Property Summary

NCBI Gene PubMed Count 2,258
PubMed Score 22444.19
PubTator Score 11110.47

Knowledge Summary


No data available


  Disease (5)

Disease Target Count
Alzheimer's disease 644
Asthma 349
Multiple Sclerosis 498
psoriasis 6685
Pleurisy 18
Myopathy 128
Brain Ischemia 87
Schizophrenia 503
Adenocarcinoma 115
Anorexia 15
Anthracosis 4
Arsenic Poisoning 59
Arthritis, Experimental 39
Bronchopulmonary Dysplasia 5
Calcinosis 63
Cardiomegaly 66
Cardiomyopathies 90
Cerebrovascular accident 44
Chronic progressive external ophthalmoplegia 18
Colitis 46
Colonic Neoplasms 126
Degenerative polyarthritis 93
Dermatitis, Atopic 45
Dermatologic disorders 65
Diabetes Mellitus, Experimental 106
Drug-Induced Liver Injury 118
Entamoebiasis 6
Fever 34
Fibrosis 40
Gastritis, Atrophic 1
Glomerulonephritis 36
Gout 93
HIV Wasting Syndrome 4
Heart failure 80
Heart valve disease 24
Heat Stroke 12
Hyperalgesia 71
Hyperemia 13
Hypersensitivity 63
Hypoglycemia 81
Hypotension 53
Inflammation 109
Inflammatory disease of mucous membrane 8
Kearns-Sayre syndrome 6
Learning Disorders 27
Leishmaniasis, Cutaneous 8
Leishmaniasis, Visceral 13
Lethargy 4
Leukocytosis 2
Liver Cirrhosis, Experimental 108
Lung Neoplasms 171
Lymphopenia 35
MELAS syndrome 17
MERRF syndrome 5
Mammary Neoplasms 410
Manganese Poisoning 11
Memory Disorders 36
Mitochondrial Myopathies 6
Myocardial Infarction 126
Myocardial Ischemia 169
Necrosis 51
Neutropenia 78
Optic Atrophy, Hereditary, Leber 14
Osteoporosis, Postmenopausal 7
Peptic ulcer 22
Pneumonia 133
Polymyositis 5
Pulmonary Fibrosis 66
Reperfusion Injury 84
Rheumatoid Arthritis 1170
Seizures 95
Silicosis 10
Sleep Wake Disorders 5
Spontaneous abortion 108
Stomach Neoplasms 282
Thyroid Neoplasm 33
Urticaria 53
dermatomyositis 966
glioblastoma 5572
hemolytic-uremic syndrome 28
ulcerative colitis 2087
Disease Target Count Z-score Confidence
Arthritis 248 7.257 3.6
periodontitis 269 6.369 3.2
Inflammatory bowel disease 142 6.282 3.1
Lung disease 136 5.873 2.9
Cancer 2346 5.866 2.9
diabetes mellitus 1663 5.635 2.8
Atherosclerosis 275 5.348 2.7
Hypersensitivity reaction type II disease 235 5.276 2.6
Brain disease 84 5.138 2.6
Cerebrovascular disease 231 5.098 2.5
Kidney disease 397 5.059 2.5
Peritonitis 37 5.029 2.5
Eye disease 55 5.024 2.5
Pancreatitis 97 4.893 2.4
Synovitis 72 4.858 2.4
Dermatitis 141 4.834 2.4
Obesity 616 4.802 2.4
Gastritis 44 4.723 2.4
Toxic encephalopathy 131 4.677 2.3
Gingivitis 19 4.637 2.3
Meningitis 46 4.6 2.3
Coronary artery disease 240 4.546 2.3
Muckle-Wells syndrome 11 4.53 2.3
tuberculosis 1563 4.527 2.3
Chorioamnionitis 15 4.501 2.3
Mastitis 48 4.462 2.2
Liver disease 219 4.444 2.2
Heart disease 279 4.423 2.2
Bacterial vaginosis 15 4.418 2.2
Hypertension 293 4.404 2.2
Parkinson's disease 364 4.26 2.1
Vasculitis 64 4.237 2.1
Acquired immunodeficiency syndrome 164 4.233 2.1
Influenza 142 4.223 2.1
Endometriosis 535 4.155 2.1
Hyperglycemia 120 4.132 2.1
Diarrhea 155 4.091 2.0
Degenerative disc disease 28 4.083 2.0
Otitis media 32 4.033 2.0
Dementia 129 3.982 2.0
cystic fibrosis 1670 3.957 2.0
Metabolic syndrome X 155 3.876 1.9
Allergic hypersensitivity disease 123 3.835 1.9
Toxic shock syndrome 28 3.793 1.9
Endometritis 21 3.783 1.9
Common cold 63 3.67 1.8
Leukopenia 42 3.621 1.8
Malaria 140 3.598 1.8
Mevalonic aciduria 12 3.588 1.8
Osteoporosis 259 3.585 1.8
Prostatitis 15 3.547 1.8
Anemia 252 3.544 1.8
Pain agnosia 99 3.537 1.8
Rhinitis 46 3.536 1.8
Perinatal necrotizing enterocolitis 18 3.462 1.7
Neuropathy 210 3.457 1.7
Cystitis 16 3.437 1.7
Lymphadenitis 12 3.423 1.7
Shigellosis 16 3.375 1.7
Major Depressive Disorder 106 3.364 1.7
Arthropathy 34 3.357 1.7
Exanthem 39 3.343 1.7
Bronchitis 44 3.307 1.7
Amyloidosis 68 3.241 1.6
Fatty liver disease 86 3.232 1.6
Candidiasis 48 3.222 1.6
Parasitic helminthiasis infectious disease 13 3.213 1.6
sarcoidosis 368 3.206 1.6
Irritable bowel syndrome 59 3.184 1.6
Infertility 163 3.168 1.6
Leishmaniasis 49 3.143 1.6
Root resorption 21 3.123 1.6
Collagen disease 25 3.102 1.6
Esophagitis 26 3.076 1.5
Chlamydia 18 3.041 1.5
Osteomyelitis 20 3.039 1.5
Leukostasis 5 3.023 1.5
Aortic aneurysm 34 3.021 1.5
Eosinophilia 65 3.016 1.5
Gingival recession 14 3.013 1.5
Tularemia 22 3.008 1.5


  Differential Expression (24)

Disease log2 FC p
ulcerative colitis 4.200 2.1e-06
glioblastoma 1.300 3.6e-02
psoriasis 3.000 1.3e-59
gastric cancer 1.100 4.1e-02
hepatocellular carcinoma 1.200 3.1e-02
pancreatic cancer 2.000 4.7e-03
malignant mesothelioma -4.000 2.1e-08
Barrett's esophagus 1.900 1.5e-02
cutaneous lupus erythematosus 2.400 2.7e-04
posterior fossa group A ependymoma 1.500 2.3e-06
cystic fibrosis 3.273 3.5e-05
tuberculosis -4.500 5.6e-06
non-small cell lung cancer -1.820 3.0e-09
lung cancer -4.000 3.5e-07
Breast cancer -1.700 4.8e-02
interstitial cystitis 2.400 1.7e-02
pediatric high grade glioma 1.300 3.9e-07
pilocytic astrocytoma 2.100 2.3e-05
pancreatic carcinoma 2.000 4.7e-03
aldosterone-producing adenoma -1.184 8.6e-03
lung adenocarcinoma -1.039 1.8e-06
lung carcinoma -2.300 2.8e-11
Bipolar Disorder 3.295 2.0e-02
head and neck cancer 1.400 4.8e-04
See source...

Protein-protein Interaction (12)

MLP Assay (1)

AID Type Active / Inconclusive / Inactive Description
743279 screening 17206 / 16386 / 328767 qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen

Gene RIF (2525)

27116880 Exposure to nosocomial pneumonia associated with haplotypes IL-1RN * 4-IL-1beta (-511) C-->T gene of the same name cytokines having polar biological effects.
27078871 The study investigates Il-1 gene cluster polymorphisms and their association with coronary artery disease. Significant differences in association statuses were seen for IL1A +4845 G>T, IL1B -511 C>T.
27055013 Dynorphin 1-17 and Its N-Terminal Biotransformation Fragments Modulate Lipopolysaccharide-Stimulated Nuclear Factor-kappa B Nuclear Translocation, Interleukin-1beta and Tumor Necrosis Factor-alpha
27046197 LX-2 exposure to IL-1, TNF-alpha and IL-8 can reverse the phenotype of pro-fibrogenic activated cells
27010153 The levels of ESM1, CLDN5, IL-1beta, IL-6, and TNF-alpha were significantly higher in the migraine attack group than in the control group
26944557 Suggest that high glucose-induced phenotypic transition of endothelial cells might require IL-beta activation via the PKCbeta pathway.
26937653 The IL-1beta-31TT genotype and homozygous APOEepsilon4 combined are associated with increased risk of developing Alzheimer disease with sleep disturbance.
26909953 IL-1A rs17561 and IL-1B rs1143634 polymorphisms are associated with periodontitis.
26858253 These findings thereby provide new mechanistic insight into the regulation of TXNIP and beta-cell biology and reveal novel links between proinflammatory cytokines, carbohydrate response element binding protein-mediated transcription, and microRNA signaling.
26842496 IL1ss rs16944 polymorphism may be a potential marker of severe renal manifestations and renal sequelae in Henoch-Schonlein purpura.
26831735 Data suggest elevated interleukin-1beta secretion from tyrosine kinase inhibitor- (TKI-)resistant chronic myeloid leukemia (CML) cells contributes to TKI/imatinib resistance via promotion of cell viability/migration; cells used lack BCR-ABL mutation.
26823694 IL-1beta-511TT/CC influence on the risk of myocardial infarction and ischemic stroke at young age through NF-kappaB, iNOS, MMP-2 and Bax.
26813462 there is a poor correlation of T/C substitution at the -31 position of IL-1beta promoter in febrile convulsions
26811540 IL-1beta promotes FGF-2 expression in chondrocytes
26808616 Inactivation of the EGFR with a blocking antibody decreased the S. aureus-mediated IL-1beta induction in primary keratinocytes. Inflammasomes mediate induced secretion but not induced gene expression of IL-1beta .
26799482 Role of IL-1beta in the Il-6 induction in the developing enterocyte
26798640 Effect of Short-Term Stimulation with Interleukin-1beta and Differentiation Medium on Human Mesenchymal Stromal Cell Paracrine Activity in Coculture with Osteoblasts.
26790130 Effects of the New Generation Synthetic Reconstituted Surfactant CHF5633 on Pro- and Anti-Inflammatory Cytokine Expression in Native and LPS-Stimulated Adult CD14+ Monocytes.
26786651 Tuberculosis antigen specific IL-1beta may be an additional biomarker for active TB diagnosis among HIV positive subjects.
26753875 Our data imply that at sites of tissue damage, when inflammatory mediators are present, for example in lungs of COPD patients, MSCs become more potent inducers of repair, in addition to their well-known immune-modulatory properties.
26753456 results suggest that tested SNPs associated with differential production of IL-1 female and IL-10 are not risk factors for PCa and do not correlate with the presence of distant metastasis in eastern Croatians
26728383 Data show that the expressions of interleukins IL-1 and IL-6 in the discs of discogenic low back pain (DLBP) patients were significantly elevated and negatively correlated with the Japanese Orthopedic Association (mJOA) scores of low back pain.
26718437 The IL-1B -511 C/T polymorphism is associated with susceptibility to rheumatoid arthritis (RA) in Caucasians; the IL-1B +3953 C/T polymorphism is associated with susceptibility to RA in Caucasians and Asians. (Meta-analysis)
26711529 These results indicate that the LPS/IL-1beta-MyD88 axis plays a crucial role for stabilization of IkappaB-zeta mRNA.
26707272 These results indicate that MF inhibited the production and expression of MMP-1 and -13 and inflammatory mediators, at least in part, through suppressing the activation of either NF-kappaB or p38 MAPK in IL-1b-treated SW1353 chondrocytes.
26663052 Data show that the single nucleotide polymorphism (SNP) rs16944 in the interleukin 1 beta (IL1B) gene and its interaction with childhood maltreatment may influence the effect of antidepressant treatment for patients with major depressive disorder (MDD).
26657940 The IL6 rs1818879 (GA) heterozygous genotype was associated with severe influenza A (H1N1) virus infection and two IL1B SNPs were associated with a decreased risk of infection
26608362 MiR-29a and MiR-140 synergistically protect chondrocytes against the anti-proliferation and cell matrix signaling changes by IL-1b.
26596049 The lower content of secretory immunoglobulin A and interferon-gamma plus increased level of interleukin l-beta in saliva of patients with caries of contact surfaces of lateral teeth can be considered as factor predisposing to development of caries.
26585190 Our study suggests that CC genotype and C allele at -31 and + 3954 polymorphic sites of IL-1beta gene are associated with an increased risk for FMF.
26581830 Data indicate that better cognitive control specifically following an emotional stressor is uniquely associated with less pronounced salivary IL1B increase in response to such stress.
26575253 Interleukin-1beta plasma levels were positively correlated with depression scores in patients with temporal lobe epilepsy.
26560040 Altered expression of EP2 in patients with aspirin-exacerbated respiratory disease contributes to deficient induction of IL-1RI, reducing the capacity of IL-1beta to increase COX-2 and mPGES-1 expression, which results in low PGE2 production
26559977 these data suggest that, following calcium influx into the cell, pro-IL-1beta interacts with calmodulin and that this interaction is important for IL-1beta processing and release.
26531703 Haplotype analysis for IL-1beta -31 and IL-1beta -511, with moderate linkage disequilibrium
26523392 The authors found that cytoplasmic IL-1beta associates with the autophagosome and m-IL-1beta enters into the lumen of a vesicle intermediate but not into the cytoplasmic interior formed by engulfment of the autophagic membrane.
26520031 Results indicate that IL-1beta plays an important role in development of uterine luminal epithelium by stimulating cell proliferation, and these effects are coordinately regulated by activation of the ERK1/2 and P38 MAPK cell signaling cascades.
26517486 The authors demonstrated that polymorphisms in the promoter region of the IL-1B gene (at positions -511 and -31) are associated with an enhanced risk of Helicobacter pylori infection as well as gastritis in Helicobacter pylori-positive patients.
26515928 Necrotic trophoblastic debris induced endothelial cell activation through the IL-1beta/IL-1R pathway. However, the NALP3 inflammasome in endothelial cells was not involved in this process.
26515063 results clarify how commensal bacteria affect hepcidin expression and reveal a novel connection between IL-1beta and activation of BMP signaling.
26505399 we...investigate the genetic variants Interleukin-1beta(IL-1beta) +3953 C/T (rs1143634), IL-6 -174G/C (rs1800795), IL-8 -251T/A (rs4073), and IL-10 -1082A/G (rs1800896) and -819C/T (rs1800871) in the development of coronary artery disease
26504029 Interleukin-1beta Polymorphism is associated with Prostate Cancer.
26496436 Genetic polymorphisms in Il-1beta are not associated with individual susceptibility to silicosis.
26481854 SHIP levels and activity are lower in intestinal tissues and peripheral blood samples from patients with Crohn's disease, resulting in induction of Il1-beta.
26462562 There is evidence for association of gout with functional variants in CARD8, IL1B and CD14.
26404542 Data show reduced cytokines IL-10 and IL-19 expression, and enhanced IL-20 and il-1 beta expression in chronic recurrent multifocal osteomyelitis (CRMO) monocytes.
26401715 IL1B polymorphisms may contribute to metformin's glucose-lowing efficacy in overweight or obese Chinese Type 2 diabetes mellitus patients.
26396484 Glaucomatous MYOC mutations activate the IL-1beta/NF-kappaB inflammatory stress response and the glaucoma marker SELE in trabecular meshwork cells.
26391839 Data suggest that production of reactive oxygen species finely tunes vascular endothelial cell function and inflammatory response; mechanisms include pro-inflammatory and pro-oxidant effects of IL1B in up-regulation of production of superoxide anions.
26385345 It is concluded that IL6 -174 G>C and IL1B +3954 C>T SNPs might be involved in the development of congenital Toxoplasma gondii infection.
26366788 Our findings indicate that epidermal growth factor, interleukin-1beta and angiotensin II receptor, type 1 may play important roles in the pathogenesis of endometriosis.
26363312 individuals carrying the -511T and -31 C alleles experience HPA activation in response to opioid administration and therefore may be less likely to undertake subsequent self-administration
26362269 Aggressive breast cancer cells secrete IL-1beta, which increases the production of chemokines by mesenchymal stem cells.
26357657 The data identifies IL-1beta as a novel target in ovarian surface epithelial cells expressing the 185delAG BRCA1 mutation.
26341894 expression profiles, roles and therapeutic potential of IL-1beta in intervertebral disk degeneration
26330006 Results indicate there is a lack of association between the IL1B (-511 and +3954) polymorphisms and tuberculosis risk. [Meta-Analysis]
26324708 formation of the 20-kDa form of IL-1beta may prevent the generation of mature bioactive IL-1beta and thus may limit inflammation
26317859 results demonstrate AT-RvD1 treatment reduced IL-1beta-mediated alveolar epithelial cell activation. This is a key step in unraveling the protective effects of resolvins, especially AT-RvD1, during injury.
26314292 IL-1beta is elevated in patients with connective tissue diseases that have both anti-Ro/SSA antibodies and prolonged QTc intervals.
