Property Summary

NCBI Gene PubMed Count 2,258
PubMed Score 22444.19
PubTator Score 11110.47

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (5)

Disease Target Count
Alzheimer's disease 644
Asthma 349
Multiple Sclerosis 498
psoriasis 6685
Pleurisy 18
Myopathy 128
Brain Ischemia 87
Schizophrenia 503
Adenocarcinoma 115
Anorexia 15
Anthracosis 4
Arsenic Poisoning 59
Arthritis, Experimental 39
Bronchopulmonary Dysplasia 5
Calcinosis 63
Cardiomegaly 66
Cardiomyopathies 90
Cerebrovascular accident 44
Chronic progressive external ophthalmoplegia 18
Colitis 46
Colonic Neoplasms 126
Degenerative polyarthritis 93
Dermatitis, Atopic 45
Dermatologic disorders 65
Diabetes Mellitus, Experimental 106
Drug-Induced Liver Injury 118
Entamoebiasis 6
Fever 34
Fibrosis 40
Gastritis, Atrophic 1
Glomerulonephritis 36
Gout 93
HIV Wasting Syndrome 4
Heart failure 80
Heart valve disease 24
Heat Stroke 12
Hyperalgesia 71
Hyperemia 13
Hypersensitivity 63
Hypoglycemia 81
Hypotension 53
Inflammation 109
Inflammatory disease of mucous membrane 8
Kearns-Sayre syndrome 6
Learning Disorders 27
Leishmaniasis, Cutaneous 8
Leishmaniasis, Visceral 13
Lethargy 4
Leukocytosis 2
Liver Cirrhosis, Experimental 108
Lung Neoplasms 171
Lymphopenia 35
MELAS syndrome 17
MERRF syndrome 5
Mammary Neoplasms 410
Manganese Poisoning 11
Memory Disorders 36
Mitochondrial Myopathies 6
Myocardial Infarction 126
Myocardial Ischemia 169
Necrosis 51
Neutropenia 78
Optic Atrophy, Hereditary, Leber 14
Osteoporosis, Postmenopausal 7
Peptic ulcer 22
Pneumonia 133
Polymyositis 5
Pulmonary Fibrosis 66
Reperfusion Injury 84
Rheumatoid Arthritis 1171
Seizures 95
Silicosis 10
Sleep Wake Disorders 5
Spontaneous abortion 108
Stomach Neoplasms 282
Thyroid Neoplasm 33
Urticaria 53
dermatomyositis 967
glioblastoma 5572
hemolytic-uremic syndrome 28
ulcerative colitis 2087
Disease Target Count P-value
lung carcinoma 2844 2.83109813667984E-11
non-small cell lung cancer 2798 3.03830311201248E-9
malignant mesothelioma 3163 2.0828284244293E-8
lung cancer 4473 3.45774559399694E-7
pediatric high grade glioma 2712 3.86988654145806E-7
lung adenocarcinoma 2714 1.789155351503E-6
posterior fossa group A ependymoma 1511 2.26467339149908E-6
pilocytic astrocytoma 3086 2.28242772433814E-5
cutaneous lupus erythematosus 1056 2.66931781355887E-4
head and neck cancer 270 4.83225731908644E-4
pancreatic cancer 2300 0.00470418015637748
pancreatic carcinoma 567 0.00470418015637754
aldosterone-producing adenoma 664 0.00861904716305805
Barrett's esophagus 185 0.0146253726519363
interstitial cystitis 2299 0.016531825722431
