increased that of IL-6 and CCL2. |
|
21843369 |
IL-1beta gene polymorphism rs1143633 is associated with schizophrenia susceptibility in a Japanese population. |
|
21840356 |
data suggest that allele (-31)C of IL1B may be a risk factor for hypertension in the Polish population with CAD in the western Pomeranian region of Poland |
|
21837414 |
Carriers of the CC genotype of IL-1beta (+3953 T/C) polymorphisms are more frequent among patients with lumbar disc herniation, suggesting a potential role of IL-1beta in its pathogenesis. |
|
21819478 |
IFN-gamma, IL-1beta, and IL-2 were elevated in the early-pregnancy mothers whose children developed presistent islet autoantibodies, type 1 diabetes, or both before 7 years of age. |
|
21811191 |
This suggests that IL1B exerts an influence on left ventricular systolic dysfunction through its effect on IL-1beta secretion. |
|
21804018 |
the results obtained demonstrate for the first time that IRAK1 and PKCdelta functionally interact to regulate IL-1beta production in monocytic cells |
|
21784976 |
latter property is associated with decreased caspase-1-dependent IL-1beta maturation in the BCG-infected macrophages |
|
21776298 |
study of IL-1 beta, IL-6 and TNF alpha blood dynamics, offers valuable information about the severity of a systemic inflammatory response syndrome in peritonitis. |
|
21771656 |
cPLA(2)alpha gene activation by IL-1beta is dependent on an upstream kinase pathway, enzymatic activation and downstream 15-lipoxygenase activity: a positive feedback loop |
|
21768915 |
This study suggested that functional polymorphisms within the IL-1B gene are associated with Brain arteriovenous malformations and influence the clinical characteristics of the disease. |
|
21762900 |
COX-2 and IL-1beta regulate the invasion ability of ectopicendometrioma derived ectopic endometrial mesenchymal stem cells. |
|
21762124 |
While interleukin (IL)-1beta plays an important role in combating the invading pathogen as part of the innate immune response, its dysregulation is responsible for a number of autoinflammatory disorders. (Review) |
|
21732076 |
(IL)-1beta down-regulated ADAMTS-13 mRNA expression in cultured human astroglioma cells & microglial cells. |
|
21731057 |
IL1B is a modifier gene of cystic fibrosis disease. |
|
21728024 |
The emerging role of interleukin-1beta in autoinflammatory diseases. |
|
21726461 |
results suggest that genetic variations in the IL-1b gene contribute to the HPA axis alteration ssessed by DST-Cortisol in healthy subjects. |
|
21717421 |
increased leukocyte expression of IL-1beta identifies a subset of patients with osteoarthritis who have increased pain and are at higher risk of radiographic progression of osteoarthritis. |
|
21712624 |
association between carriage of IL-1 rare alleles and periodontitis differed between Down and non-Down subjects. carriage of IL-1 rare alleles in Down subjects tended to confer protective effect against loss of periodontal attachment. |
|
21708940 |
NSMase-2- and PP2A-dependent regulation of IRAK-1 degradation is a novel mechanism to fine tune the magnitude of IL-1beta response. |
|
21700772 |
monocytic microparticles contain IL-1beta and may amplify inflammation by enhancing the activation of the endothelium and expression of cell adhesion molecules |
|
21697093 |
IL-1beta induces dedifferentiation of articular chondrocytes by up-regulation of SIRT1 activity enhanced by both NAMPT and ERK signaling. |
|
21688665 |
concentration of IL-1beta, INF-gamma, TNF-alpha, S100beta, AMA-M2 increase, IL-10 decrease were detected in peripheral blood of 25 patients with stroke |
|
21687998 |
anti-inflammatory protein solution blocks the effect of IL-1beta on human macrophages |
|
21682548 |
Data indicate that in fetal term and preterm groups, TNFalpha -238G/A, TNFalpha -308G/A, IL-1alpha 4845G/T, and IL-1beta -511G/T polymorphisms were statistically significant. |
|
21671260 |
hip osteoarthritis in Croatian population might have a different genetic risk regarding the IL1 locus |
|
21664353 |
Tumor-produced, active interleukin-1beta regulates gene expression in carcinoma-associated fibroblasts |
|
21659743 |
Compared with patients without peritonitis, the carriage of C allele in IL-1beta gene polymorphism (C/C and C/T genotypes) was significantly associated with the occurrence of peritonitis (p = 0.013). |