26308798 NF-kappaB stimulates BMP-2 mRNA expression in rat and human beta cells upon IL-1b cytokine exposure.
26301593 IL-1b secretion induced by infectious supernatant harvested from two independent Vero cell lines was not enhanced by antibody. Secretion of multiple other inflammatory cytokines was also independent of antibody signaling
26300289 Data suggest that the interleukin-1beta-511 T>C (rs16944) gene polymorphism plays an important role in the development of silent myocardial ischemia (SMI) in diabetic patients.
26284424 Data show that human monoclonal antibody canakinumab does not cross-react with Interleukin-1beta (IL-1beta) from mouse, rat, rabbit, or macaques.
26279136 Elevated IL-1beta levels and IL-1beta-to-IL-1RA ratio as early as 4 days before the first pregnancy test are associated with an ectopic pregnancy after embryo transfer.
26277062 possible role for IL-1beta in chondrocyte differentiation of vascular smooth muscle cells and calcification stimulated by glucose
26276670 It is demonstrated that IL-1beta is crucial in the development of blood-induced joint damage, whereas TNFalpha is not.
26276663 Polymorphic changes were observed for IL-1beta gene in 26 of 62 patients (41.9%), and 16 of the 80 (25.8%) in the control group.
26269588 analysis of the mechanistic link between neutrophil elastase expression in atherosclerotic plaques and concomitant pro-inflammatory bioactive IL-1beta secretion from endothelial cells
26269197 RTD-1 reduced the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, and IL-8 in lipopolysaccharide (LPS)-stimulated human blood monocytes and THP-1 macrophages
26263533 significant differences were found in carriage rate of both minor alleles of IL-1A (C-889T) and IL-1B (C+3954T) polymorphisms of aggressive periodontitis (AgP) cases compared with healthy controls in the Algerian population; the polymorphisms of the IL-1 genes appear to be associated with susceptibility to AgP in the Algerian population
26232108 This study, besides defining a serum panel for glioblastoma discrimination, identified IL1beta as a potential candidate for developing targeted therapy.
26223656 Data show that VvpE elastase induces the hypomethylation of the interleukin 1 beta {IL-1beta) promoter and the transcriptional regulation of NF-kappaappaB through annexin A (ANXA)2 recruitment to promote IL-1beta production in intestinal epithelial cells.
26208636 Collectively, our findings indicate that DLX4 exerts opposing effects on the megakaryocytic and erythroid lineages in part by inducing IL-1beta and NF-kappaB signaling.
26204886 CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells
26202987 Data show that nicotinic agonists decrease interleukin 1 beta (IL-1beta) release from primary blood cells.
26201022 strong expression of TGF-beta1, IL-1beta and VEGF was evident in the extracellular matrix and in the cytoplasm of fibroblasts and myofibroblasts in Dupuytren's nodular tissues, as compared to control tissues
26198339 Inhibition of interleukin-1 beta in patients with Schnitzler's syndrome is associated with suppression of inflammation.
26188264 This meta-analysis demonstrated that IL1B -31C > T polymorphism might increase Helicobacter pylori infection risk in Asian and Latin American population.
26187330 TNF-alpha (-308 G > A) and IL-1beta (-511 C < T) polymorphisms that lead to increased production of TNF-alpha and IL-1beta appear to be risk for development of brain abscess in North Indian population
26184031 miR-381 was induced in vitro by IL-1beta in ATDC5 cells, PMCs, and PHCs, and was expressed in areas of cartilage degradation or absorption in vivo
26182076 IL-1beta is involved in the pathogenesis of juvenile-onset systemic lupus erythematosus.
26176534 IL-1beta and IL-1R1 promote cancer growth and metastasis by up-regulating CXCR4 expression and that CXCR4 may be a link between inflammation and cancer.
26169021 indicates that the IL-1beta -511T/C polymorphism is associated with TB decreased risk in Africans, and IL-6 -174C/G polymorphism in Asians. Further well-designed, large scale studies are required to confirm this conclusion
26162701 Farrerol inhibited IL-1beta-induced inflammatory responses in osteoarthritis chondrocytes by blocking PI3K/Akt/NF-kappaB signaling pathway.
26158864 Data show that SNP interactions among H. pylori-related genes PGC, PTPN11, and IL1B, are associated with susceptibility to gastric carcinogenesis.
26156812 Calcitriol suppresses Il-1beta induced inflammatory response in periodontal tissues.
26156811 Thymoquinone inhibited IL-1beta-induced inflammatory mediator production by inhibition of NF-kappaB and MAPKs signaling pathways in osteoarthritis chondrocytes.
26156202 In Tunisian ischemic stroke patients, there was no significant difference in the distribution of IL-1beta -31 T/C genotypes and allele frequencies between patients with or without type 2 diabetes and controls. IL-1beta correlated positively with blood glucose.
26141218 Our study provided evidence that IL1B SNPs might be implicated in the pathogenesis of NSCLC in the Chinese population.
26125891 IL-1beta+3954 C/T and IL-10-1082 A/G polymorphisms are associated with an increased risk of recurrent oral ulceration.
26125871 We found that the IL-8 -251T/A polymorphism is associated with an increased risk of acute pancreatitis, and no significant association between IL-1betaand IL-10 gene polymorphisms and risk of acute pancreatitis was detected
26120586 Patients with Primary Open-Angle Glaucoma are characterized by an increased mRNA expression of MMP1, MMP9, MMP12, TIMP1 and IL-1b genes as compared to the control group .
26118062 Frequency of allelic variants of IL-1beta and IL-10 genes in chronic glomerulonephritis in children are related to the disease course and indices of hematopoiesis.
26116704 Data show that P2 purinergic receptor P2X7R and the NLRP3 inflammasome pathway are involved in the secretion of interleukin-1beta (IL-1beta) from monosodium urate (MSU)-stimulated macrophages.
26096304 Study provides evidence that IL-1b is key regulatory factor for the postictal suppression, and its receptor IL-1R1 may be a potential target for adjuvant treatment of postictal problems
26076780 IL1B-511C/T was not associated with presence of immune thrombocytopenia.
26075243 Nampt/PBEF/visfatin upregulation in colorectal tumors, mirrored in normal tissue and whole blood of colorectal cancer patients, is associated with metastasis, hypoxia, IL1beta, and anemia.
26074413 familial Mediterranean fever demonstrate reduced NLRP3-mediated IL-1beta production
26069103 Our study found that TNF-alpha expression may play a vital role in peritoneal metastasis of gastric cancer, while IL-1B expression might not be correlated with peritoneal metastasis
26067154 DLX4 induces CD44 by stimulating IL-1beta-mediated NF-kappaB activity, thereby promoting peritoneal metastasis of ovarian cancer
26065428 IL-1beta promotes nuclear DNaseI translocation in inactive form in lupus nephritis renal tubular cells .
26045743 Sclareol exerts anti-osteoarthritic activities in interleukin-1beta-induced rabbit chondrocyte model of osteoarthritis.
26041434 3D topography transiently induces concomitant upregulation of IL-1beta and MAPK ERK1/2 through nuclear factor-kappaB-dependent signaling pathway.
26038188 IL-1b -511C>T and +3954C>T polymorphisms are not the risk factors for developing aggressive periodontitis.
26032420 An inflammatory Syk-ERK signaling axis requires DENV immune complexes, because DENV-2 in the presence of serotype-matched anti-DENV-2 mAb, but not anti-DENV-1 mAb, activates Syk, ERK, and IL-1beta secretion.
26031165 The occurrence of bone fractures was inversely correlated with level of soluble receptors of TNF (gamma = 0.3; p = 0.0029), and occurrence of ischemic heart disease with soluble receptors of IL-1
26021263 The results suggests LCN2 upregulation protects hepatocytes from IL-1beta-induced stress.
26003199 For IL1- beta gene, a significantly higher frequency of the -511C/C genotype was observed in RA patients in comparison to controls, especially in women. Men with this genotype had less erosive forms.
25993444 Uropathogenic Escherichia coli activates an NLRP3-independent cell death pathway and an aalpha-hemolysin-independent IL-1beta secretion pathway in human macrophages.
25975153 Our results confirm the significant role of rs1143634 of the IL1B gene in Peptic ulcer disease development.
25966220 This meta-analysis suggests that the IL-1beta-511C/T promoter polymorphism deceases the risk of chronic obstructive pulmonary disease in Asians.
25954061 IL-1beta has a role in bone resorption during rheumatic diseases [review]
25948251 IL-1Beta secretion is increased in mononuclear phagocytes dependent on increased CX3CR1.
25941031 IL1beta was higher in synovial fluid of rheumatoid arthritis patients than spondyloarthritis patients.
25922276 the various mechanisms by which macrophages have been proposed to secrete IL-1 family cytokines, and the potential involvement of caspase-1 therein.
25922060 Elevated concentrations of IL-1 beta were observed in patients with poorer response speed performance and perceived cognitive disturbances in breast cancer.
25910374 IL-1beta genetic polymorphisms may take part in the pathophysiology of gastroesophageal reflux disease.
25907558 Stress-activated Dendritic Cells (DC) Induce Dual Interleukin (IL)-15- and IL1beta-mediated Pathways, Which May Elicit CD4+ Memory T Cells and Interferon (IFN)-stimulated Genes.
25896300 studies showed that miR-146a was crucial for monocytic cell-based IL-1beta tolerance and cross-tolerance, and thus opens the way for future research in the development of therapeutics for inflammatory diseases.
25895146 Hormone and Cytokine Responses to Repeated Endotoxin Exposures-No Evidence of Endotoxin Tolerance After 5 Weeks in Humans.
25893807 persistent HPV16/18 infection in the cervix due to the presence of the HLA-DQB1 A-allele and chronic inflammation due to the presence of the IL-1beta -511 T-allele might predispose women to uterine cervical cancer development.
25876154 These observations add further evidence in favor of anti-NGF therapy in autoimmune diseases and also unlock a new area of research about the role of NGF in IL-1beta mediated diseases.
25872797 H2S inhibited the activation of the extracellular signal-regulated kinase (ERK)/IkappaBalpha/NF-kappaB pathway which was induced by IL-1beta.
25858413 The findings of this study suggested that the IL-1beta-511C/T polymorphism may not be related to schizophrenia or smoking status in Chinese individuals, but may affect the severity of nicotine dependence among male smokers with schizophrenia.
25853464 Here we show that downregulation of MITF-M expression by IL-1ss was paralleled by an upregulation of miR-155 expression in four melanoma lines.
25847326 Hantavirus induces the formation of the NLRP3 inflammasome in THP-1 cells and this may be responsible for the elevated IL-1beta levels in HFRS patients.
25821855 This meta-analysis provided strong evidence that the IL-1RA polymorphism was a risk factor of asthma, especially in Caucasian populations. However, no association was found for IL-1beta -511C/T genotype carriers.
25809479 Interleukin-1beta has a role in reduction of CD44 Ser-325 phosphorylation in human epidermal keratinocytes that promotes CD44 homomeric complexes, binding to ezrin, and extended, monocyte-adhesive hyaluronan coats
25802122 secreted IL-1beta by the endothelial cells contributes to influenza-induced inflammation, and blockade of IL-1beta signals is a potential treatment or therapeutic target for influenza-induced inflammation.
25787827 The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture.
25786687 CT, mmCT, and dmLT promote human Th17 responses via cAMP-dependent protein kinase A and caspase-1/inflammasome-dependent IL-1 signaling.
25773799 Haplotype analysis of IL-1beta-31 and IL-1beta-511 showed decreased association of IL- 1beta-31 T with IL-1beta-511 C with gastric carcinoma (OR 0.728; P value 0.03). Expression study of 50 samples by immunohistochemistry (IHC) and RT-PCR showed association with grade III and stage III+IV. After correlating the expression with polymorphism no association was found
25760020 NF-kappaBp65 bound to elements located at -1177 and -1335 in the ADAMTS9 promoter region, in contrast to the untreated samples. The results of the present study suggested that NF-kappaB may be involved in IL-1beta-induced activation of ADAMTS9 in human chondrocytes
25754623 Cord blood IL-1beta were predictive for the development of bronchitis and wheezing by the age of 2 years.
25741583 IL-1beta C-511T polymorphism is not associated with the risk of developing chronic periodontitis. Additional research is warranted to further explore and confirm the association of genetic polymorphism and chronic periodontitis.
25738867 The results of the current study demonstrated that pro-inflammatory cytokines, including TGF-beta1, IL-1beta and IL-6 exhibited increased expression in human vestibular schwannoma tissue compared with normal vestibular nerve samples
25735143 Combinations of cytokine gene network polymorphic markers as potential predictors of myocardial infarction
25730877 In CAPS monocytes, LPS induces the externalization of copious amounts of ATP (10-fold), which drive IL-1beta, IL-18, and IL-1alpha release via activation of the P2X purinoceptor 7.
25730036 In the current study, we evaluated the effect of IL-1b +3954 C/T (rs1143634) and IL-1b -511 C/T (rs16944) and IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796) on the development of acute pancreatitis risk.
25728492 IL-1beta was higher in RA synovial fluid than in osteoarthritis synovial fluid.
25710474 the study population examined, the SNP in the IL1B gene (+3954) and VNTR polymorphisms in the IL1RN gene were found to have a significant association with chronic periodontitis susceptibility
25693732 Data indicate that the interleukin (IL)-1 family of cytokines are key regulators of the inflammatory network.
25684535 IL-1B (C+3954T) gene polymorphism is associated with gastric cancer.
25681340 Date show significantly increased interleukin 1 beta (IL-1beta) production in patients' stimulated leukapheresis concentrates and peripheral blood samples after extracorporeal photopheresis (ECP).
25658624 This study examined the relative influence of adversities during childhood and adulthood in accounting for individual differences in pro-inflammatory gene expression, IL1B, in late life
25652861 Mycoplasma genitalium LAMP negatively regulate TNF-alpha and IL-1beta secretion by inducing HO-1 expression in placental trophoblast cells.
25639477 Both 1,25(OH)2D3 - and 25(OH)D3 induced IL-1beta release from THP-1 cells, and these effects were blocked with application of the caspase-1 inhibitor YVAD and the NLRP3 inhibitors glyburide and Bay 11-7082.
25634659 Results show no significant association was found between TNF-alpha (-308 G/A) and IL-1beta (-511 C/T) polymorphisms and polycystic ovary syndrome (PCOS) risk in the overall population or subgroup analysis under all genetic models; results indicate that the IL-6 (-174 G/C) polymorphism likely conveys a protective effect against PCOS.[Meta-analysis]
25629767 NFKBIZ gene knockdown in bronchial epithelial cells suppresses the release of IL-1b-induced IL-6 and GMCSF.
25616863 Patients with neutrophilic asthma have impairment in anti-inflammatory ratio of gal-3/gal-3BP and IL-1RA/IL-1beta.
25613133 Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta
25609807 Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta
25600910 Data suggest that secretion of IL1B and HSP70 (heat-shock protein 70) by fetal membranes is up-regulated during chorioamnionitis/infection with Escherichia coli; secretion of IL1B, HSP70, and HSP60 follow different temporal patterns.
25596176 -511C allele in IL1beta was associated with more severe depression following chronic interpersonal stress exposure, relative to T/T homozygotes. The moderating effect was specific to interpersonal stressors and did not generalize to non-interpersonal stress.
25595815 These data indicate that IL-1beta and IL-6 gene single nucleotide polymorphisms are associated with sickle cell anemia (SCA) complications among Brazilian patients and may act as genetic predictors of SCA clinical heterogeneity.
25586177 These results indicate that 2 h of exposure of beta cells to a low but not a high concentration of IL-1b enhances glucose-stimulated insulin secretion through focal adhesion and actin remodeling, as well as modulation of gene expression.
25580516 O157:H7-induced IL-1beta production was largely dependent upon caspase-1 activation and partially dependent upon ATP signalling and cathepsin B release, which were both involved in NLRP3 activation.
25571868 the IL1beta 31 CC genotype was inversely associated with susceptibility to dyspeptic symptoms, in particular, upper abdominal pain and EPSlike symptoms.
25562992 The data conclude that IL-6 plays an important role in the pathogenesis of Vt-T1D patients and is likely to gain favour as a therapeutic target in these patients.
25560300 SNPs across IL-1b and BDNF Val66Met may influence antipsychotic-induced weight gain
25555350 (PEG+PVA)-NH2 and PVA-NH2 AuNPs were internalized to a higher extent and caused interleukin-1beta secretion.
25551602 The mRNA levels of Homer1, IL-1beta, and TNF-alpha in coronary artery disease patients were significantly higher than those in the control group, but not Homer2 and Homer3.
25548434 IL-6, TNF-alpha, and IL-1beta are involved in systemic lupus erythematosus in Indian patients
25548252 the secretion of IL-1alpha, IL-1beta, IL-12b, and CCL4 occurs during gelatinase degranulation, a process controlled by STX3.
25546243 low levels of active JNK is significantly associated with the presence of IL-1beta in stage III melanoma.
25545008 treatment of transfected cells with tumour necrosis factor (TNF), interleukin (IL)-1beta and IL-10 exerted variable effects on TNF-R1 ectodomain cleavage.
25529283 Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta
25521228 Findings were SNPs in TICAM2 (P = 3.6 x 10(-6)) and IL1B (P = 4.3 x 10(-5)) associated with TB.
25476526 These results suggest that XT-1 expression is refractory to the disease process and to inhibition by inflammatory cytokines and that signaling through AP-1, Sp1, and Sp3 is important in the maintenance of XT-1 levels in NP cells.