Bipolar Disorder 266 0.0195874051290645
hepatocellular carcinoma 550 0.031030821942909
gastric cancer 436 0.0407064712000133
Breast cancer 3099 0.0484623512100447
Disease Target Count Z-score Confidence
Arthritis 248 7.257 3.6
periodontitis 269 6.369 3.2
Inflammatory bowel disease 142 6.282 3.1
Lung disease 136 5.873 2.9
Cancer 2346 5.866 2.9
diabetes mellitus 1663 5.635 2.8
Atherosclerosis 275 5.348 2.7
Hypersensitivity reaction type II disease 235 5.276 2.6
Brain disease 84 5.138 2.6
Cerebrovascular disease 231 5.098 2.5
Kidney disease 397 5.059 2.5
Peritonitis 37 5.029 2.5
Eye disease 55 5.024 2.5
Pancreatitis 97 4.893 2.4
Synovitis 72 4.858 2.4
Dermatitis 141 4.834 2.4
Obesity 616 4.802 2.4
Gastritis 44 4.723 2.4
Toxic encephalopathy 131 4.677 2.3
Gingivitis 19 4.637 2.3
Meningitis 46 4.6 2.3
Coronary artery disease 240 4.546 2.3
Muckle-Wells syndrome 11 4.53 2.3
tuberculosis 1563 4.527 2.3
Chorioamnionitis 15 4.501 2.3
Mastitis 48 4.462 2.2
Liver disease 219 4.444 2.2
Heart disease 279 4.423 2.2
Bacterial vaginosis 15 4.418 2.2
Hypertension 293 4.404 2.2
Parkinson's disease 364 4.26 2.1
Vasculitis 64 4.237 2.1
Acquired immunodeficiency syndrome 164 4.233 2.1
Influenza 142 4.223 2.1
Endometriosis 535 4.155 2.1
Hyperglycemia 120 4.132 2.1
Diarrhea 155 4.091 2.0
Degenerative disc disease 28 4.083 2.0
Otitis media 32 4.033 2.0
Dementia 129 3.982 2.0
cystic fibrosis 1670 3.957 2.0
Metabolic syndrome X 155 3.876 1.9
Allergic hypersensitivity disease 123 3.835 1.9
Toxic shock syndrome 28 3.793 1.9
Endometritis 21 3.783 1.9
Common cold 63 3.67 1.8
Leukopenia 42 3.621 1.8
Malaria 140 3.598 1.8
Mevalonic aciduria 12 3.588 1.8
Osteoporosis 259 3.585 1.8
Prostatitis 15 3.547 1.8
Anemia 252 3.544 1.8
Pain agnosia 99 3.537 1.8
Rhinitis 46 3.536 1.8
Perinatal necrotizing enterocolitis 18 3.462 1.7
Neuropathy 210 3.457 1.7
Cystitis 16 3.437 1.7
Lymphadenitis 12 3.423 1.7
Shigellosis 16 3.375 1.7
Major Depressive Disorder 106 3.364 1.7
Arthropathy 34 3.357 1.7
Exanthem 39 3.343 1.7
Bronchitis 44 3.307 1.7
Amyloidosis 68 3.241 1.6
Fatty liver disease 86 3.232 1.6
Candidiasis 48 3.222 1.6
Parasitic helminthiasis infectious disease 13 3.213 1.6
sarcoidosis 368 3.206 1.6
Irritable bowel syndrome 59 3.184 1.6
Infertility 163 3.168 1.6
Leishmaniasis 49 3.143 1.6
Root resorption 21 3.123 1.6
Collagen disease 25 3.102 1.6
Esophagitis 26 3.076 1.5
Chlamydia 18 3.041 1.5
Osteomyelitis 20 3.039 1.5
Leukostasis 5 3.023 1.5
Aortic aneurysm 34 3.021 1.5
Eosinophilia 65 3.016 1.5
Gingival recession 14 3.013 1.5
Tularemia 22 3.008 1.5