|
21659536 |
Stimulation of yeast telomerase activity by the ever shorter telomere 3 (Est3) subunit is dependent on direct interaction with the catalytic protein Est2. |
|
21653279 |
IL1B -31C allele is a low-penetrance protective factor for the development of cancer, in particular for that associated with infection. |
|
21637346 |
The deregulated secretion of IL-1beta secondary to mutations in NLRP3 could affect the IL-23/IL-17 axis. |
|
21628463 |
Inflammasome activation by bacterial DNA is not modulated by redox responses, suggesting that redox-dependent regulation of IL-1beta secretion is restricted to some inflammasomes including NLRP3 but excluding AIM-2 |
|
21623995 |
Serum IL-6, IL-1beta and hCG levels were significantly increased in women with pre-eclampsia compared to controls. |
|
21621860 |
IL1B-511 TT genotype is associated with later occurrence of multiple sclerosis but faster progression of disability. progression. |
|
21614008 |
Results suggest that IL-1beta gene variation may have a role in cognitive functions in aging females as well as males. |
|
21611201 |
Silencing of SFRS3 increased IL-1beta secretion due to elevation of IL-1beta and caspase-1 mRNA in addition to active caspase-1 levels. |
|
21604462 |
IL-1beta gene 31CC genotype may be an independent risk factor with chronic rhinosinusitis. |
|
21585612 |
Children with IL-1B-511TT/-31CC have a risk to develop severe gastric mucosal histological changes in South China. |
|
21572958 |
IL-1ss and lactoferrin are biomarkers for sexually transmitted diseases/colonizations providing insights into immune responses and pathogenesis at genital tract mucosal site. |
|
21571945 |
Primary human monocytes, a human monocytic cell line, and monocyte-derived macrophages are useful for measuring expression of proinflammatory mediator IL-1beta responding to lipopolysaccharide with or without alpha1-adrenergic receptor activation. |
|
21535449 |
melatonin dramatically improved IL-1beta-induced Rac inactivation |
|
21523343 |
A significant association of the IL1 gene cluster (IL1B-IL1RN) with severe knee osteoarthritis was not found. |
|
21509504 |
No difference was found by a cross-sectional approach comparing IL-1alpha rs1800587, IL-1beta rs3087258 and TNF-alpha rs1799724 genotypic and allelic frequencies between those affected and not affected by dementia. |
|
21496483 |
Even after exclusion of depressed individuals neither the SNPs nor the mRNA IL1beta and IL6R expression levels were associated with chronic or persistent fatigue in breast cancer survivors. |
|
21486440 |
Findings suggest that the coordinated expression of CCL2 & CCL5 and TNFalpha & IL-1beta may be important for disease course. |
|
21484857 |
IL-1beta produced by bursal syvoviocytes and inflammatory cells in the human subacromial bursa is an important signal in the inflammatory response that occurs in subacromial bursitis and rotator cuff disease. |
|
21465264 |
Data suggest that genotype T/T at -31 and genotype C/C at -511 in the interleukin-1beta promoter are associated with major recurrent depression. |
|
21449691 |
The IL-1-polymorphism is associated with lower number of teeth in non-smokers with untreated periodontal disease |
|
21445336 |
Pro-inflammatory cytokine IL1B repress gastrin expression by activating Smad 7 and subsequent inhibition of nuclear localization of Smad 3/4 complex. Polymorphic promoter variants of IL1B gene can modulate the IL1B expression which |
|
21440944 |
Acute otitis media severity is associated with interleukin-1-beta gene polymorphism. |
|
21433061 |
IL-1beta can favor osteoclastogenesis by altering the phenotypic characteristics of the supporting periodontal ligament fibroblasts |
|
21431944 |
Sustained elevation of serum and/or synovial levels of IL-33 may account for a poor response to TNF inhibitors via persistent Il-1 beta signaling. |
|
21430222 |
Traf6 couples MyD88 to the Akt pathway and, remarkably, a Traf6 interacting peptide-antennapedia chimera was more effective than LPS in stimulating IL-1beta splicing |
|
21427492 |
flap surgery has a significant effect on decreasing IL-1beta concentration in the gingival crevicular fluid of patients with moderate to severe chronic periodontitis. |
|
21424904 |
Results suggest that plasma IL-1beta level and IL-1beta C-511T polymorphism may be considered as candidate biomarkers for cervical cancer in Egyptian women. |