25469832 Single-nucleotide polymorphism in IL-1beta gene was associated with a high symptom burden in multiple myeloma.
25463072 Interleukin-1 has an important role in 25-hydroxycholesterol-induced synergistic cytokine production in smooth muscle cell-monocyte interactions
25460081 HPV16 E2 potentiated NF-kappaB activation induced by inflammatory mediators, IL-1beta and SDF-1alpha, in HEK293 cells
25451151 review of caspase-8 and its role in modulating IL-1beta and inflammation [review]
25449573 Authors conclude that ECSIT appears to be a novel Hepatitis B virus X protein-interacting signal molecule and their interaction is mechanistically important in IL-1beta induction of NF-kappaB activation.
25446437 The the IL-1B SNP rs187238,not contribute to late-onset Alzheimers disease susceptibility in the Hunan Han Chinese population.
25437548 The exocytosed granzyme A enters target cells and mediates IL-1beta maturation independently of caspase-1 and without inducing cytotoxicity.
25436985 Inflammatory status in rheumatoid arthritis is associated with an increased expression of TLR3 and of IL-1beta in CD34+ cells, which appear to affect cell number.
25436214 Data indicate the role of tumor necrosis factor-alpha (TNFalpha) in the Th17 cell differentiation in rheumatoid arthritis through interleukin-6 (IL-6) and interleukin-1 beta (IL-1beta) production.
25433580 data indicate that 30-day supplementation with 112 mg/day CFB (CFB-1) resulted in a significant reduction of LDL, TG, TC, IL-1beta, IL-6, MCP-1, and CRP.
25428391 We for the first time proposed the role interleukin-1beta-mir-101-EZH2 axes in the particle-induced lung cancer
25422961 Genetic variants of IL1B may modulate the development of internalizing symptoms in the face of childhood adversity.
25421594 It is a pro-inflammatory cytokine.
25418470 IL-1b, which normally bridges innate and adaptive immunity, induces the production of the major haematopoietic/proleukaemic growth factor SCF through the PI-3K/mTOR pathway and the HIF-1a transcription complex.
25398456 Functional polymorphisms in IL1B and DEFB1 influence susceptibility to mold infection in solid-organ transplant recipients.
25389708 Decreased production of IL-1beta in low birth weight newborns was correlated with reduced expression of TLR-4 and MyD88 mRNA.
25374200 IL1-Beta polymorphism is significantly associated with prostate cancer risk.
25372293 caspase-1/ASC inflammasomes play a significant role in the activation of IL-1beta/ROS and NF-kappaB signaling of cytokine gene expression for T. cruzi control in human and mouse macrophages.
25353097 Results show that an increase in IL-1b and CXCL10 correlated with a decreased progression free survival, indicating their important prognostic role.
25329476 Higher IL-1beta expression did not suppress the activity of IFN-gamma-producing T cells
25315113 TNF-alpha -308G/A and IL-8 -251T/A were significantly associated with AD and IL-1beta +3953C/T with late-life depression, while the significance of these associations was lost after Bonferroni correction.
25311115 Impaired NLRP3 inflammasome activity during fetal development regulates IL-1beta production in human monocytes.
25310146 An association between the SNPs of the IL1 beta and susceptibility to Hashimoto's thyroiditis among the group of Caucasian-Polish population studied was found.
25294684 IL-1beta stimulation causes sequential phosphorylation of IRAK-1, c-Jun N-terminal kinase, and p300 and enhances recruitment of the p300/CBP/NF-Y complex to Gankyrin promoter
25292060 IL1B gene polymorphism is associated with gastritis.
25284686 NLRP3 was higher in degenerated intervertebral discs than in healthy controls.
25263616 Choriodecidual tissue punches released IL-1alpha and IL-1beta in response to group-B-Streptococcus and this medium significantly stimulated release of HBD-2 by amnion cell cultures.
25261722 results show that U373 cells produce and secrete CRYAB via exosomes and that stimulation with IL-1beta and TNF-alpha significantly increase the levels of CRYAB in not only the cells but also in the secreted exosomes
25258120 The IL-1beta-511 C/T polymorphism was found to enhance the risk of stomach cancer.
25252591 present study suggests strong association of TT genotype of -511 and CT genotype of +3954 variant of interleukin 1beta with chronic periodontitis. the -31 variant did not show significant association with disease.
25240611 Cleaved IL1B was present in sera from familial Mediterranean fever patients during febrile attack periods, but not in healthy controls or FMF patients in remission periods. FMF patients had increased cleaved IL1B levels compared to RA patients.
25231464 keratinocyte-derived SAA triggers a key inflammatory mediator, IL-1beta, via NLRP3 inflammasome activation, providing new potential targets for the treatment of this chronic skin disease.
25229885 the role of C5a as an endogenous priming signal that is required for the initiation of uric acid crystal-induced IL-1beta production.
25223243 Inflammation of the fetal side of the placenta was associated with elevated fetal IL1B at delivery.
25223242 IL-1b gene polymorphisms were associated with more severe impairments after stroke.
25222025 Polymorphisms within IL1B are associated with preeclampsia in a Chinase Han population.
25221996 Polymorphisms within IL1B are associated with vitiligo susceptibility.
25207923 The IL1A (T)/IL1RN (A) genotype, but not the IL1B (T)/IL1RN (A) genotype, may increase the risk of a chronic pain outcome in patients following disc herniation.
25205101 we report that ATP-mediated suppression of IFNgamma production by Th17 cells can be overcome by genetic ablation of CD73 or by using IL1beta instead of TGFbeta to program Th17 cells ex vivo
25204733 IL-1beta can be induced participates in the early and late stages of oral carcinogenesis
25201247 SFAs, but not unsaturated fatty acids (UFAs), increased interleukin (IL)-1beta secretion and decreased IL-1 receptor antagonist (IL-1Ra) secretion
25200056 IL-1beta protein levels in human thoracic aortic aneurysms were approximately 20-fold more than in normal thoracic aortas.
25185259 Hypoxia potentiates IL-1B expression in cultured macrophages.
25174605 The IL1B (-511), (-31) and IL1RN (VNTR) polymorphisms are associated with COPD risk in East Asians.
25172489 Helicobacter pylori-induced IL-1beta secretion in innate immune cells is regulated by the NLRP3 inflammasome and requires the cag pathogenicity island.
25135735 The results showed that the expression of SP and CGRP was significantly enhanced in the neurogenic SMSCs in response to IL-1beta, IL-6 and TNF-alpha, and the effect was remarkably inhibited by HA.
25135221 an IL-1beta/IL-1RI/beta-catenin signaling pathway induces beta-catenin accumulation due to GSK3beta inactivation by Akt phosphorylation
25130968 relationship between IL-6-643 (C/G) and IL-1beta-31 (C/T) polymorphisms and lung cancer risk among female non-smokers
25117345 IL-1B-31 locus polymorphism may be associated with gastric cancer susceptibility
25109676 A remarkable positive association has been found between the IL-1beta -511 T/T polymorphism and the development of juvenile systemic lupus erythematosus in Iranian patients.
25103771 IL-1B can drive prostate cancer (PCa) progression in an inflammatory microenvironment through androgen receptor repression and p62 induction to promote the development and survival of androgen independent PCa.
25098998 IL-1 beta (+3954) TT genotype and T allele were significantly associated with CHPDM group when compared with CHP, whereas CC genotype and allele C was higher in CHP subjects
25095741 Cyclooxygenase 2, toll-like receptor 4 and interleukin 1beta mRNA expression in atherosclerotic plaques of type 2 diabetic patients
25080789 The detection of basal level of IgM rheumatoid factor, IgM and also certain cytokines can be useful in prognosis of effectiveness of rituximab therapy under rheumatoid arthritis.
25080058 activating effect of PI3K inhibitor on IL-1beta release was mediated mainly by the enhancement of the intracellular IL-1beta and caspase-1 content release to the extracellular medium and not by increasing the corresponding mRNA and protein expression levels
25066273 interleukin-1beta (IL-1beta)-induced IER3 expression is mediated by the ERK1/2 target, transcription factor Elk-1.
25061439 Increased IL-1beta secretion by peripheral blood mononuclear cells of Chronic recurrent multifocal osteomyelitis patients during active disease was shown. IL-1beta transcript levels were significantly higher also in remission compared to healthy controls.
25058342 The frustrated host response to Legionella pneumophila is bypassed by MyD88-dependent translation of pro-inflammatory cytokines.
25054228 IL-1beta expression is aberrantly induced in malignant glioma cells.
25048991 Human macrophage inflammasome activation and IL-1beta secretion requires calcium but does not involve NADPH oxidases
25039313 IL-1beta and TNFalpha prevent IL-2- and TGF-beta1-driven CD8(+) iTregs suppressive function in human T cells.
25036364 Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta
25025954 Higher levels of IL-1beta and IL-1alpha were found in peripheral blood mononuclear cells supernatants of patients during crises compared to those in remission and to controls.
25022753 Studies show transient induction of Wnt5a by interleukin-1beta (IL-1beta) stimulation proceeds through NF-kappaB in human corneal endothelial cells.
25012128 THP-1 monocyte-secreted IL-1beta/IL-18 promotes vascular smooth muscle cell proliferation.
25009387 Suggest cagA status, Il-1beta genotype and pork consumption are associated with the development of gastric cancer.
25004092 IL-1beta and IFNgamma induces mSREBP-1 and iPLA2beta expression and induce beta-cell apoptosis.
25003726 p53 and nitric oxide are involved in cytokine-induced apoptosis in Kasumi-1 and Molt-4 Leukemics cells.
24996056 IL-32theta; reduces PKCdelta-mediated phosphorylation of PU.1, resulting in attenuation of IL-1beta production
24988959 This is the first report of the interaction between IL-1Beta and IDO genes in schizophrenia.
24981555 spermatozoa from the asthenozoospermic group presented an increased expression of IL-1beta, COX-2, and HIF-1alpha compared with the normospermic fertile subjects
24974860 IL-1beta is suggested to stimulate tryptophan catabolism and production of IL-6 and IL-8 by increasing TDO expression in endometriosis.
24960456 ratio of lipoxin A4/IL-1beta in the pre-eclampsia groups were significantly decreased compared to the control group
24958470 IL-1beta upregulated Lin28B by downregulating miR-101.
24952309 meta-analysis. Our results indicate that IL-6, IL-1A, and IL-1B genetic polymorphisms are statistically correlated with an increased risk of osteoarthritis under the allele and dominant models.
24939850 HIV-1 infection induced the expression of pro-IL-1beta via TLR8-mediated mechanisms and activated caspase-1 through the NLRP3 inflammasome to cleave pro-IL-1beta into bioactive IL-1beta
24939850 Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta
24933945 The character of the morphological changes of the mucous membrane of the large intestine and the genetic polymorphism of IL-1RA, IL-1B, IL-4 TNFA in patient with irritable bowel syndrome
24928389 In conclusion, we demonstrated that IL-1beta can amplify the TNF downstream protein signals in human synoviocytes in a TNF-independent manner; in addition, p62 is a potential FLS biomarker for synovitis.
24918199 Data suggest that macrophages secret IL1B to modulate signal transduction in white adipocytes in response to insulin; IL1B-mediated macrophage-adipocyte cross-talk may be involved in insulin resistance.
24905619 IL-1beta-511C/T polymorphism was associated with increased risk of cervical cancer.
24890729 interfering with IL-1beta and IL-12 signaling in Th17 cells during inflammation may be a promising therapeutic approach to reduce their differentiation into "pathogenic" CCR6+ CXCR3+ Th1/17 cells in patients with autoimmune diseases.
24878968 There is an association of IL-1B gene polymorphisms with osteosarcoma risk in humans.
24876157 IL1B was not associated with demyelination and secondary neurodegeneration of the optic nerve in optic neuritis in multiple sclerosis patients.
24874542 Results suggest that infiltrating CCR2(+) monocytes do not contribute to IL-1beta-mediated amyloid plaque clearance
24873879 Modulation of miR-145 affects the expression of Smad3 causing a change of its downstream target gene expression as well as IL1B-induced extracellular matrix degradation.
24867167 The results of this study found that the expression level of IL-1B in MS patients increased 3.336 times more than controls in PBMCs but the rs16944 SNP in the promoter region of IL-1B did not affect the expression level of this gene.
24866792 Thus, this study demonstrated that Pseudomonas aeruginosa, through the combined effects of Ndk and flagellin, upregulates the expression of proinflammatory cytokines IL1-alpha and IL1-beta via the Akt/NF-kappaB signaling pathways.
24855648 Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta
24853301 Pro-inflammatory SNPs of the IL-8, IL-10 and IL-1beta genes, but not TNF-alpha, were associated with more severe lung disease in cystic fibrosis patients.
24846290 the innate neutrophil immune response against SAA involves a two-step activation process: an initial signal promoting expression of pro-IL-1beta and a second signal involving Syk-dependent activation of the NLRP3 inflammasome and caspase-1.
24843315 The polymorphisms observed in IL-1alpha(+4845) and IL-1beta(+3954) single nucleotide polymorphisms (SNPs), was significantly different among the study groups (healthy controls, mild, moderate and severe periodontitis with p<0.05, d.f.=1.
24840847 IL-1beta (+3954) polymorphisms did not play a role in the pathogenesis of colorectal cancer.
24839897 provided evidence that the IL1B C-511T variant might be associated with development of diabetic nephropathy
24837562 Methylation increased in PDK4, IL1 B, IL6, and TNF promoters 12 months after gastric bypass.
24820890 human sebocytes are important immunocompetent cells that induce the NLRP3 inflammasome, and P. acnes-induced IL-1beta activation in sebaceous glands may have a role in combating skin infections and in acne pathogenesis
24806317 -1beta and TNF-alpha significantly inhibited the expression of chondrogenic-related genes in SDSCs, an effect which was antagonized by knockdown of NF-kappaB and C/EBPbeta.
24796745 Data indicate that both classical and nonclassical pathway secretion vectors could express human IL-1beta in HepG2 cells, but erythropoietin(EPO) signal-peptide mediated classical pathway secreted much higher mature IL-1beta than that of nonclassical pathway.
24789460 Results show that EGF and IL-1beta additively activated ERK1/2, increased migration and invasion than either EGF or IL-1beta alone in gastric adenocarcinoma cells.
24787052 show here that IL1A, IL1B and IL1F7 regulatory regions come in close proximity in LPS stimulated cells but not in resting human monocytes
24784935 IL-1beta -511T>C genetic variant may be a predisposing factor to recurrent pregnancy loss susceptibility.
24782217 IL-6 rs1800796 and IL-1beta rs1864169 polymorphisms are associated with ischemic stroke risk in the Chinese population.
24771848 Differently, costimulation of TLR2, TLR4, and TLR7/8 enhances IL-1beta secretion but severely inhibits IL-1Ra production.
24768095 demonstrated a key role of IL-1beta and TGF-beta in the disappearance of occludin at cellular border in placentas with chorioamnionitis
24754437 IL-1beta gene variability is linked to posttraumatic epilepsy development.
24747159 IL1-beta levels were related with cancer onset status.
24738292 In patients with exudative erythema multiforme Immunovac-VP-4 therapy facilitated a significant (p < 0.05) increase of serum IFN-gamma level, insignificant (p > 0.05) increase of IL-1beta and decrease of IL-17.
24716804 The complex crosstalk between leptin, IL-1 and Notch could differentially drive breast cancer growth and angiogenesis
24712845 IL-1B -511 C/T polymorphism is associated with cervical cancer.
24701032 caspase-1, IL-1beta, and IL-18 are regulated by AIM2, which mediates inflammation-associated renal damage in hepatitis B virus-associated glomerulonephritis
24690098 analysis demonstrated IL1B gene variations had in predicting chronic periodontitis. study validated influence of IL-1 genetic factors on severity of chronic periodontitis in 4 different ethnicities.
24668571 The risk of susceptibility to nasal polyps was significantly higher in patients with nasal polyps who had -511 T/T genotype of IL-1beta than in controls.
24665821 H2S upregulates GCLC and GSH and inhibits IL-1beta levels, which may be what mediates the beneficial effects of H2S-rich compounds in mitigating the pathogenesis of metabolic syndrome and atherosclerosis
24654313 presence of SNPs in IL12B, TNFA, and IL1B was significantly associated with asthma, atopy, and severity of asthma.
24626561 IL-1beta-induced urokinase plasminogen activator expression via activation of the ERK1/2 and NF-kappaB pathways, which results in invasion of gastric cancer cells.
24625401 HIV-1 Tat proteins induce neuroglial cells to produce tumor necrosis factor (TNF)-alpha and IL-1beta.
24622053 the effects of IL1beta, TGFbeta1, and IL1beta in combination with TGFbeta1 on myofibroblast formation
24621265 The secretion of IL-1beta from glioblastoma cells in turn stimulates the expression of COX-2 in human or mouse neuroblastoma cells. Similar
24613731 IL-1beta-induced MMP-13 expression and changes in cell proliferation and apoptosis in alpha7(+)hSMSC-OB cells are regulated by ADAM-28.
24611340 found no association of rs1143634 in IL1-B with LBP Permutation test showed significant association of rs1143634 in IL1-RN with LBP group and presence of wild type allele A was protective in LBP group
24598699 statistical evidence for the interactions between 1) TNF/LTA SNP rs2229094 and depression symptoms for average pain intensity and duration and 2) IL1B two SNP diplotype and kinesiophobia for average shoulder pain intensity
24582800 Exposure resulted in significant downregulation of GDF-5 during both TNF-a exposure (5.83-fold change, p=0.044) and IL-1b exposure (3.38-fold change, p=0.015).
