| Tclin | Interleukin-1 beta |
Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| Ligand Count | 2 |
| NCBI Gene PubMed Count | 2,441 |
| PubMed Score | 24522.36 |
| PubTator Score | 11110.47 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 2.8e-11 |
| non-small cell lung cancer | 2890 | 3.0e-09 |
| malignant mesothelioma | 3232 | 2.0e-08 |
| lung adenocarcinoma | 2716 | 1.8e-06 |
| tuberculosis | 2010 | 5.6e-06 |
| Astrocytoma, Pilocytic | 3081 | 1.8e-05 |
| cystic fibrosis | 1696 | 3.5e-05 |
| adult high grade glioma | 3801 | 4.1e-05 |
| lung cancer | 4740 | 8.4e-05 |
| ependymoma | 4679 | 1.5e-04 |
| head and neck cancer | 271 | 4.8e-04 |
| pancreatic cancer | 2398 | 4.8e-03 |
| pancreatic carcinoma | 562 | 4.8e-03 |
| cutaneous lupus erythematosus | 1057 | 7.0e-03 |
| aldosterone-producing adenoma | 665 | 8.6e-03 |
| Barrett's esophagus | 182 | 1.2e-02 |
| interstitial cystitis | 2312 | 1.9e-02 |
| hepatocellular carcinoma | 547 | 3.1e-02 |
| active ulcerative colitis | 764 | 3.6e-02 |
| gastric cancer | 459 | 4.1e-02 |
| Breast cancer | 3578 | 4.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Type 2 diabetes mellitus | 272 | 0.0 | 0.8 |
| Disease | Target Count |
|---|---|
| Peptic ulcer disease | 11 |
| Atrophic gastritis | 5 |
| Gastric Cancer, Hereditary Diffuse | 12 |
| Gastric ulcer | 33 |
| Disease | log2 FC | p |
|---|---|---|
| tuberculosis | -4.500 | 5.6e-06 |
| psoriasis | 1.400 | 7.6e-05 |
| cystic fibrosis | 3.273 | 3.5e-05 |
| Bipolar Disorder | 3.295 | 2.0e-02 |
| glioblastoma | 1.100 | 3.7e-05 |
| active ulcerative colitis | 1.705 | 3.6e-02 |
| adult high grade glioma | 1.100 | 4.1e-05 |
| aldosterone-producing adenoma | -1.184 | 8.6e-03 |
| Astrocytoma, Pilocytic | 1.900 | 1.8e-05 |
| Barrett's esophagus | 1.800 | 1.2e-02 |
| Breast cancer | -1.700 | 4.8e-02 |
| cutaneous lupus erythematosus | 1.700 | 7.0e-03 |
| ependymoma | 1.100 | 1.5e-04 |
| gastric cancer | 1.100 | 4.1e-02 |
| head and neck cancer | 1.400 | 4.8e-04 |
| hepatocellular carcinoma | 1.200 | 3.1e-02 |
| interstitial cystitis | 2.000 | 1.9e-02 |
| lung adenocarcinoma | -1.039 | 1.8e-06 |
| lung cancer | -2.700 | 8.4e-05 |
| lung carcinoma | -2.300 | 2.8e-11 |
| malignant mesothelioma | -3.600 | 2.0e-08 |
| non-small cell lung cancer | -1.820 | 3.0e-09 |
| pancreatic cancer | 1.800 | 4.8e-03 |
| pancreatic carcinoma | 1.800 | 4.8e-03 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG |
MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKGFRQAASVVVA 1 - 70 MDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPY 71 - 140 ELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKK 141 - 210 MEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS 211 - 269 //