|
21421008 |
This review discusses the role of the NLRP3 inflammasome and its associated inflammatory mediators IL-1beta and IL-18 in the pathogenesis of asthma and chronic obstructive pulmonary disease. |
|
21419289 |
significant difference in distribution of polymorphic genotype among cases (70.6%) and controls (24.6%) was shown. findings suggest specific genetic markers associated with increased IL-1beta production may contribute to increased susceptibility to PAP. |
|
21418526 |
polymorphisms in IL-1beta gene may affect host susceptibility to BD. |
|
21414132 |
There was no correlation between the concentration of IL-1beta and IL-6 in the crevicular sulcular fluid present in healthy or diseased osseointegrated implants in comparison with healthy teeth. |
|
21411094 |
IL-1 beta has a role in atherosclerosis and cardiovascular disease |
|
21403867 |
Both IL-1beta and TNF-alpha regulate NGAL expression in polymorphonuclear granulocytes of chronic hemodialysis patients. |
|
21400614 |
These results indicated the first evidence that the genetic polymorphisms of IL-1beta and TNF-alpha may be involved in DNA methylation in nonneoplastic human gastric mucosa. |
|
21394384 |
Data show that weight loss led to a significant reduction in liver IL-1beta, IL-18 and IL-1Ra expression, whereas hepatic IL-37 expression remained stable, adipose/liver NLRP3 inflammasome and IL-1alpha expression were not affected by weight loss. |
|
21385879 |
Varicella-zoster virus infection triggers formation of an interleukin-1beta (IL-1beta)-processing inflammasome complex. |
|
21385549 |
Letter: No association between interleukin-1 beta gene polymorphism and biopsy-proven erythema nodosum. |
|
21380730 |
The association of TNF-alpha G308A and IL-1beta (+3953) C/T polymorphism with myocardial infarction in Turkish population, was studied. |
|
21368235 |
Substance P- and hemokinin-1-stimulated monocytes potentiate T helper type (Th)17 cell generation in vitro through IL-1beta, IL-23, and tumor necrosis factor-like (TNF)1A expression. |
|
21366387 |
MEFV E148Q polymorphism has no effect on IL-1beta in Henoch-Schonlein purpura. |
|
21323660 |
Data indicate that down-regulation of TLR-4-mediated IL-1beta, IL-6, TNF-alpha, interferon (IFN)-gamma and IL-10 production in summer was observed compared to winter. |
|
21311438 |
The study demonstrated a correlation between high frequency of genetic polymorphism in IL-1alpha -899 and IL-1beta +3953 loci and development of severe periodontitis among patients less than 35 years of age. |
|
21307135 |
inflammatory genes may regulate fasting and postprandial lipids because the carriers of the minor allele of an IL1b gene variant have altered lipid metabolism |
|
21288573 |
Significant structural and sequence differences occur in the terminal and some loop regions between human and chicken IL-1betas. |
|
21276216 |
Both IL-1 and IL-4 are involved in the response of annulus fibrosus cells derived from nondegenerative tissue to 1.0-Hz cyclic tensile strain. |
|
21266527 |
Cyst fluid levels of IL1beta can differentiate low- from high-risk intraductal papillary mucinous neoplasms of the pancreas |
|
21265111 |
There is no evidence to support a relationship of IL-1B and IL-1RN polymorphism with risk of gastric cancer. |
|
21251078 |
The borderline association of the study polymorphism with implant loss suggests further IL1 haplotype analysis to elucidate the global involvement of IL-1 proteins in the modulation of the osseointegration process. |
|
21246243 |
IL-1beta-31CC, IL-1beta-511TT genotype, and TNF-alpha-857T carrier may have protective effect against gastric cancer progression. |
|
21243433 |
The genotype CC or CT of IL-1B-31, TT or CT of IL-1B-511, and 2L of IL-1 receptor antagonist increased the risk of gastric cancer in the Chinese population and the risk was further enhanced by H. pylori infection. |
|
21239716 |
After crystal stimulation, primary human monocytes and macrophages produce high concentrations of IL-1beta by activating the NLRP3 inflammasome. |
|
21235388 |
the levels and cellular origin of IL-1 family members [IL-1alpha, IL-beta, and IL-1 receptor antagonist (IL-1ra)] in human testicular normal and abnormal biopsies with incomplete maturation arrest (IMA) or Sertoli only syndrome (SOS) |
|
21228685 |