24581590 secreted from macrophages but not tumors in melanoma
24571667 our data support a critical role for NF-kappaB-dependent upregulation of miR-425, which represents a new pathway for the repression of phosphatase and tensin homolog activation and the promotion of cell survival upon IL-1beta induction.
24568914 There is no association between rs16944 polymorphism of the IL-1beta-511T gene and the incidence of FS in Han children in Northern China.
24563688 Angiopoietin-1 upregulates de novo expression of IL-1beta and Il1-Ra, and the exclusive release of Il1-Ra from human neutrophils
24561215 the interleukin-1beta -511 C/T polymorphism may have a role in tobacco-associated cancer in northeast India
24557417 Genetic variations in the IL-1beta and IL-1RN genes influence disease progression in gastric cancer.Heterozygous genotypes of the IL-1RN and IL-1beta C-511T variation are associated with enhanced disease-free survival in gastric cancer patients.
24557363 Genipin inhibits IL-1beta-induced CCL20 and IL-6 production from human periodontal ligament cells
24557062 In the Han Chinese population, genetic variants in IL1B were significantly correlated to susceptibility to colorectal cancer.
24554772 Data indicate that cholesterol crystals (CC) employed C5a in the release of IL-1beta.
24552038 IL-1beta-511 polymorphism may not play a major role in the genetic predisposition to obsessive-compulsive disorder (OCD) in Chbetainese Han population.
24550444 IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans.
24535893 Urgent section (foetal distress) and vaginal delivery (labour) were each associated with elevated IL-1beta cord blood levels in noninfected full-term neonates, while only elective caesarean section was associated with decreased IL-1beta levels.
24534280 Our data identified for the first time synchronous changes in endometrial IL-1R throughout early gestation in vivo and point to a deep modulation of endometrial receptivity to IL-1 by embryo-driven signals.
24520123 Human data identified IL-1beta as a key player of a paracrine inflammatory pathway previously unidentified in adipose tissue, with a pathological relevance to obesity-induced type 2 diabetes.
24515998 The present meta-analysis showed that two alleles of proinflammatory cytokines (IL-1alpha-889 and IL-1beta-511) in addition to the serum concentration of IL-6 were significantly associated with febrile seizures and epilepsy or both [review]
24504887 Results show that IL-1RN rs2234663/IL-1b rs16944 haplotypes are associated with pulmonary pulmonary function test parameters in Chronic obstructive pulmonary disease patients.
24490166 In children with single episode of urticaria, level of IL-1RA correlated with C-reactive protein (CRP), D-dimer, and IL-1beta levels.
24484294 Our findings suggest that the IL1b -511 'C' allele has a protective role from disease development.
24479681 the IL-1beta/p38/AP-1(c-fos)/MMP2 & MMP9 pathway play an important role in metastasis in gastric adenocarcinoma
24477584 Our study provided evidence to IDE, PON1, WFS1, POU2F1, IL1alpha and IL1beta associated with T2D in Pakistanis.
24472657 report that shear stress upregulates cyclic AMP (cAMP) and interleukin-1beta (IL-1beta) release, which in turn promotes the invasion of chondrosarcoma cells via the induction of MMP-1 in a phosphoinositide 3-kinase (PI3-K)- and ERK1/2-dependent manner
24470197 These results suggest that FSTL-1 may act on the NLRP3 inflammasome to promote IL-1beta secretion from monocytes/macrophages.
24465880 The IL1B (-511) polymorphism, but not the IL1B (+3954) and IL1RN (VNTR) polymorphisms was associated with Grave's disease risk in Asians.
24460370 The heterozygous variant genotype of the IL1 rs16944 was significantly associated with a reduced risk of periodontal disease in young Japanese women.
24458711 IL1R1- and IL1beta-related transcripts are elevated in the setting of obesity; IL1R1/IL1beta augment both megakaryocyte and platelet functions, promoting a prothrombotic environment during infection and obesity; potentially contributing to the development of atherothrombotic disease
24457964 Interleukin-1beta promotes hypoxia-induced apoptosis of glioblastoma cells by inhibiting HIF-1 mediated adrenomedullin production.
24452718 These findings support a potential role of IL-1 polymorphisms, particularly the composite genotype of IL-1A (-889) and IL-1B (+3954), in peri-implant disease susceptibility.
24446526 Patients with IL1B -31C carrier, or IL1RA 2/4 genotype carry a risk for DSS, implying that IL1B may play a role in pathogenesis of dengue shock syndrome.
24446182 IL1B_1473G/C and TLR4_896A/G SNPs are implicated in rectal cancer development in a Russian population.
24439748 Vascular endothelial cadherin is lost at the membrane when endothelial cells are exposed to TNF-alpha, IFN-gamma, and peripheral blood mononuclear cells (PBMC). IL-1ss can mimic the effects of PBMCs, indicating a role of IL-1ss in this process.
24434549 conclude that TRIM38 negatively regulates TNFalpha- and IL-1beta-induced signaling by mediating lysosome-dependent degradation of TAB2/3, two critical components in TNFalpha- and IL-1beta-induced signaling pathways
24431314 alveolar bone regeneration proceeds more slowly in patients with the IL-1B-511 2/2 genotype compared to those with alleles 1/1 and 1/2.
24424266 Thrombin-activated microglia expression of tumor necrosis factor-a, interleukin-1b and MMP-12 was significantly reduced through contact-dependent and paracrine mechanisms when the HAESCs were co-cultured with microglia cells
24403855 TNF and IL-1beta induce dissemination of nontransformed breast epithelial cells and their reseeding at the primary tumor site.
24399675 The proinflammatory cytokine interleukin 1beta (IL-1beta) was the most investigated and also gene associated with susceptibility to febrile seizures.
24379597 TNF-alpha and IL-1beta genotypes may be related to susceptibility to H. pylori infection in Indonesian population.
24379400 N-terminal hydrophobic amino acids play an important role in the regulation of ATF5 protein expression in IL-1beta-mediated immune response and that ATF5 is a negative regulator for IL-1beta-induced expression of SAA1 and SAA2 in HepG2 cells.
24356959 defective autophagy can prime monocytes for mitochondria-mediated NLRP3 inflammasome activation, thereby contributing to hypersecretion of IL-1beta in mevalonate kinase deficiency.
24356306 Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta
24342296 a critical role of IL-1beta gene polymorphisms in susceptibility to bacteremia after kidney transplantation
24340055 The release of IL-8 and IL-1beta after stimulation of whole blood with A. versicolor was increased in subjects exposed to moisture damage.
24339952 IL-34 expression in human gingival fibroblasts, stimulated by TNF-alpha and IL-1beta
24338609 The combination of tumor necrosis factor (TNF)-alpha and IL1beta leads to a decrease of matrix synthesis gene expression, such as collagen type II, and increases the degradation gene expression of cyclooxygenase (COX)-2 and matrix (MMP)-3 in cell culture.
24322806 Because the genotype and allele frequency of both polymorphisms are identical, it is most likely that IL1beta-511C>T and IL1RN VNTR polymorphisms do not play a role in the development of KC in the Turkish population.
24314919 Interleukin-1beta levels were markedly higher in menstrual effluents of women with chronic endometritis.
24313836 Data indicate a significant increase in the levels of IL-8, TNF-alpha and IL-1R2 in the CSF of both meningitis groups as compared to controls, and the concentrations of IFN-gamma and IL-1 differed significantly only between the mumps group and control.
24275551 leptin enhances IL-18 secretion via modulation of the caspase-1 inflammasome function but has no effect on IL-1betamRNA levels or IL-1beta secretion.
24275344 we did not confirmed the previously suggested association between Periodontitis and IL1 gene cluster polymorphisms.
24274595 The association of single nucleotide polymorphisms in IL1B, IL1RN and IL15 with chronic cavitary pulmonary aspergillosis supports a role for the IL1 pathway, as well as implicating the IL15 gene, in disease susceptibility.
24265545 Aqueous humor concentrations of the cytokines (IL-1 alpha, IL-1 beta, IL-6, FasL, and TNF- alpha) in patients with open angle glaucoma, were measured using multiplex bead analysis.
24256257 the endocannabinoid system, which has neuroprotective and immunomodulatory actions mediated by IL-1 signalling cascades in the brain, could assist the process of proliferation and differentiation of embryonic or adult neural stem cells
24252536 Data suggest that interleukin-1 beta released in neuromyelitis optica (NMO)lesions and interleukin-1 beta-induced production/accumulation of complement factors facilitate neutrophil entry and blood-brain barrier breakdown in the vicinity of NMO lesions
24246233 cord blood level elevated in funisitis
24246157 High interleukin 1 beta expression is associated with cardiomyocyte hypertrophy in Type 1 diabetes mellitus and fatal diabetic ketoacidosis patients.
24238405 Our results show that SOCS1 is induced by IL1-beta in osteoarthritis chondrocytes
24222244 No evidence of association between the IL-1beta +3954 C>T polymorphism and risk of external apical root resorption in orthodontic treatment patients. [Meta-analysis]
24217014 IL1B polymorphism is associated with the late age of onset of psoriasis.
24194923 Genetically determined low COX-2 and high IL-1beta activity were associated with increased risk of colorectal cancer in a prospective Danish cohort.
24186874 Expression of IL-1beta in the epithelium of the distal airways disrupts the development of the airspaces and capillaries in the fetal lung.
24162774 Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta
24158569 Identify a novel innate immune signaling pathway (NLRP3-ASC-caspase-1-IL-1beta) activated by Ni(2+).
24157462 We show that IL-1beta mRNA and the active processed form of IL-1beta are abundant in inflammatory acne lesions.
24155145 The present study does not support a role for IL1B in schizophrenia susceptibility
24147028 Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta
24146121 Il-1 blockade may affect morbidity and mortality in cardiovascular disease with an acceptible risk.
24142467 interleukin-1beta-induced vascular endothelial growth factor in airway smooth muscle cells
24136334 NLRP3 inflammasome is upregulated in neutrophilic asthma and may regulate the inflammation process observed in this asthma phenotype through production of IL-1beta
24081990 IL-1beta is a platelet agonist, IL-1beta acts through an autocrine stimulatory loop, an IL-1beta autocrine loop is required to amplify platelet activation by LPS, and platelets immobilized in occlusive thrombi are activated over time to produce IL-1beta.
24081898 IL-6 produced from IL-1beta-stimulated human periodontal ligament cells could increase CCL20 production.
24080970 IL-1B +3954 C/T polymorphism is associated with the risk of gastric cancer.
24080160 These results provide evidence for a key role of Rac1 in a pathway that regulates IL-1-induced gene expression depending on receptor endocytosis.
24078775 palmitic acid can stimulate IL-6, TNF- alpha, and IL-1 beta production and cell proliferation in HaCaT keratinocytes
24072654 There were no significant associations between IL-1beta, IL-6 and IL-10 gene polymorphisms and acute pancreatitis risk.
24067094 study found the C + 3953T of the IL-1B gene is associated with male infertility risk in the asthenozoospermic patients from an Indian population
24063999 This study evaluated the prognostic capability for biochemical progression after radical prostatectomy of expression of IL-1, TNF-alpha and related signaling components, in the tumor and surrounding stroma
24063998 IL-1 beta in unstimulated whole saliva may be useful for detection of early stage oral squamous cell carcinoma.
24063019 The relationships between IL-1 beta (C-511T) and IL-1 alpha (C-889T) genes polymorphisms and the risk of ischemic stroke (IS) classified by TOAST criteria in the north Chinese Han population, were investigated.
24054992 is a major proinflammatory cytokine that initiates and amplifies diverse cellular responses. Elevated IL-1b has been linked to diseases, such as Alzheimer's disease.
24046015 Data indicate that TLR-induced IL-1beta overproduction in FANCA- and FANCC-deficient mononuclear phagocyte cell lines and primary cells requires activation of the inflammasome.
24037056 The objective of this study is to investigate the possible role of inflammatory mediators such as IL-6, IL-1beta, and TNF-alpha in Kashin-Beck disease (KBD) children and rats fed with T-2 toxin under a selenium-deficient nutrition.
24036988 TLR4-NFkappaB-IL1beta signaling might play a crucial role in the development of acute inflammation in primary gout patients.
24035972 IL-1b is upregulated in amnion epithelial cells following exposure to zinc ferrite nanoparticles; in situ nanoparticles induce oxidative stress, alterations in cellular membrane and DNA strand breaks.
24025329 proinflammatory cytokines IL-1/TNFalpha trigger a novel antiviral mechanism involving AID to regulate host cell permissiveness to HBV infection.
24024208 It was observed that the release of IL-1beta increases instantaneously after the initiation of incubation and reaches a maximum at 3 to 5 hours and then gradually decreases and gets stabilized for both pyrogens.
24023501 IL-1beta induces dose-dependent methylation of TGF-beta1 in gastric cancer patients.
24022484 Lactic acidosis, induced by the addition of 25 mm lactic acid, also induced the release of 20-kDa IL-1beta. This 20-kDa product was produced independently of NLRP3 and caspase-1 but was inhibited by the cathepsin D inhibitor pepstatin A.
23996710 investigation do not substantiates the role of IL-1beta +3954 and TNF-alpha -308 polymorphisms, separately, as risk determinants for aggressive periodontitis in Iranian population
23995914 associated with gastritis and intestinal carcinogenesis in Helicobacter pylori-infected patients
23963575 The complex ROS-mediated regulation of neutrophil IL-1beta secretion might constitute a physiological mechanism to control IL-1beta-dependent inflammatory processes where neutrophils play a crucial role.
23953530 Recipient IL-1beta polymorphisms were not associated with the presence of pneumonia in kidney transplantation.
23936458 induction and tolerance regulate the immediate early genes encoding interleukin 1beta and tumor necrosis factor alpha
23936223 Data indicate that recombinant bacterial interleukin receptor I (BilRI) bound human IL-1beta both in the outer membrane of E. coli and as soluble protein.
23935506 pro-IL-1beta is degraded in a proteasome-dependent manner in E6-positive cells which is mediated via the ubiquitin ligase E6-AP and p53.
23927441 genetic variants of IL-1A and IL-1B may exert a substantial impact on the susceptibility of A(H1N1)pdm09 virus infection.
23911403 Data indicate that Aloe vera-mediated reduction of IL-1beta appears to be the consequence of the reduced expression of both pro-IL-1beta as well as Nlrp3 inflammasome components via suppressing specific signal transduction pathways.
23898208 Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta
23892937 Continuous theta-burst transcranial magnetic stimulation caused a long-term potentiation (LTP)-like synaptic phenomenon correlated with the concentration of the pro-inflammatory cytokine interleukin-1beta in the cerebrospinal fluid.
23892591 On stimulation with IL-1beta or CpG-A, an increased level of IL-20 expression was also observed in psoriatic lesions of patients carrying the risk-associated G allele.
23891856 Conditions which lead to increased systemic maternal or placental IL-1beta levels may attenuate the effects of maternal insulin on placental function and consequently fetal growth.
23884363 These results show that late caspase-1 activation within DENV-infected monocytes can contribute to pro-inflammatory outcomes that might play a role in dengue immunopathogenesis.
23884315 Oour results indicate that Propionibacterium acnes triggers a key inflammatory mediator, IL-1beta, via NLRP3 and caspase-1 activation, suggesting a role for inflammasome-mediated inflammation in acne pathogenesis.
23849770 The association between allele 1 of IL-1 RN VNTR, T allele of IL1B-511 and C allele of IL1-B +3953 polymorphisms seems to predispose to the synthesis of citrullinated antipeptide antibodies(ACPA) and occurrence of ACPA positive rheumatoid arthritis.
23845419 TLR3 stimulation in keratinocytes induces a caspase-4 dependent release of pro-IL-1beta, but further processing to active IL-1beta is limited. Furthermore, TLR3 stimulation results in pyroptotic- and apoptotic cell death.
23841472 Effects of omalizumab on eosinophil cationic peptide, 25-hydroxyvitamin-D, IL-1beta and sCD200 in cases of Samter's syndrome
23840644 The pattern recognition receptor NLRP3 is involved in the activation of inflammation mediators, including Il-1B in retinal pigment epithelial cells .
23839215 Study shows that T. gondii-induced IL-1beta production is dependent on the classical inflammasome components caspase-1 and ASC.Additionally, a role for a specific parasite factor, dense granule protein GRA15, in T. gondii induction of IL-1beta was demonstrated.
23822621 No significant association of IL1 composite genotype (IL1 -889A:IL1B +3962) with periodontitis in Macedonians was found
23821953 Association between IL1B, IL6, and IL8 gene polymorphisms and risk of recurrent erosion development in patients with hereditary corneal stromal dystrophies.
23800300 In conclusion, we suggest that the -1607 1G/2G MMP1, -1562 C/T MMP9, -511 C/T IL-1beta gene polymorphisms can be considered as an important risk factors associated with POAG.
23793845 Studies suggest that caspase 1, IL-1 beta and IL-18 are involved in inflammasosme activation and prostate cancer initiation.
23784458 Studies suggest that the interleukin 1, beta (IL1B) -31 T/C and +3954 C/T polymorphisms are associated with lung cancer risk.
23773024 These results suggest that tissue damage and ulcers occur in Helicobacter pylori-infected patients who produce more IL-8 and IL-1beta than patients who do not develop ulcers.