Expression

  Differential Expression (24)

Disease log2 FC p
ulcerative colitis 4.200 0.000
glioblastoma 1.300 0.036
psoriasis 3.000 0.000
gastric cancer 1.100 0.041
hepatocellular carcinoma 1.200 0.031
pancreatic cancer 2.000 0.005
malignant mesothelioma -4.000 0.000
Barrett's esophagus 1.900 0.015
cutaneous lupus erythematosus 2.400 0.000
posterior fossa group A ependymoma 1.500 0.000
cystic fibrosis 3.273 0.000
tuberculosis -4.500 0.000
non-small cell lung cancer -1.820 0.000
lung cancer -4.000 0.000
Breast cancer -1.700 0.048
interstitial cystitis 2.400 0.017
pediatric high grade glioma 1.300 0.000
pilocytic astrocytoma 2.100 0.000
pancreatic carcinoma 2.000 0.005
aldosterone-producing adenoma -1.184 0.009
lung adenocarcinoma -1.039 0.000
lung carcinoma -2.300 0.000
Bipolar Disorder 3.295 0.020
head and neck cancer 1.400 0.000
See source...

Synonym

Accession P01584 Q53X59 Q53XX2 Q7M4S7 Q7RU01 Q96HE5 Q9UCT6 IL-1 beta
Symbols IL-1
IL1F2
IL1-BETA

Gene

PDB

1ITB   4DEP   4GAF   1HIB   1I1B   1IOB   1L2H   1S0L   1T4Q   1TOO   1TP0   1TWE   1TWM   21BI   2I1B   2KH2   2NVH   31BI   3LTQ   3O4O   3POK   41BI   4G6J   4G6M   4GAI   4I1B   5BVP   5I1B   6I1B   7I1B   9ILB  

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG
Opossum EggNOG Inparanoid
Platypus OMA EggNOG
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA Inparanoid

MLP Assay (1)

AID Type Active / Inconclusive / Inactive Description
743279 screening 17206 / 16386 / 328767 qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen

Gene RIF (2525)

PMID Text
27116880 Exposure to nosocomial pneumonia associated with haplotypes IL-1RN * 4-IL-1beta (-511) C-->T gene of the same name cytokines having polar biological effects.
27078871 The study investigates Il-1 gene cluster polymorphisms and their association with coronary artery disease. Significant differences in association statuses were seen for IL1A +4845 G>T, IL1B -511 C>T.
27055013 Dynorphin 1-17 and Its N-Terminal Biotransformation Fragments Modulate Lipopolysaccharide-Stimulated Nuclear Factor-kappa B Nuclear Translocation, Interleukin-1beta and Tumor Necrosis Factor-alpha
27046197 LX-2 exposure to IL-1, TNF-alpha and IL-8 can reverse the phenotype of pro-fibrogenic activated cells
27010153 The levels of ESM1, CLDN5, IL-1beta, IL-6, and TNF-alpha were significantly higher in the migraine attack group than in the control group
26944557 Suggest that high glucose-induced phenotypic transition of endothelial cells might require IL-beta activation via the PKCbeta pathway.
26937653 The IL-1beta-31TT genotype and homozygous APOEepsilon4 combined are associated with increased risk of developing Alzheimer disease with sleep disturbance.
26909953 IL-1A rs17561 and IL-1B rs1143634 polymorphisms are associated with periodontitis.
26858253 These findings thereby provide new mechanistic insight into the regulation of TXNIP and beta-cell biology and reveal novel links between proinflammatory cytokines, carbohydrate response element binding protein-mediated transcription, and microRNA signaling.
26842496 IL1ss rs16944 polymorphism may be a potential marker of severe renal manifestations and renal sequelae in Henoch-Schonlein purpura.
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AA Sequence

MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKGFRQAASVVVA      1 - 70
MDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPY     71 - 140
ELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKK    141 - 210
MEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS               211 - 269
//

Text Mined References (2264)

PMID Year Title
27116880 [Polymorphism of genes of interleukin-1 family as factor of pathogenesis of nozokomialny pneumonia].
27078871 2016 Interleukin-1 Gene Cluster Polymorphisms and Their Association with Coronary Artery Disease: Separate Evidences from the Largest Case-Control Study amongst North Indians and an Updated Meta-Analysis.
27055013 2016 Dynorphin 1-17 and Its N-Terminal Biotransformation Fragments Modulate Lipopolysaccharide-Stimulated Nuclear Factor-kappa B Nuclear Translocation, Interleukin-1beta and Tumor Necrosis Factor-alpha in Differentiated THP-1 Cells.
27046197 2016 Characterization of the MMP/TIMP Imbalance and Collagen Production Induced by IL-1? or TNF-? Release from Human Hepatic Stellate Cells.
27010153 2016 Serum levels of endocan, claudin-5 and cytokines in migraine.
26944557 2016 Interleukin-1? mediates high glucose induced phenotypic transition in human aortic endothelial cells.
26937653 2016 Interleukin-1? Promoter Polymorphism Enhances the Risk of Sleep Disturbance in Alzheimer's Disease.
26909953 2016 Association between IL-1? rs17561 and IL-1? rs1143634 polymorphisms and periodontitis: a meta-analysis.
26858253 2016 Cytokines Regulate ?-Cell Thioredoxin-interacting Protein (TXNIP) via Distinct Mechanisms and Pathways.
26842496 Interleukin 1 beta (IL1ß) rs16944 genetic variant as a genetic marker of severe renal manifestations and renal sequelae in Henoch-Schönlein purpura.
More...