prevalence of Il-1 beta-31 allele was higher in multifocal atrophic gastritis than autoimmune gastritis |
|
21217200 |
These data suggest that during phagocytosis of autophagic dying cells ATP, acting through its receptor, initiates K (+) efflux, inflammasome activation and secretion of IL-1beta. |
|
21211511 |
the implication of H-Ras and NADPH oxidase-generated superoxide production in MMP-13 gene regulation by IL-1beta and TNF-alpha |
|
21199393 |
IL-1 and IL-6 single nucleotide polymorphisms may not be a risk factor for susceptibility to MI in Turkish population. |
|
21181220 |
Inflammatory synovitis in reactive arthritis (ReA)/undifferentiated spondyloarthropathy (uSpA) is mediated by pro-inflammatory cytokines like IL-17, IL-6, IL-1beta, and IL-21. |
|
21181166 |
IL-1beta and TNF-alpha, induced the expression of IL-34 mRNA via JNK and p44/42 MAPK. |
|
21178846 |
Results suggest maneuvers to diminish IL-6 production in the disc could provide some protection against the adverse effects of IL-1 and TNF-alpha, thus, helping preserve disc composition, structure, and function. |
|
21173731 |
IL-1 beta expression in the arterial wall is comparable in primary and secondary lesions. Serum concentrations of IL-1 beta are independent of its arterial wall expression. |
|
21173653 |
+3954 C>T polymorphism is not associated with preterm birth |
|
21166654 |
These results indicate that IL-1beta-induced IL-6 production in A549 cells is mediated by both PI3K and IRAK4 and suggest that involvement of PI3K in the IL-1-induced IL-6 production is cell type specific. |
|
21138659 |
Interleukin-1beta was higher in CSF of bipolar disorder patients than in healthy volunteers. |
|
21133705 |
Significant differences between the sexes for the basic amounts of urinary IL-1alpha and IL-1beta were observed. |
|
21107607 |
TNF-alpha-238 G/A, IL-1B-31 T/C, -511 C/T, and IL-10-1082 G/A polymorphisms were not detected to be related to the risk for hepatocellular carcinoma. |
|
21088871 |
Report interleukin-1beta as the first known activator of endogenous ADP-ribosylation of eEF-2. |
|
21086908 |
Observational study of gene-disease association. (HuGE Navigator) |
|
21078560 |
Facultative heterochromatin (fHC) silences IL-1beta expression during sepsis. |
|
21061265 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
|
21057224 |
study demonstrates the presence of nuclear proIL1beta in transformed mammary epithelial cells providing the first evidence that IL1beta may be a dual function cytokine |
|
21054877 |
Observational study of gene-disease association. (HuGE Navigator) |
|
21054222 |
The IL-1 genotype was not a risk indicator for early (slight) periodontitis as defined in this subject population. |
|
21054222 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
|
21048327 |
Observational study of gene-disease association. (HuGE Navigator) |
|
21048223 |
Data show that MEKK-1 plays an integral role in IL-1beta modulation of Caco-2 TJ barrier function by regulating the activation of the canonical NF-kappaB pathway and the MLCK gene. |
|
21041296 |
RelA is cleaved by chlamydial protease-like activity factor (CPAF), which impairs proinflammatory signaling in cells infected with Chlamydiae; IL-1beta-dependent secretion of IL-8 is also reduced by CPAF expression |
|
21037510 |
Observational study of gene-disease association. (HuGE Navigator) |
|
21037509 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
|
21035110 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20979861 |
Expressions of IL-1beta, TNF-alpha and IgA in specimens of chronic prostatitis were significantly higher than those in non-prostatitis specimens. |
|
20979650 |
In the southern Mexican population, the IL-1B -511C and -31T alleles and the -511C/-31T and -511T/-31T haplotypes are associated with increased risk of chronic gastritis and gastric ulcer. |
|
20979650 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20975573 |
These results suggest that IL-1RN and IL-1B gene polymorphisms were associated with the development of ulcerative colitis (UC) and steorid dependence in UC in the Mexican Mestizo population. |
|
20975573 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20965572 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
|
20963558 |
genetic association studies: SNP in IL1B promoter (C[-511]T) is associated with polycystic ovary syndrome in Chinese women; SNP in exon 5 (C[+3953]T) is not |