23762029 1,25D-stimulated autophagy in macrophages but dependent upon epithelial IL1R1 signaling and IL-1beta-driven epithelial production of the antimicrobial peptide DEFB4/HBD2.
23749763 A combined biomarker model of IL-1alpha, IL-1beta, and IL-1ra can predict term labor with 86% sensitivity and 92% specificity.
23747396 no sufficient evidence was available to support any associations between IL1beta+3953C/T and susceptibility to systemic lupus erythematosus. [META-ANALYSIS]
23740952 The CXCL10 gene is activated by interleukin (IL)-1beta, a response that is synergistic with concomitant activation of the interferon (IFN)-gamma-signaling pathway.
23737648 H1N1 virus infection induces an early and significant upregulation of both interleukins IL1 beta and IL-6 plasma expressions.
23728092 It is produced by macrophages and exhibits proliferative activity on thymocytes and fibroblasts, B cell activation and endogenous pyrogen activity. (review)
23726808 Interleukin 1B rs16944 G>A polymorphism is associated with a decreased risk of esophageal cancer in a Chinese population.
23723976 Interleukin-1alpha (IL-1alpha), interleukin-1beta (IL-1beta) and interleukin-18 (IL-18), were released from rhinovirus infected epithelia.
23722873 There was no difference in IL1 SNPs between patients with systemic lupus erythematosus and healthy controls.
23717664 data further identified a complex interaction between IL1 and hCG, which, despite a synergistic action on several significant endometrial target genes, may encompass a tight control of endogenous IL1 and extends to other IL1 family members
23704929 Both the IL-1B -511C/T and +3954C/T polymorphisms might modulate cancer susceptibility.
23702978 Studies indicate that inflammasomes activate the highly pro-inflammatory cytokines interleukin-1beta (IL-1beta) and IL-18.
23689297 There was no significant association between polymorphism in gene IL-1beta and hearing loss associated with occupational exposure.
23680697 Data indicate that cobalt-alloy particles induce expression of IL-1beta, TNF-alpha and IL-8 via toll-like receptor 4 signaling pathway.
23666803 Sphingosine 1-phosphate counteracts the effects of interleukin-1beta in human chondrocytes.
23660804 Data indicate that RANTES/C-C motif ligand 5 (CCL5) expression was correlated significantly with expression of IL-1beta.
23659674 genetic polymorphism in the donor is associated with development of graft-versus-host disease in Brazil
23657597 TNF-alpha and IL-1beta increased the in vitro osteoblastic differentiation of cultured human periosteal-derived cells by enhancing the ALP activity and mineralization process, but not by Runx2 activation.
23656735 these studies show that the IL-1beta-induced increase in intestinal tight junction permeability was regulated by p38 kinase activation of ATF-2 and by ATF-2 regulation of MLCK gene activity
23654353 polymorphisms of IL-1beta and IL-10 genes may be valuable markers to predict the risk for the development of TB in household contacts.
23651237 Data indicate that interleukin-1beta (IL-1beta) +3954 in oral lichen planus was associated with other comorbid factors in both allelic and genotypic combinations.
23650922 There was a significant positive association between distribution of IL-1beta genotypes and the risk of periodontitis disease
23643268 In Bcap-37 cells, S.aureus exposure could up-regulate the expression of TLR2 at both mRNA and protein levels, increase the production of IL-1beta and TNF-alpha, and stimulate the expression of NF-kappaB.
23633957 viral engagement of the NLRP3 inflammasome stimulates IL-1beta production to drive proinflammatory cytokine, chemokine, and immune-regulatory gene expression networks linked with Chronic hepatitis C disease severity.
23630220 Lonlier breast cancer survivors exposed to acute stress exhibited greater synthesis of interleukin-1 beta lipopolysaccharide stimulated peripheral blood mononuclear cells than their counterparts who felt more socially connected.
23610862 Interleukin-1 beta is thought to play an important role in the pathogenesis of periodontal disease.
23594042 we have found significantly decreased frequency of IL-1B -511 genotype (p = 0.004) in Multiple sclerosis
23592922 IL1B may play an important role in the development of keratoconus through genetic polymorphisms.
23592910 miR-146a and miR-146b-5p are expressed in human RPE cells in culture and their expression is highly induced by proinflammatory cytokines (IFN-gamma + TNF-alpha + IL-1beta).
23592003 genotype and protein production of IL-1alpha, IL-1beta and IL-1RN are associated with chronic periodontitis in a Chinese population.
23584371 These results showed that IL-1beta and IL-1RN VNTR are significantly associated with the susceptibility to alopecia areata.
23571448 reduced secretion by neutrophils in synovial fluid from patients with rheumatic arthritis
23564444 IL-1beta was downregulated in CD34+/CD38- acute myelogenous leukemia cells via epigenetic mechanisms. Therefore, the inhibition of STAT5 signaling by IL-1beta may be a promising treatment strategy to eradicate leukemia stem cells.
23555186 Epithelial cancer cells use IL-1beta as a communication factor instructing stromal fibroblasts through p53 to generate a protumorigenic inflammatory microenvironment.
23554905 Neutrophil priming led to the rapid expression of a common set of transcripts for cytokines, chemokines and cell surface receptors (CXCL1, CXCL2, IL1A, IL1B, IL1RA, ICAM1).
23546865 Data indicate that p38 MAPK and toll-like receptor 2 (TLR2) are required for pLGV440_p5 (ORF5) protein induced tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and interleukin-8 (IL-8) in human monocyte.
23536554 Findings indicate that IL-1beta supports the skeletal colonization and metastatic progression of prostate cancer cells with an acquired neuroendocrine phenotype.
23533059 Different molecular weight hyaluronic acid effects on human macrophage interleukin 1beta production.
23531221 The study evaluates insulin secretion and IL1-BETA dependent mechanisms in human diabetes remission after gastric bypass and sleeve gastrectomy.
23509682 Particulate matter induces release of IL-1 beta in the absence of LPS priming in human THP-1 derived macrophages
23508571 IL-1beta inhibits human osteoblast migration.
23500159 Acrp30, in dose- and time-dependent manner, reduces cytotoxic effects of TNFalpha and/or IL-1ss improving cell viability and decreasing apoptosis. In addition, Acrp30 inhibits NF-kappaB nuclear trans-activation
23484124 the expression of resistin, TNF- alpha , IL-6, and IL-1 beta from human mononuclear cells, might be enhanced by the hyperinsulinemia and hyperleptinemia and possibly by the hyperglycemia in metabolic diseases as obesity, type 2 diabetes, and atherosclerosis.
23472661 IL-1B and IL-1RN gene polymorphisms could be involved in the risk of developing Takayasu's arteritis in the Mexican population.
23460908 IL-1beta was identified as a major factor contributing to the decrease in RBP4.
23460603 study provides preliminary evidence of a genetic association between IL1B and IL17A genes and RLS
23460134 the ability of LfcinB to antagonize IL-1 and LPS-mediated suppression of PG is upheld in an en bloc intradiscal microinjection model followed by ex vivo organ culture using both mouse and rabbit IVD tissue
23459183 The Hirsutella sinensis mycelium extract suppresses IL-1beta and IL-18 secretion, and ATP-induced activation of caspase-1.
23457635 ERK1/2 signals downstream of C/EBPbeta to facilitate IL-1beta-induced astrocyte TIMP-1 expression.
23452206 CSC induced IL-1beta production from RA patient-derived synoviocytes.
23442095 Based on our data, IL1 B C+3953T polymorphism does not seem to contribute to Early Pregnancy loss in North Indian Population.
23437386 CIRBP regulates the expression of interleukin-1beta in an NF-kappaB-dependent fashion.
23437386 RNA interference against cold inducible RNA binding protein inhibits UV-, LPS- and cisplatin-induced expression of interleukin 1 through decreased NFkappaB activity.
23425136 PBMNs and macrophages from healthy subjects with previous ReA show normal inflammasome activation and low TNF-alpha and IL-23 production.
23421536 Data indicate that thrombin-induced IL-1ss and IL-6 cytokine release in naive PBMCs is PAR-1-dependent.
23417678 methylation of different CpG sites in the proximal promoters of the human MMP13 and IL1B genes modulates their transcription by distinct mechanisms
23406266 HO-1 down-regulation is involved in the inhibition of SOX9 and COL2A1 expression by IL-1beta.
23391392 lymphangiogenesis triggered by IL-1beta overexpression in mouse airways is driven by VEGF-C/D from macrophages, but not neutrophils, recruited by chemokines from epithelial cells that express IL1R1.
23386602 Induction of autophagy and modulatation of cytokine IL-1beta production by B. burgdorferi.
23383347 The activation of EGF signaling and increase of IL-1beta contributed to chemotherapeutic resistance of cancer cells, suggesting that the expression of IL-1beta may be used as a biomarker to evaluate successful cancer treatment.
23383108 Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta
23375040 T allele of the 511 site of IL-1beta gene and V allele of the second introne of IL-1Ra gene are associated with the infertility occurrence of polycystic ovary syndrome patients
23363559 The polymorphisms studied in the promoter regions of IL-1beta and IL-6 genes did not reveal a strong association with urolithiasis
23349093 metal particles induced higher amounts of IL-6 and IL-1 but very low amounts of TNF-alpha. T-lymphocyte activation was evaluated by the quantification of IL-2 and IFN-gamma levels
23331079 Il-1beta enhances cell migration through AP-1 and NF-kappaB pathway-dependent FGF2 expression in human corneal endothelial cells.
23328930 Resveratrol attenuates TNF-alpha-induced production of IL-1beta and MMP-3 via inhibition of PI3K-Akt signaling pathway in rheumatoid arthritis fibroblast-like synoviocytes.
23328087 Results suggest a TET1-dependent anti-inflammatory pathway, which may include TET2. In particular, IL-1beta transcriptional regulation is likely to depend on TET1-regulated chromatin domains.
23323013 IL-1B and IL-RN genotypes may differentially contribute to gastric cancer among the Tibet, Hui, and Han ethnicities in the Qinghai area of China
23322904 Studies indicate that interleukin-1 (IL-1), IL-6, IL-17, and tumor necrosis factor are critical for the pathogenesis of inflammation in specific brain disorders.
23317890 Studied association between SNP of rs3811047 in IL-1 F7 gene and RA susceptibility among the Han population in central plains of China. No significant correlation between RA susceptibility and rs3811047 SNP inIL-1 F7 gene is observed.
23315075 Human monocytes produce IL-1beta in response to self double-stranded (ds)DNA in the presence of anti-dsDNA antibody-positive serum.
23314944 This study observed a significant genotype effect on the cingulate cortex and the T/T carriers had significantly reduced FC with several prefrontal areas and putamen compared to the C/C or C/T carriers.
23313749 These data show that OSM and IL-1beta are not only a biological characteristic signature of hypertensive leg ulcer, but these cytokines reflect a specific inflammatory state, directly involved in the pathogenesis.
23276701 IL-1beta-511T/T genotype individually was independently associated with both prevalent depression at baseline and persistent depression at one year follow-up
23269671 Transfection of caspase-1 into airway epithelial cells restored their ability to secrete IL-1beta following B. cenocepacia infection, suggesting that a deficiency in caspase-1 is responsible, at least in part, for the attenuated IL-1beta secretion.
23264411 Could not find a significant relationship between serum interleukin 1beta concentration and febrile convulsion.
23241110 subjects homozygous for allele2 of the IL-1beta+3954 and IL-1alpha-889 were significantly more at risk for severe periodontitis with OR of 51.42.
23239492 TiO NPs are potent inducers and regulators of MMP-1 expression and activity, partly via an IL-1beta-dependent mechanism.
23237500 The total mole fraction of unelongated xylose residues per aggrecan was significantly less (p = 0.03) after IL-1beta treatment compared to control cultures.
23233369 Our findings indicate that TNFalpha and IL-1beta modulate the expression of CCL3 in nucleus pulposis cells by controlling the activation of MAPK, NF-kappaB, and C/EBPbeta signaling.
23229544 findings suggest that DUSP14 negatively regulates TNF- or IL-1-induced NF-kappaB activation by dephosphorylating TAK1 at Thr-187
23226468 Monocyte/macrophage-expressed A1PI-M antagonizes IL-1beta secretion possibly via caspase-1 inhibition.
23226210 Chronic IL-1beta overproduction in the skin of NOMID patients results in the deregulated genes and pathways leading to "adaptive" mechanisms to control inflammation and maintain tissue homeostasis.
23220433 Studies indicate evidence for association between interleukin-1beta C (3953/4)T polymorphism and chronic periodontitis (CP).
23217179 The IL1B gene -5839C > T and IL4R 1902A > G polymorphisms and IL12RB1 -1094A/-641C and TNF -1031 T/-863A/-857 T/-308 G/-238 G haplotypes were associated with malaria susceptibility.
23216199 Women carriers of the 1-2-1-1 haplotype [IL-1A(rs1800587) - IL-1B(rs1143634) - IL-1B(rs16944) - IL-1RN(VNTR)] had sixfold lower risk to develop knee osteoarthritis.
23215728 genetic polymorphism is associated with lymph node metastasis in Korean patients with papillary thyroid carcinoma
23215648 Modulation of the release of inflammatory IL-1beta by activated peritoneal macrophages of tumor necrosois factor (TNF)-transgenic mice is examined after exposure to distinct low and intermediate doses of X-ray.
23210983 These preliminary findings indicate a key role of IL-1 in the hepatitis b virus-mediated disease chronicity, in the Indian population.
23209696 Ehx plays a crucial role in EHEC O157:H7-induced IL-1beta production and its cytotoxicity to THP-1 cells and activation of NLRP3 inflammasome
23209664 progesterone acts via GR to repress IL-1beta-driven COX-2 activation; p65 and PRB may have roles in the repression of progesterone driven gene expression, but not necessarily in progesterone repression of IL-1beta-induced COX-2 expression
23209411 Our studies thus define the NLRP3 inflammasome pathway and IL-1beta signaling as key features controlling WNV infection and immunity in the CNS
23209292 Deubiquitinases regulate the activity of caspase-1 and interleukin-1beta secretion via assembly of the inflammasome
23208827 Rage in rugby players was related to il1b. We propose the IL-1beta as a potential biological marker of anger.
23199001 The study of this study provided evidence that the rs1143627 C/T polymorphism of the IL1B gene may modulate regional spontaneous brain activity in amnestic mild cognitive impairment patients.
23195574 Results indicate that the ability to express IL-1beta and TNFalpha is linked to a cell type specific promoter structure, which is established during monocytic but not granulocytic differentiation.
23195019 Recipient IL-1 beta -511CC genotype or IL-1 beta -511C allele was associated with susceptibility to bacteremia within the first year after kidney transplantation.
23192617 We did not find any association between any of the IL-1B polymorphisms and colorectal cancer
23184659 Bacterial LPS enhances NLRP3 inflammasome components in endometrial cells and induces Il-1beta secretion.
23181791 Our study demonstrates that eosinophils can enhance the production of IL-17A in activated CD4+ T lymphocytes through the release of IL-1ss.
23169178 Report synergistic effect of IL-1beta and TNF-alpha polymorphisms on the H. pylori-related gastric pre-malignant disease.
23110185 Data indicate that IL-1beta, TNFalpha and IL-8 seem to be involved in the enhanced release of neutrophil extracellular traps (NETs) in systemic inflammatory response syndrome (SIRS) subjects.
23105097 Study concludes that IL-1beta regulates FoxO1 activity through a novel neutral sphingomyelinase 2 -dependent pathway.
23079713 The IL-1beta -511C/T polymorphism might be associated with Alzheimer's disease risk.
23065753 IL-1beta-mediated anti-tumour effects depend on infiltrated immunostimulatory neutrophils
23062767 A high simvastatin dose or the combination of a low-dose simvastatin with ezetimibe reduce to a similar extent TLR2, TLR4 membrane expression and LPS-induced IL-6 and IL-1beta production in monocytes of hypercholesterolemic patients.
23052182 No association between common variants in the IL-1 region and multiple sclerosis risk was found in a meta-analysis.
23029154 This meta-analysis suggested that there were no associations between IL-1 gene cluster polymorphisms and CHD.
23020284 we found a significant relationship between IL-1B genetic polymorphism and the gastric mucosal IL-1b level. In addition, the risk of erosive esophagitis was related to the low gastric mucosal IL-1b level.
23018032 RPA and ELISA data showed that alloferon decreased the production of UVB-induced pro-inflammatory cytokines, such as IL-1alpha, IL-1beta, IL-6 and IL-18, both on the mRNA and protein level.
23013363 Polymorphisms in the IL-1beta -511 and IL-1beta +3953 loci were assessed for evidence of association with SSNHL.
23009887 Data indicate that SNP (rs452204) in the IL1RN gene was significantly associated with higher levels of IL-2 secretion, and IL12RB2 SNP rs3790567 was associated with a decrease in IL-1beta secretion.
23006543 Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome is linked to dysregulated monocyte IL-1beta production.
22997256 The inability of renal parenchymal cells to secrete IL-1beta may explain why uromodulin remains immunologically inert inside the luminal compartment of the urinary tract.
22995155 IL-1beta serum concentrations allow the discrimination between atrophic thyroiditis and papillary thyroid cancer groups.
22960943 found an association between the rs1143634 C allele and higher serum IL1beta concentrations and a lower response to infliximab treatment in Crohn's disease.
22955577 human cementoblasts in vitro express increased levels of RANKL, in particular during the combination of inflammation and compression.
22951596 a lung cancer risk haplotype in the IL1B gene regulatory region is associated with increased expression of IL1B and increased lung cancer risk
22947907 IL-lbeta (C+3954T) polymorphism not considered as a marker of susceptibility to preeclampsia in Iranian population.
22946471 concentration in maternal plasma is an indicator of Group B Streptococcus status
22937208 Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta
22923190 The study suggested for the first time a role for epigenetic modifications in the regulation of the expression of IL1B, IL6, and IL8.
22911481 The IL-1beta (-511) G/A and the IL-10 (-1082) G/A genotype combination was found to be higher in patients with febrile seizure.And IL-1 beta production was not influenced by the single nucleotide polymorphisms in the pathogenesis of febrile seizures.
22909148 the placenta may contribute to the elevation in serum IL-1beta and IL-1Ra in preeclampsia by increased secretion of these cytokines into the maternal circulation, and that MgSO(4) is able to attenuate this increased secretion of IL-1beta, and possibly IL-1Ra
22904187 MARCH8-mediated polyubiquitination and degradation of IL1RAP is an important mechanism for negative regulation of IL-1beta-induced signaling pathways.
22902304 identified polymorphic markers in TNFalpha, IL10, IL1beta and TGFbeta1 genes to be associated with alcoholic liver disease in the Bengali population
22898394 Viable Aggregatibacter actinomycetemcomitans biofilms may disturb the critical first steps of local inflammation in periodontitis by binding and internalising IL-1beta.
22894561 There is no relationship between concentration of IL-1beta and the level of bone mineral density in menopausal women.
22884587 genetic association studies in population in Austria: Data suggest that an SNP in exon 5 of IL1B (rs1143634) is associated with risk reduction for preterm birth in Caucasian women; an SNP/mutation in IL1B promoter (rs16944) is not associated.
22884582 COX-2 level was significantly higher in cancer associated fibroblasts than that in normal fibroblasts with or without stimulation of IL-1beta.
22878044 IL-1beta could play a role in the pathogenesis of thyroid autoimmunity.
22869038 This study demonistrated that IL-1B is changed in the dorsolateral prefrontal cortex of individuals with schizophrenia
22829643 These findings suggest that IL-1beta, IL-1Ra, and granulocyte colony-stimulating factor are functional markers of EV71-related cardiac dysfunction.
22829602 The antagonistic actions of endogenous interleukin-1beta and 15-deoxy-Delta12,14-prostaglandin J2 regulate the temporal synthesis of matrix metalloproteinase-9 in sheared chondrocytes
22822059 Cyclooxygenase-2, not microsomal prostaglandin E synthase-1, is the mechanism for interleukin-1beta-induced prostaglandin E2 production and inhibition of insulin secretion in pancreatic islets
22818222 An essential role in the central nervous system is supported for IL-1beta in the central nervous system. New CCAAT enhancer-binding protein (C/EBP)beta functions in astrocytes are also identified.
22818022 Data indicate that IL-1beta [+3954 C>T (rs1143634)], IL-6 [-174 G>C (rs1800795)] and IL-10 [-1082 A>G (rs1800896)] were associated with breast cancer risk.
22815289 Use of a ratiometric biosensor allows monitoring of IL-1beta processing in real time, as well as a kinetic study of inflammasome activity in individual living macrophages.
22811570 Human chorionic gonadotropin triggers angiogenesis via the modulation of endometrial stromal cell responsiveness to interleukin 1.
22808497 carriers of -31TT/+3954CT genotype were characterized by low IL-1beta stimulation index in response to mitogen in comparison with carriers of other genotype combinations
22805115 Data indicate that children exposed to secondhand smoke had lower concentrations of IL-1beta, IL-4, IL-5, and IFN-gamma than those with no exposure.
22804923 The results of this study supported that IL1B contributes to the genetic risk of schizophrenia.
22796605 IL-1B & TGFB3 synergistically activated MMP)-1, MMP-3,& MMP-10 gene expression in NSCLC cells via MAPK-dependent pathways. Consistent with this, both cytokines stimulated epithelial to mesenchymal transition and MAPK-dependent invasion
22796220 the phagocytosis of ox-LDL can induce human macrophages to secrete IL-1beta by activating the NLRP3 inflammasome.
22796164 endogenous IL-1beta play a role in elastin gene upregulation and this upregulation is mediated by the Ras-ERK1/2 pathway in 3D cultures
22795647 Simultaneous stimulation of monocyte-derived DCs resulted in highly increased production of IL-1beta, IL-23 and SOCS2
22795101 In this series, we observed that polymorphisms of the IL-1b gene do not play a major role in the development of preeclampsia in the Taiwanese women.
22791816 Stromal cell and colonocyte EGFRs are required for robust EGFR signals and efficient tumor growth, which involve EGFR-interleukin-1 crosstalk.
22768033 Genetic variation in the promoter region of IL1B may not be associated with incident acute coronary syndrome in men or women above the age of 50 years.
22764136 up-regulation of L1CAM augmented expression of IL-1beta and NF-kappaB activation.
22763186 findings support a role for IL1B variability in the dorsolateral prefrontal cortex dysfunction classically associated with schizophrenia.
22763042 Data show in pulmonary microvascular endothelial cells (HPMECs), unfractionated heparin (UFH) significantly attenuated LPS-induced production of IL-1beta, IL-6, E-selectin and ICAM-1, as well as phosphorylation of p38 MAPK and NF-kappaB translocation.
22759516 meta-analysis suggests that there was no evidence of a significant association between IL-1beta -511 C/T polymorphism and duodenal ulcer with or without Helicobacter pylori infection
22750393 beta-carotene reverses the IL-1beta-mediated reduction in paraoxonase-1 expression via induction of the CaMKKII pathway in human endothelial cells
22739237 the microenvironment at the verge between inflammation (IL-1beta) and tissue remodeling (TGFbeta2) can strongly promote the process of EndMT.
22738689 Three genes, MMP9, IL1B, and SOD2 were down regulated in all the 3 ethnic groups making them potential biomarker candidates for CAD across all three ethnicities.
22727020 Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta
22714811 Our results indicate that the IL-1beta -511 C/C and C/T gene polymorphisms are associated with chronic gastritis and gastric cancer development in H. pylori-infected individuals.
22710193 data suggest that interleukin-1beta directly promotes trophoblast motility of first trimester extravillous trophoblasts
22708826 This study demonistrated that the expression of proinflammatory cytokine IL-1beta and posttranscriptional inflammation-associated miR-146a is variable depending on the disease stage in children with mesial temporal lobe epilepsy.
22673037 Data indicate that heritabilities were moderate for IL-1beta (range: 0.27-0.32) and IL-10 (0.30) and low for IL-6 (range: 0.15-0.16) and TNF-alpha (range: 0.17-0.23).
22649552 Our data do not support the hypothesis that increased IL-1beta production in cystic fibrosis subjects is due to an intrinsic increase in NF-kappaB activity through loss of CFTR function.
22629855 Effect of myelopeptides on reactive oxygen species generation and IL-1beta and TNF-alpha production by peripheral blood cells
22629474 These data suggest that IL-1beta possibly is a key player determining the severity of the disease in diffuse cutaneous leishmaniasis patients.
22622830 A review of interleukin-1beta (IL-1beta) gene polymorphisms, changes of IL-1beta levels and the putative role of IL-1beta in the generation of febrile seizures.
22621214 subjects homozygous for the IL1B gene have a two times increased risk of post-orthodontic external apical root resorption in root filled teeth
22621205 proinflammatory cytokines, such as IL-1beta and TNF, influence the presence and rhythm of molecular clocks
22596214 IL-1beta measurement in LPS-stimulated WBC is useful to predict responsiveness to anti-TNF agents.
22580886 This study did not reveal sufficient evidence for a significant association of the investigated IL-1beta polymorphisms with asbestos or silica-induced diseases in the population studied.
22569251 Data suggest differential usage of IKK subunits in activation of NFkappaB in pancreatic beta cells; TNFalpha uses both IKK-alpha and IKK-beta, IL-1beta uses IKK-alpha only (by induction of IKK-beta degradation via proteasomes).
22568934 functional variant of the gene contributes to the susceptibility to prosthetic joint infection
22547706 IL-1beta is important for neutrophil-mediated host immunity against Klebsiella pneumoniae infection in the lung, consistent with findings showing requirement of IL-1 receptor activation in host immunity against systemic infections.
22545750 low doses of X-rays induce an anti-inflammatory phenotype of activated macrophages by lowering the amount of secreted IL-1beta in a NF-kappaB dependent manner
22540426 A functional polymorphism in the promoter region of the IL1B gene is associated with risk of multiple myeloma.
22537218 higher secretion by peritoneal macrophages in endometriosis
22513786 IL-1beta contributes to psoriasis by dual effects. First, it induces insulin resistance through p38MAPK (mitogen-activated protein kinase), which blocks insulin-dependent differentiation of keratinocytes, and at the same time IL-1beta drives proliferation of keratinocytes, both being hallmarks of psoriasis.
22503230 Microbial keratitis were less likely to occur in wearers with the nonmutated IL-6 haplotype; wearers carrying an IL-12B SNP had an increased risk of sterile keratitis compared with controls.
22498095 The results of this study suggested that there is a relevant role of IL-1 genes cluster in Alzheimer's disease pathogenesis in this Brazilian population.
22493010 IL-1beta release was detected after HRV infection in both BECs and brushed cells, but BzATP did not significantly increase IL-1beta release further
22487523 We have identified three potential invasive markers, uPA, MMP-1 and IL1-R1, whose gene expression may differentiate PDAC from other pancreatic neoplasms.
22481167 Serum levels of TNF-alpha, IL-1beta, and IL-6 do not correlate with involuntary weight loss but are associated with cancer.
22467534 the presence of a C allele at the -31 position may lead to decreased expression of the IL1B gene due to a specific binding of YY1 in lung epithelial cells.
22466287 findings demonstrate that by eliciting different cytokines C. albicans and S. aureus prime TH17 cells that produce either IFN-gamma or IL-10, and identify IL-1beta and IL-2 as pro- and anti-inflammatory regulators of TH17 cells both at priming and in the effector phase
22455686 Polycystic ovarian syndrome patients who carried T allele of IL-1beta gene promoter region (-511) and V allele of IL-1ra gene were high risk of obesity.
22449968 Results describe an important role of KLF4 in regulating expression of IL-1beta.
22425785 The molecular mechanism that controls TssRII fate in IL-1ss treated cells, was investigated.
22425603 IL-1B gene polymorphism affects the modulation of serum oxLDL levels.
22417897 IL1beta-511C/T polymorphism might be moderately associated with increased risk of ischemic stroke.
22414649 high capsaicin consumption synergistically increased GC risk in genetically susceptible individuals il1b 31c alleles carriers infected with the more virulent H. pylori strains
22395218 IL-1beta -511 polymorphism is associated with severe veno-occlusive disease in pediatric-matched allogeneic hematopoietic stem cell transplantation
22389405 S. dysenteriae-induced expression of interleukin-1beta upregulates MUC2 expression and the differential expression of MUC5AC.
22386525 higher plasma concentrations are associated with depression score in pregnant African-American women
22384091 analysis of shear stress modulation of IL-1beta-induced E-selectin expression in human endothelial cells
22384041 Interleukin-1 stimulates ADAM17 through a mechanism independent of its cytoplasmic domain or phosphorylation at threonine 735
22382666 IL-1beta levels was two times lower in triathletes than in cyclists (p < 0.05) and IL-1beta levels were lower in cyclists than in recreational athletes
22371121 the present study demonstrates the functional role of inflammatory cytokine IL-1beta to stimulate peripheral blood endothelial progenitor cmigration, adhesion, and proliferation functions and positively modulate the VEGF-A level
22349547 human primary cementoblasts subjected to compression and IL-1beta stimulation impeded BSP and CEMP-1 expression, proteins that are associated with cementogenesis.
22348697 IL1A and IL1B genetic variations are significant contributors to chronic periodontitis in whites
22344672 The presence of the IL-1B 3954 gene polymorphism does not appear to be a risk factor for chronic periodontal disease.
22341060 The development of EARR in subjects with root-filled teeth who undergo orthodontic treatment might be attributable to genetic variations in the interleukin-1beta gene (rs1143634).
22340390 Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta
22312160 None of the single nucleotide polymorphisms showed an association with anklyosing spondyloarthritis.
22311026 IL-1beta polymorphisms are susecptibility factors for visceral leishamaniasis.
22286731 There is a possible heterogeneity in the association of IL-1B gene polymorphism with cancer, in populations of similar ethnic background and settled in the same risk area.
22285242 There is no significant association between the risk of recurrent pregnancy loss and IL1B gene variants.
22280559 There was no synergy between Streptococcus agalactiae and Escherichia coli for inducing the secretion of inflammatory factors IL-1beta, TNFalpha or degradative metalloproteinase proMMP-9; thus these two bacteria could initiate different pathways to induce chorioamnioitis.
22275254 During an acute attack of multiple sclerosis, inflammation increases brain IL-1beta signaling, which enhances in turn glutamate-mediated synaptic excitability and neurotoxicity.
22267217 dectin-1 acted as an extracellular sensor for pathogens that induced both IL-1beta production and maturation through a noncanonical caspase-8-dependent inflammasome for protective immunity
22266275 this is the first study that demonstrates association between TNFalpha 1031 T/C and IL1beta 511 C/T polymorphisms and cerebral palsy in very preterm infants.
22251538 The genetic polymorphisms of IL-1ss-2023 C allele, IL- 1RAcP -8261 T allele and -8183 A allele are probable host factors for persistent HBV infection.
22227487 Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects. Polymorphism in IL1B was significantly associated to the HIV-1 infection.
22195044 These findings document for the first time that activation of neutrophils in gout is associated with the formation of proinflammatory neutrophil extracellular traps and links this process to both autophagy and IL-1beta.
22183425 Serum levels of TNF-alpha and IL-1beta in patients with mild preeclampsia were similar to those in the control group.
22178859 IL-1beta-induced CXCL10 protein expression in astrocytes was potentiated by co-exposure to alpha-synuclein
22173128 Data suggest that c-kit is an important regulator of IL-1 receptor 1/IL-1beta signaling and effector functions in mast cells; such signaling is IL-relevant for IL-6 release.
22172512 RANKL induced large resorption pits (10,876 +/- 2190mum(2)) whereas TNF-alpha/IL-1 and LIGHT generated smaller pits (respectively 1328 +/- 210 and 1267 +/- 173mum(2))
22160471 The results show a significant association between IL-1beta -511 C/T gene polymorphism and febrile seizures.
22155307 The inhibition of nuclear factor-kappaB activation induced by IL-1beta in osteoarthritis (OA) osteoblasts may contribute to some of the heme oxygenase-1 effects.
22154780 Low values of intracellular pH enhance the production of IL-1beta, at least in part, by stimulating the synthesis of its precursor.
22128229 Single nucleotide polymorphisms rs1143634 of IL-1beta and rs8192284 of IL-6 receptor act as susceptibility variations in Korean non-Sjogren dry eye patients.
22126705 Elevated cerebrospinal fluid and serum concentrations of interleukin (IL)-8, but not IL-1beta, are reported in fibromyalgia patients.
22125454 inflammasome is an important innate immune pathway that regulates at least two host responses protective against infections: (1) secretion of the proinflammatory cytokines IL-1beta and IL-18 and (2) induction of pyroptosis, a form of cell death
22124068 Association was not found for the effect of allele, genotype, composite genotype, and haplotypes of IL-1B+3954 polymorphism with periodontitis. Its utility as a risk marker in this population was not borne out by the study.
22108531 p65-Dependent production of interleukin-1beta by osteolytic prostate cancer cells causes an induction of chemokine expression in osteoblasts.
22103356 findings show PSA production and proliferation of LNCaP prostate cancer cells were down-regulated by NF-kappaB mediated by IL-1beta promoting anti-apoptotic signalling and co-suppressor factors of PSA expression
22101739 A molecular understanding of the interactions of apoE4 with Abeta, nitric oxide and IL-1beta on the regulation of the COX-2/prostaglandin pathway may open new avenues in understanding the mechanism of development of neurodegenerative disease.
22095718 Inhibition of IL-1beta signaling provides disease-modifying benefits in an Alzheimer's disease (AD) transgenic mouse model; the IL-1 signaling cascade may be a key mechanism for AD.
22092925 The alleles 1 and 2 of IL1A gene and the alleles 1 and 2 of IL1B gene were statistically associated with the success or no success of the dental implants.
22073367 lumican and fibromodulin display different behaviors and that lumican may promote regeneration of the TMJ after degeneration and deformation induced by IL-1 beta.
22073249 investigate the relationship between host (mucin) and pathogen interaction, including Shigella induced expression of MUC2 and IL-1beta during shigellosis
22072054 genetic polymorphism is associated with increased myocardial infarction risk
22071871 IL-1beta regulates neurogenesis by inhibition of the kynurenine pathway, which may provide a new therapy to revert inflammatory-induced reduction in neurogenesis.
22068351 serum levels of IL1-beta in Kashin-Beck disease were increased compared with healthy controls, but the increase was not correlated with disease severity.
22065068 Sp1 transcription factor partly mediates IL-1 induction of ADAMTS-4.
22064385 Data suggest that IL-1beta facilitates progesterone metabolism in cervical fibroblasts by regulating expression of aldo-keto reductases AKR1C1 and AKR1C2.