|
20963558 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20962853 |
EGFR and IL-1 signaling synergistically promote keratinocyte antimicrobial defenses in a differentiation-dependent manner. |
|
20961668 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20959405 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20942594 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20942272 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20940514 |
These results suggest that the pathogenesis of osteoporosis is associated with IL-1beta (-511C/T) polymorphism in postmenopausal women. |
|
20940514 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20936699 |
Up-regulation of matrix metalloproteinase-9 along with IL-1beta in the early course of Guillain-Barre syndrome appears to be associated with immune-mediated disease progression resulting from inflammation in the peripheral nervous system. |
|
20935210 |
These results identify a homeostatic function of IL-1beta in suppressing early osteoclast precursors |
|
20934730 |
The present results show that circulating IL-1beta and IL-6 concentrations are strongly and independently associated with gamma-GTP activity in middle-aged Japanese men without obvious cardiovascular diseases. |
|
20934174 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20929277 |
increased serum levels in cryoglobulinemic patients with hepatitis C virus chronic infection |
|
20890567 |
No significant differences were found between the genotype frequencies of the H. pylori-infected and the non-infected populations with one exception. The CC genotype in the -31 polymorphic region was associated with benign pathologies |
|
20890567 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
|
20889944 |
IL-1 plays a major role in regulating inflammatory mediator production in wounds through a novel mechanism; by stimulating the production of multiple cytokines and chemokines, it impacts clinically important aspects of wound biology. |
|
20887233 |
Gentle level of cyclic mechanical stretch exerts a protective effect on rheumatoid arthritis-fibroblast-like synoviocytes as it downregulates the level of MMP-1 protease, COX-2, and proinflammatory PGE(2). |
|
20880267 |
Further studies are warranted to clarify the role of the TNF-alpha-308GG/IL-1beta-511T+ combined genotype in this Italian population. |
|
20880267 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20865400 |
IL-1beta-induced HIF-1alpha drives a HIF-1alpha-IL-1beta autocrine loop to maintain persistently elevated IL-1beta level. |
|
20848793 |
rs16944 IL-1beta polymorphism is associated with Kashin-Beck disease. |
|
20848793 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20848459 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20848209 |
1,25(OH)(2)D(3) strongly stimulated the production of interleukin-1beta (IL-1beta) in human monocyte-derived macrophages. |
|
20841404 |
interleukin 1 beta (IL-1beta) may play a role in Andean protection from altitude-associated reductions in fetal growth |
|
20812962 |
Activated CD4+ T cells can be stimulated by keratinocyte derived Il-1 beta to release high amounts of IL-17. |
|
20811626 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
|
20802483 |
the crystal structure of IL-1beta in complex with the ectodomains of IL-1RII and IL-1RAcP was determined. |
|
20799933 |
In osteoarthritis synoviocytes, HMGB1 cooperates with IL-1beta to amplify the inflammatory response leading to the production of a number of cytokines, chemokines and MMPs |
|
20731121 |
Influence of polyoxidonium on IL-1 beta, TNF-alpha and IL-6 production by mononuclears and monocytes under the dexamethasone effect |
|
20729213 |
Inhibitors of MAPK pathway ERK1/2 or p38 prevent the IL-1{beta}-induced up-regulation of SRP72 autoantigen in Jurkat cells. |
|
20724540 |
These results support a central role of the IL-1 network, which seemed to be overstimulated in Erdheim-Chester disease. |
|
20711808 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
|
20702408 |
CCAAT/Enhancer-binding protein {beta} and NF-{kappa}B mediate high level expression of chemokine genes CCL3 and CCL4 by human chondrocytes in response to IL-1{beta}. |
|
20702406 |
Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta}. |
|
20698171 |