22059992 study showed that variation in the IL1RN associates with susceptibility to idiopathic pulmonary fibrosis (IPF); the subsequent imbalance between IL-1beta and IL-1Ra might have a significant pathogenetic effect in IPF patients
22027397 Data show that in HIV-1-infected astrocytes, IL-1beta-induced increases in CD38 levels were regulated through the MAPK signaling pathway and by the transcription factor NF-kappaB.
22023756 Interleukin-1beta released during an immune response acts as messenger that helps to modulate behaviour by influencing relevant neurotransmitter systems, and in some cases, by directly acting within the brain.
22021895 Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta
22019906 secretion of IL-1beta occurs on a continuum, dependent upon stimulus strength and the extracellular IL-1beta requirement
22010855 IL-1beta polymorphisms are risk factors in the pathogenesis of recurrent spontaneous abortion in the Chinese Han population.
22003203 IL-1beta and IL-23 are identified as critical factors in the generation of egg antigen-specific transgenic T helper (Th)17 cells involved in the pathogenesis of severe schistosomiasis.
21994456 These results indicate that the V protein of measles virus suppresses NLRP3 inflammasome-mediated IL-1beta secretion by directly or indirectly interacting with NLRP3.
21992747 Significant differences were found in the response to induced ketosis among non-carriers of putative gain-of-function polymorphisms in rs1143627 and rs16944 in the IL-1beta gene and among variants of the polymorphism rs2251101 in the insulysin gene.
21988351 Carriers of -511/+3954 CTCT are at risk of developing functional pancreatic neuroendocrine tumors (pNETs) (p=0.006) and carriers of -511/+3954 CTCC are at risk of developing nonfunctional pNETs.
21978003 Data show that the modulation of both TNF-alpha and IL-1beta production by autophagy was induced at the level of gene transcription.
21968104 study evaluated genetic variation in genes encoding IL1A, IL1B and IL1RN with repeated measures of global cognition and processing speed; results provide evidence that genetic variants in IL1 genes may be involved in inflammatory-related lowered cognition
21962386 IL-1F10.3 and IL-1A+889 polymorphisms are associated with the development of ankylos-ing spondylitis in Europeans but not in Asians.
21949132 in nucleus pulposus, TNF-alpha and IL-1beta regulate SDC4 expression, which plays a key role in pathogenesis of degenerative disc disease by promoting aggrecan degradation by ADAMTS-5.
21948112 Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta
21940680 Hemorrhagic shock, via HMGB1, activates interleukin (IL)-1beta release at an early stage following inflammatory stimulation and resuscitation in transgenic mice.
21935932 Macrophage accumulation in adipose tissue has a central role in stimulating matrix metalloproteinase 1 and 3 production by preadipocytes, and this is partially mediated by IL-1beta via activation of the MAPK and NF-kappa B signaling pathways.
21923858 The activation of platelets with anti-HLA Class I alloantibody caused the formation of platelet-monocyte aggregates, followed by the production of IL-1beta and IL-8.
21914069 The authors showed that the precursor form of the precore protein, p25, inhibits NF-kappaB activation by up to 30% and the cytosolic form, p22, inhibits NF-kappaB activation by 70% in PH5CH8 cells stimulated with IL-1beta.
21898353 DDAH-2 could play an important role in IL-1beta-induced NO production and in osteoarthritis pathogenesis.
21878622 Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta8 through altering chromatin architecture.
21878338 Results show that cryopreservation of monocytes or iDCs leads to an impaired cytokine response for IL-10, TNF-alpha, IL-12p70 and IL-1beta.
21871094 HMGB1 in complex with lipopolysaccharide, IL-1alpha or IL-1beta boosted proinflammatory cytokine- and matrix metalloproteinase production in synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients
21866808 An association between more pronounced inflammation of gastric mucosa with the T allele of interleukin-1beta C -511 C > T gene polymorphous locus (Chi2 = 14.006; p = 0.001).
21862584 Mutation of HuR Thr-118 reduced the association between HuR and cPLA(2)alpha mRNA under IL-1beta treatment
21854541 Recombinant human OSM and native OSM secreted by human granulocytes both reduced the gene expression and secretion of IL-1beta and CXCL8, but increased that of IL-6 and CCL2.
21843369 IL-1beta gene polymorphism rs1143633 is associated with schizophrenia susceptibility in a Japanese population.
21840356 data suggest that allele (-31)C of IL1B may be a risk factor for hypertension in the Polish population with CAD in the western Pomeranian region of Poland
21837414 Carriers of the CC genotype of IL-1beta (+3953 T/C) polymorphisms are more frequent among patients with lumbar disc herniation, suggesting a potential role of IL-1beta in its pathogenesis.
21819478 IFN-gamma, IL-1beta, and IL-2 were elevated in the early-pregnancy mothers whose children developed presistent islet autoantibodies, type 1 diabetes, or both before 7 years of age.
21811191 This suggests that IL1B exerts an influence on left ventricular systolic dysfunction through its effect on IL-1beta secretion.
21804018 the results obtained demonstrate for the first time that IRAK1 and PKCdelta functionally interact to regulate IL-1beta production in monocytic cells
21784976 latter property is associated with decreased caspase-1-dependent IL-1beta maturation in the BCG-infected macrophages
21776298 study of IL-1 beta, IL-6 and TNF alpha blood dynamics, offers valuable information about the severity of a systemic inflammatory response syndrome in peritonitis.
21771656 cPLA(2)alpha gene activation by IL-1beta is dependent on an upstream kinase pathway, enzymatic activation and downstream 15-lipoxygenase activity: a positive feedback loop
21768915 This study suggested that functional polymorphisms within the IL-1B gene are associated with Brain arteriovenous malformations and influence the clinical characteristics of the disease.
21762900 COX-2 and IL-1beta regulate the invasion ability of ectopicendometrioma derived ectopic endometrial mesenchymal stem cells.
21762124 While interleukin (IL)-1beta plays an important role in combating the invading pathogen as part of the innate immune response, its dysregulation is responsible for a number of autoinflammatory disorders. (Review)
21732076 (IL)-1beta down-regulated ADAMTS-13 mRNA expression in cultured human astroglioma cells & microglial cells.
21731057 IL1B is a modifier gene of cystic fibrosis disease.
21728024 The emerging role of interleukin-1beta in autoinflammatory diseases.
21726461 results suggest that genetic variations in the IL-1b gene contribute to the HPA axis alteration ssessed by DST-Cortisol in healthy subjects.
21717421 increased leukocyte expression of IL-1beta identifies a subset of patients with osteoarthritis who have increased pain and are at higher risk of radiographic progression of osteoarthritis.
21712624 association between carriage of IL-1 rare alleles and periodontitis differed between Down and non-Down subjects. carriage of IL-1 rare alleles in Down subjects tended to confer protective effect against loss of periodontal attachment.
21708940 NSMase-2- and PP2A-dependent regulation of IRAK-1 degradation is a novel mechanism to fine tune the magnitude of IL-1beta response.
21700772 monocytic microparticles contain IL-1beta and may amplify inflammation by enhancing the activation of the endothelium and expression of cell adhesion molecules
21697093 IL-1beta induces dedifferentiation of articular chondrocytes by up-regulation of SIRT1 activity enhanced by both NAMPT and ERK signaling.
21688665 concentration of IL-1beta, INF-gamma, TNF-alpha, S100beta, AMA-M2 increase, IL-10 decrease were detected in peripheral blood of 25 patients with stroke
21687998 anti-inflammatory protein solution blocks the effect of IL-1beta on human macrophages
21682548 Data indicate that in fetal term and preterm groups, TNFalpha -238G/A, TNFalpha -308G/A, IL-1alpha 4845G/T, and IL-1beta -511G/T polymorphisms were statistically significant.
21671260 hip osteoarthritis in Croatian population might have a different genetic risk regarding the IL1 locus
21664353 Tumor-produced, active interleukin-1beta regulates gene expression in carcinoma-associated fibroblasts
21659743 Compared with patients without peritonitis, the carriage of C allele in IL-1beta gene polymorphism (C/C and C/T genotypes) was significantly associated with the occurrence of peritonitis (p = 0.013).
21659536 Stimulation of yeast telomerase activity by the ever shorter telomere 3 (Est3) subunit is dependent on direct interaction with the catalytic protein Est2.
21653279 IL1B -31C allele is a low-penetrance protective factor for the development of cancer, in particular for that associated with infection.
21637346 The deregulated secretion of IL-1beta secondary to mutations in NLRP3 could affect the IL-23/IL-17 axis.
21628463 Inflammasome activation by bacterial DNA is not modulated by redox responses, suggesting that redox-dependent regulation of IL-1beta secretion is restricted to some inflammasomes including NLRP3 but excluding AIM-2
21623995 Serum IL-6, IL-1beta and hCG levels were significantly increased in women with pre-eclampsia compared to controls.
21621860 IL1B-511 TT genotype is associated with later occurrence of multiple sclerosis but faster progression of disability. progression.
21614008 Results suggest that IL-1beta gene variation may have a role in cognitive functions in aging females as well as males.
21611201 Silencing of SFRS3 increased IL-1beta secretion due to elevation of IL-1beta and caspase-1 mRNA in addition to active caspase-1 levels.
21604462 IL-1beta gene 31CC genotype may be an independent risk factor with chronic rhinosinusitis.
21585612 Children with IL-1B-511TT/-31CC have a risk to develop severe gastric mucosal histological changes in South China.
21572958 IL-1ss and lactoferrin are biomarkers for sexually transmitted diseases/colonizations providing insights into immune responses and pathogenesis at genital tract mucosal site.
21571945 Primary human monocytes, a human monocytic cell line, and monocyte-derived macrophages are useful for measuring expression of proinflammatory mediator IL-1beta responding to lipopolysaccharide with or without alpha1-adrenergic receptor activation.
21535449 melatonin dramatically improved IL-1beta-induced Rac inactivation
21523343 A significant association of the IL1 gene cluster (IL1B-IL1RN) with severe knee osteoarthritis was not found.
21509504 No difference was found by a cross-sectional approach comparing IL-1alpha rs1800587, IL-1beta rs3087258 and TNF-alpha rs1799724 genotypic and allelic frequencies between those affected and not affected by dementia.
21496483 Even after exclusion of depressed individuals neither the SNPs nor the mRNA IL1beta and IL6R expression levels were associated with chronic or persistent fatigue in breast cancer survivors.
21486440 Findings suggest that the coordinated expression of CCL2 & CCL5 and TNFalpha & IL-1beta may be important for disease course.
21484857 IL-1beta produced by bursal syvoviocytes and inflammatory cells in the human subacromial bursa is an important signal in the inflammatory response that occurs in subacromial bursitis and rotator cuff disease.
21465264 Data suggest that genotype T/T at -31 and genotype C/C at -511 in the interleukin-1beta promoter are associated with major recurrent depression.
21449691 The IL-1-polymorphism is associated with lower number of teeth in non-smokers with untreated periodontal disease
21445336 Pro-inflammatory cytokine IL1B repress gastrin expression by activating Smad 7 and subsequent inhibition of nuclear localization of Smad 3/4 complex. Polymorphic promoter variants of IL1B gene can modulate the IL1B expression which
21440944 Acute otitis media severity is associated with interleukin-1-beta gene polymorphism.
21433061 IL-1beta can favor osteoclastogenesis by altering the phenotypic characteristics of the supporting periodontal ligament fibroblasts
21431944 Sustained elevation of serum and/or synovial levels of IL-33 may account for a poor response to TNF inhibitors via persistent Il-1 beta signaling.
21430222 Traf6 couples MyD88 to the Akt pathway and, remarkably, a Traf6 interacting peptide-antennapedia chimera was more effective than LPS in stimulating IL-1beta splicing
21427492 flap surgery has a significant effect on decreasing IL-1beta concentration in the gingival crevicular fluid of patients with moderate to severe chronic periodontitis.
21424904 Results suggest that plasma IL-1beta level and IL-1beta C-511T polymorphism may be considered as candidate biomarkers for cervical cancer in Egyptian women.
21421008 This review discusses the role of the NLRP3 inflammasome and its associated inflammatory mediators IL-1beta and IL-18 in the pathogenesis of asthma and chronic obstructive pulmonary disease.
21419289 significant difference in distribution of polymorphic genotype among cases (70.6%) and controls (24.6%) was shown. findings suggest specific genetic markers associated with increased IL-1beta production may contribute to increased susceptibility to PAP.
21418526 polymorphisms in IL-1beta gene may affect host susceptibility to BD.
21414132 There was no correlation between the concentration of IL-1beta and IL-6 in the crevicular sulcular fluid present in healthy or diseased osseointegrated implants in comparison with healthy teeth.
21411094 IL-1 beta has a role in atherosclerosis and cardiovascular disease
21403867 Both IL-1beta and TNF-alpha regulate NGAL expression in polymorphonuclear granulocytes of chronic hemodialysis patients.
21400614 These results indicated the first evidence that the genetic polymorphisms of IL-1beta and TNF-alpha may be involved in DNA methylation in nonneoplastic human gastric mucosa.
21394384 Data show that weight loss led to a significant reduction in liver IL-1beta, IL-18 and IL-1Ra expression, whereas hepatic IL-37 expression remained stable, adipose/liver NLRP3 inflammasome and IL-1alpha expression were not affected by weight loss.
21385879 Varicella-zoster virus infection triggers formation of an interleukin-1beta (IL-1beta)-processing inflammasome complex.
21385549 Letter: No association between interleukin-1 beta gene polymorphism and biopsy-proven erythema nodosum.
21380730 The association of TNF-alpha G308A and IL-1beta (+3953) C/T polymorphism with myocardial infarction in Turkish population, was studied.
21368235 Substance P- and hemokinin-1-stimulated monocytes potentiate T helper type (Th)17 cell generation in vitro through IL-1beta, IL-23, and tumor necrosis factor-like (TNF)1A expression.
21366387 MEFV E148Q polymorphism has no effect on IL-1beta in Henoch-Schonlein purpura.
21323660 Data indicate that down-regulation of TLR-4-mediated IL-1beta, IL-6, TNF-alpha, interferon (IFN)-gamma and IL-10 production in summer was observed compared to winter.
21311438 The study demonstrated a correlation between high frequency of genetic polymorphism in IL-1alpha -899 and IL-1beta +3953 loci and development of severe periodontitis among patients less than 35 years of age.
21307135 inflammatory genes may regulate fasting and postprandial lipids because the carriers of the minor allele of an IL1b gene variant have altered lipid metabolism
21288573 Significant structural and sequence differences occur in the terminal and some loop regions between human and chicken IL-1betas.
21276216 Both IL-1 and IL-4 are involved in the response of annulus fibrosus cells derived from nondegenerative tissue to 1.0-Hz cyclic tensile strain.
21266527 Cyst fluid levels of IL1beta can differentiate low- from high-risk intraductal papillary mucinous neoplasms of the pancreas
21265111 There is no evidence to support a relationship of IL-1B and IL-1RN polymorphism with risk of gastric cancer.
21251078 The borderline association of the study polymorphism with implant loss suggests further IL1 haplotype analysis to elucidate the global involvement of IL-1 proteins in the modulation of the osseointegration process.
21246243 IL-1beta-31CC, IL-1beta-511TT genotype, and TNF-alpha-857T carrier may have protective effect against gastric cancer progression.
21243433 The genotype CC or CT of IL-1B-31, TT or CT of IL-1B-511, and 2L of IL-1 receptor antagonist increased the risk of gastric cancer in the Chinese population and the risk was further enhanced by H. pylori infection.
21239716 After crystal stimulation, primary human monocytes and macrophages produce high concentrations of IL-1beta by activating the NLRP3 inflammasome.
21235388 the levels and cellular origin of IL-1 family members [IL-1alpha, IL-beta, and IL-1 receptor antagonist (IL-1ra)] in human testicular normal and abnormal biopsies with incomplete maturation arrest (IMA) or Sertoli only syndrome (SOS)
21228685 prevalence of Il-1 beta-31 allele was higher in multifocal atrophic gastritis than autoimmune gastritis
21217200 These data suggest that during phagocytosis of autophagic dying cells ATP, acting through its receptor, initiates K (+) efflux, inflammasome activation and secretion of IL-1beta.
21211511 the implication of H-Ras and NADPH oxidase-generated superoxide production in MMP-13 gene regulation by IL-1beta and TNF-alpha
21199393 IL-1 and IL-6 single nucleotide polymorphisms may not be a risk factor for susceptibility to MI in Turkish population.
21181220 Inflammatory synovitis in reactive arthritis (ReA)/undifferentiated spondyloarthropathy (uSpA) is mediated by pro-inflammatory cytokines like IL-17, IL-6, IL-1beta, and IL-21.
21181166 IL-1beta and TNF-alpha, induced the expression of IL-34 mRNA via JNK and p44/42 MAPK.
21178846 Results suggest maneuvers to diminish IL-6 production in the disc could provide some protection against the adverse effects of IL-1 and TNF-alpha, thus, helping preserve disc composition, structure, and function.
21173731 IL-1 beta expression in the arterial wall is comparable in primary and secondary lesions. Serum concentrations of IL-1 beta are independent of its arterial wall expression.
21173653 +3954 C>T polymorphism is not associated with preterm birth
21166654 These results indicate that IL-1beta-induced IL-6 production in A549 cells is mediated by both PI3K and IRAK4 and suggest that involvement of PI3K in the IL-1-induced IL-6 production is cell type specific.
21138659 Interleukin-1beta was higher in CSF of bipolar disorder patients than in healthy volunteers.
21133705 Significant differences between the sexes for the basic amounts of urinary IL-1alpha and IL-1beta were observed.
21107607 TNF-alpha-238 G/A, IL-1B-31 T/C, -511 C/T, and IL-10-1082 G/A polymorphisms were not detected to be related to the risk for hepatocellular carcinoma.
21088871 Report interleukin-1beta as the first known activator of endogenous ADP-ribosylation of eEF-2.
21086908 Observational study of gene-disease association. (HuGE Navigator)
21078560 Facultative heterochromatin (fHC) silences IL-1beta expression during sepsis.
21061265 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
21057224 study demonstrates the presence of nuclear proIL1beta in transformed mammary epithelial cells providing the first evidence that IL1beta may be a dual function cytokine
21054877 Observational study of gene-disease association. (HuGE Navigator)
21054222 The IL-1 genotype was not a risk indicator for early (slight) periodontitis as defined in this subject population.
21054222 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
21048327 Observational study of gene-disease association. (HuGE Navigator)
21048223 Data show that MEKK-1 plays an integral role in IL-1beta modulation of Caco-2 TJ barrier function by regulating the activation of the canonical NF-kappaB pathway and the MLCK gene.
21041296 RelA is cleaved by chlamydial protease-like activity factor (CPAF), which impairs proinflammatory signaling in cells infected with Chlamydiae; IL-1beta-dependent secretion of IL-8 is also reduced by CPAF expression
21037510 Observational study of gene-disease association. (HuGE Navigator)
21037509 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
21035110 Observational study of gene-disease association. (HuGE Navigator)
20979861 Expressions of IL-1beta, TNF-alpha and IgA in specimens of chronic prostatitis were significantly higher than those in non-prostatitis specimens.
20979650 In the southern Mexican population, the IL-1B -511C and -31T alleles and the -511C/-31T and -511T/-31T haplotypes are associated with increased risk of chronic gastritis and gastric ulcer.
20979650 Observational study of gene-disease association. (HuGE Navigator)
20975573 These results suggest that IL-1RN and IL-1B gene polymorphisms were associated with the development of ulcerative colitis (UC) and steorid dependence in UC in the Mexican Mestizo population.
20975573 Observational study of gene-disease association. (HuGE Navigator)
20965572 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20963558 genetic association studies: SNP in IL1B promoter (C[-511]T) is associated with polycystic ovary syndrome in Chinese women; SNP in exon 5 (C[+3953]T) is not
20963558 Observational study of gene-disease association. (HuGE Navigator)
20962853 EGFR and IL-1 signaling synergistically promote keratinocyte antimicrobial defenses in a differentiation-dependent manner.
20961668 Observational study of gene-disease association. (HuGE Navigator)
20959405 Observational study of gene-disease association. (HuGE Navigator)
20942594 Observational study of gene-disease association. (HuGE Navigator)
20942272 Observational study of gene-disease association. (HuGE Navigator)
20940514 These results suggest that the pathogenesis of osteoporosis is associated with IL-1beta (-511C/T) polymorphism in postmenopausal women.
20940514 Observational study of gene-disease association. (HuGE Navigator)
20936699 Up-regulation of matrix metalloproteinase-9 along with IL-1beta in the early course of Guillain-Barre syndrome appears to be associated with immune-mediated disease progression resulting from inflammation in the peripheral nervous system.
20935210 These results identify a homeostatic function of IL-1beta in suppressing early osteoclast precursors
20934730 The present results show that circulating IL-1beta and IL-6 concentrations are strongly and independently associated with gamma-GTP activity in middle-aged Japanese men without obvious cardiovascular diseases.
20934174 Observational study of gene-disease association. (HuGE Navigator)
20929277 increased serum levels in cryoglobulinemic patients with hepatitis C virus chronic infection
20890567 No significant differences were found between the genotype frequencies of the H. pylori-infected and the non-infected populations with one exception. The CC genotype in the -31 polymorphic region was associated with benign pathologies
20890567 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20889944 IL-1 plays a major role in regulating inflammatory mediator production in wounds through a novel mechanism; by stimulating the production of multiple cytokines and chemokines, it impacts clinically important aspects of wound biology.
20887233 Gentle level of cyclic mechanical stretch exerts a protective effect on rheumatoid arthritis-fibroblast-like synoviocytes as it downregulates the level of MMP-1 protease, COX-2, and proinflammatory PGE(2).
20880267 Further studies are warranted to clarify the role of the TNF-alpha-308GG/IL-1beta-511T+ combined genotype in this Italian population.
20880267 Observational study of gene-disease association. (HuGE Navigator)
20865400 IL-1beta-induced HIF-1alpha drives a HIF-1alpha-IL-1beta autocrine loop to maintain persistently elevated IL-1beta level.
20848793 rs16944 IL-1beta polymorphism is associated with Kashin-Beck disease.
20848793 Observational study of gene-disease association. (HuGE Navigator)
20848459 Observational study of gene-disease association. (HuGE Navigator)
20848209 1,25(OH)(2)D(3) strongly stimulated the production of interleukin-1beta (IL-1beta) in human monocyte-derived macrophages.
20841404 interleukin 1 beta (IL-1beta) may play a role in Andean protection from altitude-associated reductions in fetal growth
20812962 Activated CD4+ T cells can be stimulated by keratinocyte derived Il-1 beta to release high amounts of IL-17.
20811626 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20802483 the crystal structure of IL-1beta in complex with the ectodomains of IL-1RII and IL-1RAcP was determined.
20799933 In osteoarthritis synoviocytes, HMGB1 cooperates with IL-1beta to amplify the inflammatory response leading to the production of a number of cytokines, chemokines and MMPs
20731121 Influence of polyoxidonium on IL-1 beta, TNF-alpha and IL-6 production by mononuclears and monocytes under the dexamethasone effect
20729213 Inhibitors of MAPK pathway ERK1/2 or p38 prevent the IL-1{beta}-induced up-regulation of SRP72 autoantigen in Jurkat cells.
20724540 These results support a central role of the IL-1 network, which seemed to be overstimulated in Erdheim-Chester disease.
20711808 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20702408 CCAAT/Enhancer-binding protein {beta} and NF-{kappa}B mediate high level expression of chemokine genes CCL3 and CCL4 by human chondrocytes in response to IL-1{beta}.
20702406 Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta}.
20698171 Our results suggest a complex association between IL-1B gene polymorphism, H. pylori infection, and gastric secretion.
20697295 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20696775 These data demonstrate a phenotypic modulation role for IL-1 in the pathogenesis of squamous metaplasia
20690185 positive correlation between IL-1beta and VEGF/NGF/BDNF expression in intervertebral discs suggests that IL-1beta is generated during intervertebral disc degeneration
20685652 Nuclear S100A4 was bound to the promoter region of MMP-13 in IL-1beta-treated cells.
20673868 Observational study of gene-disease association. (HuGE Navigator)
20671275 IL1B polymorphisms and the association of Graves Disease and Graves ophthalmopathy with plasma IL1beta levels show that IL1B polymorphisms may be associated with the development of GD and GO.
20671275 Observational study of gene-disease association. (HuGE Navigator)
20659236 Il-1beta genotype significantly influences the risk of reflux esophagitis in Taiwanese patients.
20659236 Observational study of gene-disease association. (HuGE Navigator)
20650788 Meta-analysis of gene-disease association. (HuGE Navigator)
20644561 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20639647 In this study, we found that the CC genotype of IL-1-beta C3593T was positively associated with the risk of premature rupture of membranes in preterm delivery, although this association did not achieve statistical significance.
20639647 Observational study of gene-disease association. (HuGE Navigator)
20631624 none of the major four IL1B polymorphisms (IL1B-3737C>T, -1464G>C, -511C>T, -31T>C) and the IL1RN*2 is individually, or in its haplotype configuration, linked to the presence of premalignant gastric lesions in Caucasians
20631624 Observational study of gene-disease association. (HuGE Navigator)
20628624 Meta-analysis of gene-disease association. (HuGE Navigator)
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20626741 Observational study of gene-disease association. (HuGE Navigator)
20625956 possible correlation between IL-1 polymorphism and periimplantitis [review]
20620944 dendritic cell derived IL-1beta preserves and expands IL-1R1(hi)IL-22(+)AHR(+) iNK cells, potentially influencing human mucosal innate immunity during infection.
20603871 Tensile strain and magnetic particle force application do not induce MAP3K8 and IL-1B differential gene expression in a similar manner to fluid shear stress in human mesenchymal stem cells.
20603050 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20603037 Observational study of gene-disease association. (HuGE Navigator)
20602615 Observational study of gene-disease association. (HuGE Navigator)
20596075 Data show that regulation of interleukin-1beta by interferon-gamma is different in humans and mice, is limited by suppressor of cytokine signalling 1 and influences interleukin-17 production.
20595916 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20594066 polymorphism at IL-1A(-889) and IL-1B(+3954) may affect outcomes of treatment for peri-implantitis in genotype-positive individuals
20594066 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20588114 Monotherapy or add-on therapy targeting IL-1beta in type 2 diabetes holds promise for long-term benefits in glycemic control and possibly reducing cardiovascular events.
20587610 Observational study of gene-disease association. (HuGE Navigator)
20585978 This work contributes to understanding of the complex interaction between H. pylori virulence factors and cytokine genotypes involved in gastrointestinal diseases.
20585978 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20581747 Interleukin 1 receptor antagonist gene polymorphism may affect the clinical course of lumbar nucleus pulposus herniation.
20574532 Observational study of gene-disease association. (HuGE Navigator)
20574123 genetic polymorphism contributes to gastric ulcer susceptibility upon H.pylori infections
20574123 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20568250 Observational study of gene-disease association. (HuGE Navigator)
20565898 the genomic region containing the IL1A and IL1B gene cluster influences primary open angle glaucoma pathogenesis mostly in non-high tension glaucoma patients in eastern India
20565898 Observational study of gene-disease association. (HuGE Navigator)
20565774 Observational study of genotype prevalence. (HuGE Navigator)
20564140 Observational study of gene-disease association. (HuGE Navigator)
20561568 No associations found between the SNPs of IL-1alpha-889, IL-1beta-511 and risk for PD.[meta-analysis]
20561568 Meta-analysis of gene-disease association. (HuGE Navigator)
20551628 common variants in five interleukin genes, IL1A, IL1B, IL1RN, IL6 and IL10, are not significantly associated ESRD in a white European population
20551628 Observational study of gene-disease association. (HuGE Navigator)
20536609 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20536507 Observational study of gene-disease association. (HuGE Navigator)
20535924 The Chinese herbal compound TCM could reduce the expression of TNF-alpha and IL-1 beta in the gingival crevicular fluid of patients with chronic periodontitis.
20534741 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20529668 The IL-1beta -31T allele was positively associated with a risk of NSCLC, and the carriers of IL-1beta -31T/T or -511C/C would have a higher risk of suffering from NSCLC if they drank alcohol or smoke heavily.
20529668 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20528961 Observational study of gene-disease association. (HuGE Navigator)
20522558 interleukin 1beta and tumor necrosis factors alpha and beta, but not transforming growth factors alpha and beta, strongly induced HA synthesis by NF-kappaB pathway, activating hyaluronan synthase 2
20518842 Observational study of gene-disease association. (HuGE Navigator)
20517696 The MMP-1, COX-2 and IL-1beta expression in synovium decreased depending upon the severity of knee osteoarthritis, while the TGF-beta expression increased.
20509889 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20503287 Observational study of gene-disease association. (HuGE Navigator)
20495422 Genetic variation in polymorphisms of the IL-1 cluster genes is not associated with aneurysmal subarachnoid cerebral hemorrhage; however, the IL-1ss gene may modify disease severity and may be regarded as a disease severity gene.
20495422 Observational study of gene-disease association. (HuGE Navigator)
20495003 Release of IL-1beta from monocytes showed selectivity for specific TLR agonists and was accelerated by P2X7 receptor activation.
20490891 Observational study of gene-disease association. (HuGE Navigator)
20490394 there is limited evidence to implicate a specific IL-1 genotype as risk factor for chronic periodontitis in white populations; limited evidence that genetic variation in IL-1B polymorphism could be a risk factor for aggressive periodontitis [review]
20486195 There was no significant difference between patients with febrile seizures and controls in the distribution of allele frequencies of the IL-1beta promoter, IL-1beta exon 5, IL-6 promoter, IL-8, IL-10, or TNF-alpha gene polymorphisms.
20486195 Observational study of gene-disease association. (HuGE Navigator)
20485444 Observational study of gene-disease association. (HuGE Navigator)
20484876 Meta-analysis of gene-disease association. (HuGE Navigator)
20484443 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20483667 The blockade of IL-1beta with anakinra and its effects on interleukin 8 (IL-8) levels and CD11b integrin expression in monocytes of type 1 diabetics are reported.
20482626 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
20478455 IL-1beta induced expression of SOCS-3 but not SOCS-2 in human PDL cells. IL-1beta simultaneously induced IL-8 and MCP-1 secretion in PDL cells, whereas SOCS-3 overexpression suppressed secretion of these chemokines.
20473875 Observational study of gene-disease association. (HuGE Navigator)
20472930 Observational study of gene-disease association. (HuGE Navigator)
20472558 IL-1-induced signaling through focal adhesions leading to MMP3 release and interactions between SHP-2 and PTPalpha are dependent on the integrity of the catalytic domains of PTPalpha.
20470442 All donors showed a response towards IL-1beta production, drawing special attention for its possible protective role in early innate immune responses to malaria
20468064 Observational study of gene-disease association. (HuGE Navigator)
20467172 The IL-1b -31 T allele and MMP-3 5A allele are cooperative risk factors for poor prognosis in HCC patients, suggesting that these gene polymorphisms might be potential markers for predicting the prognosis of HCC patients.
20467172 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20463618 Observational study of gene-disease association. (HuGE Navigator)
20453000 Observational study of gene-disease association. (HuGE Navigator)
20452482 Observational study of gene-disease association. (HuGE Navigator)
20447254 The IL-1beta/IL-10 ratio differed significantly among different subgingival biofilm profiles in aggressive periodontitis suggesting an imbalance between pro- and anti-inflammatory cytokines.
20445104 show in a large cohort of patients that IL-1beta secretion by cryopyrin-associated periodic syndromes monocytes is much faster than that by healthy monocytes.
20437198 The present meta-analysis suggests that Il-1beta rs1143627 is associated with breast cancer risk.
20437198 Meta-analysis of gene-disease association. (HuGE Navigator)
20431935 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20427258 results suggest that IL-1 alpha (-889), IL-1Ra and IL-1 beta (+3953) gene polymorphisms have no association with PD, while allele 1 (C) of IL-1 beta (-511) is associated with PD and provide a susceptibility factor for this disease in Turkish population
20427258 Observational study of gene-disease association. (HuGE Navigator)
20418110 Observational study of gene-disease association. (HuGE Navigator)
20417488 Observational study of gene-disease association. (HuGE Navigator)
20413850 Observational study of gene-disease association. (HuGE Navigator)
20405297 IL1B-511T/T allele is associated with enhanced hypermethylation of multiple CpG island loci, which might contribute to an increase in the risk for gastric cancer in individuals with H. pylori infection and IL1B-511T/T allele.
20405297 Observational study of gene-disease association. (HuGE Navigator)
20400062 Observational study of gene-disease association. (HuGE Navigator)
20399512 We found a positive association between nontuberculous mycobacterial lymphadenitis and +3953TT in IL1B.
20399512 Clinical trial of gene-disease association. (HuGE Navigator)
20399384 Observational study of gene-disease association. (HuGE Navigator)
20399210 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20388088 Observational study of gene-disease association. (HuGE Navigator)
20385987 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20380698 Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta
20378664 Observational study of gene-disease association. (HuGE Navigator)
20378615 Observational study of gene-disease association. (HuGE Navigator)
20376628 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20372910 Pulsed electromagnetic field irradiation does not alter the immunophenotype of the cultured fibroblast-like cell population but does provoke a decrease in the production of inflammatory-type cytokines (IL-1beta, TNF-alpha).
20369436 Results indicate that amniotic fluid IL-1beta and IL-10 were associated with interactions between pregnancy status and both maternal and fetal SNPs, with the most significant interactions being observed for African Americans with IL-1beta concentration.
20369436 Observational study of gene-disease association. (HuGE Navigator)
20364673 Association of mucosal inflammation with T allele in polymorphous C-511T locus of IL-1beta agA + strains of HP were more frequently identified in patients with erosive ulcerative defects of gastric mucosa than in children with superficial gastritis
20364673 Observational study of gene-disease association. (HuGE Navigator)
20363151 Observational study of genotype prevalence. (HuGE Navigator)
20353565 Observational study of gene-disease association. (HuGE Navigator)
20349753 Observational study of gene-disease association. (HuGE Navigator)
20347268 This study suggested the IL1B gene or the IL1 gene complex may play a moderate role in the etiology of schizophrenia in the Caucasian population.
20347268 Meta-analysis of gene-disease association. (HuGE Navigator)
20336759 The present study shows that TAT increases the production of IL-1beta in human monocytes.
20336759 Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta
20335539 Observational study of gene-disease association. (HuGE Navigator)
20334922 Data suggest that both TNF-alpha and IL-1 beta are downstream mediators and as single mediators play a limited role within the complex inflammatory reactions induced by E. coli.