Our results suggest a complex association between IL-1B gene polymorphism, H. pylori infection, and gastric secretion. |
|
20697295 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
|
20696775 |
These data demonstrate a phenotypic modulation role for IL-1 in the pathogenesis of squamous metaplasia |
|
20690185 |
positive correlation between IL-1beta and VEGF/NGF/BDNF expression in intervertebral discs suggests that IL-1beta is generated during intervertebral disc degeneration |
|
20685652 |
Nuclear S100A4 was bound to the promoter region of MMP-13 in IL-1beta-treated cells. |
|
20673868 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20671275 |
IL1B polymorphisms and the association of Graves Disease and Graves ophthalmopathy with plasma IL1beta levels show that IL1B polymorphisms may be associated with the development of GD and GO. |
|
20671275 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20659236 |
Il-1beta genotype significantly influences the risk of reflux esophagitis in Taiwanese patients. |
|
20659236 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20650788 |
Meta-analysis of gene-disease association. (HuGE Navigator) |
|
20644561 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
|
20639647 |
In this study, we found that the CC genotype of IL-1-beta C3593T was positively associated with the risk of premature rupture of membranes in preterm delivery, although this association did not achieve statistical significance. |
|
20639647 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20631624 |
none of the major four IL1B polymorphisms (IL1B-3737C>T, -1464G>C, -511C>T, -31T>C) and the IL1RN*2 is individually, or in its haplotype configuration, linked to the presence of premalignant gastric lesions in Caucasians |
|
20631624 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20628624 |
Meta-analysis of gene-disease association. (HuGE Navigator) |
|
20628086 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
|
20626741 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20625956 |
possible correlation between IL-1 polymorphism and periimplantitis [review] |
|
20620944 |
dendritic cell derived IL-1beta preserves and expands IL-1R1(hi)IL-22(+)AHR(+) iNK cells, potentially influencing human mucosal innate immunity during infection. |
|
20603871 |
Tensile strain and magnetic particle force application do not induce MAP3K8 and IL-1B differential gene expression in a similar manner to fluid shear stress in human mesenchymal stem cells. |
|
20603050 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
|
20603037 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20602615 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20596075 |
Data show that regulation of interleukin-1beta by interferon-gamma is different in humans and mice, is limited by suppressor of cytokine signalling 1 and influences interleukin-17 production. |
|
20595916 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
|
20594066 |
polymorphism at IL-1A(-889) and IL-1B(+3954) may affect outcomes of treatment for peri-implantitis in genotype-positive individuals |
|
20594066 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
|
20588114 |
Monotherapy or add-on therapy targeting IL-1beta in type 2 diabetes holds promise for long-term benefits in glycemic control and possibly reducing cardiovascular events. |
|
20587610 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20585978 |
This work contributes to understanding of the complex interaction between H. pylori virulence factors and cytokine genotypes involved in gastrointestinal diseases. |
|
20585978 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
|
20581747 |
Interleukin 1 receptor antagonist gene polymorphism may affect the clinical course of lumbar nucleus pulposus herniation. |
|
20574532 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20574123 |
genetic polymorphism contributes to gastric ulcer susceptibility upon H.pylori infections |
|
20574123 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
|
20568250 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20565898 |
the genomic region containing the IL1A and IL1B gene cluster influences primary open angle glaucoma pathogenesis mostly in non-high tension glaucoma patients in eastern India |
|
20565898 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20565774 |
Observational study of genotype prevalence. (HuGE Navigator) |
|
20564140 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20561568 |
No associations found between the SNPs of IL-1alpha-889, IL-1beta-511 and risk for PD.[meta-analysis] |
|
20561568 |
Meta-analysis of gene-disease association. (HuGE Navigator) |
|
20551628 |
common variants in five interleukin genes, IL1A, IL1B, IL1RN, IL6 and IL10, are not significantly associated ESRD in a white European population |
|
20551628 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20536609 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
|
20536507 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20535924 |
The Chinese herbal compound TCM could reduce the expression of TNF-alpha and IL-1 beta in the gingival crevicular fluid of patients with chronic periodontitis. |
|
20534741 |
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) |
|
20529668 |
The IL-1beta -31T allele was positively associated with a risk of NSCLC, and the carriers of IL-1beta -31T/T or -511C/C would have a higher risk of suffering from NSCLC if they drank alcohol or smoke heavily. |
|
20529668 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
|
20528961 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20522558 |
interleukin 1beta and tumor necrosis factors alpha and beta, but not transforming growth factors alpha and beta, strongly induced HA synthesis by NF-kappaB pathway, activating hyaluronan synthase 2 |
|
20518842 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20517696 |
The MMP-1, COX-2 and IL-1beta expression in synovium decreased depending upon the severity of knee osteoarthritis, while the TGF-beta expression increased. |
|
20509889 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
|
20503287 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20495422 |
Genetic variation in polymorphisms of the IL-1 cluster genes is not associated with aneurysmal subarachnoid cerebral hemorrhage; however, the IL-1ss gene may modify disease severity and may be regarded as a disease severity gene. |
|
20495422 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20495003 |
Release of IL-1beta from monocytes showed selectivity for specific TLR agonists and was accelerated by P2X7 receptor activation. |
|
20490891 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20490394 |
there is limited evidence to implicate a specific IL-1 genotype as risk factor for chronic periodontitis in white populations; limited evidence that genetic variation in IL-1B polymorphism could be a risk factor for aggressive periodontitis [review] |
|
20486195 |
There was no significant difference between patients with febrile seizures and controls in the distribution of allele frequencies of the IL-1beta promoter, IL-1beta exon 5, IL-6 promoter, IL-8, IL-10, or TNF-alpha gene polymorphisms. |
|
20486195 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20485444 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20484876 |
Meta-analysis of gene-disease association. (HuGE Navigator) |
|
20484443 |
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) |
|
20483667 |
The blockade of IL-1beta with anakinra and its effects on interleukin 8 (IL-8) levels and CD11b integrin expression in monocytes of type 1 diabetics are reported. |
|
20482626 |
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) |
|
20478455 |
IL-1beta induced expression of SOCS-3 but not SOCS-2 in human PDL cells. IL-1beta simultaneously induced IL-8 and MCP-1 secretion in PDL cells, whereas SOCS-3 overexpression suppressed secretion of these chemokines. |
|
20473875 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20472930 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20472558 |
IL-1-induced signaling through focal adhesions leading to MMP3 release and interactions between SHP-2 and PTPalpha are dependent on the integrity of the catalytic domains of PTPalpha. |
|
20470442 |
All donors showed a response towards IL-1beta production, drawing special attention for its possible protective role in early innate immune responses to malaria |
|
20468064 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20467172 |
The IL-1b -31 T allele and MMP-3 5A allele are cooperative risk factors for poor prognosis in HCC patients, suggesting that these gene polymorphisms might be potential markers for predicting the prognosis of HCC patients. |
|
20467172 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
|
20463618 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20453000 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20452482 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20447254 |
The IL-1beta/IL-10 ratio differed significantly among different subgingival biofilm profiles in aggressive periodontitis suggesting an imbalance between pro- and anti-inflammatory cytokines. |
|
20445104 |
show in a large cohort of patients that IL-1beta secretion by cryopyrin-associated periodic syndromes monocytes is much faster than that by healthy monocytes. |
|
20437198 |
The present meta-analysis suggests that Il-1beta rs1143627 is associated with breast cancer risk. |
|
20437198 |
Meta-analysis of gene-disease association. (HuGE Navigator) |
|
20431935 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
|
20427258 |
results suggest that IL-1 alpha (-889), IL-1Ra and IL-1 beta (+3953) gene polymorphisms have no association with PD, while allele 1 (C) of IL-1 beta (-511) is associated with PD and provide a susceptibility factor for this disease in Turkish population |
|
20427258 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20418110 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20417488 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20413850 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20405297 |
IL1B-511T/T allele is associated with enhanced hypermethylation of multiple CpG island loci, which might contribute to an increase in the risk for gastric cancer in individuals with H. pylori infection and IL1B-511T/T allele. |
|
20405297 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20400062 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20399512 |
We found a positive association between nontuberculous mycobacterial lymphadenitis and +3953TT in IL1B. |
|
20399512 |
Clinical trial of gene-disease association. (HuGE Navigator) |
|
20399384 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20399210 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
|
20388088 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20385987 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
|
20380698 |
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta |
|
20378664 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20378615 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20376628 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
|
20372910 |
Pulsed electromagnetic field irradiation does not alter the immunophenotype of the cultured fibroblast-like cell population but does provoke a decrease in the production of inflammatory-type cytokines (IL-1beta, TNF-alpha). |
|
20369436 |
Results indicate that amniotic fluid IL-1beta and IL-10 were associated with interactions between pregnancy status and both maternal and fetal SNPs, with the most significant interactions being observed for African Americans with IL-1beta concentration. |
|
20369436 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20364673 |
Association of mucosal inflammation with T allele in polymorphous C-511T locus of IL-1beta agA + strains of HP were more frequently identified in patients with erosive ulcerative defects of gastric mucosa than in children with superficial gastritis |
|
20364673 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20363151 |
Observational study of genotype prevalence. (HuGE Navigator) |
|
20353565 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20349753 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20347268 |
This study suggested the IL1B gene or the IL1 gene complex may play a moderate role in the etiology of schizophrenia in the Caucasian population. |
|
20347268 |
Meta-analysis of gene-disease association. (HuGE Navigator) |
|
20336759 |
The present study shows that TAT increases the production of IL-1beta in human monocytes. |
|
20336759 |
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta |
|
20335539 |
Observational study of gene-disease association. (HuGE Navigator) |
|
20334922 |
Data suggest that both TNF-alpha and IL-1 beta are downstream mediators and as single mediators play a limited role within the complex inflammatory reactions induced by E. coli. |
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